Gi2 - OXE receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 194 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 194 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 297 6x37 G.H5 L 354 G.H5.25
Polar ICL2 H 198 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 H 198 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 H 198 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM4 S 205 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 205 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 203 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 203 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 284 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 L 284 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 L 284 - G.S6 Y 321 G.S6.02
Polar C-term S 381 - G.H3 K 258 G.H3.16
Van-der-waals C-term S 381 - G.H3 K 258 G.H3.16
Ionic ICL2 R 203 34x56 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 203 34x56 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 R 203 34x56 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 203 34x56 G.s2s3 D 194 G.s2s3.02
Polar TM2 N 127 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 N 127 2x39 G.H5 C 352 G.H5.23
Polar H8 S 359 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 S 359 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 359 8x47 G.H5 G 353 G.H5.24
Hydrophobic C-term W 392 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term W 392 - G.h2s4 E 217 G.h2s4.02
Polar TM6 A 293 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 293 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 293 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 279 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 P 290 6x30 G.H5 F 355 G.H5.26
Polar TM6 Q 287 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM6 Q 287 6x27 G.S6 Y 321 G.S6.02
Van-der-waals TM6 Q 287 6x27 G.S6 Y 321 G.S6.02
Ionic C-term E 383 - G.H3 K 258 G.H3.16
Polar C-term E 383 - G.H3 K 258 G.H3.16
Hydrophobic C-term E 383 - G.H3 K 258 G.H3.16
Van-der-waals C-term E 383 - G.H3 K 258 G.H3.16
Aromatic C-term Y 386 - G.H3 W 259 G.H3.17
Hydrophobic C-term Y 386 - G.H3 W 259 G.H3.17
Van-der-waals C-term Y 386 - G.H3 W 259 G.H3.17
Hydrophobic C-term Y 394 - G.HN I 19 G.HN.43
Van-der-waals C-term Y 394 - G.HN I 19 G.HN.43
Hydrophobic TM3 K 193 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 K 193 3x53 G.H5 C 352 G.H5.23
Hydrophobic C-term S 384 - G.H3 K 258 G.H3.16
Van-der-waals C-term S 384 - G.H3 K 258 G.H3.16
Hydrophobic ICL2 P 197 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 197 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM4 V 206 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL2 H 198 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 190 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 190 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 H 198 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 H 198 34x51 G.s2s3 K 193 G.s2s3.01
Ionic ICL1 R 122 12x49 G.HN D 20 G.HN.44
Polar ICL1 R 122 12x49 G.HN D 20 G.HN.44
Ionic ICL3 R 282 - G.H5 D 342 G.H5.13
Polar ICL3 R 282 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 282 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 282 - G.H5 D 342 G.H5.13
Polar TM3 R 190 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 190 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 190 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 G 289 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 G 289 6x29 G.H5 F 355 G.H5.26
Hydrophobic H8 P 360 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 P 360 8x48 G.H5 F 355 G.H5.26
Hydrophobic C-term R 393 - G.HN L 23 G.HN.47
Van-der-waals C-term R 393 - G.HN L 23 G.HN.47
Aromatic ICL2 H 198 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 H 198 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 H 198 34x51 G.H5 F 337 G.H5.08
Ionic ICL3 R 282 - G.H5 D 338 G.H5.09
Polar ICL3 R 282 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 R 282 - G.H5 D 338 G.H5.09
Hydrophobic TM6 A 293 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL3 R 282 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 R 282 - G.H5 I 345 G.H5.16
Hydrophobic ICL3 L 284 - G.H5 I 345 G.H5.16
Polar TM2 N 127 2x39 G.H5 D 351 G.H5.22
Polar TM6 Q 287 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Q 287 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 287 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 194 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 V 194 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 H 198 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 198 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 P 290 6x30 G.H5 L 349 G.H5.20
Hydrophobic ICL2 R 203 34x56 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 203 34x56 G.S3 L 195 G.S3.01
Hydrophobic TM6 R 292 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 292 6x32 G.H5 F 355 G.H5.26
Polar TM3 K 193 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 193 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 193 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM4 G 207 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 V 296 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 T 278 5x64 G.H5 I 345 G.H5.16
Hydrophobic ICL3 R 282 - G.H5 T 341 G.H5.12
Van-der-waals ICL3 R 282 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 P 197 34x50 G.H5 T 341 G.H5.12
Polar TM4 V 206 4x39 G.HN E 28 G.HN.52
Ionic TM3 K 193 3x53 G.H5 D 351 G.H5.22
Polar TM3 K 193 3x53 G.H5 D 351 G.H5.22