Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL17860 ada2c_human Human Yes 8.9 EC50 = 1.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
259 3 1 2 2.6 CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl
CHEMBL17860 ada2c_human Human Yes 8.9 EC50 = 1.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
259 3 1 2 2.6 CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL2089156 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL2089156 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL2089156 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL297827 ada2c_human Human No 8.7 EC50 = 2.0 Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
296 5 1 2 3.9 C1CC2CC1C(C2NC3=NCCO3)CC=CC4=CC=CC=C4
CHEMBL242693 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL1956192 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
269 3 1 2 2.0 CC(C1=NCCN1)OC2=CC=CC=C2Br
CHEMBL495096 ada2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
258 4 1 2 3.3 CC(C1=NCCN1)OC2=CC=CC=C2C3CCCC3
CHEMBL242693 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL242693 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL1956192 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
269 3 1 2 2.0 CC(C1=NCCN1)OC2=CC=CC=C2Br
CHEMBL1956192 ada2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
269 3 1 2 2.0 CC(C1=NCCN1)OC2=CC=CC=C2Br
CHEMBL495096 ada2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
258 4 1 2 3.3 CC(C1=NCCN1)OC2=CC=CC=C2C3CCCC3
CHEMBL1276247 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL14208 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
248 5 1 3 2.1 CC(C)OC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL156336 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 2 2.1 CCC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL1956201 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 3 0.8 CC(C1=NCCN1)OC2=CC=CC=C2C=O
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL1276247 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL14208 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
248 5 1 3 2.1 CC(C)OC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL156336 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 2 2.1 CCC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL1956201 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 3 0.8 CC(C1=NCCN1)OC2=CC=CC=C2C=O
CHEMBL306792 ada2c_human Human No 7.0 EC50 = 100 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL492639 ada2c_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
261 6 1 4 1.7 CCON=CC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL2431280 ada2c_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
232 5 1 3 1.4 C1CC1OC2=CC=CC=C2OCC3=NCCN3
CHEMBL492639 ada2c_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
261 6 1 4 1.7 CCON=CC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL371300 ada2c_human Human Yes 5.0 EC50 = 10000 Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL1956196 ada2c_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
234 5 1 3 1.7 CCOC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL371300 ada2c_human Human Yes 5.0 EC50 = 10000 Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL1956196 ada2c_human Human No 5.0 EC50 = 10000 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
234 5 1 3 1.7 CCOC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL74283 ada2c_human Human Yes 7.0 EC50 = 104.7 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
296 2 4 3 1.0 C1CNC2=C(N1)C=CC(=C2Br)NC3=NCCN3
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL71479 ada2c_human Human No 6.0 EC50 = 1122.0 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
267 4 2 4 1.1 CC1=CC(=C(C=C1)S(=O)(=O)C)NCC2=NCCN2
CHEMBL1956194 ada2c_human Human No 6.9 EC50 = 114.8 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
230 4 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2C(=C)C
CHEMBL1956194 ada2c_human Human No 6.9 EC50 = 114.8 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
230 4 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2C(=C)C
CHEMBL1276219 ada2c_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL493675 ada2c_human Human Yes 6.9 EC50 = 125.9 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
233 4 2 4 1.0 CC(C1=NCCN1)OC2=CC=CC=C2C=NO
CHEMBL1276219 ada2c_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276219 ada2c_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL493675 ada2c_human Human Yes 6.9 EC50 = 125.9 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
233 4 2 4 1.0 CC(C1=NCCN1)OC2=CC=CC=C2C=NO
CHEMBL295186 ada2c_human Human No 7.9 EC50 = 13.8 Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
270 4 1 2 3.2 C1CC2CC1C(C2NC3=NCCO3)CC4=CC=CC=C4
CHEMBL286080 ada2c_human Human Yes 5.9 EC50 = 1380.4 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
255 1 3 3 2.5 C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3
CHEMBL286080 ada2c_human Human Yes 5.9 EC50 = 1380.4 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
255 1 3 3 2.5 C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3
CHEMBL49137 ada2c_human Human Yes 7.9 EC50 = 14.1 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
227 2 2 3 0.3 CC1=C(C=CC2=NC=CN=C12)NC3=NCCN3
CHEMBL337862 ada2c_human Human No 6.8 EC50 = 147.9 Funct
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
251 4 2 2 2.6 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=C3
CHEMBL3588911 ada2c_human Human Yes 3.8 EC50 = 147910.8 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
243 5 1 2 2.2 CC1=CC=CC=C1CN2C=CN=C2CNC(C)C
CHEMBL3588911 ada2c_human Human Yes 3.8 EC50 = 147910.8 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
243 5 1 2 2.2 CC1=CC=CC=C1CN2C=CN=C2CNC(C)C
CHEMBL70692 ada2c_human Human No 7.8 EC50 = 15.9 Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
239 4 2 4 1.5 CSC1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL569933 ada2c_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
218 5 1 2 2.5 CCCC1=CC=CC=C1COC2=NCCN2
CHEMBL569933 ada2c_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
218 5 1 2 2.5 CCCC1=CC=CC=C1COC2=NCCN2
CHEMBL13917 ada2c_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
218 5 1 2 2.3 CCCC1=CC=CC=C1OCC2=NCCN2
CHEMBL222928 ada2c_human Human Yes 6.8 EC50 = 158.5 Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL222928 ada2c_human Human Yes 6.8 EC50 = 158.5 Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL222973 ada2c_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=CC(=C1)C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL222973 ada2c_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=CC(=C1)C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL1956191 ada2c_human Human No 6.8 EC50 = 166.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
225 3 1 2 2.0 CC(C1=NCCN1)OC2=CC=CC=C2Cl
CHEMBL1956191 ada2c_human Human No 6.8 EC50 = 166.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
225 3 1 2 2.0 CC(C1=NCCN1)OC2=CC=CC=C2Cl
CHEMBL3588902 ada2c_human Human Yes 6.8 EC50 = 173.8 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
187 3 2 2 1.9 CC1=CC=CC=C1NCC2=CN=CN2
CHEMBL3588902 ada2c_human Human Yes 6.8 EC50 = 173.8 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
187 3 2 2 1.9 CC1=CC=CC=C1NCC2=CN=CN2
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL289480 ada2c_human Human Yes 6.7 EC50 = 190.6 Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
180 4 1 2 1.2 C1CC1C(C2CC2)NC3=NCCO3
CHEMBL1956202 ada2c_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 3 1.0 CC(C1=NCCN1)OC2=CC=CC=C2C(=O)C
CHEMBL1956202 ada2c_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 3 1.0 CC(C1=NCCN1)OC2=CC=CC=C2C(=O)C
CHEMBL72958 ada2c_human Human Yes 5.7 EC50 = 1995.3 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
248 4 3 6 -0.8 CS(=O)(=O)NC1=CC(=C(C=C1)F)C(CN)O
CHEMBL74467 ada2c_human Human No 5.7 EC50 = 1995.3 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL75030 ada2c_human Human Yes 8.7 EC50 = 2.2 Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
216 2 1 2 1.9 C1CC(C2=CC=CC=C2C1)NC3=NCCO3
CHEMBL70751 ada2c_human Human No 8.6 EC50 = 2.8 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
256 4 2 3 2.1 CSC1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL451229 ada2c_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
272 4 1 2 3.9 CC(C1=NCCN1)OC2=CC=CC=C2C3CCCCC3
CHEMBL451229 ada2c_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
272 4 1 2 3.9 CC(C1=NCCN1)OC2=CC=CC=C2C3CCCCC3
CHEMBL296660 ada2c_human Human No 7.7 EC50 = 21.4 Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
222 4 1 2 2.7 CCCC1C2CCC(C2)C1NC3=NCCO3
CHEMBL51358 ada2c_human Human No 6.7 EC50 = 223.9 Funct
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
210 3 2 2 1.6 C1CN=C(N1)CNC2=CC=CC=C2Cl
CHEMBL2431281 ada2c_human Human No 6.6 EC50 = 234.4 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 2 2.3 C1CC1CC2=CC=CC=C2OCC3=NCCN3
CHEMBL306377 ada2c_human Human No 7.6 EC50 = 24.6 Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
230 2 1 2 2.3 C1CC(C2=CC=CC=C2C1)NC3=NCCCO3
CHEMBL576078 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
232 5 1 2 2.9 CCCC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL1278084 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL576078 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
232 5 1 2 2.9 CCCC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL1278084 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL2431282 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
232 5 1 2 2.7 CCCC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1278085 ada2c_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1278085 ada2c_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL50720 ada2c_human Human No 7.6 EC50 = 26.9 Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
286 6 1 2 4.2 C1CCC(C(C1)CCCC2=CC=CC=C2)NC3=NCCO3
CHEMBL222933 ada2c_human Human No 5.6 EC50 = 2691.5 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
264 3 1 2 2.1 C1CN=C(N1)C2C(O2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL222933 ada2c_human Human No 5.6 EC50 = 2691.5 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
264 3 1 2 2.1 C1CN=C(N1)C2C(O2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL155866 ada2c_human Human No 7.6 EC50 = 27.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 3 1 2 2.1 CC1=C(C(=CC=C1)C)OC(C)C2=NCCN2
CHEMBL157955 ada2c_human Human No 7.6 EC50 = 27.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 2 2.9 CCC1=C(C(=CC=C1)CC)OC(C)C2=NCCN2
CHEMBL155866 ada2c_human Human No 7.6 EC50 = 27.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 3 1 2 2.1 CC1=C(C(=CC=C1)C)OC(C)C2=NCCN2
