Gs - PTH1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 Y 459 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 412 6x44 G.H5 L 393 G.H5.25
Polar TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 405 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 416 6x48 G.H5 Y 391 G.H5.23
Van-der-waals TM4 K 318 4x40 G.hns1 R 38 G.hns1.02
Polar H8 G 464 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 464 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL3 N 393 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 L 309 3x57 G.H5 H 387 G.H5.19
Ionic ICL3 R 396 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 396 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 F 314 - G.S3 F 219 G.S3.03
Hydrophobic TM3 L 309 3x57 G.H5 Y 391 G.H5.23
Ionic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM6 K 405 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 405 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 405 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 313 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 313 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 385 5x61 G.H5 L 394 G.H5.26
Polar TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Aromatic ICL2 F 314 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 314 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 314 - G.S1 H 41 G.S1.02
Ionic ICL3 R 396 - G.H4 D 343 G.H4.13
Polar ICL3 R 396 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 R 396 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 396 - G.H4 D 343 G.H4.13
Hydrophobic TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 389 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 223 2x50 G.H5 Y 391 G.H5.23
Polar TM3 E 302 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 302 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 302 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 413 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 314 - G.S3 V 217 G.S3.01
Van-der-waals ICL3 R 396 - G.H4 R 342 G.H4.12
Hydrophobic H8 N 463 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 463 8x47 G.H5 E 392 G.H5.24
Polar C-term S 569 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term S 569 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term S 569 - G.hns1 R 38 G.hns1.02
Polar TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 388 5x64 G.H5 R 385 G.H5.17
Ionic C-term D 572 - G.HN K 34 G.HN.51
Polar C-term D 572 - G.HN K 34 G.HN.51
Van-der-waals C-term D 572 - G.HN K 34 G.HN.51
Ionic TM6 K 408 6x40 G.H5 E 392 G.H5.24
Polar TM6 K 408 6x40 G.H5 E 392 G.H5.24
Hydrophobic C-term G 562 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term G 562 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term L 564 - G.H5 R 389 G.H5.21
Van-der-waals C-term L 564 - G.H5 R 389 G.H5.21
Hydrophobic TM5 K 388 5x64 G.H5 L 388 G.H5.20
Ionic ICL3 E 391 - G.H5 R 385 G.H5.17
Hydrophobic TM3 I 310 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 388 G.H5.20
Polar TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Polar TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 314 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 314 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 A 394 - G.H4 L 346 G.H4.16
Hydrophobic TM5 L 385 5x61 G.H5 L 393 G.H5.25
Polar TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Polar TM6 K 405 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 405 6x37 G.H5 E 392 G.H5.24
Hydrophobic ICL3 T 392 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 T 392 - G.H5 R 385 G.H5.17
Polar C-term D 572 - G.HN Q 31 G.HN.48
Van-der-waals C-term D 572 - G.HN Q 31 G.HN.48
Ionic TM4 E 317 4x39 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 385 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL3 T 392 - G.h4s6 Y 358 G.h4s6.20
Aromatic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 306 3x54 G.H5 L 393 G.H5.25
Aromatic ICL2 F 314 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 314 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 376 G.H5.08
Hydrophobic ICL3 R 396 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 396 - G.hgh4 P 321 G.hgh4.11