Gi1 - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 333 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 309 5x64 G.H5 F 354 G.H5.26
Hydrophobic N-term T 3 - G.HN L 5 G.HN.11
Van-der-waals N-term T 3 - G.HN L 5 G.HN.11
Polar N-term M 1 - G.HN K 10 G.HN.34
Hydrophobic N-term M 1 - G.HN K 10 G.HN.34
Van-der-waals N-term M 1 - G.HN K 10 G.HN.34
Hydrophobic TM6 L 332 6x44 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 315 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 M 234 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 M 234 - G.H5 I 343 G.H5.15
Polar ICL2 L 235 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 235 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 D 314 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 M 234 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 234 - G.H5 T 340 G.H5.12
Hydrophobic TM5 L 306 5x61 G.H5 F 354 G.H5.26
Hydrophobic ICL2 M 234 - G.H5 I 344 G.H5.16
Polar TM3 L 230 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 230 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 235 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 235 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 235 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 235 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 231 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 231 3x58 G.H5 L 348 G.H5.20
Aromatic TM4 F 241 4x43 G.HN R 24 G.HN.48
Hydrophobic TM5 I 305 5x60 G.H5 I 344 G.H5.16
Hydrophobic TM2 R 158 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 158 2x46 G.H5 C 351 G.H5.23
Ionic ICL1 R 152 12x48 G.HN D 20 G.HN.44
Polar ICL1 R 152 12x48 G.HN D 20 G.HN.44
Hydrophobic ICL1 R 152 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 R 152 12x48 G.HN D 20 G.HN.44
Hydrophobic TM3 L 231 3x58 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 306 5x61 G.H5 L 348 G.H5.20
Ionic TM5 K 309 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 309 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 309 5x64 G.H5 D 341 G.H5.13
Hydrophobic N-term R 2 - G.HN K 10 G.HN.34
Van-der-waals N-term R 2 - G.HN K 10 G.HN.34
Hydrophobic ICL2 M 234 - G.S3 L 194 G.S3.01
Hydrophobic TM3 L 227 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 309 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM3 L 227 3x54 G.H5 L 353 G.H5.25
Hydrophobic N-term R 2 - G.HN V 13 G.HN.37
Hydrophobic N-term M 1 - G.HN K 17 G.HN.41
Van-der-waals N-term M 1 - G.HN K 17 G.HN.41
Polar N-term M 1 - G.HN E 14 G.HN.38
Hydrophobic N-term M 1 - G.HN E 14 G.HN.38
Van-der-waals N-term M 1 - G.HN E 14 G.HN.38
Hydrophobic TM5 K 309 5x64 G.H5 I 344 G.H5.16
Hydrophobic N-term M 1 - G.HN V 13 G.HN.37
Van-der-waals N-term M 1 - G.HN V 13 G.HN.37
Hydrophobic ICL2 L 235 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 235 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 310 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 310 5x65 G.H5 F 354 G.H5.26
Hydrophobic N-term T 3 - G.HN V 13 G.HN.37
Polar TM2 R 158 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 158 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 158 2x46 G.H5 D 350 G.H5.22
Polar TM4 P 236 4x38 G.hns1 R 32 G.hns1.03
Polar ICL1 R 152 12x48 G.HN S 16 G.HN.40
Van-der-waals ICL1 R 152 12x48 G.HN S 16 G.HN.40
Polar N-term R 2 - G.HN T 4 G.HN.10
Hydrophobic N-term R 2 - G.HN T 4 G.HN.10
Van-der-waals N-term R 2 - G.HN T 4 G.HN.10
Polar TM6 R 325 6x37 G.H5 F 354 G.H5.26
Aromatic TM6 R 325 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 325 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 325 6x37 G.H5 F 354 G.H5.26
Ionic TM4 R 238 4x40 G.HN E 28 G.HN.52
Polar TM4 R 238 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 238 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 238 4x40 G.HN E 28 G.HN.52
Polar N-term R 2 - G.HN L 5 G.HN.11
Hydrophobic N-term R 2 - G.HN L 5 G.HN.11
Van-der-waals N-term R 2 - G.HN L 5 G.HN.11
Polar TM6 S 329 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 329 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 329 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 231 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 I 344 G.H5.16
Polar TM2 T 157 2x45 G.HN R 24 G.HN.48
Van-der-waals TM2 T 157 2x45 G.HN R 24 G.HN.48