CHEMBL157955 ada2c_human Human No 7.6 EC50 = 27.5 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 2 2.9 CCC1=C(C(=CC=C1)CC)OC(C)C2=NCCN2
CHEMBL576819 ada2c_human Human No 5.5 EC50 = 2884.0 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
190 3 1 2 1.5 CC1=CC=CC=C1COC2=NCCN2
CHEMBL576819 ada2c_human Human No 5.5 EC50 = 2884.0 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
190 3 1 2 1.5 CC1=CC=CC=C1COC2=NCCN2
CHEMBL844 ada2c_human Human Yes 8.5 EC50 = 3.4 Funct
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cellsEffective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL72753 ada2c_human Human Yes 7.5 EC50 = 30.9 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
248 2 2 3 0.5 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Cl
CHEMBL1956200 ada2c_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
268 4 1 4 0.6 CC(C1=NCCN1)OC2=CC=CC=C2S(=O)(=O)C
CHEMBL2089155 ada2c_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL1956200 ada2c_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
268 4 1 4 0.6 CC(C1=NCCN1)OC2=CC=CC=C2S(=O)(=O)C
CHEMBL2089155 ada2c_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL2089155 ada2c_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 2 2.7 CC(C1=NCCN1)OC2=CC=CC=C2CC3CC3
CHEMBL522151 ada2c_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 3 2.3 C1CN=C(N1)C2COC3=CC=CC(=C3O2)C4=CC=CC=C4
CHEMBL2087646 ada2c_human Human Yes 5.5 EC50 = 3162.3 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
194 3 1 4 1.8 C1=CC=C2C(=C1)N=C(O2)SCCN
CHEMBL522151 ada2c_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 3 2.3 C1CN=C(N1)C2COC3=CC=CC(=C3O2)C4=CC=CC=C4
CHEMBL2087646 ada2c_human Human Yes 5.5 EC50 = 3162.3 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
194 3 1 4 1.8 C1=CC=C2C(=C1)N=C(O2)SCCN
CHEMBL1327 ada2c_human Human Yes 3.5 EC50 = 338844.2 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
257 3 1 2 2.6 C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)O
CHEMBL1327 ada2c_human Human Yes 3.5 EC50 = 338844.2 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
257 3 1 2 2.6 C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)O
CHEMBL3588904 ada2c_human Human No 5.5 EC50 = 3467.4 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
261 4 1 3 2.9 C1=CC=C(C(=C1)C2=CN=CC=C2)NCC3=CC=NC=C3
CHEMBL3588904 ada2c_human Human No 5.5 EC50 = 3467.4 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
261 4 1 3 2.9 C1=CC=C(C(=C1)C2=CN=CC=C2)NCC3=CC=NC=C3
CHEMBL1276220 ada2c_human Human No 7.5 EC50 = 35.5 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276220 ada2c_human Human No 7.5 EC50 = 35.5 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276220 ada2c_human Human No 7.5 EC50 = 35.5 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL495097 ada2c_human Human No 5.5 EC50 = 3548.1 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
323 7 1 4 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C=NOCC3=CC=CC=C3
CHEMBL495097 ada2c_human Human No 5.5 EC50 = 3548.1 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
323 7 1 4 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C=NOCC3=CC=CC=C3
CHEMBL223830 ada2c_human Human No 6.4 EC50 = 363.1 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=CC=C1C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL223830 ada2c_human Human No 6.4 EC50 = 363.1 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=CC=C1C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL242693 ada2c_human Human No 7.4 EC50 = 38 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL242693 ada2c_human Human No 7.4 EC50 = 38 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL576623 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 4 1 2 2.4 CC(C1=CC=CC=C1C2CC2)OC3=NCCN3
CHEMBL1276218 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL373535 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL576623 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 4 1 2 2.4 CC(C1=CC=CC=C1C2CC2)OC3=NCCN3
CHEMBL1276218 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL373535 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL1276218 ada2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL13852 ada2c_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL266613 ada2c_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 2 2.4 CC(C)C1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL13852 ada2c_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL266613 ada2c_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 2 2.4 CC(C)C1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL13852 ada2c_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL310335 ada2c_human Human No 8.4 EC50 = 4.1 Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
210 4 1 2 2.8 CCCC1CCCCC1NC2=NCCO2
CHEMBL297752 ada2c_human Human No 8.4 EC50 = 4.1 Funct
Alpha-2C adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2C adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
210 4 1 2 2.8 CCCC1CCCCC1NC2=NCCO2
CHEMBL74114 ada2c_human Human No 6.4 EC50 = 446.7 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=CC=CC(=C1NCC2=NCCN2)F
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1956197 ada2c_human Human No 7.3 EC50 = 47.9 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 3 1.8 CC(C1=NCCN1)OC2=CC=CC=C2OC3CC3
CHEMBL1956197 ada2c_human Human No 7.3 EC50 = 47.9 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 3 1.8 CC(C1=NCCN1)OC2=CC=CC=C2OC3CC3
CHEMBL1956197 ada2c_human Human No 7.3 EC50 = 47.9 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
246 5 1 3 1.8 CC(C1=NCCN1)OC2=CC=CC=C2OC3CC3
CHEMBL3588905 ada2c_human Human No 3.3 EC50 = 478630.1 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
264 5 2 3 1.6 C1=CC=C(C=C1)C2=NC=C(N2)CNCC3=CN=CC=C3
CHEMBL3588905 ada2c_human Human No 3.3 EC50 = 478630.1 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
264 5 2 3 1.6 C1=CC=C(C=C1)C2=NC=C(N2)CNCC3=CN=CC=C3
CHEMBL72768 ada2c_human Human No 8.3 EC50 = 5.6 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL570973 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 5 1 2 2.6 CC(C1=CC=CC=C1CC=C)OC2=NCCN2
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL570973 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 5 1 2 2.6 CC(C1=CC=CC=C1CC=C)OC2=NCCN2
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL495095 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CN=CC=C3
CHEMBL222371 ada2c_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
281 4 2 3 2.3 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)N
CHEMBL442815 ada2c_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
247 5 1 4 1.4 CC(C1=NCCN1)OC2=CC=CC=C2C=NOC
CHEMBL222371 ada2c_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
281 4 2 3 2.3 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)N
CHEMBL442815 ada2c_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
247 5 1 4 1.4 CC(C1=NCCN1)OC2=CC=CC=C2C=NOC
CHEMBL419448 ada2c_human Human No 6.3 EC50 = 501.2 Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
271 4 2 5 0.8 CS(=O)(=O)C1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL70973 ada2c_human Human No 5.3 EC50 = 5011.9 Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
267 5 2 4 1.1 CCS(=O)(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL761 ada2c_human Human Yes 7.3 EC50 = 55.0 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL761 ada2c_human Human Yes 7.3 EC50 = 55.0 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL70676 ada2c_human Human Yes 7.3 EC50 = 55.0 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
339 2 2 3 0.5 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)I
CHEMBL157206 ada2c_human Human No 7.3 EC50 = 56.2 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
270 7 1 2 3.5 CC(C1=NCCN1)OC2=C(C=CC=C2CC=C)CC=C
CHEMBL157206 ada2c_human Human No 7.3 EC50 = 56.2 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
270 7 1 2 3.5 CC(C1=NCCN1)OC2=C(C=CC=C2CC=C)CC=C
CHEMBL437314 ada2c_human Human No 5.3 EC50 = 5660 Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL437314 ada2c_human Human No 5.3 EC50 = 5660 Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 7.2 EC50 = 57.5 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL223829 ada2c_human Human No 7.2 EC50 = 58.9 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 3 2.7 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CS3
CHEMBL223829 ada2c_human Human No 7.2 EC50 = 58.9 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 3 2.7 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CS3
CHEMBL1276248 ada2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL1276248 ada2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL308570 ada2c_human Human No 8.2 EC50 = 6.6 Funct
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cellsEffective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
231 2 2 4 2.0 CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL48341 ada2c_human Human No 7.2 EC50 = 60.3 Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
298 6 1 2 4.1 C1CC2CC1C(C2NC3=NCCO3)CCCC4=CC=CC=C4
CHEMBL14107 ada2c_human Human No 7.2 EC50 = 61.7 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
216 5 1 2 2.0 C=CCC1=CC=CC=C1OCC2=NCCN2
CHEMBL570863 ada2c_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
204 3 1 2 1.9 CC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL570863 ada2c_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
204 3 1 2 1.9 CC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL1956198 ada2c_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 5 1 3 1.8 CC(C1=NCCN1)OC2=CC=CC=C2OC=C
CHEMBL1956198 ada2c_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 5 1 3 1.8 CC(C1=NCCN1)OC2=CC=CC=C2OC=C
CHEMBL70740 ada2c_human Human No 5.2 EC50 = 6309.6 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
279 3 2 4 0.6 C1CC2=C(C(=CC=C2)NCC3=NCCN3)S(=O)(=O)C1
CHEMBL3588909 ada2c_human Human Yes 3.2 EC50 = 630957.3 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
242 4 2 3 1.5 C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CN
CHEMBL3588909 ada2c_human Human Yes 3.2 EC50 = 630957.3 Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
242 4 2 3 1.5 C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CN
CHEMBL72724 ada2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
289 4 2 6 2.3 CSC1=C(C=C(C=C1)C(F)(F)F)NCC2=NCCN2
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL305928 ada2c_human Human Yes 7.1 EC50 = 77.6 Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
182 2 1 2 2.0 C1CCCC(CC1)NC2=NCCO2
CHEMBL523048 ada2c_human Human No 6.1 EC50 = 776.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
328 5 1 2 4.2 C1CN=C(N1)C(C2=CC=CC=C2)OC3=CC=CC=C3C4=CC=CC=C4
