Gi3 -
SST1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | K | 268 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 268 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 268 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | S | 327 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL2 | R | 169 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | C-term | E | 371 | - | G.s4h3 | E | 238 | G.s4h3.12 |
Van-der-waals | C-term | E | 371 | - | G.s4h3 | E | 238 | G.s4h3.12 |
Hydrophobic | C-term | F | 368 | - | G.s4h3 | M | 240 | G.s4h3.14 |
Van-der-waals | C-term | F | 368 | - | G.s4h3 | M | 240 | G.s4h3.14 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 379 | - | H.HA | I | 82 | H.HA.20 |
Ionic | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Ionic | C-term | E | 349 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Polar | C-term | E | 349 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Hydrophobic | C-term | E | 349 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Van-der-waals | C-term | E | 349 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Polar | C-term | N | 381 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | E | 371 | - | G.s4h3 | E | 236 | G.s4h3.10 |
Hydrophobic | C-term | E | 371 | - | G.s4h3 | E | 236 | G.s4h3.10 |
Van-der-waals | C-term | E | 371 | - | G.s4h3 | E | 236 | G.s4h3.10 |
Polar | TM4 | T | 172 | 4x40 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | T | 172 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | F | 368 | - | G.s4h3 | L | 234 | G.s4h3.08 |
Polar | ICL3 | Q | 261 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | Q | 261 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | Q | 261 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 162 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL3 | Q | 261 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | Q | 261 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM4 | R | 170 | 4x38 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 170 | 4x38 | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | G | 382 | - | H.hbhc | E | 116 | H.hbhc.04 |
Hydrophobic | C-term | G | 382 | - | H.hbhc | E | 116 | H.hbhc.04 |
Van-der-waals | C-term | G | 382 | - | H.hbhc | E | 116 | H.hbhc.04 |
Hydrophobic | TM5 | M | 250 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | N | 381 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | N | 381 | - | H.HA | S | 75 | H.HA.13 |
Ionic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | T | 91 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 91 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Polar | H8 | N | 329 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | N | 329 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Aromatic | C-term | Y | 353 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | Y | 353 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | Y | 353 | - | G.H3 | K | 257 | G.H3.16 |
Ionic | C-term | D | 367 | - | G.H3 | K | 248 | G.H3.07 |
Polar | C-term | D | 367 | - | G.H3 | K | 248 | G.H3.07 |
Van-der-waals | C-term | D | 367 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | C-term | F | 379 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | I | 163 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL3 | W | 259 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Ionic | ICL3 | R | 264 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | ICL3 | R | 264 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 379 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | F | 379 | - | H.HA | Q | 79 | H.HA.17 |
Polar | TM2 | T | 93 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 93 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL2 | R | 167 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 167 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL3 | W | 259 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | W | 259 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 373 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | L | 373 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | F | 368 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | M | 250 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 368 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | W | 259 | - | G.h4s6 | T | 316 | G.h4s6.10 |
Polar | C-term | E | 371 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | C-term | E | 371 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Van-der-waals | C-term | E | 371 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL3 | Q | 261 | - | G.h4s6 | T | 316 | G.h4s6.10 |
Hydrophobic | ICL3 | Q | 261 | - | G.h4s6 | T | 316 | G.h4s6.10 |
Hydrophobic | C-term | Y | 353 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | Y | 353 | - | G.H3 | W | 258 | G.H3.17 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | A | 166 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 166 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL3 | R | 262 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | R | 262 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | Q | 261 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | C | 384 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | K | 249 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 249 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | D | 352 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | D | 352 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | D | 352 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM2 | T | 93 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 368 | - | G.H3 | E | 245 | G.H3.04 |