G12 - SST5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term M 359 - G.H5 H 364 G.H5.09
Hydrophobic TM3 V 141 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term L 364 - G.H4 D 336 G.H4.16
Hydrophobic TM2 T 75 2x39 G.H5 M 379 G.H5.24
Hydrophobic ICL3 V 235 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 235 - G.S6 F 347 G.S6.02
Hydrophobic TM5 V 228 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 249 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 249 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 141 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 141 3x54 G.H5 I 378 G.H5.23
Polar TM3 V 142 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 246 6x33 G.H5 L 375 G.H5.20
Hydrophobic H8 S 308 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 308 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL3 V 235 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 145 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 145 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 M 249 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 380 G.H5.25
Polar ICL3 R 234 - G.H5 H 364 G.H5.09
Aromatic ICL3 R 234 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 R 234 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 R 234 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 L 145 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 145 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 P 144 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM7 Y 304 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 304 7x53 G.H5 M 379 G.H5.24
Hydrophobic C-term M 359 - G.H5 A 365 G.H5.10
Van-der-waals C-term M 359 - G.H5 A 365 G.H5.10
Polar ICL2 R 151 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 151 34x57 G.H5 N 374 G.H5.19
Hydrophobic C-term T 361 - G.S6 L 346 G.S6.01
Van-der-waals C-term T 361 - G.S6 L 346 G.S6.01
Polar TM2 T 75 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM6 R 239 6x26 G.h4s6 P 345 G.h4s6.20
Polar TM3 A 140 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 145 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 239 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 239 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM4 R 154 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 R 154 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 V 246 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 380 G.H5.25
Ionic ICL3 R 234 - G.H5 D 368 G.H5.13
Polar ICL3 R 234 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 234 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 234 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 144 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 144 34x50 G.H5 K 367 G.H5.12
Polar ICL2 R 149 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 149 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 149 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 145 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 145 34x51 G.H5 I 370 G.H5.15
Polar TM3 R 137 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 137 3x50 G.H5 M 379 G.H5.24
Polar TM3 R 137 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term T 361 - G.S6 H 348 G.S6.03
Van-der-waals C-term T 361 - G.S6 H 348 G.S6.03
Polar C-term S 362 - G.S6 H 348 G.S6.03
Hydrophobic C-term S 362 - G.S6 H 348 G.S6.03
Van-der-waals C-term S 362 - G.S6 H 348 G.S6.03
Hydrophobic TM2 T 75 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 A 231 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 A 231 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 K 245 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 Q 381 G.H5.26
Hydrophobic C-term M 359 - G.S6 F 347 G.S6.02
Van-der-waals C-term M 359 - G.S6 F 347 G.S6.02
Hydrophobic TM5 A 231 5x68 G.H5 D 368 G.H5.13
Polar H8 S 308 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 246 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 239 6x26 G.S6 F 347 G.S6.02
Hydrophobic C-term S 362 - G.H4 V 332 G.H4.12
Van-der-waals C-term S 362 - G.H4 V 332 G.H4.12
Hydrophobic ICL2 R 151 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 151 34x57 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 141 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 A 148 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 C 237 6x24 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 C 237 6x24 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 364 - G.H4 Q 333 G.H4.13
Van-der-waals C-term L 364 - G.H4 Q 333 G.H4.13
Hydrophobic TM4 R 152 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 152 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 148 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 148 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic C-term T 361 - G.h4s6 P 345 G.h4s6.20
Polar C-term Q 360 - G.S6 H 348 G.S6.03
Hydrophobic C-term Q 360 - G.S6 H 348 G.S6.03
Van-der-waals C-term Q 360 - G.S6 H 348 G.S6.03
Hydrophobic TM3 A 140 3x53 G.H5 I 378 G.H5.23
Polar H8 N 310 8x49 G.H5 K 376 G.H5.21
Van-der-waals H8 N 310 8x49 G.H5 K 376 G.H5.21
Polar TM4 R 152 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 R 152 4x38 G.HN R 52 G.HN.52
Hydrophobic C-term M 359 - G.H5 F 361 G.H5.06
Van-der-waals C-term M 359 - G.H5 F 361 G.H5.06
Hydrophobic C-term T 361 - G.S6 F 347 G.S6.02
Hydrophobic TM3 R 137 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 250 6x37 G.H5 L 380 G.H5.25
Polar C-term S 362 - G.H4 D 336 G.H4.16
Van-der-waals TM6 S 242 6x29 G.H5 Q 381 G.H5.26
Polar TM6 R 239 6x26 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 145 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 145 34x51 G.S3 I 221 G.S3.01
Polar H8 D 309 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 309 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 309 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 144 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 I 79 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 I 79 2x43 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 145 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 K 227 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL3 V 235 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 V 235 - G.H5 D 368 G.H5.13
Hydrophobic TM5 I 224 5x61 G.H5 L 380 G.H5.25