CHEMBL523048 ada2c_human Human No 6.1 EC50 = 776.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
328 5 1 2 4.2 C1CN=C(N1)C(C2=CC=CC=C2)OC3=CC=CC=C3C4=CC=CC=C4
CHEMBL1956203 ada2c_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
342 5 1 2 4.6 CC(C1=NCCN1)OC2=C(C=CC=C2C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1956203 ada2c_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
342 5 1 2 4.6 CC(C1=NCCN1)OC2=C(C=CC=C2C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1956193 ada2c_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
258 3 1 5 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C(F)(F)F
CHEMBL493272 ada2c_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(C=CC=C3O2)C4=CC=CC=C4
CHEMBL1956193 ada2c_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
258 3 1 5 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C(F)(F)F
CHEMBL493272 ada2c_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(C=CC=C3O2)C4=CC=CC=C4
CHEMBL70634 ada2c_human Human No 6.1 EC50 = 794.3 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
288 4 2 4 1.4 CS(=O)(=O)C1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL844 ada2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL72441 ada2c_human Human No 8.1 EC50 = 8.9 Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
235 4 2 3 1.8 CC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL426900 ada2c_human Human No 6.1 EC50 = 831.8 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=C(C=C1)C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL426900 ada2c_human Human No 6.1 EC50 = 831.8 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 2 3.3 CC1=CC=C(C=C1)C2=CC=CC=C2OC(C)C3=NCCN3
CHEMBL72995 ada2c_human Human No 6.1 EC50 = 831.8 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
306 2 2 3 1.0 CC1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL72147 ada2c_human Human No 6.1 EC50 = 831.8 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
306 2 2 3 1.0 CC1=CN=C2C(=N1)C=CC(=C2Br)NC3=NCCN3
CHEMBL844 ada2c_human Human Yes 8.0 EC50 = 9.6 Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL130884 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
265 4 2 2 3.0 CC(C1=NCCN1)NC2=CC=CC=C2C3=CC=CC=C3
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL130884 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
265 4 2 2 3.0 CC(C1=NCCN1)NC2=CC=CC=C2C3=CC=CC=C3
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL2431279 ada2c_human Human Yes 7.0 EC50 = 97.7 Funct
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
255 3 1 2 1.6 C1CN=C(N1)COC2=CC=CC=C2Br
CHEMBL1956199 ada2c_human Human No 5.0 EC50 = 9772.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
220 4 1 3 1.3 CC(C1=NCCN1)OC2=CC=CC=C2OC
CHEMBL1956199 ada2c_human Human No 5.0 EC50 = 9772.4 Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
220 4 1 3 1.3 CC(C1=NCCN1)OC2=CC=CC=C2OC
CHEMBL162682 ada2c_human Human No 9.2 IC50 = 0.6 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
485 3 0 4 3.0 CC1=C(C(=O)N2C=C(C=CC2=N1)I)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL165350 ada2c_human Human No 9.2 IC50 = 0.7 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
438 3 0 4 3.2 CC1=C(C(=O)N2C=C(C=CC2=N1)Br)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL162490 ada2c_human Human No 9.2 IC50 = 0.7 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
389 4 0 5 3.0 CC1=C(C(=O)N2C=CC=C(C2=N1)OC)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL351483 ada2c_human Human No 9.1 IC50 = 0.7 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
394 3 0 4 3.1 CC1=C(C(=O)N2C=C(C=CC2=N1)Cl)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL162232 ada2c_human Human No 9.1 IC50 = 0.9 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
387 3 0 4 3.1 CC1=CC2=NC(=C(C(=O)N2C(=C1)C)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL163190 ada2c_human Human No 9.0 IC50 = 1.1 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 4 3.1 CC1=CC=CC2=NC(=C(C(=O)N12)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL165796 ada2c_human Human No 8.9 IC50 = 1.2 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 4 2.7 CC1=CC2=NC(=C(C(=O)N2C=C1)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL162370 ada2c_human Human No 8.9 IC50 = 1.3 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 4 2.7 CC1=CN2C(=NC(=C(C2=O)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C)C=C1
CHEMBL351200 ada2c_human Human No 8.9 IC50 = 1.3 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 4 3.1 CC1=CC=CN2C1=NC(=C(C2=O)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL163247 ada2c_human Human No 8.9 IC50 = 1.3 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
428 3 0 4 4.0 CC1=C(C(=O)N2C=C(C=C(C2=N1)Cl)Cl)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL162826 ada2c_human Human No 8.8 IC50 = 1.6 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
375 3 1 5 2.6 CC1=C(C(=O)N2C=CC=C(C2=N1)O)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL162501 ada2c_human Human Yes 8.8 IC50 = 1.7 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
359 3 0 4 2.8 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL219916 ada2c_human Human Yes 6.0 IC50 = 1011 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL219916 ada2c_human Human Yes 6.0 IC50 = 1011 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL515170 ada2c_human Human No 5.0 IC50 = 10400 Funct
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
361 3 1 7 4.2 CCC1C(=O)NC2=C(C(=C(C=C2)F)F)C(O1)(C=CC3CC3)C(F)(F)F
CHEMBL515170 ada2c_human Human No 5.0 IC50 = 10400 Funct
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
361 3 1 7 4.2 CCC1C(=O)NC2=C(C(=C(C=C2)F)F)C(O1)(C=CC3CC3)C(F)(F)F
CHEMBL2203713 ada2c_human Human No 5.0 IC50 = 11000 Funct
Inhibition of alpha2C adrenergic receptorInhibition of alpha2C adrenergic receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL84931 ada2c_human Human No 5.9 IC50 = 1174.9 Funct
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
312 2 0 4 4.0 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)F
CHEMBL833 ada2c_human Human Yes 5.9 IC50 = 1175 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
264 2 0 2 3.6 C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl
CHEMBL833 ada2c_human Human Yes 5.9 IC50 = 1175 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
264 2 0 2 3.6 C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl
CHEMBL165181 ada2c_human Human No 7.9 IC50 = 14.1 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
375 3 0 4 3.4 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=CC=CC=C5S4
CHEMBL133455 ada2c_human Human Yes 4.9 IC50 = 14000 Funct
Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand
230 2 2 2 2.2 CC(CC1=CNC2=C1C3=C(C=C2)OCCC3)N
CHEMBL415 ada2c_human Human Yes 5.9 IC50 = 1413 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL415 ada2c_human Human Yes 5.9 IC50 = 1413 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL195437 ada2c_human Human Yes 4.9 IC50 = 14234 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL195437 ada2c_human Human Yes 4.9 IC50 = 14234 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL954 ada2c_human Human Yes 5.8 IC50 = 1482 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL954 ada2c_human Human Yes 5.8 IC50 = 1482 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL411 ada2c_human Human Yes 4.8 IC50 = 15151 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL411 ada2c_human Human Yes 4.8 IC50 = 15151 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL1909065 ada2c_human Human No 5.8 IC50 = 1610 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL508112 ada2c_human Human Yes 5.8 IC50 = 1658 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
332 3 0 6 5.6 C1=CC=C2C(=C1)N=C(S2)SSC3=NC4=CC=CC=C4S3
CHEMBL479 ada2c_human Human Yes 6.8 IC50 = 171 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL479 ada2c_human Human Yes 6.8 IC50 = 171 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL1108 ada2c_human Human Yes 5.8 IC50 = 1763 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1108 ada2c_human Human Yes 5.8 IC50 = 1763 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1491 ada2c_human Human Yes 5.8 IC50 = 1800 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
409 10 2 7 3.0 CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
CHEMBL1491 ada2c_human Human Yes 5.8 IC50 = 1800 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
409 10 2 7 3.0 CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
CHEMBL50588 ada2c_human Human Yes 6.7 IC50 = 182 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
481 7 1 6 4.7 CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC
CHEMBL50588 ada2c_human Human Yes 6.7 IC50 = 182 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
481 7 1 6 4.7 CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC
CHEMBL54 ada2c_human Human Yes 5.7 IC50 = 1845 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL83658 ada2c_human Human No 5.7 IC50 = 1862.1 Funct
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
294 2 0 3 3.9 CN(C)CC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL621 ada2c_human Human Yes 5.7 IC50 = 1942 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL621 ada2c_human Human Yes 5.7 IC50 = 1942 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL296419 ada2c_human Human Yes 5.7 IC50 = 1959 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL296419 ada2c_human Human Yes 5.7 IC50 = 1959 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL654 ada2c_human Human Yes 6.7 IC50 = 199.5 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
265 0 0 3 3.3 CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
CHEMBL164612 ada2c_human Human No 8.7 IC50 = 2.2 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
394 3 0 4 3.4 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=C(O4)C(=CC=C5)Cl
CHEMBL162436 ada2c_human Human No 8.6 IC50 = 2.7 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
436 5 0 4 4.3 C1CN(CC2=C1OC3=CC=CC=C23)CCC4=C(N=C5C=CC=CN5C4=O)CC6=CC=CC=C6
CHEMBL445 ada2c_human Human Yes 6.7 IC50 = 203 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL445 ada2c_human Human Yes 6.7 IC50 = 203 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL584554 ada2c_human Human No 6.7 IC50 = 215 Funct
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
429 4 2 2 3.8 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C(=O)NC5=CC=CC=C5
CHEMBL584554 ada2c_human Human No 6.7 IC50 = 215 Funct
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
429 4 2 2 3.8 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C(=O)NC5=CC=CC=C5
