Gs - V2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 149 34x55 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 149 34x55 G.S3 V 217 G.S3.01
Hydrophobic TM6 K 268 6x32 G.H5 L 393 G.H5.25
Polar TM6 K 268 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 268 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 268 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 P 240 5x73 G.S6 C 359 G.S6.01
Hydrophobic ICL2 M 145 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 P 240 5x73 G.S6 Y 360 G.S6.02
Van-der-waals TM5 P 240 5x73 G.S6 Y 360 G.S6.02
Van-der-waals ICL3 E 258 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 Y 148 34x54 G.hns1 A 39 G.hns1.03
Polar TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 P 240 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 M 145 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 144 34x50 G.H5 H 387 G.H5.19
Polar TM5 R 243 5x76 G.H5 N 377 G.H5.09
Van-der-waals TM5 R 243 5x76 G.H5 N 377 G.H5.09
Hydrophobic ICL2 Y 148 34x54 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 232 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 232 5x65 G.H5 L 388 G.H5.20
Polar TM5 G 239 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 G 239 5x72 G.H5 R 385 G.H5.17
Ionic TM5 R 243 5x76 G.H5 D 381 G.H5.13
Polar TM5 R 243 5x76 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 243 5x76 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 243 5x76 G.H5 D 381 G.H5.13
Polar TM5 S 235 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 S 235 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 235 5x68 G.H5 Q 384 G.H5.16
Ionic ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 Y 148 34x54 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 236 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 137 3x50 G.H5 Y 391 G.H5.23
Polar C-term S 357 - G.H3 R 280 G.H3.16
Hydrophobic C-term S 357 - G.H3 R 280 G.H3.16
Van-der-waals C-term S 357 - G.H3 R 280 G.H3.16
Hydrophobic TM3 I 141 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 141 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 144 34x50 G.H5 Q 384 G.H5.16
Polar TM4 G 153 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM4 G 153 4x39 G.HN Q 35 G.HN.52
Hydrophobic ICL2 Y 148 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 148 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 G 151 34x57 G.hns1 A 39 G.hns1.03
Polar TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 P 240 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM6 A 265 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 137 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM4 W 156 4x42 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 145 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 145 34x51 G.H5 I 383 G.H5.15
Polar TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 149 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM6 A 265 6x29 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 265 6x29 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 145 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM6 M 272 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 145 34x51 G.S3 V 217 G.S3.01
Polar TM4 H 155 4x41 G.HN Q 35 G.HN.52
Hydrophobic C-term T 360 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 P 144 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 Y 148 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 148 34x54 G.H5 H 387 G.H5.19
Aromatic ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 E 242 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 E 242 5x75 G.hgh4 D 323 G.hgh4.13
Ionic C-term D 355 - G.h4s6 R 356 G.h4s6.12
Polar C-term D 355 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term D 355 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term D 355 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 I 74 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 232 5x65 G.H5 L 393 G.H5.25
Polar H8 S 329 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 329 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 329 8x47 G.H5 E 392 G.H5.24
Polar TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 236 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 236 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 S 241 5x74 G.H4 L 346 G.H4.16
Polar H8 S 331 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 S 331 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 S 331 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 141 3x54 G.H5 L 388 G.H5.20
Ionic ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Polar ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL2 P 144 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 G 151 34x57 G.HN Q 35 G.HN.52
Ionic TM5 R 243 5x76 G.H5 D 378 G.H5.10
Polar TM5 R 243 5x76 G.H5 D 378 G.H5.10
Hydrophobic ICL2 M 145 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 145 34x51 G.H5 R 380 G.H5.12
Polar H8 S 330 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 330 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 330 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 S 241 5x74 G.S6 P 361 G.S6.03