Gi2 - EP3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 284 6x37 G.H5 L 354 G.H5.25
Polar TM3 R 155 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 C 352 G.H5.23
Polar ICL3 Q 268 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 Q 268 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 H 163 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 163 34x51 G.S3 L 195 G.S3.01
Polar ICL2 S 167 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 167 34x55 G.hns1 R 32 G.hns1.03
Polar TM5 K 263 5x72 G.S6 Y 321 G.S6.02
Hydrophobic TM5 K 263 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 K 263 5x72 G.S6 Y 321 G.S6.02
Hydrophobic TM2 F 88 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 F 88 2x39 G.H5 D 351 G.H5.22
Polar TM6 W 273 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 W 273 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 W 273 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 Y 165 34x53 G.H5 N 348 G.H5.19
Polar ICL2 P 162 34x50 G.H5 N 348 G.H5.19
Polar TM6 Q 272 6x25 G.H5 K 346 G.H5.17
Hydrophobic TM6 Q 272 6x25 G.H5 K 346 G.H5.17
Van-der-waals TM6 Q 272 6x25 G.H5 K 346 G.H5.17
Hydrophobic ICL1 R 84 - G.H5 D 351 G.H5.22
Van-der-waals ICL1 R 84 - G.H5 D 351 G.H5.22
Polar TM5 R 259 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM5 R 259 5x68 G.H5 T 341 G.H5.12
Van-der-waals TM5 R 259 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM5 R 259 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 259 5x68 G.H5 I 345 G.H5.16
Ionic TM5 K 263 5x72 G.H5 D 342 G.H5.13
Polar TM5 K 263 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 263 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 263 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM3 A 158 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 C 352 G.H5.23
Ionic TM5 R 259 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 259 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 259 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 259 5x68 G.H5 D 342 G.H5.13
Polar TM6 S 269 6x22 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 269 6x22 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 269 6x22 G.h4s6 E 319 G.h4s6.12
Polar TM6 Q 272 6x25 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM6 Q 272 6x25 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 Q 272 6x25 G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 P 162 34x50 G.H5 T 341 G.H5.12
Polar TM6 T 280 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 280 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 W 273 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 W 273 6x26 G.H5 D 342 G.H5.13
Polar TM6 Q 272 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 Q 272 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 Q 272 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 I 276 6x29 G.H5 K 346 G.H5.17
Hydrophobic TM6 I 276 6x29 G.H5 L 349 G.H5.20
Polar H8 R 350 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 R 350 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 R 350 8x47 G.H5 F 355 G.H5.26
Polar ICL2 H 163 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 H 163 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 H 163 34x51 G.H5 T 341 G.H5.12
Polar TM5 R 259 5x68 G.H5 D 338 G.H5.09
Van-der-waals TM5 R 259 5x68 G.H5 D 338 G.H5.09
Hydrophobic TM6 T 280 6x33 G.H5 L 349 G.H5.20
Polar ICL2 Y 165 34x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 Y 165 34x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 H 163 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 H 163 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 W 273 6x26 G.H5 I 345 G.H5.16
Ionic H8 R 361 8x58 G.h4s6 D 316 G.h4s6.09
Polar H8 R 361 8x58 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 R 361 8x58 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 R 361 8x58 G.h4s6 D 316 G.h4s6.09
Aromatic ICL2 H 163 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 H 163 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 H 163 34x51 G.H5 F 337 G.H5.08
Ionic TM4 K 170 4x38 G.HN E 28 G.HN.52
Polar TM4 K 170 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 K 170 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 170 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 L 256 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 162 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 162 34x50 G.H5 I 345 G.H5.16
Polar TM2 K 85 2x36 G.H5 D 351 G.H5.22
Hydrophobic TM2 K 85 2x36 G.H5 D 351 G.H5.22
Van-der-waals TM2 K 85 2x36 G.H5 D 351 G.H5.22
Polar TM6 Q 283 6x36 G.H5 G 353 G.H5.24
Polar TM2 K 85 2x36 G.H5 K 350 G.H5.21
Hydrophobic TM2 K 85 2x36 G.H5 K 350 G.H5.21
Van-der-waals TM2 K 85 2x36 G.H5 K 350 G.H5.21
Hydrophobic TM2 F 88 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 88 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 159 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 159 3x54 G.H5 L 349 G.H5.20
Ionic TM5 K 263 5x72 G.h4s6 E 319 G.h4s6.12
Polar TM5 K 263 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 K 263 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 159 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 159 3x54 G.H5 I 345 G.H5.16
Polar TM6 W 273 6x26 G.S6 Y 321 G.S6.02
Polar TM3 A 158 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 F 88 2x39 G.H5 G 353 G.H5.24
Van-der-waals TM2 F 88 2x39 G.H5 G 353 G.H5.24
Hydrophobic TM6 Q 283 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 Q 283 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 162 34x50 G.H5 I 344 G.H5.15
Hydrophobic H8 R 350 8x47 G.H5 L 354 G.H5.25
Hydrophobic TM6 I 276 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 I 276 6x29 G.H5 F 355 G.H5.26
Polar H8 R 350 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 R 350 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 R 350 8x47 G.H5 G 353 G.H5.24