GPCRdb

Ligand source activities (1 row/activity)

ChEMBL ID	Receptor	Species	Purchasable	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles

CHEMBL2335047	lpar1_human	Human	No	8.0	EC50	=	10.1	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	455	23	2	6	8.8	CCCCCCCCCCCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL325288	lpar1_human	Human	No	5.9	EC50	=	1225	Funct	Agonistic activity against lysophosphatidic acid receptor 1 receptor using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 receptor using [35S]GTP-gamma-S as radioligand tested in vitro	420	19	4	5	5.0	CCCCCCCCC=CCCCCCCCC(=O)NCCC(O)P(=O)(O)O
CHEMBL357053	lpar1_human	Human	No	7.8	EC50	=	14.7	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	469	23	2	7	8.4	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=S)(O)O)OC
CHEMBL2017139	lpar1_human	Human	No	7.8	EC50	=	16.6	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	469	23	2	7	8.4	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=S)(O)O)OC
CHEMBL117021	lpar1_human	Human	Yes	7.8	EC50	=	17	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL117021	lpar1_human	Human	Yes	7.8	EC50	=	18	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL190328	lpar1_human	Human	Yes	5.7	EC50	=	1850	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	423	19	4	7	4.7	CCCCCCCCCCCCCCCC(=O)NC(COP(=O)(O)O)C(=O)O
CHEMBL190328	lpar1_human	Human	Yes	5.7	EC50	=	1850	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	423	19	4	7	4.7	CCCCCCCCCCCCCCCC(=O)NC(COP(=O)(O)O)C(=O)O
CHEMBL187459	lpar1_human	Human	No	6.7	EC50	=	193	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	365	17	2	4	8.1	CCCCCCCCC=CCCCCCCCCOP(=S)(O)O
CHEMBL187459	lpar1_human	Human	No	6.7	EC50	=	193	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	365	17	2	4	8.1	CCCCCCCCC=CCCCCCCCCOP(=S)(O)O
CHEMBL331661	lpar1_human	Human	No	5.7	EC50	=	1950	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	404	19	3	4	5.5	CCCCCCCCC=CCCCCCCCC(=O)NCCCP(=O)(O)O
CHEMBL117754	lpar1_human	Human	Yes	6.7	EC50	=	197	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	406	19	3	5	5.2	CCCCCCCCC=CCCCCCCCC(=O)NCCOP(=O)(O)O
CHEMBL117754	lpar1_human	Human	Yes	6.7	EC50	=	197	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	406	19	3	5	5.2	CCCCCCCCC=CCCCCCCCC(=O)NCCOP(=O)(O)O
CHEMBL117754	lpar1_human	Human	Yes	6.7	EC50	=	197	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	406	19	3	5	5.2	CCCCCCCCC=CCCCCCCCC(=O)NCCOP(=O)(O)O
CHEMBL117529	lpar1_human	Human	No	6.7	EC50	=	221	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	418	19	3	5	4.9	CCCCCCCCC=CCCCCCCCC(=O)NCCC(=O)P(=O)(O)O
CHEMBL117529	lpar1_human	Human	No	6.7	EC50	=	221	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	418	19	3	5	4.9	CCCCCCCCC=CCCCCCCCC(=O)NCCC(=O)P(=O)(O)O
CHEMBL117529	lpar1_human	Human	No	6.7	EC50	=	221	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	418	19	3	5	4.9	CCCCCCCCC=CCCCCCCCC(=O)NCCC(=O)P(=O)(O)O
CHEMBL153043	lpar1_human	Human	No	7.6	EC50	=	24	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	469	23	2	7	8.4	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=S)(O)O)OC
CHEMBL3621958	lpar1_mouse	Mouse	No	8.5	EC50	=	3.4	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	420	19	3	5	5.7	CCCCCCCCC=CCCCCCCCC(=O)NC(C)COP(=O)(O)O
CHEMBL3621958	lpar1_mouse	Mouse	No	8.5	EC50	=	3.4	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	420	19	3	5	5.7	CCCCCCCCC=CCCCCCCCC(=O)NC(C)COP(=O)(O)O
CHEMBL2335048	lpar1_human	Human	No	7.5	EC50	=	30.9	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	455	23	2	6	8.8	CCCCCCCCCCCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL117021	lpar1_human	Human	Yes	7.5	EC50	=	31	Funct	Agonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assay	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL117021	lpar1_human	Human	Yes	7.5	EC50	=	31	Funct	Agonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assay	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL3621960	lpar1_human	Human	No	6.5	EC50	=	318	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	422	19	3	5	5.6	CCCCCCCCC=CCCCCCCCC(=O)NCCSP(=O)(O)O
CHEMBL3621960	lpar1_human	Human	No	6.5	EC50	=	318	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	422	19	3	5	5.6	CCCCCCCCC=CCCCCCCCC(=O)NCCSP(=O)(O)O
CHEMBL325970	lpar1_human	Human	No	6.5	EC50	=	318	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	434	19	3	5	5.5	CCCCCCCCC=CCCCCCCCC(=O)NCCC(=S)P(=O)(O)O
CHEMBL202243	lpar1_human	Human	No	5.5	EC50	=	3260	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	397	20	2	6	5.1	CCCCCCCCOCC(COP(=O)(O)O)OCCCCCCCC
CHEMBL202243	lpar1_human	Human	No	5.5	EC50	=	3260	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	397	20	2	6	5.1	CCCCCCCCOCC(COP(=O)(O)O)OCCCCCCCC
CHEMBL117021	lpar1_human	Human	Yes	6.5	EC50	=	350	Funct	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL117021	lpar1_human	Human	Yes	6.5	EC50	=	350	Funct	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	437	21	3	7	5.2	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL3621957	lpar1_mouse	Mouse	No	8.3	EC50	=	4.9	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	435	20	4	6	2.1	CCCCCCCCC=CCCCCCCCC(=O)NC(CN)COP(=O)(O)O
CHEMBL3621957	lpar1_mouse	Mouse	No	8.3	EC50	=	4.9	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	435	20	4	6	2.1	CCCCCCCCC=CCCCCCCCC(=O)NC(CN)COP(=O)(O)O
CHEMBL3621959	lpar1_human	Human	No	7.4	EC50	=	40	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	422	19	3	5	7.0	CCCCCCCCC=CCCCCCCCC(=O)NCCOP(=S)(O)O
CHEMBL3621959	lpar1_human	Human	No	7.4	EC50	=	40	Funct	Agonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	422	19	3	5	7.0	CCCCCCCCC=CCCCCCCCC(=O)NCCOP(=S)(O)O
CHEMBL117798	lpar1_human	Human	No	7.4	EC50	=	40	Funct	Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro	434	19	3	5	6.6	CCCCCCCCC=CCCCCCCCC(=O)NCCC(=O)P(=S)(O)O
CHEMBL3621962	lpar1_human	Human	Yes	6.2	EC50	=	571	Funct	Agonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysisAgonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysis	453	22	2	6	7.8	CCCCCCCCC=CCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL3621962	lpar1_human	Human	Yes	6.2	EC50	=	571	Funct	Agonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysisAgonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysis	453	22	2	6	7.8	CCCCCCCCC=CCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL201482	lpar1_human	Human	Yes	6.2	EC50	=	695	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	413	20	2	6	6.8	CCCCCCCCOCC(COP(=S)(O)O)OCCCCCCCC
CHEMBL201482	lpar1_human	Human	Yes	6.2	EC50	=	695	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	413	20	2	6	6.8	CCCCCCCCOCC(COP(=S)(O)O)OCCCCCCCC
CHEMBL3621956	lpar1_mouse	Mouse	No	8.1	EC50	=	7.9	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	436	20	4	6	4.6	CCCCCCCCC=CCCCCCCCC(=O)NC(CO)COP(=O)(O)O
CHEMBL3621956	lpar1_mouse	Mouse	No	8.1	EC50	=	7.9	Funct	Agonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at mouse LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	436	20	4	6	4.6	CCCCCCCCC=CCCCCCCCC(=O)NC(CO)COP(=O)(O)O
CHEMBL364797	lpar1_human	Human	Yes	7.2	EC50	=	71	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	411	20	3	7	5.0	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CHEMBL3621961	lpar1_human	Human	No	6.1	EC50	=	790	Funct	Agonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysisAgonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysis	453	22	2	6	7.8	CCCCCCCCC=CCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL3621961	lpar1_human	Human	No	6.1	EC50	=	790	Funct	Agonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysisAgonist activity at human LPA1 receptor transfected in RH7777 cells assessed as mobilization of Ca2+ by fluorometric analysis	453	22	2	6	7.8	CCCCCCCCC=CCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL2335052	lpar1_human	Human	No	8.1	EC50	=	8.3	Funct	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	455	23	2	6	8.8	CCCCCCCCCCCCCCCCCCOCC(COP(=S)(O)O)OC
CHEMBL246942	lpar1_rat	Rat	No	7.0	IC50	=	100	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCSCC(=O)O
CHEMBL2182029	lpar1_human	Human	Yes	7.0	IC50	=	100	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	483	8	2	6	5.0	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5
CHEMBL246942	lpar1_rat	Rat	No	7.0	IC50	=	100	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCSCC(=O)O
CHEMBL210117	lpar1_human	Human	No	7.0	IC50	=	106	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	437	19	1	6	7.9	CCCCCCCCCCCCCCCCCC(=O)OCC1CC(P(=O)(O1)O)F
CHEMBL210117	lpar1_human	Human	No	7.0	IC50	=	106	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	437	19	1	6	7.9	CCCCCCCCCCCCCCCCCC(=O)OCC1CC(P(=O)(O1)O)F
CHEMBL2182025	lpar1_human	Human	No	7.0	IC50	=	106	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	448	8	2	5	5.0	CC(C)C(C)OC(=O)NC1=C(C=NN1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O
