G12 - TAAR8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM4 T 144 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 140 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 140 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 Q 226 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 Q 226 5x68 G.H5 Q 372 G.H5.17
Polar ICL3 S 239 - G.h4s6 R 342 G.h4s6.11
Polar TM6 R 251 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 251 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 251 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 136 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 136 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 A 256 6x34 G.H5 M 379 G.H5.24
Hydrophobic H8 Y 314 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 314 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 136 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 137 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 137 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 A 223 5x65 G.H5 L 375 G.H5.20
Polar TM3 T 134 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 T 134 3x55 G.H5 K 367 G.H5.12
Polar TM5 E 238 5x80 G.H4 Q 333 G.H4.13
Hydrophobic TM3 R 129 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 Q 226 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 133 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 133 3x54 G.H5 L 371 G.H5.16
Polar ICL3 S 239 - G.H4 D 336 G.H4.16
Hydrophobic TM7 F 313 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 313 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 255 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 A 255 6x33 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 136 34x50 G.H5 L 371 G.H5.16
Polar TM5 Q 226 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 226 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 226 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 226 5x68 G.H5 L 375 G.H5.20
Polar ICL2 T 141 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 141 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 141 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 230 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 230 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 137 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM4 V 145 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 V 145 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 V 132 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 132 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 133 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 259 6x37 G.H5 I 378 G.H5.23
Polar TM6 T 258 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 258 6x36 G.H5 M 379 G.H5.24
Hydrophobic H8 P 315 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 315 8x48 G.H5 Q 381 G.H5.26
Van-der-waals ICL2 P 136 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 137 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 370 G.H5.15
Polar ICL3 Y 244 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 Y 244 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 Y 244 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 T 258 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 133 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 133 3x54 G.H5 I 378 G.H5.23
Polar ICL3 Y 244 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Y 244 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 A 223 5x65 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 137 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 V 237 5x79 G.S6 H 348 G.S6.03
Polar TM6 E 252 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM5 V 237 5x79 G.H4 D 336 G.H4.16
Van-der-waals TM5 V 237 5x79 G.H4 D 336 G.H4.16
Hydrophobic TM6 L 259 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 137 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 I 222 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 T 233 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM5 V 237 5x79 G.H4 V 332 G.H4.12
Hydrophobic ICL2 V 138 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 138 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM5 I 230 5x72 G.h4s6 P 345 G.h4s6.20
Polar ICL3 Y 244 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 Y 244 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 Y 244 - G.h4s6 R 342 G.h4s6.11
Polar ICL3 Y 244 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 Y 244 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 Y 244 - G.h4s6 K 344 G.h4s6.19
Ionic TM5 K 229 5x71 G.H5 D 368 G.H5.13
Polar TM5 K 229 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 229 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 229 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM6 A 255 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 255 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 137 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 137 34x51 G.S1 V 58 G.S1.02
Ionic TM5 E 238 5x80 G.H4 R 329 G.H4.09
Polar TM5 E 238 5x80 G.H4 R 329 G.H4.09
Hydrophobic TM5 E 238 5x80 G.H4 R 329 G.H4.09
Van-der-waals TM5 E 238 5x80 G.H4 R 329 G.H4.09
Polar ICL1 H 63 12x51 G.hns1 R 55 G.hns1.02
Polar ICL2 A 140 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 140 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 140 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM7 I 309 7x52 G.H5 L 380 G.H5.25
Polar TM3 V 132 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 132 3x53 G.H5 N 374 G.H5.19