G12 - EP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 R 228 5x69 G.H5 H 364 G.H5.09
Aromatic TM5 R 228 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 228 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM2 F 67 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 67 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 222 5x63 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 138 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Y 142 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 Y 142 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 E 258 6x29 G.H5 L 375 G.H5.20
Polar ICL2 V 148 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 148 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 F 315 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 315 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 142 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 Y 142 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 Y 144 34x53 G.H5 N 374 G.H5.19
Ionic ICL1 R 60 - G.H5 E 373 G.H5.18
Polar ICL1 R 60 - G.H5 E 373 G.H5.18
Hydrophobic TM3 I 138 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 375 G.H5.20
Polar TM1 R 49 1x60 G.H5 L 380 G.H5.25
Hydrophobic TM1 R 49 1x60 G.H5 L 380 G.H5.25
Van-der-waals TM1 R 49 1x60 G.H5 L 380 G.H5.25
Hydrophobic TM1 L 46 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 134 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 M 225 5x66 G.H5 L 371 G.H5.16
Polar ICL3 P 236 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 P 236 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 P 236 - G.H4 R 329 G.H4.09
Hydrophobic TM3 I 138 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM7 A 316 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 H 262 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 H 262 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 M 225 5x66 G.H5 Q 372 G.H5.17
Van-der-waals TM5 M 225 5x66 G.H5 Q 372 G.H5.17
Hydrophobic TM3 S 137 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM2 H 68 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 H 68 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 138 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 E 259 6x30 G.H5 L 375 G.H5.20
Hydrophobic H8 P 321 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 321 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 R 60 - G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL1 R 60 - G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 P 320 8x48 G.H5 M 379 G.H5.24
Polar TM3 S 137 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 E 258 6x29 G.H5 M 379 G.H5.24
Polar TM1 R 49 1x60 G.H5 Q 381 G.H5.26
Hydrophobic TM1 R 49 1x60 G.H5 Q 381 G.H5.26
Van-der-waals TM1 R 49 1x60 G.H5 Q 381 G.H5.26
Polar ICL2 Y 142 34x51 G.H5 F 363 G.H5.08
Aromatic ICL2 Y 142 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 Y 142 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 Y 142 34x51 G.H5 F 363 G.H5.08
Polar ICL2 Y 142 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Q 145 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 145 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 Y 142 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Y 142 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM4 S 149 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 141 34x50 G.H5 L 371 G.H5.16
Polar TM2 S 65 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 65 2x37 G.H5 D 377 G.H5.22
Polar ICL2 R 146 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 146 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 146 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 S 232 5x73 G.S6 H 348 G.S6.03
Polar TM5 R 233 5x74 G.h4s6 S 343 G.h4s6.12
Polar TM3 G 139 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 G 139 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Polar ICL2 Q 145 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 145 34x54 G.hns1 R 55 G.hns1.02
Ionic TM6 E 258 6x29 G.H5 K 376 G.H5.21
Polar TM6 E 258 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 E 258 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 E 258 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 H 262 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 262 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 238 - G.H4 R 329 G.H4.09
Polar TM5 S 232 5x73 G.S6 L 346 G.S6.01
Hydrophobic TM2 F 67 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 F 67 2x39 G.H5 L 380 G.H5.25
Ionic TM5 R 228 5x69 G.H5 D 368 G.H5.13
Polar TM5 R 228 5x69 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 228 5x69 G.H5 D 368 G.H5.13
Polar H8 R 319 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 R 319 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 R 319 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 V 71 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM2 F 67 2x39 G.H5 D 377 G.H5.22
Polar ICL2 R 146 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 146 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 M 225 5x66 G.H5 L 375 G.H5.20