CHEMBL91058	lpar1_human	Human	No	6.0	IC50	=	1070	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	632	25	3	7	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC(=CC=C2)OC)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.0	IC50	=	109	Funct	Antagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAntagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.0	IC50	=	109	Funct	Antagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAntagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.0	IC50	=	109	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.0	IC50	=	109	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL394038	lpar1_rat	Rat	No	7.0	IC50	=	110	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	493	10	2	8	2.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CS(=O)(=O)CCC(=O)O
CHEMBL394038	lpar1_rat	Rat	No	7.0	IC50	=	110	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	493	10	2	8	2.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CS(=O)(=O)CCC(=O)O
CHEMBL3326534	lpar1_human	Human	No	7.0	IC50	=	111	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	341	6	1	7	2.4	CC(C)N=C(C(=O)C1=C(C=C(C=C1)OC)OC)N2C(=C(C=N2)C#N)N
CHEMBL3326534	lpar1_human	Human	No	7.0	IC50	=	111	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	341	6	1	7	2.4	CC(C)N=C(C(=O)C1=C(C=C(C=C1)OC)OC)N2C(=C(C=N2)C#N)N
CHEMBL2182031	lpar1_human	Human	No	7.0	IC50	=	112	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	551	8	2	9	5.9	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5C(F)(F)F
CHEMBL182446	lpar1_human	Human	No	6.9	IC50	=	114	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	677	28	3	9	7.5	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCCOC)COP(=O)(O)O
CHEMBL246734	lpar1_rat	Rat	No	6.9	IC50	=	120	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	471	10	2	6	5.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCC(C)(C)CC(=O)O
CHEMBL246734	lpar1_rat	Rat	No	6.9	IC50	=	120	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	471	10	2	6	5.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCC(C)(C)CC(=O)O
CHEMBL3621965	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 1 min followed by LPA induction measured for 15 secs by Fura-2 AM probe-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 1 min followed by LPA induction measured for 15 secs by Fura-2 AM probe-based fluorometric analysis	447	9	2	7	4.2	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCC(=O)O
CHEMBL247959	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	451	10	2	7	3.2	CC(C1=C(CCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246942	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCSCC(=O)O
CHEMBL3621965	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 1 min followed by LPA induction measured for 15 secs by Fura-2 AM probe-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 1 min followed by LPA induction measured for 15 secs by Fura-2 AM probe-based fluorometric analysis	447	9	2	7	4.2	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCC(=O)O
CHEMBL247959	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	451	10	2	7	3.2	CC(C1=C(CCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246942	lpar1_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCSCC(=O)O
CHEMBL246735	lpar1_human	Human	No	6.9	IC50	=	140	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	458	9	3	7	2.7	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)NC(=O)CCC(=O)O
CHEMBL246735	lpar1_human	Human	No	6.9	IC50	=	140	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	458	9	3	7	2.7	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)NC(=O)CCC(=O)O
CHEMBL291229	lpar1_human	Human	No	6.9	IC50	=	141	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	661	27	3	8	8.6	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCCC)COP(=O)(O)O
CHEMBL183143	lpar1_human	Human	No	6.9	IC50	=	143	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	647	26	3	8	8.0	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC)COP(=O)(O)O
CHEMBL360131	lpar1_human	Human	No	5.9	IC50	=	1430	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	653	24	3	7	9.0	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC3=CC=CC=C3C=C2)COP(=O)(O)O
CHEMBL2182052	lpar1_human	Human	Yes	6.8	IC50	=	150	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	456	8	2	6	5.0	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL3621964	lpar1_human	Human	No	5.8	IC50	=	1500	Funct	Antagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization by Fura-2 AM probe-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization by Fura-2 AM probe-based fluorometric analysis	485	19	3	6	5.3	CCCCCCC=CCCCCCCCC(=O)OCC(CC(P(=O)(O)O)Br)O
CHEMBL3621964	lpar1_human	Human	No	5.8	IC50	=	1500	Funct	Antagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization by Fura-2 AM probe-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization by Fura-2 AM probe-based fluorometric analysis	485	19	3	6	5.3	CCCCCCC=CCCCCCCCC(=O)OCC(CC(P(=O)(O)O)Br)O
CHEMBL203986	lpar1_human	Human	No	5.8	IC50	=	1580	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	397	20	2	6	5.1	CCCCCCCCOCC(COP(=O)(O)O)OCCCCCCCC
CHEMBL203986	lpar1_human	Human	No	5.8	IC50	=	1580	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	397	20	2	6	5.1	CCCCCCCCOCC(COP(=O)(O)O)OCCCCCCCC
CHEMBL361501	lpar1_rat	Rat	Yes	6.8	IC50	=	160	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL361501	lpar1_human	Human	Yes	6.8	IC50	=	160	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL361501	lpar1_rat	Rat	Yes	6.8	IC50	=	160	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182035	lpar1_human	Human	No	6.8	IC50	=	161	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	461	8	2	6	4.8	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5CCC5
CHEMBL3621966	lpar1_human	Human	Yes	7.8	IC50	=	17	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis	491	8	2	6	5.6	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL3621966	lpar1_human	Human	Yes	7.8	IC50	=	17	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis	491	8	2	6	5.6	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL2182046	lpar1_human	Human	No	7.8	IC50	=	17	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	551	8	2	9	5.5	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL246943	lpar1_human	Human	No	6.8	IC50	=	170	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	465	10	2	7	3.7	CC(C1=C(CCCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246943	lpar1_human	Human	No	6.8	IC50	=	170	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	465	10	2	7	3.7	CC(C1=C(CCCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182032	lpar1_human	Human	No	6.8	IC50	=	174	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	551	8	2	9	5.9	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC(=CC=C5)C(F)(F)F
CHEMBL2182053	lpar1_human	Human	No	4.8	IC50	=	17500	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	321	5	1	3	3.7	CC(C1=CC=CC=C1)OC(=O)NC2=C(C=NN2C)C3=CC=CC=C3
CHEMBL2182026	lpar1_human	Human	No	6.8	IC50	=	176	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	431	7	2	5	4.1	CN1C(=C(C=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC5CCC5
CHEMBL2182046	lpar1_human	Human	No	7.8	IC50	=	18	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	551	8	2	9	5.5	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182043	lpar1_human	Human	No	7.8	IC50	=	18	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	483	8	2	6	4.6	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182044	lpar1_human	Human	No	7.8	IC50	=	18	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	501	8	2	7	4.7	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=C(C=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O)F
CHEMBL2182043	lpar1_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	483	8	2	6	4.6	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182044	lpar1_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	501	8	2	7	4.7	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=C(C=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O)F
CHEMBL2182049	lpar1_human	Human	No	7.7	IC50	=	18.8	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	560	9	2	7	3.9	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)NS(=O)(=O)C
CHEMBL2182049	lpar1_human	Human	No	7.7	IC50	=	19	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	560	9	2	7	3.9	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)NS(=O)(=O)C
CHEMBL2182043	lpar1_human	Human	No	7.7	IC50	=	20	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	483	8	2	6	4.6	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182044	lpar1_human	Human	No	7.7	IC50	=	20	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	501	8	2	7	4.7	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=C(C=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O)F
CHEMBL2182063	lpar1_human	Human	No	7.7	IC50	=	20	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	482	8	2	5	5.1	CC(C1=CC=CC=C1)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL246527	lpar1_human	Human	No	6.7	IC50	=	200	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	443	10	2	6	4.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCCCC(=O)O
CHEMBL246527	lpar1_human	Human	No	6.7	IC50	=	200	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	443	10	2	6	4.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCCCC(=O)O
