Gz - CRF2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 315 6x45 G.H5 L 354 G.H5.25
Polar TM2 R 148 2x46 G.H5 Y 351 G.H5.22
Aromatic TM2 R 148 2x46 G.H5 Y 351 G.H5.22
Hydrophobic TM2 R 148 2x46 G.H5 Y 351 G.H5.22
Van-der-waals TM2 R 148 2x46 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 Y 217 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 Y 217 - G.S3 L 195 G.S3.01
Hydrophobic TM3 I 213 3x58 G.H5 I 352 G.H5.23
Hydrophobic C-term F 402 - G.H3 S 253 G.H3.11
Van-der-waals C-term F 402 - G.H3 S 253 G.H3.11
Polar ICL2 Y 217 - G.H5 F 337 G.H5.08
Hydrophobic TM5 L 290 5x61 G.H5 C 355 G.H5.26
Van-der-waals TM5 L 290 5x61 G.H5 C 355 G.H5.26
Polar H8 E 365 8x49 G.H5 Y 351 G.H5.22
Hydrophobic H8 E 365 8x49 G.H5 Y 351 G.H5.22
Van-der-waals H8 E 365 8x49 G.H5 Y 351 G.H5.22
Polar C-term S 401 - G.H2 K 210 G.H2.05
Van-der-waals C-term S 401 - G.H2 K 210 G.H2.05
Ionic ICL2 E 220 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 220 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 220 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 220 - G.hns1 R 32 G.hns1.03
Aromatic ICL2 Y 217 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 Y 217 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 Y 217 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 I 213 3x58 G.H5 L 354 G.H5.25
Polar C-term Q 407 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term Q 407 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term Q 407 - G.s4h3 E 237 G.s4h3.10
Ionic C-term K 406 - G.H2 E 208 G.H2.03
Polar C-term K 406 - G.H2 E 208 G.H2.03
Hydrophobic C-term K 406 - G.H2 E 208 G.H2.03
Van-der-waals C-term K 406 - G.H2 E 208 G.H2.03
Ionic ICL2 R 221 - G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 221 - G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 221 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 221 - G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 A 296 5x67 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 A 296 5x67 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 L 209 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 I 352 G.H5.23
Polar TM3 A 212 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 212 3x57 G.H5 N 348 G.H5.19
Polar ICL3 S 297 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 S 297 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 S 297 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 K 293 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM5 K 293 5x64 G.H5 L 349 G.H5.20
Hydrophobic TM5 I 289 5x60 G.H5 I 345 G.H5.16
Polar TM2 C 146 2x44 G.H5 Y 351 G.H5.22
Hydrophobic TM2 C 146 2x44 G.H5 Y 351 G.H5.22
Van-der-waals TM2 C 146 2x44 G.H5 Y 351 G.H5.22
Hydrophobic TM5 I 286 5x57 G.H5 L 354 G.H5.25
Hydrophobic C-term I 405 - G.H3 R 249 G.H3.07
Hydrophobic ICL2 Y 217 - G.S2 F 192 G.S2.08
Hydrophobic TM3 I 213 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 213 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 290 5x61 G.H5 L 349 G.H5.20
Hydrophobic C-term T 395 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 T 216 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 T 216 - G.H5 I 345 G.H5.16
Hydrophobic C-term F 402 - G.H2 K 210 G.H2.05
Polar C-term S 404 - G.H2 E 208 G.H2.03
Hydrophobic C-term S 404 - G.H2 E 208 G.H2.03
Van-der-waals C-term S 404 - G.H2 E 208 G.H2.03
Ionic TM5 K 293 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 293 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 293 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 293 5x64 G.H5 D 342 G.H5.13
Polar ICL2 Y 217 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 Y 217 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 Y 217 - G.H5 T 341 G.H5.12
Hydrophobic TM6 A 311 6x41 G.H5 L 354 G.H5.25
Hydrophobic C-term I 405 - G.H3 E 246 G.H3.04
Van-der-waals C-term I 405 - G.H3 E 246 G.H3.04
Hydrophobic ICL2 T 216 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 T 216 - G.H5 I 344 G.H5.15