CHEMBL30008 ada2c_human Human Yes 6.7 IC50 = 222 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL30008 ada2c_human Human Yes 6.7 IC50 = 222 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL1479 ada2c_human Human Yes 4.6 IC50 = 23752 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
337 1 1 3 3.8 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
CHEMBL1479 ada2c_human Human Yes 4.6 IC50 = 23752 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
337 1 1 3 3.8 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
CHEMBL643 ada2c_human Human Yes 5.6 IC50 = 2431 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL282575 ada2c_human Human Yes 4.6 IC50 = 24650 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
376 3 1 3 4.5 CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
CHEMBL282575 ada2c_human Human Yes 4.6 IC50 = 24650 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
376 3 1 3 4.5 CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
CHEMBL564 ada2c_human Human Yes 6.6 IC50 = 253 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL165677 ada2c_human Human No 7.6 IC50 = 27.5 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
394 3 0 4 3.4 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=C(O4)C=CC(=C5)Cl
CHEMBL305660 ada2c_human Human Yes 6.6 IC50 = 275.7 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL305660 ada2c_human Human Yes 6.6 IC50 = 275.7 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL162147 ada2c_human Human No 8.4 IC50 = 3.6 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
462 3 0 7 4.0 CC1=C(C(=O)N2C=C(C=C(C2=N1)Cl)C(F)(F)F)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL21731 ada2c_human Human Yes 5.5 IC50 = 3044 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL21731 ada2c_human Human Yes 5.5 IC50 = 3044 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL1221512 ada2c_human Human Yes 5.5 IC50 = 3136 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
560 19 4 9 2.6 CCC(C)C(COC(CC1=CC=CC=C1)C(=O)NC(CCS(=O)(=O)C)C(=O)OC(C)C)NCC(CS)N
CHEMBL481 ada2c_human Human Yes 5.5 IC50 = 3171 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
587 5 1 8 3.0 CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
CHEMBL481 ada2c_human Human Yes 5.5 IC50 = 3171 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
587 5 1 8 3.0 CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
CHEMBL1113 ada2c_human Human Yes 5.5 IC50 = 3174 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL1113 ada2c_human Human Yes 5.5 IC50 = 3174 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL588119 ada2c_human Human Yes 5.5 IC50 = 3446 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
338 12 2 3 5.8 CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O
CHEMBL71 ada2c_human Human Yes 6.4 IC50 = 374 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL71 ada2c_human Human Yes 6.4 IC50 = 374 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL1403281 ada2c_human Human Yes 7.4 IC50 = 38 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL7568 ada2c_human Human Yes 5.4 IC50 = 3857 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL7568 ada2c_human Human Yes 5.4 IC50 = 3857 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL1289 ada2c_human Human Yes 5.4 IC50 = 4045 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
361 2 0 1 4.6 C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI
CHEMBL1289 ada2c_human Human Yes 5.4 IC50 = 4045 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
361 2 0 1 4.6 C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI
CHEMBL1262 ada2c_human Human Yes 5.4 IC50 = 4164.5 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
429 6 0 3 6.1 C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL1262 ada2c_human Human Yes 5.4 IC50 = 4164.5 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
429 6 0 3 6.1 C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL1306 ada2c_human Human Yes 6.4 IC50 = 418 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL290106 ada2c_human Human Yes 5.4 IC50 = 4392 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
356 2 2 3 5.8 C1=C(C=C(C(=C1Cl)O)SC2=CC(=CC(=C2O)Cl)Cl)Cl
CHEMBL290106 ada2c_human Human Yes 5.4 IC50 = 4392 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
356 2 2 3 5.8 C1=C(C=C(C(=C1Cl)O)SC2=CC(=CC(=C2O)Cl)Cl)Cl
CHEMBL809 ada2c_human Human Yes 5.4 IC50 = 4477 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL809 ada2c_human Human Yes 5.4 IC50 = 4477 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL1909072 ada2c_human Human Yes 7.4 IC50 = 45 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1909072 ada2c_human Human Yes 7.4 IC50 = 45 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1221 ada2c_human Human Yes 5.3 IC50 = 4934 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL787 ada2c_human Human Yes 5.3 IC50 = 5279 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
586 12 2 5 7.7 CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
CHEMBL715 ada2c_human Human Yes 6.3 IC50 = 531 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL1381098 ada2c_human Human Yes 4.3 IC50 = 54539 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
185 1 0 2 4.3 C1=CC=C2C(=C1)C=CC=C2N=C=S
CHEMBL1381098 ada2c_human Human Yes 4.3 IC50 = 54539 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
185 1 0 2 4.3 C1=CC=C2C(=C1)C=CC=C2N=C=S
CHEMBL162058 ada2c_human Human No 7.2 IC50 = 57.5 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
419 5 0 6 2.2 CC1=C(C(=O)N2C=C(C(=CC2=N1)OC)OC)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL165776 ada2c_human Human No 8.2 IC50 = 6.6 Funct
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 4 0 4 3.1 CC1=C(C(=O)N2C=CC=CC2=N1)CCCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL611 ada2c_human Human Yes 5.2 IC50 = 6042 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada2c_human Human Yes 5.2 IC50 = 6042 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL862 ada2c_human Human Yes 5.2 IC50 = 6447 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL862 ada2c_human Human Yes 5.2 IC50 = 6447 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL43064 ada2c_human Human Yes 6.2 IC50 = 652 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL43064 ada2c_human Human Yes 6.2 IC50 = 652 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL496 ada2c_human Human Yes 5.2 IC50 = 6975.4 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
407 2 2 2 7.5 C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
CHEMBL42 ada2c_human Human Yes 8.1 IC50 = 7.9 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL12131 ada2c_human Human Yes 5.2 IC50 = 7100 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
663 4 2 3 7.2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2O)I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl
CHEMBL81 ada2c_human Human Yes 6.1 IC50 = 738 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL81 ada2c_human Human Yes 6.1 IC50 = 738 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL470432 ada2c_human Human No 6.1 IC50 = 741.3 Funct
Displacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptorDisplacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL470432 ada2c_human Human No 6.1 IC50 = 741.3 Funct
Displacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptorDisplacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL1358628 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1358628 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada2c_human Human Yes 6.1 IC50 = 780 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1630578 ada2c_human Human Yes 5.1 IC50 = 7898 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
625 6 0 8 5.9 CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
CHEMBL1630578 ada2c_human Human Yes 5.1 IC50 = 7898 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
625 6 0 8 5.9 CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
CHEMBL728 ada2c_human Human Yes 7.1 IC50 = 82 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL315772 ada2c_human Human No 6.1 IC50 = 871.0 Funct
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
329 2 0 3 4.5 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)Cl
CHEMBL85 ada2c_human Human Yes 8.0 IC50 = 9.6 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL85 ada2c_human Human Yes 8.0 IC50 = 9.6 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL1626 ada2c_human Human Yes 7.0 IC50 = 95 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL435352 ada2c_human Human No 10.5 Ki = 0.0 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
478 9 0 7 4.1 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OCCOC
CHEMBL390718 ada2c_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
463 7 1 7 2.9 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4CN=C5C=C(C(=CC5=C4NO3)OC)OC
CHEMBL176261 ada2c_human Human No 10.0 Ki = 0.1 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
491 9 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OCCN(C)C
CHEMBL180470 ada2c_human Human No 10.0 Ki = 0.1 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
420 5 1 6 2.9 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=O)C=CC5=C4NO3
CHEMBL2112985 ada2c_human Human No 10.0 Ki = 0.1 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
463 7 1 7 2.9 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4CN=C5C=C(C(=CC5=C4NO3)OC)OC
CHEMBL91157 ada2c_human Human No 10.0 Ki = 0.1 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
464 7 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL91157 ada2c_human Human No 10.0 Ki = 0.1 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
464 7 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL1256414 ada2c_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1255723 ada2c_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 3.1 CCC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1255723 ada2c_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 3.1 CCC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1256414 ada2c_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL176116 ada2c_human Human No 9.7 Ki = 0.2 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
462 7 0 7 4.0 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)C
CHEMBL176002 ada2c_human Human No 9.7 Ki = 0.2 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
434 6 0 6 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC
CHEMBL175853 ada2c_human Human No 9.7 Ki = 0.2 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
492 9 0 8 3.9 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)COC
CHEMBL179237 ada2c_human Human No 9.7 Ki = 0.2 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