CHEMBL2182063	lpar1_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	482	8	2	5	5.1	CC(C1=CC=CC=C1)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182033	lpar1_human	Human	No	6.7	IC50	=	217	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	449	8	2	6	4.9	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C(C)C
CHEMBL246929	lpar1_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182051	lpar1_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	463	8	2	6	4.9	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4CCC(CC4)CC(=O)O
CHEMBL246929	lpar1_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL188591	lpar1_human	Human	No	5.7	IC50	=	2200	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	292	13	2	4	4.2	CCC=CCCCCCCCCCCOP(=O)(O)O
CHEMBL188591	lpar1_human	Human	No	5.7	IC50	=	2200	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	292	13	2	4	4.2	CCC=CCCCCCCCCCCOP(=O)(O)O
CHEMBL2182038	lpar1_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	507	8	2	7	5.0	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C5=NNN=N5)NC(=O)OC(C)C6=CC=CC=C6
CHEMBL187633	lpar1_human	Human	Yes	5.6	IC50	=	2300	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	294	14	2	4	5.1	CCCCCCCCCCCCCCOP(=O)(O)O
CHEMBL187633	lpar1_human	Human	Yes	5.6	IC50	=	2300	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	294	14	2	4	5.1	CCCCCCCCCCCCCCOP(=O)(O)O
CHEMBL2182050	lpar1_human	Human	No	7.6	IC50	=	24	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	628	9	2	10	4.8	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)NS(=O)(=O)C
CHEMBL2182064	lpar1_human	Human	No	7.6	IC50	=	24	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	500	8	2	6	5.2	CC(C1=CC=CC=C1F)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182050	lpar1_human	Human	No	7.6	IC50	=	24.5	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	628	9	2	10	4.8	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)NS(=O)(=O)C
CHEMBL3621963	lpar1_human	Human	No	5.6	IC50	=	2490	Funct	Antagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAntagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	616	24	3	7	8.1	CCCCCCCCC=CCCCCCCCC(=O)NC(COP(=O)(O)O)C(=O)C1=CC=C(C=C1)OCC2=CC=CC=C2
CHEMBL3621963	lpar1_human	Human	No	5.6	IC50	=	2490	Funct	Antagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAntagonist activity at human LPA1 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay	616	24	3	7	8.1	CCCCCCCCC=CCCCCCCCC(=O)NC(COP(=O)(O)O)C(=O)C1=CC=C(C=C1)OCC2=CC=CC=C2
CHEMBL327240	lpar1_human	Human	Yes	5.6	IC50	=	2490	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	602	24	3	6	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL2182052	lpar1_human	Human	Yes	7.6	IC50	=	25	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis	456	8	2	6	5.0	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL2182052	lpar1_human	Human	Yes	7.6	IC50	=	25	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysisAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis	456	8	2	6	5.0	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL2182029	lpar1_human	Human	Yes	7.6	IC50	=	25.2	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	483	8	2	6	5.0	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5
CHEMBL188859	lpar1_human	Human	No	5.6	IC50	=	2500	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	328	14	2	5	6.4	CCCCCCCCCCCCCCC(F)(F)P(=O)(O)O
CHEMBL188859	lpar1_human	Human	No	5.6	IC50	=	2500	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	328	14	2	5	6.4	CCCCCCCCCCCCCCC(F)(F)P(=O)(O)O
CHEMBL246928	lpar1_human	Human	No	6.6	IC50	=	260	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246928	lpar1_human	Human	No	6.6	IC50	=	260	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182047	lpar1_human	Human	No	5.6	IC50	=	2650	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	551	8	2	9	5.5	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182047	lpar1_human	Human	No	5.6	IC50	=	2660	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	551	8	2	9	5.5	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL482498	lpar1_human	Human	Yes	4.6	IC50	=	27354	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentrationAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration	488	10	4	8	2.9	C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O
CHEMBL482498	lpar1_human	Human	Yes	4.6	IC50	=	27354	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	488	10	4	8	2.9	C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O
CHEMBL482498	lpar1_human	Human	Yes	4.6	IC50	=	27354	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentrationAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration	488	10	4	8	2.9	C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O
CHEMBL482498	lpar1_human	Human	Yes	4.6	IC50	=	27354	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	488	10	4	8	2.9	C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O
CHEMBL394038	lpar1_human	Human	No	6.6	IC50	=	280	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	493	10	2	8	2.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CS(=O)(=O)CCC(=O)O
CHEMBL394038	lpar1_human	Human	No	6.6	IC50	=	280	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	493	10	2	8	2.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CS(=O)(=O)CCC(=O)O
CHEMBL187711	lpar1_human	Human	Yes	5.6	IC50	=	2800	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	266	12	2	4	4.0	CCCCCCCCCCCCOP(=O)(O)O
CHEMBL187711	lpar1_human	Human	Yes	5.6	IC50	=	2800	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	266	12	2	4	4.0	CCCCCCCCCCCCOP(=O)(O)O
CHEMBL185287	lpar1_human	Human	No	5.6	IC50	=	2840	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	633	25	3	8	8.0	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC(=CC=C2)OC)COP(=O)(O)O
CHEMBL247959	lpar1_rat	Rat	No	7.5	IC50	=	29	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	451	10	2	7	3.2	CC(C1=C(CCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL247959	lpar1_rat	Rat	No	7.5	IC50	=	29	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	451	10	2	7	3.2	CC(C1=C(CCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL313413	lpar1_human	Human	No	5.5	IC50	=	2930	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	628	23	3	6	9.3	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OC2CC3=CC=CC=C3C2)COP(=O)(O)O
CHEMBL3326525	lpar1_human	Human	No	5.5	IC50	=	2940	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	386	4	1	5	3.6	C1CCC(C1)N=C(C(=O)C2=CC=C(C=C2)Br)N3C(=C(C=N3)C#N)N
CHEMBL3326525	lpar1_human	Human	No	5.5	IC50	=	2940	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	386	4	1	5	3.6	C1CCC(C1)N=C(C(=O)C2=CC=C(C=C2)Br)N3C(=C(C=N3)C#N)N
CHEMBL190430	lpar1_human	Human	No	5.5	IC50	=	3000	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	292	13	2	4	4.2	CCCCC=CCCCCCCCCOP(=O)(O)O
CHEMBL190430	lpar1_human	Human	No	5.5	IC50	=	3000	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	292	13	2	4	4.2	CCCCC=CCCCCCCCCOP(=O)(O)O
CHEMBL2182037	lpar1_human	Human	No	7.5	IC50	=	32	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	560	9	2	7	4.3	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)NS(=O)(=O)C)NC(=O)OC(C)C5=CC=CC=C5
CHEMBL427017	lpar1_human	Human	Yes	6.5	IC50	=	328	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	413	20	2	6	6.8	CCCCCCCCOCC(COP(=S)(O)O)OCCCCCCCC
CHEMBL3326529	lpar1_human	Human	No	5.5	IC50	=	3358	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	397	7	1	8	2.8	COC1=CC(=C(C=C1C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)OC)OC
CHEMBL3326529	lpar1_human	Human	No	5.5	IC50	=	3358	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	397	7	1	8	2.8	COC1=CC(=C(C=C1C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)OC)OC
CHEMBL2182030	lpar1_human	Human	No	7.5	IC50	=	34.5	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	501	8	2	7	5.1	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5F
CHEMBL2182046	lpar1_human	Human	No	6.5	IC50	=	340	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	551	8	2	9	5.5	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182061	lpar1_human	Human	No	7.5	IC50	=	35	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	456	8	2	5	4.8	CC(C1=CC=CC=C1)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL2182056	lpar1_human	Human	No	5.5	IC50	=	3590	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	356	5	1	3	4.3	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(C=NN2C)C3=CC=CC=C3
CHEMBL2182040	lpar1_human	Human	No	7.4	IC50	=	36	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	469	8	2	6	4.6	CC(C1=CC=CC=C1)OC(=O)NC2=CN=NN2C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL181917	lpar1_human	Human	No	5.4	IC50	=	3690	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	661	25	3	8	8.4	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=C(C(=C2C)OC)C)COP(=O)(O)O
CHEMBL246734	lpar1_human	Human	No	6.4	IC50	=	370	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	471	10	2	6	5.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCC(C)(C)CC(=O)O
