Gi3 -
EP4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | R | 256 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | F | 476 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 270 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Y | 127 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM4 | R | 134 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | H8 | T | 335 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | F | 196 | G.S3.03 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | F | 217 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | TM4 | D | 132 | 4x38 | G.HN | R | 24 | G.HN.48 |
Polar | TM4 | D | 132 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | A | 266 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | L | 396 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | L | 396 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | I | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | H8 | R | 333 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM6 | R | 262 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 262 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | E | 116 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | S | 128 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | S | 128 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL3 | H | 228 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | H | 228 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | H | 228 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | H | 228 | - | G.H4 | Y | 302 | G.H4.10 |
Polar | ICL3 | R | 256 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 273 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 476 | - | H.HA | V | 71 | H.HA.09 |
Ionic | ICL3 | R | 256 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | R | 256 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | Y | 127 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | Y | 127 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | R | 220 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Ionic | ICL3 | R | 255 | - | G.H4 | D | 309 | G.H4.17 |
Polar | ICL3 | R | 255 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | H | 129 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Aromatic | ICL2 | H | 129 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | H | 129 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | TM2 | T | 52 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | T | 52 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 52 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL3 | Q | 227 | - | G.H4 | E | 298 | G.H4.05 |
Hydrophobic | ICL3 | Q | 227 | - | G.H4 | E | 298 | G.H4.05 |
Van-der-waals | ICL3 | Q | 227 | - | G.H4 | E | 298 | G.H4.05 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | A | 124 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 124 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 472 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | L | 472 | - | H.HA | Q | 68 | H.HA.06 |
Polar | TM6 | R | 262 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | R | 262 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM4 | R | 134 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | ICL3 | H | 228 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | ICL3 | H | 228 | - | G.H4 | A | 301 | G.H4.08 |
Polar | ICL2 | Y | 125 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | L | 396 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | L | 396 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 348 | G.H5.20 |