Gs - EP3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 163 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 H 163 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 I 276 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM4 K 170 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM3 R 155 3x50 G.H5 L 393 G.H5.25
Polar ICL2 Y 165 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 165 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 165 34x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 Q 283 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 Q 283 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 Q 268 - G.H4 L 346 G.H4.16
Ionic TM5 K 263 5x72 G.H5 D 381 G.H5.13
Polar TM5 K 263 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 263 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 263 5x72 G.H5 D 381 G.H5.13
Hydrophobic ICL1 R 84 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 84 - G.H5 Q 390 G.H5.22
Polar TM3 I 159 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 159 3x54 G.H5 Q 384 G.H5.16
Ionic TM5 R 259 5x68 G.H5 D 381 G.H5.13
Polar TM5 R 259 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 259 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 259 5x68 G.H5 D 381 G.H5.13
Polar TM6 S 269 6x22 G.H5 R 385 G.H5.17
Van-der-waals TM6 S 269 6x22 G.H5 R 385 G.H5.17
Aromatic TM6 W 273 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 W 273 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 W 273 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM2 K 85 2x36 G.H5 Q 390 G.H5.22
Hydrophobic TM3 I 159 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 159 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 162 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 162 34x50 G.H5 H 387 G.H5.19
Aromatic ICL2 Y 165 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 165 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 165 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 162 34x50 G.H5 Q 384 G.H5.16
Polar H8 R 350 8x47 G.H5 L 394 G.H5.26
Hydrophobic H8 R 350 8x47 G.H5 L 394 G.H5.26
Van-der-waals H8 R 350 8x47 G.H5 L 394 G.H5.26
Polar ICL3 S 267 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 S 267 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 S 267 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 Q 272 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 Q 272 6x25 G.h4s6 Y 358 G.h4s6.20
Polar H8 R 350 8x47 G.H5 L 393 G.H5.25
Hydrophobic H8 R 350 8x47 G.H5 L 393 G.H5.25
Van-der-waals H8 R 350 8x47 G.H5 L 393 G.H5.25
Ionic TM5 K 263 5x72 G.H5 D 378 G.H5.10
Polar TM5 K 263 5x72 G.H5 D 378 G.H5.10
Van-der-waals TM5 K 263 5x72 G.H5 D 378 G.H5.10
Hydrophobic TM3 I 159 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 166 34x54 G.H5 H 387 G.H5.19
Polar ICL2 H 163 34x51 G.S1 H 41 G.S1.02
Aromatic ICL2 H 163 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 H 163 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 W 273 6x26 G.H5 L 388 G.H5.20
Van-der-waals TM6 W 273 6x26 G.H5 L 388 G.H5.20
Polar TM3 E 154 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 154 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 154 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 158 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 162 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 H 163 34x51 G.H5 R 380 G.H5.12
Polar ICL2 M 169 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 84 - G.H5 M 386 G.H5.18
Van-der-waals ICL1 R 84 - G.H5 M 386 G.H5.18
Hydrophobic TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Polar TM6 Q 272 6x25 G.H5 R 385 G.H5.17
Ionic H8 R 350 8x47 G.H5 E 392 G.H5.24
Polar H8 R 350 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 R 350 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 350 8x47 G.H5 E 392 G.H5.24
Polar TM6 W 273 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM6 W 273 6x26 G.H5 D 381 G.H5.13
Van-der-waals TM6 W 273 6x26 G.H5 D 381 G.H5.13
Polar TM5 R 259 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 259 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 259 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM2 F 88 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 F 88 2x39 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 167 34x55 G.hns1 R 38 G.hns1.02
Polar TM2 K 85 2x36 G.H5 R 389 G.H5.21
Hydrophobic TM2 K 85 2x36 G.H5 R 389 G.H5.21
Van-der-waals TM2 K 85 2x36 G.H5 R 389 G.H5.21
Hydrophobic ICL2 P 162 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 S 167 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM2 F 88 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 88 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 276 6x29 G.H5 L 388 G.H5.20
Polar TM6 T 280 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 280 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 256 5x65 G.H5 L 388 G.H5.20
Ionic TM2 K 85 2x36 G.H5 E 392 G.H5.24
Polar TM2 K 85 2x36 G.H5 E 392 G.H5.24
Hydrophobic TM2 K 85 2x36 G.H5 E 392 G.H5.24
Van-der-waals TM2 K 85 2x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 H 163 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 H 163 34x51 G.S3 V 217 G.S3.01