Gi2 -
EP4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Polar | ICL3 | R | 256 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 270 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 273 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | A | 124 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | H8 | R | 333 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | C | 487 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Polar | ICL2 | A | 124 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | A | 124 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Polar | C-term | C | 487 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | C | 487 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Ionic | C-term | E | 485 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | C-term | E | 485 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | E | 485 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | I | 488 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | I | 488 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | T | 394 | - | G.s4h3 | E | 240 | G.s4h3.13 |
Van-der-waals | C-term | T | 394 | - | G.s4h3 | E | 240 | G.s4h3.13 |
Hydrophobic | C-term | C | 487 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | C | 487 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 342 | G.H5.13 |
Polar | TM2 | F | 54 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Polar | C-term | I | 488 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Hydrophobic | C-term | I | 488 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Van-der-waals | C-term | I | 488 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Polar | ICL3 | S | 259 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | ICL3 | S | 259 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Polar | ICL2 | Y | 127 | 34x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Ionic | C-term | K | 486 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | K | 486 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | K | 486 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | K | 486 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | I | 488 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM6 | A | 266 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | T | 480 | - | H.hbhc | E | 116 | H.hbhc.04 |
Polar | ICL2 | Y | 127 | 34x53 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | S | 128 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Polar | C-term | K | 486 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | K | 486 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | K | 486 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM2 | T | 53 | 2x38 | G.H5 | D | 351 | G.H5.22 |
Polar | C-term | C | 487 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | C-term | C | 487 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Van-der-waals | C-term | C | 487 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | C-term | V | 474 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | I | 488 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Van-der-waals | C-term | I | 488 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 338 | G.H5.09 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | Y | 127 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Aromatic | ICL2 | H | 129 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | H | 129 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Ionic | ICL3 | R | 256 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 256 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | F | 217 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Ionic | C-term | E | 485 | - | G.H2 | R | 206 | G.H2.01 |
Polar | C-term | E | 485 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | E | 485 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | E | 485 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | F | 476 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | F | 476 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Ionic | TM6 | R | 262 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | TM6 | R | 262 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | TM6 | R | 262 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 262 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | TM2 | T | 52 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | C | 487 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | C | 487 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | C | 487 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | C-term | I | 488 | - | G.H1 | K | 46 | G.H1.01 |
Hydrophobic | C-term | I | 488 | - | G.s1h1 | A | 41 | G.s1h1.02 |
Van-der-waals | C-term | I | 488 | - | G.s1h1 | A | 41 | G.s1h1.02 |