Gt2 - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 333 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 333 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 336 6x48 G.H5 L 353 G.H5.25
Polar ICL2 M 234 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 M 234 - G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 M 234 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 L 235 - G.HN A 27 G.HN.51
Van-der-waals ICL2 L 235 - G.HN A 27 G.HN.51
Polar ICL2 M 234 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 M 234 - G.S1 T 33 G.S1.01
Van-der-waals ICL2 M 234 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 M 234 - G.HN K 29 G.HN.53
Van-der-waals ICL2 M 234 - G.HN K 29 G.HN.53
Hydrophobic TM6 L 332 6x44 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 332 6x44 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 233 3x60 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 A 233 3x60 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 235 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 235 - G.hns1 K 32 G.hns1.03
Hydrophobic TM7 Y 375 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 Y 375 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM2 R 158 2x46 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 158 2x46 G.H5 G 352 G.H5.24
Polar TM4 P 236 4x38 G.hns1 E 30 G.hns1.01
Hydrophobic TM4 P 236 4x38 G.hns1 E 30 G.hns1.01
Van-der-waals TM4 P 236 4x38 G.hns1 E 30 G.hns1.01
Hydrophobic TM4 P 237 4x39 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 P 237 4x39 G.hns1 A 31 G.hns1.02
Polar TM4 P 236 4x38 G.HN A 27 G.HN.51
Hydrophobic TM4 P 236 4x38 G.HN A 27 G.HN.51
Van-der-waals TM4 P 236 4x38 G.HN A 27 G.HN.51
Hydrophobic TM3 T 229 3x56 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 T 229 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 231 3x58 G.S3 L 194 G.S3.01
Van-der-waals TM3 L 231 3x58 G.S3 L 194 G.S3.01
Hydrophobic TM3 Y 226 3x53 G.H5 C 351 G.H5.23
Polar TM3 L 230 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 230 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 227 3x54 G.H5 L 348 G.H5.20
Polar ICL2 L 235 - G.HN K 29 G.HN.53
Hydrophobic ICL2 L 235 - G.HN K 29 G.HN.53
Van-der-waals ICL2 L 235 - G.HN K 29 G.HN.53
Polar TM2 R 158 2x46 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 158 2x46 G.H5 K 349 G.H5.21
Polar ICL2 L 235 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 235 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 235 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 V 232 3x59 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 L 231 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 231 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 233 3x60 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 A 233 3x60 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 A 233 3x60 G.S3 L 194 G.S3.01
Van-der-waals TM3 A 233 3x60 G.S3 L 194 G.S3.01
Hydrophobic ICL2 M 234 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 234 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 L 235 - G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 L 235 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL3 D 314 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 D 314 - G.H5 F 334 G.H5.06
Ionic TM4 R 238 4x40 G.h2s4 E 216 G.h2s4.02
Polar TM4 R 238 4x40 G.h2s4 E 216 G.h2s4.02
Van-der-waals TM4 R 238 4x40 G.h2s4 E 216 G.h2s4.02
Hydrophobic TM3 L 230 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 230 3x57 G.H5 C 351 G.H5.23
Polar TM4 R 239 4x41 G.HN L 23 G.HN.47
Van-der-waals TM4 R 239 4x41 G.HN L 23 G.HN.47
Hydrophobic TM4 P 237 4x39 G.hns1 E 30 G.hns1.01
Van-der-waals TM4 P 237 4x39 G.hns1 E 30 G.hns1.01
Hydrophobic TM2 R 158 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 158 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM4 C 240 4x42 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 P 236 4x38 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 P 236 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 306 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 306 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 235 - G.HN D 28 G.HN.52
Van-der-waals ICL2 L 235 - G.HN D 28 G.HN.52
Hydrophobic ICL2 M 234 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 234 - G.S3 L 194 G.S3.01
Ionic TM5 K 309 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 309 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 309 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 227 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 C 351 G.H5.23
Polar ICL2 M 234 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 M 234 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 M 234 - G.hns1 K 32 G.hns1.03
Hydrophobic TM3 L 227 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 227 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM4 R 239 4x41 G.HN A 27 G.HN.51
Van-der-waals TM4 R 239 4x41 G.HN A 27 G.HN.51
Hydrophobic TM5 K 309 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 309 5x64 G.H5 I 344 G.H5.16
Polar ICL2 M 234 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 M 234 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 M 234 - G.hns1 A 31 G.hns1.02
Polar TM2 R 158 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 158 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 158 2x46 G.H5 D 350 G.H5.22
Polar TM3 V 232 3x59 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 V 232 3x59 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 V 232 3x59 G.hns1 K 32 G.hns1.03
Hydrophobic TM7 Y 375 7x57 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 232 3x59 G.S3 L 194 G.S3.01
Van-der-waals TM3 V 232 3x59 G.S3 L 194 G.S3.01
Hydrophobic TM3 L 231 3x58 G.H5 I 344 G.H5.16