CHEMBL246734	lpar1_human	Human	No	6.4	IC50	=	370	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	471	10	2	6	5.6	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCC(C)(C)CC(=O)O
CHEMBL2182024	lpar1_human	Human	No	7.4	IC50	=	38	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	434	8	2	5	4.5	CCC(C)OC(=O)NC1=C(C=NN1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O
CHEMBL2182042	lpar1_human	Human	No	6.4	IC50	=	390	Funct	Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assayAntagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction assay	457	8	2	6	4.2	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL2182057	lpar1_human	Human	No	5.4	IC50	=	3970	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	374	5	1	4	4.4	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)F
CHEMBL2182034	lpar1_human	Human	No	6.4	IC50	=	398	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	434	8	2	6	4.4	CCC(C)OC(=O)NC1=C(N=NN1C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)C
CHEMBL2182023	lpar1_human	Human	No	7.4	IC50	=	41	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	550	8	2	8	6.0	CC(C1=CC(=CC=C1)C(F)(F)F)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182039	lpar1_human	Human	No	7.4	IC50	=	42	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	497	9	2	6	5.4	CCC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5
CHEMBL181612	lpar1_human	Human	No	5.4	IC50	=	4230	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	616	24	4	6	8.5	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)CC(O)P(=O)(O)O
CHEMBL181612	lpar1_human	Human	No	5.4	IC50	=	4230	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	616	24	4	6	8.5	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)CC(O)P(=O)(O)O
CHEMBL91168	lpar1_human	Human	No	5.4	IC50	=	4250	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	600	23	3	6	8.0	CCCCCC=CCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL245295	lpar1_human	Human	No	6.4	IC50	=	430	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	497	10	2	8	3.5	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCS(=O)(=O)O
CHEMBL245295	lpar1_human	Human	No	6.4	IC50	=	430	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	497	10	2	8	3.5	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCS(=O)(=O)O
CHEMBL383095	lpar1_human	Human	No	6.4	IC50	=	433	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL360727	lpar1_human	Human	No	5.4	IC50	=	4500	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CN=CC=C2)COP(=O)(O)O
CHEMBL361501	lpar1_human	Human	Yes	7.3	IC50	=	46	Funct	Antagonist activity at LPA1 expressed in human chem1 cells assessed as effect on intracellular calcium mobilization by FLIPR assayAntagonist activity at LPA1 expressed in human chem1 cells assessed as effect on intracellular calcium mobilization by FLIPR assay	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL361501	lpar1_human	Human	Yes	7.3	IC50	=	46	Funct	Antagonist activity at LPA1 expressed in human chem1 cells assessed as effect on intracellular calcium mobilization by FLIPR assayAntagonist activity at LPA1 expressed in human chem1 cells assessed as effect on intracellular calcium mobilization by FLIPR assay	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL440396	lpar1_human	Human	No	6.3	IC50	=	476	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL440396	lpar1_human	Human	No	6.3	IC50	=	476	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL246929	lpar1_rat	Rat	No	7.3	IC50	=	48	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182042	lpar1_human	Human	No	7.3	IC50	=	48	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	457	8	2	6	4.2	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL246929	lpar1_rat	Rat	No	7.3	IC50	=	48	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL2182042	lpar1_human	Human	No	7.3	IC50	=	48	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	457	8	2	6	4.2	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
CHEMBL404575	lpar1_human	Human	No	7.3	IC50	=	50	Funct	Antagonist activity at LPA1 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assayAntagonist activity at LPA1 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assay	322	5	1	4	3.9	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL404575	lpar1_human	Human	No	7.3	IC50	=	50	Funct	Antagonist activity at LPA1 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assayAntagonist activity at LPA1 expressed in RH7777 cells with Gi4-protein and aequorin by calcium mobilization assay	322	5	1	4	3.9	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL3326533	lpar1_human	Human	No	6.3	IC50	=	510	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	381	6	1	7	3.4	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCCC2)N3C(=C(C=N3)C#N)N)OC
CHEMBL361501	lpar1_human	Human	Yes	6.3	IC50	=	510	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL3326533	lpar1_human	Human	No	6.3	IC50	=	510	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	381	6	1	7	3.4	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCCC2)N3C(=C(C=N3)C#N)N)OC
CHEMBL361501	lpar1_human	Human	Yes	6.3	IC50	=	510	Funct	Antagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at human recombinant LPA1 receptor expressed in CHOK1 cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL328016	lpar1_mouse	Mouse	No	5.3	IC50	=	5210	Funct	Antagonist activity at mouse LPA1 receptor transfected in HEK293T cellsAntagonist activity at mouse LPA1 receptor transfected in HEK293T cells	602	24	3	6	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL328016	lpar1_mouse	Mouse	No	5.3	IC50	=	5210	Funct	Antagonist activity at mouse LPA1 receptor transfected in HEK293T cellsAntagonist activity at mouse LPA1 receptor transfected in HEK293T cells	602	24	3	6	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL262906	lpar1_human	Human	Yes	5.3	IC50	=	5210	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	602	24	3	6	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL191055	lpar1_human	Human	Yes	5.3	IC50	=	5500	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	504	22	3	11	3.2	CCCCCCCC(=O)OCC(COP(=O)(O)OP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL191055	lpar1_human	Human	Yes	5.3	IC50	=	5500	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	504	22	3	11	3.2	CCCCCCCC(=O)OCC(COP(=O)(O)OP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL246943	lpar1_rat	Rat	No	7.3	IC50	=	56	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	465	10	2	7	3.7	CC(C1=C(CCCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246943	lpar1_rat	Rat	No	7.3	IC50	=	56	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	465	10	2	7	3.7	CC(C1=C(CCCC1)Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL89937	lpar1_human	Human	No	5.3	IC50	=	5660	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	632	25	3	7	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC(=CC=C2)OC)COP(=O)(O)O
CHEMBL2182065	lpar1_human	Human	No	7.2	IC50	=	57	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	500	8	2	6	5.2	CC(C1=CC=C(C=C1)F)OC(=O)NC2=C(C=NN2C)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O
CHEMBL2182051	lpar1_human	Human	No	7.2	IC50	=	58	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	463	8	2	6	4.9	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4CCC(CC4)CC(=O)O
CHEMBL2182051	lpar1_human	Human	No	7.2	IC50	=	58	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	463	8	2	6	4.9	CC(C1=CC=CC=C1)OC(=O)NC2=C(N=NN2C)C3=CC=C(C=C3)C4CCC(CC4)CC(=O)O
CHEMBL3326524	lpar1_human	Human	No	6.2	IC50	=	586	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	335	5	1	5	3.7	CCC1=CC=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N
CHEMBL3326524	lpar1_human	Human	No	6.2	IC50	=	586	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	335	5	1	5	3.7	CCC1=CC=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N
CHEMBL3621968	lpar1_human	Human	No	8.2	IC50	=	6.6	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated with protein followed by LPA induction measured for 2 mins by Fluo-4 dye-based FLIPR assayAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated with protein followed by LPA induction measured for 2 mins by Fluo-4 dye-based FLIPR assay	550	11	2	9	3.3	CC1=C(N=C(S1)CN(CCCC2=CC=CC=C2)C(=O)C(C3=C(C=C(C=C3)OC)F)O)C(=O)NS(=O)(=O)C
CHEMBL3621968	lpar1_human	Human	No	8.2	IC50	=	6.6	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated with protein followed by LPA induction measured for 2 mins by Fluo-4 dye-based FLIPR assayAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated with protein followed by LPA induction measured for 2 mins by Fluo-4 dye-based FLIPR assay	550	11	2	9	3.3	CC1=C(N=C(S1)CN(CCCC2=CC=CC=C2)C(=O)C(C3=C(C=C(C=C3)OC)F)O)C(=O)NS(=O)(=O)C
CHEMBL314555	lpar1_human	Human	No	6.2	IC50	=	604	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL314555	lpar1_human	Human	No	6.2	IC50	=	604	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL607806	lpar1_human	Human	Yes	6.2	IC50	=	609	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	311	4	1	5	2.4	CC1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=O)N(C3=O)CC(=O)O
