Gs - DP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.9
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Polar TM2 S 59 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 S 59 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 59 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 138 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 138 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM2 Y 62 2x40 G.H5 L 393 G.H5.25
Polar H8 R 327 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 327 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 R 327 8x47 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 232 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 232 5x70 G.H5 R 385 G.H5.17
Polar TM3 S 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 137 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM1 L 41 1x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 138 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 138 34x51 G.H5 I 383 G.H5.15
Polar ICL2 R 141 34x54 G.h2s4 T 242 G.h2s4.05
Hydrophobic ICL2 P 137 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 137 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM2 F 61 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 F 61 2x39 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 138 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 L 225 5x63 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 232 5x70 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 P 236 5x74 G.H4 R 342 G.H4.12
Polar TM5 R 231 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 231 5x69 G.H5 Q 384 G.H5.16
Hydrophobic H8 P 329 8x49 G.H5 L 394 G.H5.26
Polar TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM1 L 40 1x56 G.H5 L 394 G.H5.26
Hydrophobic TM2 V 65 2x43 G.H5 L 393 G.H5.25
Polar TM3 S 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 H 387 G.H5.19
Polar ICL2 Y 140 34x53 G.H5 Q 390 G.H5.22
Polar ICL2 R 142 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term M 355 - G.hgh4 E 322 G.hgh4.12
Van-der-waals C-term M 355 - G.hgh4 E 322 G.hgh4.12
Aromatic ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Polar TM1 S 44 1x60 G.H5 L 393 G.H5.25
Van-der-waals TM1 S 44 1x60 G.H5 L 393 G.H5.25
Hydrophobic TM7 I 324 7x54 G.H5 L 394 G.H5.26
Van-der-waals TM7 I 324 7x54 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 137 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 134 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 228 5x66 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 228 5x66 G.H5 Q 384 G.H5.16
Polar TM6 L 258 6x28 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 258 6x28 G.H5 E 392 G.H5.24
Van-der-waals TM6 L 258 6x28 G.H5 E 392 G.H5.24
Ionic TM6 E 260 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 260 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 260 6x30 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 138 34x51 G.H5 C 379 G.H5.11
Polar TM6 H 263 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 263 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 H 263 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 P 257 6x27 G.H5 E 392 G.H5.24
Van-der-waals TM6 P 257 6x27 G.H5 E 392 G.H5.24
Hydrophobic TM6 H 263 6x33 G.H5 Y 391 G.H5.23
Hydrophobic H8 S 328 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 S 328 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM1 S 44 1x60 G.H5 L 394 G.H5.26
Aromatic TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Aromatic ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 235 5x73 G.S6 Y 360 G.S6.02
Hydrophobic ICL2 P 137 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 H 235 5x73 G.S6 P 361 G.S6.03
Van-der-waals TM5 H 235 5x73 G.S6 P 361 G.S6.03
Polar ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 P 236 5x74 G.H4 L 346 G.H4.16
Hydrophobic TM6 P 257 6x27 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM4 T 145 4x38 G.hns1 R 38 G.hns1.02
Polar TM5 M 228 5x66 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 228 5x66 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 228 5x66 G.H5 R 385 G.H5.17
Ionic TM5 R 231 5x69 G.H5 D 381 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 231 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 231 5x69 G.H5 D 381 G.H5.13
Polar TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 138 34x51 G.S3 F 219 G.S3.03
Ionic H8 R 332 8x52 G.H5 E 392 G.H5.24
Polar H8 R 332 8x52 G.H5 E 392 G.H5.24
Hydrophobic H8 R 332 8x52 G.H5 E 392 G.H5.24
Van-der-waals H8 R 332 8x52 G.H5 E 392 G.H5.24
Polar H8 R 332 8x52 G.H5 L 394 G.H5.26
Van-der-waals H8 R 332 8x52 G.H5 L 394 G.H5.26
Hydrophobic ICL2 R 142 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 M 228 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 M 228 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM5 S 238 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 S 238 5x76 G.h4s6 T 350 G.h4s6.03