Gs - SST2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 253 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 253 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 L 394 G.H5.26
Polar TM5 S 238 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 S 238 5x68 G.H5 D 381 G.H5.13
Polar C-term S 368 - G.H2 R 231 G.H2.04
Hydrophobic C-term S 368 - G.H2 R 231 G.H2.04
Van-der-waals C-term S 368 - G.H2 R 231 G.H2.04
Hydrophobic TM6 M 257 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 257 6x36 G.H5 E 392 G.H5.24
Polar TM5 S 238 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 S 238 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 238 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 M 257 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 257 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 V 242 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 V 242 - G.S6 Y 360 G.S6.02
Polar TM6 K 246 6x25 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 R 247 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 247 6x26 G.H5 R 385 G.H5.17
Hydrophobic C-term L 365 - G.H3 S 275 G.H3.11
Van-der-waals C-term L 365 - G.H3 S 275 G.H3.11
Polar ICL2 K 152 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 152 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term R 349 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term R 349 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term T 353 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 P 147 34x50 G.H5 Q 384 G.H5.16
Hydrophobic C-term L 365 - G.H3 L 272 G.H3.08
Hydrophobic TM6 V 258 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 I 148 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 I 148 34x51 G.S3 V 217 G.S3.01
Polar TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 I 148 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 I 148 34x51 G.H5 I 383 G.H5.15
Polar TM6 K 246 6x25 G.h4s6 G 353 G.h4s6.09
Polar ICL2 R 154 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 154 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 154 34x57 G.H5 H 387 G.H5.19
Polar H8 S 316 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 316 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 316 8x47 G.H5 E 392 G.H5.24
Van-der-waals C-term Q 357 - G.H3 R 280 G.H3.16
Polar TM3 V 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 144 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 Q 384 G.H5.16
Polar C-term L 365 - G.H2 R 231 G.H2.04
Van-der-waals C-term L 365 - G.H2 R 231 G.H2.04
Hydrophobic C-term I 369 - G.H3 L 272 G.H3.08
Van-der-waals C-term I 369 - G.H3 L 272 G.H3.08
Hydrophobic C-term I 369 - G.H2 R 231 G.H2.04
Van-der-waals C-term I 369 - G.H2 R 231 G.H2.04
Hydrophobic TM5 K 234 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 234 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 I 148 34x51 G.H5 R 380 G.H5.12
Polar H8 N 318 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 N 318 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Polar C-term S 368 - G.s4h3 E 259 G.s4h3.10
Hydrophobic C-term S 368 - G.s4h3 E 259 G.s4h3.10
Van-der-waals C-term S 368 - G.s4h3 E 259 G.s4h3.10
Polar TM4 R 155 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 155 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 155 4x38 G.HN Q 35 G.HN.52
Polar H8 D 317 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 D 317 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 D 317 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 254 6x33 G.H5 L 388 G.H5.20
Polar ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 154 34x57 G.H5 Y 391 G.H5.23
Hydrophobic C-term Q 366 - G.H2 D 229 G.H2.02
Van-der-waals C-term Q 366 - G.H2 D 229 G.H2.02
Polar TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 235 5x65 G.H5 L 388 G.H5.20
Polar C-term T 367 - G.H3 E 268 G.H3.04
Hydrophobic C-term T 367 - G.H3 E 268 G.H3.04
Van-der-waals C-term T 367 - G.H3 E 268 G.H3.04
Van-der-waals ICL3 R 241 - G.H5 R 380 G.H5.12
Polar TM3 A 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term I 369 - G.s1h1 G 47 G.s1h1.01
Van-der-waals C-term I 369 - G.s1h1 G 47 G.s1h1.01
Hydrophobic C-term I 369 - G.s1h1 A 48 G.s1h1.02
Van-der-waals C-term I 369 - G.s1h1 A 48 G.s1h1.02
Hydrophobic C-term I 369 - G.H1 K 53 G.H1.01
Van-der-waals C-term I 369 - G.H1 K 53 G.H1.01
Hydrophobic ICL2 I 148 34x51 G.S1 H 41 G.S1.02
Polar C-term I 369 - G.s3h2 G 226 G.s3h2.02
Hydrophobic ICL3 V 242 - G.H5 D 381 G.H5.13
Polar TM6 V 254 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 254 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 254 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 250 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 250 6x29 G.H5 L 394 G.H5.26
Ionic TM6 R 247 6x26 G.H5 D 381 G.H5.13
Polar TM6 R 247 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 247 6x26 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 247 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM3 A 143 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 143 3x53 G.H5 Y 391 G.H5.23
Polar C-term T 367 - G.H2 R 231 G.H2.04
Hydrophobic C-term T 367 - G.H2 R 231 G.H2.04
Van-der-waals C-term T 367 - G.H2 R 231 G.H2.04
Van-der-waals C-term I 369 - G.s1h1 G 49 G.s1h1.03
Hydrophobic C-term I 369 - G.S1 L 46 G.S1.07
Hydrophobic TM3 V 144 3x54 G.H5 L 393 G.H5.25