CHEMBL607806	lpar1_human	Human	Yes	6.2	IC50	=	609	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	311	4	1	5	2.4	CC1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=O)N(C3=O)CC(=O)O
CHEMBL362053	lpar1_human	Human	No	7.2	IC50	=	62	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	661	25	3	8	8.4	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=C(C(=C2C)OC)C)COP(=O)(O)O
CHEMBL265967	lpar1_human	Human	No	5.2	IC50	=	6250	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	633	25	3	8	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OC)COP(=O)(O)O
CHEMBL2182058	lpar1_human	Human	No	6.2	IC50	=	644	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	374	5	1	4	4.4	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(C=NN2C)C3=CC=CC=C3F
CHEMBL202361	lpar1_human	Human	No	6.2	IC50	=	686	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	441	20	2	8	6.0	CCCCCCCC(=O)OCC(COP(=S)(O)O)OC(=O)CCCCCCC
CHEMBL202361	lpar1_human	Human	No	6.2	IC50	=	686	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	441	20	2	8	6.0	CCCCCCCC(=O)OCC(COP(=S)(O)O)OC(=O)CCCCCCC
CHEMBL202185	lpar1_human	Human	Yes	6.2	IC50	=	692	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL2182045	lpar1_human	Human	No	7.2	IC50	=	70	Funct	Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay: Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilutions, 10 mM stocks of compounds were prepared in 100% DMSO. The compound dilution plate was set up as follows: well #1 received 29 μL of stock compound and 31 μL DMSO. Wells 2-10 received 40 μL of DMSO. After mixing, 20 μL of solution from well #1 was transferred into well #2, followed by 1:3 serial dilutions out 10 steps. 2 μL of diluted compound was transferred into duplicate wells of 384 well "assay plate" and then 90 μL of buffer was added. After incubation, both the cell and "assay" plates were brought to the FLIPR and 20 μL of the diluted compounds were transferred to the cell plates by the FLIPR. Compound addition was monitored by the FLIPR to detect any agonist activity of the compounds. Plates were then incubated for 30 minutes at room temperature protected from light. After the incubation, plates were returned to the FLIPR and 20 μL of 4.5× concentrated agonist was added to the cell plates. During the assay, fluorescence readings were taken simultaneously from all 384 wells of the cell plate every 1.5 seconds. Five readings were taken to establish a stable baseline, then 20 μL of sample was rapidly (30 μL/sec) and simultaneously added to each well of the cell plate. The fluorescence was continuously monitored before, during and after sample addition for a total elapsed time of 100 seconds.	449	8	2	6	4.5	CC(C)C(C)OC(=O)NC1=C(N=NN1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O
CHEMBL2182045	lpar1_human	Human	No	7.2	IC50	=	70	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	449	8	2	6	4.5	CC(C)C(C)OC(=O)NC1=C(N=NN1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O
CHEMBL314554	lpar1_human	Human	No	5.2	IC50	=	7000	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	627	23	4	6	9.2	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OC2=CC3=CC=CC=C3N2)COP(=O)(O)O
CHEMBL246527	lpar1_rat	Rat	No	7.1	IC50	=	72	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	443	10	2	6	4.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCCCC(=O)O
CHEMBL246527	lpar1_rat	Rat	No	7.1	IC50	=	72	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	443	10	2	6	4.8	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CCCCC(=O)O
CHEMBL246735	lpar1_rat	Rat	No	7.1	IC50	=	73	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	458	9	3	7	2.7	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)NC(=O)CCC(=O)O
CHEMBL246735	lpar1_rat	Rat	No	7.1	IC50	=	73	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	458	9	3	7	2.7	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)NC(=O)CCC(=O)O
CHEMBL360399	lpar1_human	Human	No	6.1	IC50	=	735	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=NC=C2)COP(=O)(O)O
CHEMBL379248	lpar1_human	Human	No	5.1	IC50	=	7390	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL245295	lpar1_rat	Rat	No	7.1	IC50	=	74	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	497	10	2	8	3.5	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCS(=O)(=O)O
CHEMBL3326527	lpar1_human	Human	No	7.1	IC50	=	74	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	355	5	1	7	3.0	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)F
CHEMBL245295	lpar1_rat	Rat	No	7.1	IC50	=	74	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	497	10	2	8	3.5	CC(C1=CC=CC=C1Cl)OC(=O)NC2=CON=C2C3=CC=C(C=C3)CSCCS(=O)(=O)O
CHEMBL3326527	lpar1_human	Human	No	7.1	IC50	=	74	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	355	5	1	7	3.0	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)F
CHEMBL361501	lpar1_human	Human	Yes	6.1	IC50	=	762	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL361501	lpar1_human	Human	Yes	6.1	IC50	=	762	Funct	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL3326523	lpar1_human	Human	No	7.1	IC50	=	79	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	367	6	1	7	2.9	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)OC
CHEMBL3326523	lpar1_human	Human	No	7.1	IC50	=	79	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	367	6	1	7	2.9	COC1=CC(=C(C=C1)C(=O)C(=NC2CCCC2)N3C(=C(C=N3)C#N)N)OC
CHEMBL92452	lpar1_human	Human	No	5.1	IC50	=	7970	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	464	15	3	6	4.2	CCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL211465	lpar1_human	Human	No	6.1	IC50	=	799	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	407	17	1	5	8.1	CCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL3326531	lpar1_human	Human	No	6.1	IC50	=	805	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	387	5	1	6	4.1	COC1=CC2=CC=CC=C2C=C1C(=O)C(=NC3CCCC3)N4C(=C(C=N4)C#N)N
CHEMBL3326531	lpar1_human	Human	No	6.1	IC50	=	805	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	387	5	1	6	4.1	COC1=CC2=CC=CC=C2C=C1C(=O)C(=NC3CCCC3)N4C(=C(C=N4)C#N)N
CHEMBL246928	lpar1_rat	Rat	No	7.1	IC50	=	81	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL246928	lpar1_rat	Rat	No	7.1	IC50	=	81	Funct	Antagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influxAntagonist activity at LPA1 receptor in rat hepatic stellate cells assessed as inhibition of lysophosphatidic acid-induced intracellular calcium influx	461	10	2	7	4.1	CC(C1=CC=CC=C1Cl)OC(=O)NC2=C(ON=C2)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL3326532	lpar1_human	Human	No	6.1	IC50	=	825	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	377	5	1	6	3.7	COC1=CC2=C(CCC2)C=C1C(=O)C(=NC3CCCC3)N4C(=C(C=N4)C#N)N
CHEMBL3326532	lpar1_human	Human	No	6.1	IC50	=	825	Funct	Antagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assayAntagonist activity at human LPA1R expressed in Chem-1 cells assessed as inhibition of lysophosphatidic acid-induced calcium mobilization by FLIPR assay	377	5	1	6	3.7	COC1=CC2=C(CCC2)C=C1C(=O)C(=NC3CCCC3)N4C(=C(C=N4)C#N)N
CHEMBL183221	lpar1_human	Human	No	7.1	IC50	=	84	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	701	26	3	11	8.8	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC(F)(F)F)COP(=O)(O)O
CHEMBL272087	lpar1_human	Human	No	7.1	IC50	=	89	Funct	Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated with compound followed by LPA addition by fluorescence assayAntagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated with compound followed by LPA addition by fluorescence assay	526	12	1	6	6.2	COC1=CC(=CC(=C1)C(=O)N(CCCC2=CC=CC=C2)CC3=CC=C(C=C3)OC4=CC=CC=C4C(=O)O)OC
CHEMBL432821	lpar1_human	Human	No	5.0	IC50	=	9030	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	548	21	3	6	7.5	CCCCCCCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL604677	lpar1_human	Human	Yes	7.0	IC50	=	94	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	404	4	1	7	3.3	C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)O
CHEMBL604677	lpar1_human	Human	Yes	7.0	IC50	=	94	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium responseAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium response	404	4	1	7	3.3	C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)O
CHEMBL212029	lpar1_human	Human	No	6.0	IC50	=	941	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	435	19	1	5	9.2	CCCCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL360928	lpar1_human	Human	No	6.0	IC50	=	962	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	683	25	3	8	9.0	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC3=CC=CC=C3C(=C2)OC)COP(=O)(O)O
CHEMBL2182036	lpar1_human	Human	No	6.0	IC50	=	985	Funct	Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assayAntagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incubated for 30 mins prior to LPA-challenge measured over 100 secs by FLIPR assay	434	7	2	6	4.1	CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)(C)C
CHEMBL184055	lpar1_human	Human	Yes	6.0	IC50	=	992	Funct	Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptorInhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CN=CC=C2)COP(=O)(O)O
