Gs -
VPAC1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 450 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | F | 450 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | V | 457 | - | H.HA | D | 94 | H.HA.10 |
Hydrophobic | TM5 | L | 323 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | Y | 239 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Y | 239 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Ionic | C-term | E | 453 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Polar | C-term | E | 453 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Hydrophobic | C-term | E | 453 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Van-der-waals | C-term | E | 453 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Aromatic | ICL2 | F | 248 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 248 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 248 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | C-term | F | 450 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Van-der-waals | C-term | F | 450 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Polar | H8 | G | 393 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | G | 393 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | Q | 451 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | Q | 451 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | Q | 451 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | ICL3 | I | 328 | - | G.H4 | R | 342 | G.H4.12 |
Polar | ICL2 | S | 247 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | S | 247 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | S | 247 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | F | 248 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 248 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | C-term | V | 457 | - | G.hfs2 | V | 202 | G.hfs2.03 |
Ionic | ICL3 | R | 329 | - | G.H4 | D | 343 | G.H4.13 |
Polar | ICL3 | R | 329 | - | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | ICL3 | R | 329 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | R | 329 | - | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM2 | R | 174 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | R | 174 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | R | 174 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | S | 449 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | S | 449 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | F | 248 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | C-term | V | 457 | - | H.HA | N | 97 | H.HA.13 |
Van-der-waals | C-term | V | 457 | - | H.HA | N | 97 | H.HA.13 |
Hydrophobic | ICL3 | D | 327 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM6 | L | 346 | 6x45 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | P | 326 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | P | 326 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL3 | P | 326 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | C-term | S | 455 | - | G.hfs2 | R | 201 | G.hfs2.02 |
Hydrophobic | C-term | S | 455 | - | G.hfs2 | R | 201 | G.hfs2.02 |
Van-der-waals | C-term | S | 455 | - | G.hfs2 | R | 201 | G.hfs2.02 |
Hydrophobic | C-term | L | 456 | - | H.HA | E | 101 | H.HA.17 |
Van-der-waals | C-term | L | 456 | - | H.HA | E | 101 | H.HA.17 |
Hydrophobic | TM5 | L | 319 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | L | 319 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Ionic | TM4 | E | 251 | 4x39 | G.H5 | H | 387 | G.H5.19 |
Polar | TM5 | K | 322 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | K | 322 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | K | 322 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | K | 330 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | K | 330 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | K | 330 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | ICL3 | K | 330 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | ICL3 | K | 330 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | TM4 | R | 252 | 4x40 | G.HN | Q | 31 | G.HN.48 |
Aromatic | ICL2 | F | 248 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 248 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 248 | - | G.S1 | H | 41 | G.S1.02 |
Polar | TM5 | K | 322 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | K | 322 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | K | 322 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | S | 342 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | S | 342 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | S | 342 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM7 | Y | 388 | 7x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | S | 455 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Hydrophobic | ICL2 | F | 248 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 248 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | F | 450 | - | G.H2 | D | 229 | G.H2.02 |
Hydrophobic | TM5 | K | 322 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | L | 345 | 6x44 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | D | 327 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL2 | F | 248 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 248 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | S | 435 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | S | 435 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | TM3 | L | 240 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | F | 248 | - | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | C-term | F | 450 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | C-term | F | 450 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | TM3 | L | 240 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | L | 240 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | S | 247 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | S | 247 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM6 | L | 349 | 6x48 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL3 | P | 326 | - | G.S6 | C | 359 | G.S6.01 |
Polar | C-term | L | 456 | - | G.hfs2 | R | 201 | G.hfs2.02 |
Van-der-waals | C-term | L | 456 | - | G.hfs2 | R | 201 | G.hfs2.02 |
Hydrophobic | C-term | S | 455 | - | G.hfs2 | L | 203 | G.hfs2.04 |
Van-der-waals | C-term | S | 455 | - | G.hfs2 | L | 203 | G.hfs2.04 |
Hydrophobic | H8 | N | 392 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 392 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | R | 324 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM2 | H | 178 | 2x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | P | 326 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | P | 326 | - | G.H5 | R | 385 | G.H5.17 |
Polar | ICL3 | D | 327 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL3 | D | 327 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | D | 327 | - | G.S6 | C | 359 | G.S6.01 |
Polar | TM6 | R | 338 | 6x37 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | R | 338 | 6x37 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 338 | 6x37 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM5 | K | 322 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | K | 322 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | K | 322 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | K | 322 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | S | 247 | - | G.H5 | I | 383 | G.H5.15 |
Polar | TM3 | L | 244 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 244 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | E | 453 | - | G.s4h3 | N | 261 | G.s4h3.12 |
Polar | TM2 | R | 174 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | R | 174 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 174 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL3 | I | 328 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | I | 328 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | C-term | S | 449 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Hydrophobic | C-term | S | 449 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Van-der-waals | C-term | S | 449 | - | G.s4h3 | D | 260 | G.s4h3.11 |