536 13 0 8 4.3 CCOCCOCCOC1=CC2=C(C=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC(=CC5=CC=CC=C5)C
CHEMBL91157 ada2c_human Human No 9.7 Ki = 0.2 Funct
Binding affinity for alpha-2C-adrenergic receptorBinding affinity for alpha-2C-adrenergic receptor
464 7 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL100879 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
470 7 0 8 3.9 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CS5
CHEMBL101596 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
470 7 0 8 3.9 CC(=CC1=CSC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL263424 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
482 7 0 8 4.3 CC(=CC1=CC(=CC=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL319119 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
500 7 0 9 4.4 CC(=CC1=C(C=CC(=C1)F)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
464 7 0 7 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5
CHEMBL91157 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
464 7 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL98646 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
470 7 0 8 3.9 CC(=CC1=CC=CS1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL93171 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
464 7 0 7 4.2 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
464 7 0 7 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
464 7 0 7 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5
CHEMBL1256414 ada2c_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1256414 ada2c_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL318235 ada2c_human Human Yes 9.6 Ki = 0.3 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
482 7 0 8 4.3 CC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL318235 ada2c_human Human Yes 9.6 Ki = 0.3 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
482 7 0 8 4.3 CC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL1256378 ada2c_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.5 CC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1256378 ada2c_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.5 CC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL175911 ada2c_human Human No 9.5 Ki = 0.3 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
488 8 0 7 4.4 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)C6CC6
CHEMBL328195 ada2c_human Human No 9.5 Ki = 0.3 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
470 7 0 8 3.9 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CSC=C5
CHEMBL98541 ada2c_human Human No 9.5 Ki = 0.3 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
482 7 0 8 4.3 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=C(C=C5)F
CHEMBL319530 ada2c_human Human No 9.4 Ki = 0.4 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
454 7 0 8 3.3 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CO5
CHEMBL99868 ada2c_human Human No 9.4 Ki = 0.4 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
494 8 0 8 4.2 CC(=CC1=CC=CC=C1OC)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL1255724 ada2c_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.6 CCCC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1255724 ada2c_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.6 CCCC1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL477608 ada2c_human Human No 9.3 Ki = 0.5 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
468 8 2 7 3.7 CC(C)(C)NC1=C(C=CC=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL477608 ada2c_human Human No 9.3 Ki = 0.5 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
468 8 2 7 3.7 CC(C)(C)NC1=C(C=CC=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL180322 ada2c_human Human No 9.3 Ki = 0.5 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
474 8 0 7 4.6 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)C=C
CHEMBL369378 ada2c_human Human No 9.3 Ki = 0.5 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
488 7 0 6 5.5 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC6CCCC6
CHEMBL425324 ada2c_human Human No 9.3 Ki = 0.5 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
525 8 0 8 4.6 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)C6=CC=NC=C6
CHEMBL99916 ada2c_human Human No 9.3 Ki = 0.5 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
454 7 0 8 3.3 CC(=CC1=CC=CO1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL328114 ada2c_human Human No 9.3 Ki = 0.5 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
450 7 0 7 3.6 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC=CC5=CC=CC=C5)OC
CHEMBL1256609 ada2c_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.4 CC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256609 ada2c_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.4 CC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL476569 ada2c_human Human No 9.2 Ki = 0.6 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
469 10 1 7 3.7 CCCCOC1=CC=CC(=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL476569 ada2c_human Human No 9.2 Ki = 0.6 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
469 10 1 7 3.7 CCCCOC1=CC=CC(=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL419316 ada2c_human Human No 9.2 Ki = 0.6 Funct
Binding affinity for alpha-2C-adrenergic receptorBinding affinity for alpha-2C-adrenergic receptor
464 7 0 7 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5
CHEMBL329065 ada2c_human Human No 9.2 Ki = 0.6 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
480 7 1 8 3.8 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=C(C=C5)O
CHEMBL327875 ada2c_human Human No 9.2 Ki = 0.6 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
464 7 0 7 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5
CHEMBL196451 ada2c_human Human No 9.2 Ki = 0.7 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
516 8 3 5 4.0 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)NCCCC(=O)OCC6=CC=CC=C6)O
CHEMBL196451 ada2c_human Human No 9.2 Ki = 0.7 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
516 8 3 5 4.0 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)NCCCC(=O)OCC6=CC=CC=C6)O
CHEMBL318235 ada2c_human Human Yes 9.2 Ki = 0.7 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
482 7 0 8 4.3 CC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL318235 ada2c_human Human Yes 9.2 Ki = 0.7 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
482 7 0 8 4.3 CC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL419336 ada2c_human Human No 9.2 Ki = 0.7 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
500 7 0 9 4.4 CC(=CC1=C(C(=CC=C1)F)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL95218 ada2c_human Human No 9.2 Ki = 0.7 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
468 7 0 8 3.7 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC=CC5=CC(=CC=C5)F)OC
CHEMBL514837 ada2c_human Human No 9.1 Ki = 0.8 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
469 10 1 7 3.4 CCCCOC1=C(C=CC=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL515331 ada2c_human Human No 9.1 Ki = 0.8 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
514 8 1 8 3.4 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC(=C5)C#N
CHEMBL394218 ada2c_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
506 7 1 7 3.8 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C(=O)NC5CN6CCC5CC6
CHEMBL514837 ada2c_human Human No 9.1 Ki = 0.8 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
469 10 1 7 3.4 CCCCOC1=C(C=CC=N1)C(=O)NCCN2CCCN(CC2)CC3COC4=CC=CC=C4O3
CHEMBL515331 ada2c_human Human No 9.1 Ki = 0.8 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
514 8 1 8 3.4 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC(=C5)C#N
CHEMBL394218 ada2c_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
506 7 1 7 3.8 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C(=O)NC5CN6CCC5CC6
CHEMBL328631 ada2c_human Human No 9.1 Ki = 0.8 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
500 7 0 9 4.4 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=C(C=C(C=C5)F)F
CHEMBL92860 ada2c_human Human No 9.1 Ki = 0.8 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
474 6 0 7 4.2 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC5=CC6=CC=CC=C6C=C5)OC
CHEMBL92860 ada2c_human Human No 9.1 Ki = 0.8 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
474 6 0 7 4.2 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC5=CC6=CC=CC=C6C=C5)OC
CHEMBL524153 ada2c_human Human No 9.1 Ki = 0.9 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
489 8 1 7 3.7 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL524153 ada2c_human Human No 9.1 Ki = 0.9 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
489 8 1 7 3.7 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL101361 ada2c_human Human No 9.1 Ki = 0.9 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
494 8 0 8 4.2 CC(=CCN1CCN(CC1)CC2C3COC4=CC(=C(C=C4C3=NO2)OC)OC)C5=CC=CC=C5OC
CHEMBL390718 ada2c_human Human No 9.0 Ki = 0.9 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
463 7 1 7 2.9 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4CN=C5C=C(C(=CC5=C4NO3)OC)OC
CHEMBL369938 ada2c_human Human No 9.0 Ki = 1.1 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
531 8 4 5 3.9 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)NCCCNC(=O)OCC6=CC=CC=C6)O
CHEMBL369938 ada2c_human Human No 9.0 Ki = 1.1 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
531 8 4 5 3.9 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)NCCCNC(=O)OCC6=CC=CC=C6)O
CHEMBL42 ada2c_human Human Yes 8.9 Ki = 1.1 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 ada2c_human Human Yes 8.9 Ki = 1.1 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL1255770 ada2c_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 1 1 1 2.9 CC1(C2C1(CC3=CC=CC=C23)C4=CN=CN4)C
CHEMBL1255770 ada2c_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 1 1 1 2.9 CC1(C2C1(CC3=CC=CC=C23)C4=CN=CN4)C
CHEMBL1256610 ada2c_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 2.9 CCC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256610 ada2c_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 2.9 CCC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL85 ada2c_human Human Yes 8.9 Ki = 1.4 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL1255616 ada2c_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.5 CCCC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1255616 ada2c_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.5 CCCC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256566 ada2c_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