CHEMBL187633	lpar1_human	Human	Yes	6.0	Ki	=	1082	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	294	14	2	4	5.1	CCCCCCCCCCCCCCOP(=O)(O)O
CHEMBL187633	lpar1_human	Human	Yes	6.0	Ki	=	1082	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	294	14	2	4	5.1	CCCCCCCCCCCCCCOP(=O)(O)O
CHEMBL190430	lpar1_human	Human	No	5.9	Ki	=	1146	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	292	13	2	4	4.2	CCCCC=CCCCCCCCCOP(=O)(O)O
CHEMBL190430	lpar1_human	Human	No	5.9	Ki	=	1146	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	292	13	2	4	4.2	CCCCC=CCCCCCCCCOP(=O)(O)O
CHEMBL313413	lpar1_human	Human	No	6.9	Ki	=	134	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	628	23	3	6	9.3	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OC2CC3=CC=CC=C3C2)COP(=O)(O)O
CHEMBL482498	lpar1_human	Human	Yes	4.9	Ki	=	13470	Funct	Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentrationAntagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration	488	10	4	8	2.9	C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O
CHEMBL187711	lpar1_human	Human	Yes	5.9	Ki	=	1354	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	266	12	2	4	4.0	CCCCCCCCCCCCOP(=O)(O)O
CHEMBL187711	lpar1_human	Human	Yes	5.9	Ki	=	1354	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	266	12	2	4	4.0	CCCCCCCCCCCCOP(=O)(O)O
CHEMBL262906	lpar1_human	Human	Yes	6.9	Ki	=	137	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	602	24	3	6	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)COP(=O)(O)O
CHEMBL427017	lpar1_human	Human	Yes	6.9	Ki	=	139	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	413	20	2	6	6.8	CCCCCCCCOCC(COP(=S)(O)O)OCCCCCCCC
CHEMBL427017	lpar1_human	Human	Yes	6.9	Ki	=	139	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	413	20	2	6	6.8	CCCCCCCCOCC(COP(=S)(O)O)OCCCCCCCC
CHEMBL3218460	lpar1_human	Human	No	6.9	Ki	=	143	Funct	Competitive antagonist activity at human LPA1 receptor overexpressed in CHO cells assessed as inhibition of LPA-induced [35S]GTPgammaS binding by liquid scintillation countingCompetitive antagonist activity at human LPA1 receptor overexpressed in CHO cells assessed as inhibition of LPA-induced [35S]GTPgammaS binding by liquid scintillation counting	671	24	3	10	8.7	CCCCCCCCCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC(F)(F)F)C=CP(=O)(O)O
CHEMBL440396	lpar1_human	Human	No	6.8	Ki	=	152	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL314555	lpar1_human	Human	No	6.8	Ki	=	156	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL314555	lpar1_human	Human	No	6.8	Ki	=	156	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.8	Ki	=	18	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL440696	lpar1_human	Human	No	7.8	Ki	=	18	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	603	24	3	7	7.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=N2)COP(=O)(O)O
CHEMBL183221	lpar1_human	Human	No	7.7	Ki	=	19	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	701	26	3	11	8.8	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC(F)(F)F)COP(=O)(O)O
CHEMBL383095	lpar1_human	Human	No	6.7	Ki	=	221	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL383095	lpar1_human	Human	No	6.7	Ki	=	221	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL183143	lpar1_human	Human	No	7.6	Ki	=	26	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	647	26	3	8	8.0	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC)COP(=O)(O)O
CHEMBL362053	lpar1_human	Human	No	7.6	Ki	=	28	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	661	25	3	8	8.4	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=C(C(=C2C)OC)C)COP(=O)(O)O
CHEMBL379248	lpar1_human	Human	No	5.5	Ki	=	2850	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL379248	lpar1_human	Human	No	5.6	Ki	=	2850	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	439	18	4	6	5.3	CCCCCCCCNC(=O)C(COP(=S)(O)O)NC(=O)CCCCCCC
CHEMBL607806	lpar1_human	Human	Yes	6.5	Ki	=	311	Funct	Binding affinity to LPA1Binding affinity to LPA1	311	4	1	5	2.4	CC1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=O)N(C3=O)CC(=O)O
CHEMBL607806	lpar1_human	Human	Yes	6.5	Ki	=	311	Funct	Binding affinity to LPA1Binding affinity to LPA1	311	4	1	5	2.4	CC1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=O)N(C3=O)CC(=O)O
CHEMBL211465	lpar1_human	Human	No	6.5	Ki	=	314	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	407	17	1	5	8.1	CCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL211465	lpar1_human	Human	No	6.5	Ki	=	314	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	407	17	1	5	8.1	CCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL91058	lpar1_human	Human	No	7.5	Ki	=	34	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	632	25	3	7	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC(=CC=C2)OC)COP(=O)(O)O
CHEMBL182446	lpar1_human	Human	No	7.5	Ki	=	35	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	677	28	3	9	7.5	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCCOC)COP(=O)(O)O
CHEMBL89937	lpar1_human	Human	No	6.5	Ki	=	358	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	632	25	3	7	8.7	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=CC(=CC=C2)OC)COP(=O)(O)O
CHEMBL202361	lpar1_human	Human	No	6.4	Ki	=	360	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	441	20	2	8	6.0	CCCCCCCC(=O)OCC(COP(=S)(O)O)OC(=O)CCCCCCC
CHEMBL212029	lpar1_human	Human	No	6.4	Ki	=	403	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	435	19	1	5	9.2	CCCCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL212029	lpar1_human	Human	No	6.4	Ki	=	403	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	435	19	1	5	9.2	CCCCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
CHEMBL202185	lpar1_human	Human	Yes	6.4	Ki	=	407	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL202185	lpar1_human	Human	Yes	6.4	Ki	=	407	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	424	20	2	8	4.3	CCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL361501	lpar1_human	Human	Yes	6.4	Ki	=	425	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL361501	lpar1_human	Human	Yes	6.4	Ki	=	425	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	475	10	2	7	4.5	CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
CHEMBL191055	lpar1_human	Human	Yes	5.4	Ki	=	4300	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	504	22	3	11	3.2	CCCCCCCC(=O)OCC(COP(=O)(O)OP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL191055	lpar1_human	Human	Yes	5.4	Ki	=	4300	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	504	22	3	11	3.2	CCCCCCCC(=O)OCC(COP(=O)(O)OP(=O)(O)O)OC(=O)CCCCCCC
CHEMBL188591	lpar1_human	Human	No	6.3	Ki	=	457	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	292	13	2	4	4.2	CCC=CCCCCCCCCCCOP(=O)(O)O
CHEMBL188591	lpar1_human	Human	No	6.3	Ki	=	457	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	292	13	2	4	4.2	CCC=CCCCCCCCCCCOP(=O)(O)O
CHEMBL604677	lpar1_human	Human	Yes	7.3	Ki	=	48	Funct	Binding affinity to LPA1Binding affinity to LPA1	404	4	1	7	3.3	C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)O
CHEMBL604677	lpar1_human	Human	Yes	7.3	Ki	=	48	Funct	Binding affinity to LPA1Binding affinity to LPA1	404	4	1	7	3.3	C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)O
CHEMBL203986	lpar1_human	Human	No	6.3	Ki	=	486	Funct	Activity at LPA1 receptor transfected RH7777 cellsActivity at LPA1 receptor transfected RH7777 cells	397	20	2	6	5.1	CCCCCCCCOCC(COP(=O)(O)O)OCCCCCCCC
CHEMBL210117	lpar1_human	Human	No	7.2	Ki	=	60.7	Funct	Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayActivity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay	437	19	1	6	7.9	CCCCCCCCCCCCCCCCCC(=O)OCC1CC(P(=O)(O1)O)F
CHEMBL291229	lpar1_human	Human	No	7.2	Ki	=	64	Funct	Binding affinity towards Lysophosphatidic acid 1 (LPA1) receptorBinding affinity towards Lysophosphatidic acid 1 (LPA1) receptor	661	27	3	8	8.6	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCCC)COP(=O)(O)O
CHEMBL314554	lpar1_human	Human	No	7.1	Ki	=	73	Funct	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell linesIn vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	627	23	4	6	9.2	CCCCCCCCC=CCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OC2=CC3=CC=CC=C3N2)COP(=O)(O)O
CHEMBL188859	lpar1_human	Human	No	6.1	Ki	=	788	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	328	14	2	5	6.4	CCCCCCCCCCCCCCC(F)(F)P(=O)(O)O
CHEMBL188859	lpar1_human	Human	No	6.1	Ki	=	788	Funct	Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cellsBinding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells	328	14	2	5	6.4	CCCCCCCCCCCCCCC(F)(F)P(=O)(O)O
CHEMBL3218459	lpar1_human	Human	No	7.1	Ki	=	84	Funct	Competitive antagonist activity at human LPA1 receptor overexpressed in CHO cells assessed as inhibition of LPA-induced [35S]GTPgammaS binding by liquid scintillation countingCompetitive antagonist activity at human LPA1 receptor overexpressed in CHO cells assessed as inhibition of LPA-induced [35S]GTPgammaS binding by liquid scintillation counting	703	27	3	11	9.7	CCCCCCCCCCCCCCCCCC(=O)NC(CC1=CC=C(C=C1)OCC2=NC=CC(=C2)OCC(F)(F)F)COP(=O)(O)O

