G12 - FP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL3 H 237 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 H 237 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 I 141 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM2 F 66 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 I 141 34x51 G.H5 I 370 G.H5.15
Polar ICL3 Q 239 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 Q 239 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 Q 239 - G.H4 D 336 G.H4.16
Polar ICL3 Q 239 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Q 239 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 239 - G.h4s6 P 345 G.h4s6.20
Polar ICL2 P 140 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 I 141 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 141 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 M 247 6x33 G.H5 M 379 G.H5.24
Polar TM6 H 243 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 243 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 243 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 133 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 378 G.H5.23
Ionic ICL3 R 238 - G.H5 D 368 G.H5.13
Polar ICL3 R 238 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 238 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 368 G.H5.13
Hydrophobic TM6 H 243 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 H 243 6x29 G.H5 K 376 G.H5.21
Ionic TM6 H 244 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM3 V 137 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 L 371 G.H5.16
Polar TM6 E 246 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 246 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM2 A 70 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM5 V 230 5x66 G.H5 L 371 G.H5.16
Polar ICL3 Q 239 - G.S6 L 346 G.S6.01
Polar ICL3 Q 239 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 Q 239 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 H 237 - G.S6 F 347 G.S6.02
Hydrophobic TM1 F 58 1x64 G.H5 Q 381 G.H5.26
Van-der-waals TM1 F 58 1x64 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 244 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 H 244 6x30 G.H5 L 375 G.H5.20
Polar H8 R 308 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 R 308 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 R 308 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 145 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 T 145 34x55 G.hns1 R 55 G.hns1.02
Polar TM3 G 136 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 374 G.H5.19
Polar TM5 S 234 5x70 G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 140 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM1 L 51 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM2 F 66 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL3 R 238 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 R 238 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 239 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 M 247 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 M 247 6x33 G.H5 L 375 G.H5.20
Polar H8 R 308 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 R 308 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 R 308 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM6 H 243 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 243 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 227 5x63 G.H5 L 375 G.H5.20
Hydrophobic TM6 H 244 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM1 F 58 1x64 G.H5 L 380 G.H5.25
Polar ICL3 H 237 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 H 237 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 S 144 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 137 3x54 G.H5 L 375 G.H5.20
Polar ICL2 H 143 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 143 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 H 143 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 T 145 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 145 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 R 238 - G.S6 F 347 G.S6.02
Polar ICL3 R 238 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 R 238 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 R 238 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 M 247 6x33 G.H5 I 378 G.H5.23
Polar TM6 H 244 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 244 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 244 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM3 G 136 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM2 L 67 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 67 2x40 G.H5 L 380 G.H5.25