254 4 1 2 2.4 CCCOC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256566 ada2c_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
254 4 1 2 2.4 CCCOC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL178588 ada2c_human Human No 8.8 Ki = 1.6 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
504 8 0 7 5.4 CC(=CC1=CC=CC=C1)CN2CCN(CC2)CC3C4COC5=C(C4=NO3)C=CC(=C5)OC(=O)C(C)(C)C
CHEMBL2112969 ada2c_human Human No 8.8 Ki = 1.6 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
471 8 1 9 1.9 COC1=CC2=C3C(CN=C2C=C1OC)C(ON3)CN4CCN(CC4)CCOC5=CC=C(C=C5)F
CHEMBL491420 ada2c_human Human No 8.8 Ki = 1.7 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
500 7 0 9 4.1 C1CN(CCN(C1)CC2=NC(=NO2)C3=C(N=CC=C3)OC4=CC=CC=C4)CC5COC6=CC=CC=C6O5
CHEMBL491420 ada2c_human Human No 8.8 Ki = 1.7 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
500 7 0 9 4.1 C1CN(CCN(C1)CC2=NC(=NO2)C3=C(N=CC=C3)OC4=CC=CC=C4)CC5COC6=CC=CC=C6O5
CHEMBL2112978 ada2c_human Human No 8.8 Ki = 1.7 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
389 5 0 5 3.6 C1CN(CCN1CC=CC2=CC=CC=C2)CC3C4COC5=CC=CC=C5C4=NO3
CHEMBL90943 ada2c_human Human No 8.8 Ki = 1.7 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
389 5 0 5 3.6 C1CN(CCN1CC=CC2=CC=CC=C2)CC3C4COC5=CC=CC=C5C4=NO3
CHEMBL515331 ada2c_human Human No 8.7 Ki = 1.9 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
514 8 1 8 3.4 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC(=C5)C#N
CHEMBL524153 ada2c_human Human No 8.7 Ki = 1.9 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
489 8 1 7 3.7 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL491420 ada2c_human Human No 8.7 Ki = 1.9 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
500 7 0 9 4.1 C1CN(CCN(C1)CC2=NC(=NO2)C3=C(N=CC=C3)OC4=CC=CC=C4)CC5COC6=CC=CC=C6O5
CHEMBL3290012 ada2c_human Human No 8.7 Ki = 1.9 Funct
Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells
488 8 1 8 5.1 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=CC=CC=C5S4
CHEMBL515331 ada2c_human Human No 8.7 Ki = 1.9 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
514 8 1 8 3.4 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC(=C5)C#N
CHEMBL524153 ada2c_human Human No 8.7 Ki = 1.9 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
489 8 1 7 3.7 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL491420 ada2c_human Human No 8.7 Ki = 1.9 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
500 7 0 9 4.1 C1CN(CCN(C1)CC2=NC(=NO2)C3=C(N=CC=C3)OC4=CC=CC=C4)CC5COC6=CC=CC=C6O5
CHEMBL3290012 ada2c_human Human No 8.7 Ki = 1.9 Funct
Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells
488 8 1 8 5.1 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=CC=CC=C5S4
CHEMBL90247 ada2c_human Human No 8.7 Ki = 1.9 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
420 6 0 6 3.6 COC1=CC2=C(C=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC=CC5=CC=CC=C5
CHEMBL90419 ada2c_human Human No 8.7 Ki = 1.9 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
452 8 0 7 3.7 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CCCC5=CC=CC=C5)OC
CHEMBL1256503 ada2c_human Human No 8.7 Ki = 2.0 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
226 2 1 2 1.5 COC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL318235 ada2c_human Human Yes 8.0 Ki = 10 Funct
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
482 7 0 8 4.3 CC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL85 ada2c_human Human Yes 8.0 Ki = 10 Funct
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL101411 ada2c_human Human No 8.0 Ki = 10 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
484 7 0 7 4.2 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC=CC5=CC=C(C=C5)Cl)OC
CHEMBL1256565 ada2c_human Human No 8.0 Ki = 10.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
240 3 1 2 1.9 CCOC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256565 ada2c_human Human No 8.0 Ki = 10.2 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
240 3 1 2 1.9 CCOC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL191703 ada2c_human Human Yes 8.0 Ki = 10.5 Funct
Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells
357 1 0 2 4.9 CC1C2CCC3C2(CCC4C3CC=C5C4(CCC(C5)N(C)C)C)CN1C
CHEMBL191703 ada2c_human Human Yes 8.0 Ki = 10.5 Funct
Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells
357 1 0 2 4.9 CC1C2CCC3C2(CCC4C3CC=C5C4(CCC(C5)N(C)C)C)CN1C
CHEMBL191703 ada2c_human Human Yes 8.0 Ki = 10.6 Funct
Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells
357 1 0 2 4.9 CC1C2CCC3C2(CCC4C3CC=C5C4(CCC(C5)N(C)C)C)CN1C
CHEMBL47313 ada2c_human Human No 8.0 Ki = 10.7 Funct
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
272 5 1 2 3.7 C1CCC(C(C1)CCC2=CC=CC=C2)NC3=NCCO3
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
361 6 2 4 5.0 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)NCCN4CCCC4
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
361 6 2 4 5.0 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)NCCN4CCCC4
CHEMBL42 ada2c_human Human Yes 7.0 Ki = 100 Funct
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL715 ada2c_human Human Yes 7.0 Ki = 100 Funct
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
361 6 2 4 5.0 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)NCCN4CCCC4
CHEMBL299879 ada2c_human Human Yes 7.0 Ki = 100 Funct
Bnding affinity against cloned human Alpha-2C adrenergic receptor was evaluatedBnding affinity against cloned human Alpha-2C adrenergic receptor was evaluated
472 8 2 6 4.6 C1CC(CCC1CNCC2CCC3=CC=CC=C3C2)CNS(=O)(=O)C4=CC=CC=C4[N+](=O)[O-]
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
361 6 2 4 5.0 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)NCCN4CCCC4
CHEMBL12131 ada2c_human Human Yes 6.0 Ki = 1000 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
663 4 2 3 7.2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2O)I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl
CHEMBL2260359 ada2c_human Human No 6.0 Ki = 1000 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
598 10 2 5 6.9 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)Cl)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL314960 ada2c_human Human No 6.0 Ki = 1000 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
598 10 2 5 6.9 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)Cl)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL12131 ada2c_human Human Yes 6.0 Ki = 1000 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
663 4 2 3 7.2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2O)I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl
CHEMBL496 ada2c_human Human Yes 6.0 Ki = 1013.5 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
407 2 2 2 7.5 C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
CHEMBL496 ada2c_human Human Yes 6.0 Ki = 1013.5 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
407 2 2 2 7.5 C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
CHEMBL88628 ada2c_human Human No 6.0 Ki = 1023.3 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
607 9 3 6 5.5 CC1=C(C(C(=C(N1)C)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC6=C(C=C5)OCO6)C(=O)NC
CHEMBL3588908 ada2c_human Human Yes 5.0 Ki = 10471.3 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
223 4 1 4 1.1 COC1=CC=CC=C1OCC2CNCCO2
CHEMBL3588908 ada2c_human Human Yes 5.0 Ki = 10471.3 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
223 4 1 4 1.1 COC1=CC=CC=C1OCC2CNCCO2
CHEMBL81 ada2c_human Human Yes 7.0 Ki = 107 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL3588904 ada2c_human Human No 6.0 Ki = 1071.5 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
261 4 1 3 2.9 C1=CC=C(C(=C1)C2=CN=CC=C2)NCC3=CC=NC=C3
CHEMBL3588904 ada2c_human Human No 6.0 Ki = 1071.5 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
261 4 1 3 2.9 C1=CC=C(C(=C1)C2=CN=CC=C2)NCC3=CC=NC=C3
CHEMBL426317 ada2c_human Human No 7.0 Ki = 109 Funct
Binding affinity to alpha 2C adrenergic receptor by radioligand binding assayBinding affinity to alpha 2C adrenergic receptor by radioligand binding assay
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL426317 ada2c_human Human No 7.0 Ki = 109 Funct
Binding affinity to alpha 2C adrenergic receptor by radioligand binding assayBinding affinity to alpha 2C adrenergic receptor by radioligand binding assay
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL217768 ada2c_human Human No 7.0 Ki = 109.9 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
379 4 1 4 5.2 CCC1=C(N=C2CCCCC2=C1NC3=CC=C(C=C3)N4CCN(C(C4)C)C)C
CHEMBL217768 ada2c_human Human No 7.0 Ki = 109.9 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
379 4 1 4 5.2 CCC1=C(N=C2CCCCC2=C1NC3=CC=C(C=C3)N4CCN(C(C4)C)C)C
CHEMBL291166 ada2c_human Human No 6.0 Ki = 1096 Funct
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
525 7 1 7 3.3 CC1=C(C(CC(=O)N1C)C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC(CC3)(C#N)C4=CC=C(C=C4)F
CHEMBL3753318 ada2c_human Human No 6.0 Ki = 1096.5 Funct
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
254 7 1 1 3.7 CC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL3753318 ada2c_human Human No 6.0 Ki = 1096.5 Funct
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
254 7 1 1 3.7 CC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL393597 ada2c_human Human No 8.0 Ki = 11 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
448 6 0 6 5.4 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5F
CHEMBL426959 ada2c_human Human No 8.0 Ki = 11 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
459 7 0 5 3.8 CC(=O)N1CC2C(ON=C2C3=CC=CC=C31)CN4CCN(CC4)CCCC=CC5=CC=CC=C5
CHEMBL393597 ada2c_human Human No 8.0 Ki = 11 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
448 6 0 6 5.4 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5F
CHEMBL3590203 ada2c_human Human No 7.9 Ki = 11.8 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
222 3 1 2 2.6 C1=CC=C(C(=C1)CCN)C2=CC=CC(=C2)C#N
CHEMBL3590203 ada2c_human Human No 7.9 Ki = 11.8 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
222 3 1 2 2.6 C1=CC=C(C(=C1)CCN)C2=CC=CC(=C2)C#N
CHEMBL217768 ada2c_human Human No 7.0 Ki = 110 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
379 4 1 4 5.2 CCC1=C(N=C2CCCCC2=C1NC3=CC=C(C=C3)N4CCN(C(C4)C)C)C
CHEMBL217768 ada2c_human Human No 7.0 Ki = 110 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
379 4 1 4 5.2 CCC1=C(N=C2CCCCC2=C1NC3=CC=C(C=C3)N4CCN(C(C4)C)C)C
CHEMBL1224527 ada2c_human Human No 6.0 Ki = 1100 Funct
Binding affinity to adrenergic Alpha-2C receptorBinding affinity to adrenergic Alpha-2C receptor
295 1 3 3 3.0 C1CNCC2C1C(CC3=C2C=CC(=C3O)O)C4=CC=CC=C4
CHEMBL1224527 ada2c_human Human No 6.0 Ki = 1100 Funct