Package	Name	Version
Django		2.2.1
Python		3.6.7
debug_toolbar	Debug Toolbar	1.11
polymorphic	Polymorphic	2.0.3
rest_framework	Django REST framework	3.9.3
rest_framework_swagger	Rest_Framework_Swagger	2.2.0

Resource	Value
User CPU time	1244.141 msec
System CPU time	92.886 msec
Total CPU time	1337.027 msec
Elapsed time	1589.663 msec
Context switches	374 voluntary, 12 involuntary

Setting	Value
ABSOLUTE_URL_OVERRIDES	`{}`
ADMINS	`[]`
ALLOWED_HOSTS	`['*']`
APPEND_SLASH	`True`
AUTHENTICATION_BACKENDS	`['django.contrib.auth.backends.ModelBackend']`
AUTH_PASSWORD_VALIDATORS	`'********************'`
AUTH_USER_MODEL	`'auth.User'`
BASE_DIR	`'/home/protwis/gpcrdb_test'`
BUILD_CACHE_DIR	`'/home/protwis/gpcrdb_data/cache'`
CACHES	`{'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}`
CACHE_MIDDLEWARE_ALIAS	`'default'`
CACHE_MIDDLEWARE_KEY_PREFIX	`'********************'`
CACHE_MIDDLEWARE_SECONDS	`600`
CSRF_COOKIE_AGE	`31449600`
CSRF_COOKIE_DOMAIN	`None`
CSRF_COOKIE_HTTPONLY	`False`
CSRF_COOKIE_NAME	`'csrftoken'`
CSRF_COOKIE_PATH	`'/'`
CSRF_COOKIE_SAMESITE	`'Lax'`
CSRF_COOKIE_SECURE	`False`
CSRF_FAILURE_VIEW	`'django.views.csrf.csrf_failure'`
CSRF_HEADER_NAME	`'HTTP_X_CSRFTOKEN'`
CSRF_TRUSTED_ORIGINS	`[]`
CSRF_USE_SESSIONS	`False`
DATABASES	`{'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}`
DATABASE_ROUTERS	`[]`
DATA_DIR	`'/home/protwis/gpcrdb_data'`
DATA_UPLOAD_MAX_MEMORY_SIZE	`2621440`
DATA_UPLOAD_MAX_NUMBER_FIELDS	`1000`
DATETIME_FORMAT	`'N j, Y, P'`
DATETIME_INPUT_FORMATS	`['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']`
DATE_FORMAT	`'N j, Y'`
DATE_INPUT_FORMATS	`['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']`
DEBUG	`True`
DEBUG_PROPAGATE_EXCEPTIONS	`False`
DEBUG_TOOLBAR_PATCH_SETTINGS	`False`
DECIMAL_SEPARATOR	`'.'`
DEFAULT_CHARSET	`'utf-8'`
DEFAULT_CONTENT_TYPE	`'text/html'`
DEFAULT_EXCEPTION_REPORTER_FILTER	`'django.views.debug.SafeExceptionReporterFilter'`
DEFAULT_FILE_STORAGE	`'django.core.files.storage.FileSystemStorage'`
DEFAULT_FROM_EMAIL	`'webmaster@localhost'`
DEFAULT_INDEX_TABLESPACE	`''`
DEFAULT_NUMBERING_SCHEME	`'gpcrdb'`
DEFAULT_PROTEIN_STATE	`'inactive'`
DEFAULT_SITE	`'gpcr'`
DEFAULT_TABLESPACE	`''`
DISALLOWED_USER_AGENTS	`[]`
DOCUMENTATION_URL	`'https://docs.gpcrdb.org/'`
EMAIL_BACKEND	`'django.core.mail.backends.smtp.EmailBackend'`
EMAIL_HOST	`'localhost'`
EMAIL_HOST_PASSWORD	`'********************'`
EMAIL_HOST_USER	`''`
EMAIL_PORT	`25`
EMAIL_SSL_CERTFILE	`None`
EMAIL_SSL_KEYFILE	`'********************'`
EMAIL_SUBJECT_PREFIX	`'[Django] '`
EMAIL_TIMEOUT	`None`
EMAIL_USE_LOCALTIME	`False`
EMAIL_USE_SSL	`False`
EMAIL_USE_TLS	`False`
FILE_CHARSET	`'utf-8'`
FILE_UPLOAD_DIRECTORY_PERMISSIONS	`None`
FILE_UPLOAD_HANDLERS	`['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']`
FILE_UPLOAD_MAX_MEMORY_SIZE	`2621440`
FILE_UPLOAD_PERMISSIONS	`None`
FILE_UPLOAD_TEMP_DIR	`None`
FIRST_DAY_OF_WEEK	`0`
FIXTURE_DIRS	`[]`
FORCE_SCRIPT_NAME	`None`
FORMAT_MODULE_PATH	`None`
FORM_RENDERER	`'django.forms.renderers.DjangoTemplates'`
GOOGLE_ANALYTICS_API	`'********************'`
GOOGLE_ANALYTICS_KEY	`'********************'`
IGNORABLE_404_URLS	`[]`
INSTALLED_APPS	('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS	`'10.0.2.2'`
LANGUAGES	[('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI	`['he', 'ar', 'fa', 'ur']`
LANGUAGE_CODE	`'en-us'`
LANGUAGE_COOKIE_AGE	`None`
LANGUAGE_COOKIE_DOMAIN	`None`
LANGUAGE_COOKIE_NAME	`'django_language'`
LANGUAGE_COOKIE_PATH	`'/'`
LOCALE_PATHS	`[]`
LOGGING	{'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG	`'logging.config.dictConfig'`
LOGIN_REDIRECT_URL	`'/accounts/profile/'`
LOGIN_URL	`'/accounts/login/'`
LOGOUT_REDIRECT_URL	`None`
MANAGERS	`[]`
MEDIA_ROOT	`'/protwis/media/protwis'`
MEDIA_URL	`'/media/'`
MESSAGE_STORAGE	`'django.contrib.messages.storage.fallback.FallbackStorage'`
MIDDLEWARE	`('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')`
MIGRATION_MODULES	`{}`
MONTH_DAY_FORMAT	`'F j'`
NUMBER_GROUPING	`0`
PASSWORD_HASHERS	`'********************'`
PASSWORD_RESET_TIMEOUT_DAYS	`'********************'`
PREPEND_WWW	`False`
REFERENCE_POSITIONS	`{'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}`
ROOT_URLCONF	`'protwis.urls'`
SECRET_KEY	`'********************'`
SECURE_BROWSER_XSS_FILTER	`False`
SECURE_CONTENT_TYPE_NOSNIFF	`False`
SECURE_HSTS_INCLUDE_SUBDOMAINS	`False`
SECURE_HSTS_PRELOAD	`False`
SECURE_HSTS_SECONDS	`0`
SECURE_PROXY_SSL_HEADER	`None`
SECURE_REDIRECT_EXEMPT	`[]`
SECURE_SSL_HOST	`None`
SECURE_SSL_REDIRECT	`False`
SERVER_EMAIL	`'root@localhost'`
SESSION_CACHE_ALIAS	`'default'`
SESSION_COOKIE_AGE	`86400`
SESSION_COOKIE_DOMAIN	`None`
SESSION_COOKIE_HTTPONLY	`True`
SESSION_COOKIE_NAME	`'sessionid'`
SESSION_COOKIE_PATH	`'/'`
SESSION_COOKIE_SAMESITE	`'Lax'`
SESSION_COOKIE_SECURE	`False`
SESSION_ENGINE	`'django.contrib.sessions.backends.db'`
SESSION_EXPIRE_AT_BROWSER_CLOSE	`False`
SESSION_FILE_PATH	`None`
SESSION_SAVE_EVERY_REQUEST	`False`
SESSION_SERIALIZER	`'django.contrib.sessions.serializers.PickleSerializer'`
SETTINGS_MODULE	`'protwis.settings'`
SHORT_DATETIME_FORMAT	`'m/d/Y P'`
SHORT_DATE_FORMAT	`'m/d/Y'`
SIGNING_BACKEND	`'django.core.signing.TimestampSigner'`
SILENCED_SYSTEM_CHECKS	`[]`
SITE_NAME	`'gpcr'`
SITE_TITLE	`'GPCRdb'`
STATICFILES_DIRS	`('/home/protwis/gpcrdb_test/static',)`
STATICFILES_FINDERS	`['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']`
STATICFILES_STORAGE	`'django.contrib.staticfiles.storage.StaticFilesStorage'`
STATIC_ROOT	`'/home/protwis/static_test/'`
STATIC_URL	`'/static/'`
SWAGGER_SETTINGS	`{'USE_SESSION_AUTH': False}`
TEMPLATES	[{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS	`[]`
TEST_RUNNER	`'django.test.runner.DiscoverRunner'`
THOUSAND_SEPARATOR	`','`
TIME_FORMAT	`'P'`
TIME_INPUT_FORMATS	`['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']`
TIME_ZONE	`'Europe/Copenhagen'`
USE_I18N	`True`
USE_L10N	`True`
USE_THOUSAND_SEPARATOR	`False`
USE_TZ	`True`
USE_X_FORWARDED_HOST	`False`
USE_X_FORWARDED_PORT	`False`
WSGI_APPLICATION	`None`
X_FRAME_OPTIONS	`'SAMEORIGIN'`
YEAR_MONTH_FORMAT	`'F Y'`

