G12 - V1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term T 418 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term T 418 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM6 A 285 6x29 G.H5 L 375 G.H5.20
Hydrophobic C-term I 414 - H.HA K 114 H.HA.28
Van-der-waals C-term I 414 - H.HA K 114 H.HA.28
Polar TM6 R 288 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 288 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 288 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM2 I 90 2x43 G.H5 L 380 G.H5.25
Polar ICL3 C 275 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 C 275 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 C 275 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 V 276 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 V 276 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 157 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 157 34x51 G.H5 I 370 G.H5.15
Polar C-term Y 388 - G.H2 Q 240 G.H2.09
Hydrophobic C-term Y 388 - G.H2 Q 240 G.H2.09
Van-der-waals C-term Y 388 - G.H2 Q 240 G.H2.09
Hydrophobic ICL2 P 156 34x50 G.H5 L 371 G.H5.16
Polar ICL3 S 277 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 S 277 - G.H4 D 336 G.H4.16
Polar C-term S 417 - H.HA K 114 H.HA.28
Van-der-waals C-term S 417 - H.HA K 114 H.HA.28
Hydrophobic ICL3 V 276 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 L 160 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 160 34x54 G.H5 I 370 G.H5.15
Hydrophobic C-term V 416 - H.HA K 114 H.HA.28
Hydrophobic TM3 V 153 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 153 3x54 G.H5 L 371 G.H5.16
Polar ICL2 T 159 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 159 34x53 G.H5 N 374 G.H5.19
Polar TM6 S 281 6x25 G.H5 Q 372 G.H5.17
Polar C-term P 415 - H.HA K 114 H.HA.28
Hydrophobic C-term P 415 - H.HA K 114 H.HA.28
Van-der-waals C-term P 415 - H.HA K 114 H.HA.28
Van-der-waals TM2 M 86 2x39 G.H5 D 377 G.H5.22
Hydrophobic H8 S 352 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 352 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 M 86 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 86 2x39 G.H5 L 380 G.H5.25
Polar TM5 N 246 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 246 5x68 G.H5 D 368 G.H5.13
Polar ICL3 S 277 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ICL2 Q 162 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 162 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic C-term F 413 - H.HD E 172 H.HD.12
Van-der-waals C-term F 413 - H.HD E 172 H.HD.12
Hydrophobic TM6 R 288 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 288 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 T 289 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 289 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term I 414 - H.HA L 115 H.HA.29
Hydrophobic ICL3 P 274 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 V 276 - G.S6 L 346 G.S6.01
Hydrophobic TM2 M 86 2x39 G.H5 I 378 G.H5.23
Polar TM3 A 152 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 152 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 152 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term Y 388 - G.H3 L 285 G.H3.17
Van-der-waals C-term Y 388 - G.H3 L 285 G.H3.17
Ionic C-term R 384 - G.h2s4 D 243 G.h2s4.02
Polar C-term R 384 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term R 384 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term R 384 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term T 418 - H.HA V 107 H.HA.21
Polar C-term I 414 - H.HD E 172 H.HD.12
Hydrophobic C-term T 418 - H.hdhe Q 174 H.hdhe.02
Hydrophobic ICL3 L 272 - G.HG M 298 G.HG.01
Hydrophobic ICL2 L 157 34x51 G.H5 K 367 G.H5.12
Polar C-term S 417 - H.HA D 110 H.HA.24
Van-der-waals C-term S 417 - H.HA D 110 H.HA.24
Polar C-term S 389 - G.H3 K 284 G.H3.16
Hydrophobic TM6 M 292 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 292 6x36 G.H5 M 379 G.H5.24
Van-der-waals C-term P 415 - G.s4h3 R 265 G.s4h3.12
Polar TM2 R 85 2x38 G.H5 N 374 G.H5.19
Van-der-waals TM2 R 85 2x38 G.H5 N 374 G.H5.19
Hydrophobic C-term V 416 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term V 416 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM5 N 246 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 N 246 5x68 G.H5 L 371 G.H5.16
Polar C-term V 416 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term V 416 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL3 V 276 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 P 156 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term V 416 - H.HA A 111 H.HA.25
Hydrophobic C-term T 386 - G.H3 L 285 G.H3.17
Van-der-waals C-term T 386 - G.H3 L 285 G.H3.17
Polar ICL2 Q 161 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 161 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 161 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 160 34x54 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 160 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 160 34x54 G.hns1 R 55 G.hns1.02
Polar C-term T 418 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM2 H 87 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 S 84 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 84 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 85 2x38 G.H5 I 378 G.H5.23
Hydrophobic TM5 I 243 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 156 34x50 G.H5 K 367 G.H5.12
Hydrophobic C-term F 413 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term F 413 - G.s4h3 V 260 G.s4h3.07
Hydrophobic TM3 A 152 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 152 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM7 F 351 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 351 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 157 34x51 G.S3 I 221 G.S3.01
Polar TM3 R 149 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 I 378 G.H5.23
Ionic TM2 R 85 2x38 G.H5 D 377 G.H5.22
Polar TM2 R 85 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 85 2x38 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 85 2x38 G.H5 D 377 G.H5.22
Hydrophobic C-term V 416 - H.HA D 110 H.HA.24
Van-der-waals C-term V 416 - H.HA D 110 H.HA.24
Hydrophobic C-term F 413 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 L 157 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 157 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 E 260 - G.HG M 298 G.HG.01
Hydrophobic ICL2 L 160 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic C-term V 416 - H.HA V 107 H.HA.21
Hydrophobic ICL3 P 274 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 P 274 - G.H5 F 361 G.H5.06
Polar ICL3 S 277 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 277 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 277 - G.S6 L 346 G.S6.01
Polar TM6 R 288 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 288 6x32 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 288 6x32 G.H5 L 380 G.H5.25
Polar ICL3 L 272 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 L 272 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 L 272 - G.S6 H 349 G.S6.04
Polar C-term F 387 - G.H3 K 284 G.H3.16
Hydrophobic C-term F 387 - G.H3 K 284 G.H3.16
Van-der-waals C-term F 387 - G.H3 K 284 G.H3.16
Ionic TM5 K 250 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 250 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 250 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 250 5x72 G.H5 D 368 G.H5.13
Polar C-term Y 388 - G.H2 Q 236 G.H2.05
Hydrophobic C-term F 413 - H.HD S 171 H.HD.11
Van-der-waals C-term F 413 - H.HD S 171 H.HD.11
Hydrophobic TM3 V 153 3x54 G.H5 L 375 G.H5.20