Binding affinity to adrenergic Alpha-2C receptorBinding affinity to adrenergic Alpha-2C receptor
295 1 3 3 3.0 C1CNCC2C1C(CC3=C2C=CC(=C3O)O)C4=CC=CC=C4
CHEMBL1022 ada2c_human Human Yes 6.0 Ki = 1100 Funct
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
228 2 2 2 3.2 C1=CC(=C(C(=C1)Cl)NC2=NC=CN2)Cl
CHEMBL2112979 ada2c_human Human No 7.0 Ki = 112 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
386 5 0 4 4.4 C1CN(CCN1CC=CC2=CC=CC=C2)CC3C4C=CC5=CC=CC=C5C4=NO3
CHEMBL1278085 ada2c_human Human No 7.0 Ki = 112.2 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1278085 ada2c_human Human No 7.0 Ki = 112.2 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL1358628 ada2c_human Human Yes 7.0 Ki = 113 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada2c_human Human Yes 7.0 Ki = 113 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada2c_human Human Yes 7.0 Ki = 113 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL72768 ada2c_human Human No 6.9 Ki = 114.8 Funct
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 1.5 CSC1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL2205827 ada2c_human Human No 5.9 Ki = 1145 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
325 4 1 4 2.3 COC1=C(C=C(C=C1)CN2C3C4C5CC6C4C2(C7C6C5C73)O)OC
CHEMBL2205827 ada2c_human Human No 5.9 Ki = 1145 Funct
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
325 4 1 4 2.3 COC1=C(C=C(C=C1)CN2C3C4C5CC6C4C2(C7C6C5C73)O)OC
CHEMBL1630578 ada2c_human Human Yes 5.9 Ki = 1148 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
625 6 0 8 5.9 CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
CHEMBL2260150 ada2c_human Human No 5.9 Ki = 1148.2 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
594 11 2 6 6.2 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)OC)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL315538 ada2c_human Human No 5.9 Ki = 1148.2 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
594 11 2 6 6.2 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)OC)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL74342 ada2c_human Human No 4.9 Ki = 11481.5 Funct
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
346 2 2 3 1.9 C1CCC2C(C1)NC(=N2)NC3=C(C4=NC=CN=C4C=C3)Br
CHEMBL598391 ada2c_human Human Yes 5.9 Ki = 1174.9 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
237 2 0 1 2.3 C1=CC(=CC(=C1)Br)CN2C=CN=C2
CHEMBL598391 ada2c_human Human Yes 5.9 Ki = 1174.9 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
237 2 0 1 2.3 C1=CC(=CC(=C1)Br)CN2C=CN=C2
CHEMBL728 ada2c_human Human Yes 7.9 Ki = 12 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL2112976 ada2c_human Human No 7.9 Ki = 12 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
473 6 1 7 2.9 COC1=CC2=C3C(CN=C2C=C1OC)C(ON3)CN4CCN(CC4)CC5=CC6=CC=CC=C6C=C5
CHEMBL728 ada2c_human Human Yes 7.9 Ki = 12 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL75030 ada2c_human Human Yes 7.9 Ki = 12.0 Funct
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
216 2 1 2 1.9 C1CC(C2=CC=CC=C2C1)NC3=NCCO3
CHEMBL289480 ada2c_human Human Yes 7.9 Ki = 12.6 Funct
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter
180 4 1 2 1.2 C1CC1C(C2CC2)NC3=NCCO3
CHEMBL289480 ada2c_human Human Yes 7.9 Ki = 12.6 Funct
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter
180 4 1 2 1.2 C1CC1C(C2CC2)NC3=NCCO3
CHEMBL194849 ada2c_human Human No 7.9 Ki = 12.8 Funct
Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
282 4 3 3 2.6 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)O)NC3=NCCN3
CHEMBL194849 ada2c_human Human No 7.9 Ki = 12.8 Funct
Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
282 4 3 3 2.6 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)O)NC3=NCCN3
CHEMBL49284 ada2c_human Human Yes 6.9 Ki = 120 Funct
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
231 2 4 3 0.7 CC1=C(C=CC2=C1NCCN2)NC3=NCCN3
CHEMBL49284 ada2c_human Human Yes 6.9 Ki = 120 Funct
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
231 2 4 3 0.7 CC1=C(C=CC2=C1NCCN2)NC3=NCCN3
CHEMBL3343700 ada2c_human Human No 5.9 Ki = 1200 Funct
Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
219 2 2 3 0.8 C1CN=C(N1)NN2C3=C(C=CC=C3F)C=N2
CHEMBL3343700 ada2c_human Human No 5.9 Ki = 1200 Funct
Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
219 2 2 3 0.8 C1CN=C(N1)NN2C3=C(C=CC=C3F)C=N2
CHEMBL296660 ada2c_human Human No 6.9 Ki = 123.0 Funct
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
222 4 1 2 2.7 CCCC1C2CCC(C2)C1NC3=NCCO3
CHEMBL48341 ada2c_human Human No 6.9 Ki = 123.0 Funct
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
298 6 1 2 4.1 C1CC2CC1C(C2NC3=NCCO3)CCCC4=CC=CC=C4
CHEMBL222138 ada2c_human Human No 5.9 Ki = 1230.3 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3[N+](=O)[O-]
CHEMBL222138 ada2c_human Human No 5.9 Ki = 1230.3 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 4 1 4 2.8 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3[N+](=O)[O-]
CHEMBL1276219 ada2c_human Human No 6.9 Ki = 125.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276248 ada2c_human Human No 6.9 Ki = 125.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL3289656 ada2c_human Human Yes 6.9 Ki = 125.9 Funct
Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assay
339 5 0 6 3.3 C1CN(CCN1CCCC2=NC3=CC=CC=C3S2)C4=NC=CC=N4
CHEMBL1276219 ada2c_human Human No 6.9 Ki = 125.9 Funct
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276219 ada2c_human Human No 6.9 Ki = 125.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 4 1 2 2.2 CC(C1=NCCN1)OC2=CC=CC=C2C3CC3
CHEMBL1276248 ada2c_human Human No 6.9 Ki = 125.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL492445 ada2c_human Human No 5.9 Ki = 1258.9 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(O2)C=C(C=C3)C4=CC=CC=C4
CHEMBL221989 ada2c_human Human No 5.9 Ki = 1258.9 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=N3
CHEMBL492445 ada2c_human Human No 5.9 Ki = 1258.9 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(O2)C=C(C=C3)C4=CC=CC=C4
CHEMBL221989 ada2c_human Human No 5.9 Ki = 1258.9 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=N3
CHEMBL3289656 ada2c_human Human Yes 6.9 Ki = 126 Funct
Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assay
339 5 0 6 3.3 C1CN(CCN1CCCC2=NC3=CC=CC=C3S2)C4=NC=CC=N4
CHEMBL3289656 ada2c_human Human Yes 6.9 Ki = 126 Funct
Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assay
339 5 0 6 3.3 C1CN(CCN1CCCC2=NC3=CC=CC=C3S2)C4=NC=CC=N4
CHEMBL157206 ada2c_human Human No 6.9 Ki = 128.8 Funct
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
270 7 1 2 3.5 CC(C1=NCCN1)OC2=C(C=CC=C2CC=C)CC=C
CHEMBL157206 ada2c_human Human No 6.9 Ki = 128.8 Funct
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
270 7 1 2 3.5 CC(C1=NCCN1)OC2=C(C=CC=C2CC=C)CC=C
CHEMBL93801 ada2c_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
480 6 0 8 3.9 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC5=CSC6=CC=CC=C65)OC
CHEMBL1255582 ada2c_human Human Yes 7.9 Ki = 13.8 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
230 2 1 2 3.1 CCC1(CC2=C(C1)C=C(C=C2)F)C3=CN=CN3
CHEMBL1255582 ada2c_human Human Yes 7.9 Ki = 13.8 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
230 2 1 2 3.1 CCC1(CC2=C(C1)C=C(C=C2)F)C3=CN=CN3
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
272 4 1 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CSC=C3
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
389 3 1 4 5.6 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=CC(=CC(=C43)C)C)C)C
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
389 3 1 4 5.6 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=CC(=CC(=C43)C)C)C)C
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132.1 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
389 3 1 4 5.6 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=CC(=CC(=C43)C)C)C)C
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132.1 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
389 3 1 4 5.6 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=CC(=CC(=C43)C)C)C)C
CHEMBL448620 ada2c_human Human Yes 5.9 Ki = 1320 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
609 10 2 7 6.1 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)[N+](=O)[O-])C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL217568 ada2c_human Human No 6.9 Ki = 134.9 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
395 3 1 4 5.5 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C(=CC=C4)Cl)C)C
CHEMBL217568 ada2c_human Human No 6.9 Ki = 134.9 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
395 3 1 4 5.5 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C(=CC=C4)Cl)C)C
CHEMBL217568 ada2c_human Human No 6.9 Ki = 135 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
395 3 1 4 5.5 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C(=CC=C4)Cl)C)C
CHEMBL217568 ada2c_human Human No 6.9 Ki = 135 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
395 3 1 4 5.5 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C(=CC=C4)Cl)C)C
CHEMBL2205824 ada2c_human Human No 5.9 Ki = 1369 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
295 3 1 3 2.3 COC1=CC=CC(=C1)CN2C3C4C5CC6C4C2(C7C6C5C73)O
CHEMBL3588912 ada2c_human Human No 4.9 Ki = 13803.8 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 2 1 2 1.8 COC1=CC=C(C=C1)C2C3=CC=CN3CCCN2
CHEMBL3588912 ada2c_human Human No 4.9 Ki = 13803.8 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 2 1 2 1.8 COC1=CC=C(C=C1)C2C3=CC=CN3CCCN2
CHEMBL1626 ada2c_human Human Yes 7.9 Ki = 14 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 ada2c_human Human Yes 7.9 Ki = 14 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL49395 ada2c_human Human Yes 5.9 Ki = 1412.5 Funct
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
213 2 2 3 -0.1 C1CN=C(N1)NC2=CC3=NC=CN=C3C=C2
CHEMBL210578 ada2c_human Human No 6.8 Ki = 142.8 Funct
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
402 6 1 4 4.4 C1CC2CC(CC1N2CCCC(=O)C3=CC=C(C=C3)F)(C4=CC=C(C=C4)Cl)O
CHEMBL210578 ada2c_human Human No 6.9 Ki = 142.8 Funct
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
402 6 1 4 4.4 C1CC2CC(CC1N2CCCC(=O)C3=CC=C(C=C3)F)(C4=CC=C(C=C4)Cl)O
CHEMBL476839 ada2c_human Human No 6.8 Ki = 143 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
402 9 1 5 4.5 CC1=CC=C(C=C1)CCN2CCC(CC2)C(C3=C(C(=CC=C3)OCCF)OC)O
CHEMBL476839 ada2c_human Human No 6.9 Ki = 143 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
402 9 1 5 4.5 CC1=CC=C(C=C1)CCN2CCC(CC2)C(C3=C(C(=CC=C3)OCCF)OC)O
CHEMBL442045 ada2c_human Human No 5.8 Ki = 1445.4 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=NC=C3
CHEMBL442045 ada2c_human Human No 5.8 Ki = 1445.4 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 3 1.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=NC=C3