Key	Value
Accept	text/html,application/xhtml+xml,application/xml;q=0.9,/;q=0.8
Accept-Encoding	br,gzip
Accept-Language	en-US,en;q=0.5
Connection	close
Host	test.gpcrdb.org
User-Agent	CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For	35.172.111.47
X-Forwarded-Proto	https
X-Real-Ip	35.172.111.47

Key	Value
Content-Length	467377
Content-Type	text/html; charset=utf-8
Vary	Cookie
X-Frame-Options	SAMEORIGIN

Ligand source activities (1 row/activity)

Versions

Time

Resource usage

Browser timing

Settings from `protwis.settings`

Headers

Request headers

Response headers

WSGI environ

Request

View information

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

Key	Value
PATH_INFO	/ligand/target/all/001_004_003_001/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	test.gpcrdb.org
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.0
SERVER_SOFTWARE	gunicorn/19.9.0

Query		Timeline	Time (ms)
+	SELECT ••• "ligand_assayexperiment"."id", "ligand_assayexperiment"."ligand_id", "ligand_assayexperiment"."protein_id", "ligand_assayexperiment"."assay_id", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."published_value", "ligand_assayexperiment"."published_relation", "ligand_assayexperiment"."published_type", "ligand_assayexperiment"."published_units", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_units", "ligand_assayexperiment"."publication_id", "ligand_assayexperiment"."chembl", "ligand_assayexperiment"."smiles", "ligand_assayexperiment"."activity", "ligand_assayexperiment"."document_chembl_id", "ligand_assayexperiment"."cell_line" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_004_003_001')	43.34978066481136%	122.70
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(334) if not ps:
+	SELECT ••• "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id", COUNT(DISTINCT "ligand_assayexperiment"."protein_id") AS "num_targets" FROM "ligand_assayexperiment" INNER JOIN "ligand" ON ("ligand_assayexperiment"."ligand_id" = "ligand"."id") INNER JOIN "ligand_properities" ON ("ligand"."properities_id" = "ligand_properities"."id") INNER JOIN "ligand_properities_web_links" ON ("ligand_properities"."id" = "ligand_properities_web_links"."ligandproperities_id") INNER JOIN "web_link" ON ("ligand_properities_web_links"."weblink_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein" ON ("ligand_assayexperiment"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") INNER JOIN "species" ON ("protein"."species_id" = "species"."id") WHERE ("web_resource"."slug" = 'chembl_ligand' AND "protein_family"."slug" = '001_004_003_001') GROUP BY "ligand_assayexperiment"."standard_type", "ligand_assayexperiment"."standard_relation", "ligand_assayexperiment"."standard_value", "ligand_assayexperiment"."assay_description", "ligand_assayexperiment"."assay_type", "ligand_assayexperiment"."pchembl_value", "ligand_assayexperiment"."ligand_id", "ligand"."properities_id", "web_link"."index", "species"."common_name", "protein"."entry_name", "ligand_properities"."mw", "ligand_properities"."logp", "ligand_properities"."rotatable_bonds", "ligand_properities"."smiles", "ligand_properities"."hdon", "ligand_properities"."hacc", "ligand_assayexperiment"."protein_id"	4.251345997048577%	12.03
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(357) for record in ps:
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 85221 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.39251228074904143%	1.11
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 34544 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.2070375935796446%	0.59
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 109152 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.19204463521626922%	0.54
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 75155 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.18185279273330054%	0.51
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2889 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 6 times.	0.18682236882003733%	0.53
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 2889 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 6 times.	0.1672809848857503%	0.47
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 70699 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 2 times.	0.17166095025033187%	0.49
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 70699 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 2 times.	0.16635445375093497%	0.47
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 71310 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 2 times.	0.17182941045666192%	0.49
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 71310 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 2 times.	0.163659090449654%	0.46
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 104607 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.16787059560790552%	0.48
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 4950 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.16525946240978956%	0.47
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 4950 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.16349063024332391%	0.46
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 4950 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.1629010195211687%	0.46
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 47467 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.17326132221046744%	0.49
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 47467 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.1654279226161196%	0.47
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 47467 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries. Duplicated 3 times.	0.15970027560089756%	0.45
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'
+	SELECT ••• "ligand_ligandvendorlink"."id", "ligand_ligandvendorlink"."vendor_id", "ligand_ligandvendorlink"."lp_id", "ligand_ligandvendorlink"."url", "ligand_ligandvendorlink"."vendor_external_id", "ligand_ligandvendorlink"."sid" FROM "ligand_ligandvendorlink" INNER JOIN "ligand_ligandvendors" ON ("ligand_ligandvendorlink"."vendor_id" = "ligand_ligandvendors"."id") WHERE ("ligand_ligandvendorlink"."lp_id" = 60337 AND NOT ("ligand_ligandvendors"."name" IN ('ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'))) 294 similar queries.	0.16938673746487606%	0.48
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/ligand/views.py in TargetDetails(359) vendor__name__in=['ZINC', 'ChEMBL', 'BindingDB', 'SureChEMBL', 'eMolecules', 'MolPort', 'PubChem'])) > 0 else 'No'

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