Gs - BB3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 T 253 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 T 253 - G.H5 R 385 G.H5.17
Polar ICL2 Q 156 34x54 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 Q 156 34x54 G.H5 Q 390 G.H5.22
Hydrophobic C-term F 399 - G.h1ha N 83 G.h1ha.19
Van-der-waals C-term F 399 - G.h1ha N 83 G.h1ha.19
Hydrophobic TM5 L 244 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 153 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 153 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 E 254 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 E 254 - G.S6 P 361 G.S6.03
Polar ICL2 R 155 34x53 G.S1 H 41 G.S1.02
Aromatic ICL2 R 155 34x53 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 155 34x53 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 155 34x53 G.S1 H 41 G.S1.02
Hydrophobic TM5 P 252 5x73 G.H5 D 381 G.H5.13
Hydrophobic ICL3 T 253 - G.S6 Y 360 G.S6.02
Ionic ICL3 E 254 - G.H4 R 342 G.H4.12
Polar ICL3 E 254 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 E 254 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 E 254 - G.H4 R 342 G.H4.12
Polar ICL2 R 155 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 155 34x53 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 155 34x53 G.hns1 R 38 G.hns1.02
Polar ICL3 Q 256 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 Q 256 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 Q 256 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM2 P 82 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 82 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 269 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 L 394 G.H5.26
Ionic TM6 R 266 6x30 G.H5 D 381 G.H5.13
Polar TM6 R 266 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 266 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 266 6x30 G.H5 D 381 G.H5.13
Polar TM3 A 148 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 148 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 148 3x53 G.H5 H 387 G.H5.19
Polar TM2 N 83 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 N 83 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 83 2x40 G.H5 E 392 G.H5.24
Polar H8 S 334 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 334 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 334 8x47 G.H5 E 392 G.H5.24
Hydrophobic C-term F 399 - G.h1ha S 82 G.h1ha.18
Van-der-waals C-term F 399 - G.h1ha S 82 G.h1ha.18
Hydrophobic C-term F 399 - H.HA G 86 H.HA.02
Van-der-waals C-term F 399 - H.HA G 86 H.HA.02
Polar ICL2 R 155 34x53 G.S1 T 40 G.S1.01
Hydrophobic ICL2 R 155 34x53 G.S1 T 40 G.S1.01
Van-der-waals ICL2 R 155 34x53 G.S1 T 40 G.S1.01
Hydrophobic ICL3 E 254 - G.S6 F 363 G.S6.05
Van-der-waals ICL3 E 254 - G.S6 F 363 G.S6.05
Hydrophobic TM6 V 273 6x37 G.H5 L 393 G.H5.25
Polar TM5 S 247 5x68 G.H5 Q 384 G.H5.16
Polar ICL2 Q 156 34x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 153 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 153 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 152 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 152 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 153 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 153 34x51 G.H5 I 383 G.H5.15
Hydrophobic C-term F 399 - H.HA T 90 H.HA.06
Van-der-waals C-term F 399 - H.HA T 90 H.HA.06
Polar TM3 R 145 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 145 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 145 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 153 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM7 L 333 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 148 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 R 155 34x53 G.h2s4 T 242 G.h2s4.05
Van-der-waals ICL2 R 155 34x53 G.h2s4 T 242 G.h2s4.05
Hydrophobic TM5 P 252 5x73 G.H5 D 378 G.H5.10
Van-der-waals TM5 P 252 5x73 G.H5 D 378 G.H5.10
Hydrophobic ICL2 L 153 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM3 R 145 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM5 P 252 5x73 G.S6 H 362 G.S6.04
Aromatic TM6 H 258 6x22 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 H 258 6x22 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 H 258 6x22 G.h4s6 Y 358 G.h4s6.20
Polar TM3 V 149 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 149 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 149 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 158 34x56 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 T 253 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 T 253 - G.S6 C 359 G.S6.01
Hydrophobic TM6 I 269 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 E 255 - G.H4 L 346 G.H4.16
Polar TM6 Q 262 6x26 G.H5 D 381 G.H5.13
Van-der-waals TM6 Q 262 6x26 G.H5 D 381 G.H5.13
Polar ICL2 S 158 34x56 G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 158 34x56 G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 158 34x56 G.HN Q 35 G.HN.52
Hydrophobic ICL3 E 255 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 E 255 - G.h4s6 T 350 G.h4s6.03
Polar TM6 H 258 6x22 G.H5 R 385 G.H5.17
Van-der-waals TM6 H 258 6x22 G.H5 R 385 G.H5.17
Polar TM6 R 266 6x30 G.H5 Q 384 G.H5.16
Van-der-waals TM6 R 266 6x30 G.H5 Q 384 G.H5.16
Hydrophobic TM5 P 252 5x73 G.S6 Y 360 G.S6.02
Van-der-waals TM5 P 252 5x73 G.S6 Y 360 G.S6.02
Hydrophobic ICL1 M 78 12x50 G.H5 E 392 G.H5.24
Van-der-waals ICL1 M 78 12x50 G.H5 E 392 G.H5.24
Polar TM2 T 80 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 T 80 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 152 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 152 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 152 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 155 34x53 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 155 34x53 G.hns1 A 39 G.hns1.03
Polar C-term R 398 - H.HA T 90 H.HA.06
Polar TM7 L 333 7x56 G.H5 L 394 G.H5.26
Polar ICL2 Q 156 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM7 L 333 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 333 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM2 P 82 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 P 82 2x39 G.H5 Q 390 G.H5.22
Polar TM6 Q 262 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 262 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 262 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM7 L 330 7x53 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 152 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 152 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 153 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 V 149 3x54 G.H5 L 388 G.H5.20
Polar TM3 D 144 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 144 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 144 3x49 G.H5 Y 391 G.H5.23
Polar ICL2 R 155 34x53 G.hns1 Y 37 G.hns1.01
Aromatic ICL2 R 155 34x53 G.hns1 Y 37 G.hns1.01
Van-der-waals ICL2 R 155 34x53 G.hns1 Y 37 G.hns1.01
Polar ICL2 L 153 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 153 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 153 34x51 G.S1 H 41 G.S1.02