CHEMBL219916 ada2c_human Human Yes 6.8 Ki = 147 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL576078 ada2c_human Human No 6.8 Ki = 147.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
232 5 1 2 2.9 CCCC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL2431282 ada2c_human Human No 6.8 Ki = 147.9 Funct
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
232 5 1 2 2.7 CCCC1=CC=CC=C1OC(C)C2=NCCN2
CHEMBL576078 ada2c_human Human No 6.8 Ki = 147.9 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
232 5 1 2 2.9 CCCC1=CC=CC=C1C(C)OC2=NCCN2
CHEMBL43491 ada2c_human Human No 5.8 Ki = 1479 Funct
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
511 7 2 7 3.4 CC1=C(C(CC(=O)N1)C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC(CC3)C4=C(C=C(C=C4)F)C#N
CHEMBL2391541 ada2c_human Human Yes 5.8 Ki = 1479.1 Funct
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL2391541 ada2c_human Human Yes 5.8 Ki = 1479.1 Funct
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL402143 ada2c_human Human No 6.8 Ki = 148 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
405 9 1 6 4.2 COC1=C(C=CC=C1OCCF)C(C2CCN(CC2)CCC3=CC=C(C=C3)F)O
CHEMBL402143 ada2c_human Human No 6.8 Ki = 148 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
405 9 1 6 4.2 COC1=C(C=CC=C1OCCF)C(C2CCN(CC2)CCC3=CC=C(C=C3)F)O
CHEMBL2205825 ada2c_human Human No 5.8 Ki = 1491 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
295 3 1 3 2.3 COC1=CC=C(C=C1)CN2C3C4C5CC6C4C2(C7C6C5C73)O
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
375 3 1 4 5.2 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=CC(=C4)C)C)C
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
375 3 1 4 5.2 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=CC(=C4)C)C)C
CHEMBL2112981 ada2c_human Human No 7.8 Ki = 15 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
389 5 1 5 2.9 C1CN(CCN1CC=CC2=CC=CC=C2)CC3C4CN=C5C=CC=CC5=C4NO3
CHEMBL2413154 ada2c_human Human Yes 7.8 Ki = 15 Funct
Binding affinity to adrenergic alpha2C receptor (unknown origin)Binding affinity to adrenergic alpha2C receptor (unknown origin)
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
375 3 1 4 5.2 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=CC(=C4)C)C)C
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
375 3 1 4 5.2 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=CC(=C4)C)C)C
CHEMBL476774 ada2c_human Human No 7.8 Ki = 15.7 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
396 6 1 6 1.8 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=CN=CC=C4
CHEMBL476774 ada2c_human Human No 7.8 Ki = 15.7 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
396 6 1 6 1.8 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCNC(=O)C4=CN=CC=C4
CHEMBL3417585 ada2c_human Human No 5.8 Ki = 1500 Funct
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 CC1CCCN1CCCOC2=CC=C(C=C2)C3=NNC(=O)C4C3C4
CHEMBL308863 ada2c_human Human No 5.8 Ki = 1500 Funct
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
233 4 2 4 2.2 CC1=C(C=CC(=C1OC)OC)NC2=NC=CN2
CHEMBL3417585 ada2c_human Human No 5.8 Ki = 1500 Funct
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 CC1CCCN1CCCOC2=CC=C(C=C2)C3=NNC(=O)C4C3C4
CHEMBL2432038 ada2c_human Human No 5.8 Ki = 1510 Funct
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
257 3 1 1 4.2 C1CCC(CC1)CNC2C3C4CC5C2C6C3CC4C56
CHEMBL341473 ada2c_human Human Yes 5.8 Ki = 1513.6 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
191 1 1 3 1.2 CN1CCN(CC1)C2=CC=C(C=C2)N
CHEMBL341473 ada2c_human Human Yes 5.8 Ki = 1513.6 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
191 1 1 3 1.2 CN1CCN(CC1)C2=CC=C(C=C2)N
CHEMBL1327 ada2c_human Human Yes 4.8 Ki = 15135.6 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
257 3 1 2 2.6 C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)O
CHEMBL1327 ada2c_human Human Yes 4.8 Ki = 15135.6 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
257 3 1 2 2.6 C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)O
CHEMBL490632 ada2c_human Human No 6.8 Ki = 154 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
400 9 0 5 4.7 CC1=CC=C(C=C1)CCN2CCC(CC2)C(=O)C3=C(C(=CC=C3)OCCF)OC
CHEMBL490632 ada2c_human Human No 6.8 Ki = 154 Funct
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
400 9 0 5 4.7 CC1=CC=C(C=C1)CCN2CCC(CC2)C(=O)C3=C(C(=CC=C3)OCCF)OC
CHEMBL2205362 ada2c_human Human Yes 5.8 Ki = 1542 Funct
Displacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysis
437 8 0 5 5.2 CC1=C(OC2=CC(=C(C=C12)OC)OC)C(=O)N(CCCN3CCCCC3)C4=CC=CC=C4
CHEMBL3588909 ada2c_human Human Yes 4.8 Ki = 15488.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 4 2 3 1.5 C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CN
CHEMBL3588910 ada2c_human Human No 4.8 Ki = 15488.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
282 3 1 3 2.7 C1CCC(C1)CCC(=O)N2CCSC23CCNCC3
CHEMBL3588909 ada2c_human Human Yes 4.8 Ki = 15488.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 4 2 3 1.5 C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CN
CHEMBL3588910 ada2c_human Human No 4.8 Ki = 15488.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
282 3 1 3 2.7 C1CCC(C1)CCC(=O)N2CCSC23CCNCC3
CHEMBL2260367 ada2c_human Human No 6.8 Ki = 158.5 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
633 10 2 5 7.5 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=C(C=C2)Cl)Cl)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL327712 ada2c_human Human No 6.8 Ki = 158.5 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
633 10 2 5 7.5 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=C(C=C2)Cl)Cl)C(=O)NCCCN3CCC(CC3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL492444 ada2c_human Human No 5.8 Ki = 1584.9 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(O2)C=CC(=C3)C4=CC=CC=C4
CHEMBL492444 ada2c_human Human No 5.8 Ki = 1584.9 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 3 2.3 C1CN=C(N1)C2COC3=C(O2)C=CC(=C3)C4=CC=CC=C4
CHEMBL1535 ada2c_human Human Yes 4.8 Ki = 15848.9 Funct
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
378 3 1 5 5.0 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=C(C=C4)F)C)C
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
378 3 1 5 5.0 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=C(C=C4)F)C)C
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
378 3 1 5 5.0 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=C(C=C4)F)C)C
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
378 3 1 5 5.0 CC1CN(CCN1C)C2=CC=C(C=C2)NC3=C(C(=NC4=C3C=C(C=C4)F)C)C
CHEMBL150161 ada2c_human Human Yes 7.8 Ki = 16.4 Funct
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
362 6 1 4 2.9 C1CN(CC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL150161 ada2c_human Human Yes 7.8 Ki = 16.4 Funct
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
362 6 1 4 2.9 C1CN(CC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL40650 ada2c_human Human Yes 7.8 Ki = 16.6 Funct
Binding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL40650 ada2c_human Human Yes 7.8 Ki = 16.6 Funct
Binding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.0 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)F
CHEMBL31410 ada2c_human Human Yes 6.8 Ki = 161 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
354 2 2 4 2.9 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
CHEMBL373830 ada2c_human Human No 5.8 Ki = 1621.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3O
CHEMBL27979 ada2c_human Human Yes 5.8 Ki = 1621.8 Funct
Binding affinity towards human Alpha-2C adrenergic receptorBinding affinity towards human Alpha-2C adrenergic receptor
423 7 0 4 4.4 CC1CCC(N1CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCOCC4)C
CHEMBL373830 ada2c_human Human No 5.8 Ki = 1621.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3O
CHEMBL279436 ada2c_human Human Yes 6.8 Ki = 165 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
594 9 3 6 5.1 CC1=C(C(C(=C(N1)C)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL279436 ada2c_human Human Yes 6.8 Ki = 166.0 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
594 9 3 6 5.1 CC1=C(C(C(=C(N1)C)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL75201 ada2c_human Human Yes 4.8 Ki = 16595.9 Funct
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
156 1 0 3 -0.6 C1COC(=N1)N2CCOCC2
CHEMBL70751 ada2c_human Human No 6.8 Ki = 169.8 Funct
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
256 4 2 3 2.1 CSC1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1698.2 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
318 3 1 4 2.4 CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1698.2 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
318 3 1 4 2.4 CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 3 2.6 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC(=CC=C3)O
CHEMBL611 ada2c_human Human Yes 6.8 Ki = 170 Funct
Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1700 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
318 3 1 4 2.4 CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1700 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
318 3 1 4 2.4 CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43
CHEMBL290860 ada2c_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
610 11 1 8 6.8 CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)OC
CHEMBL3392246 ada2c_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
610 11 1 8 6.8 CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)OC
CHEMBL2205812 ada2c_human Human No 5.8 Ki = 1704 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
309 4 1 3 2.8 COC1=CC=C(C=C1)CCN2C3C4C5CC6C4C2(C7C6C5C73)O
CHEMBL833 ada2c_human Human Yes 6.8 Ki = 171 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
264 2 0 2 3.6 C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl
CHEMBL284213 ada2c_human Human No 6.8 Ki = 172 Funct
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
204 1 1 2 2.3 C1CC(C2=C(C1)SC=C2)C3=CN=CN3
CHEMBL284213 ada2c_rat Rat No 6.8 Ki = 172 Funct
in vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
204 1 1 2 2.3 C1CC(C2=C(C1)SC=C2)C3=CN=CN3
CHEMBL2413153 ada2c_human Human No 6.8 Ki = 173.7 Funct
Binding affinity to adrenergic alpha2C receptor (unknown origin)Binding affinity to adrenergic alpha2C receptor (unknown origin)
405 9 0 7 2.1 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OCCF
CHEMBL3104091 ada2c_human Human No 6.8 Ki = 173.8 Funct
Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)
288 0 0 1 3.9 CN1CCC2=C(C1)C3=C4N2C5=CC=CC=C5CCC4=CC=C3
CHEMBL6310 ada2c_human Human Yes 5.8 Ki = 1740 Funct
Binding affinity towards Alpha-2C adrenergic receptorBinding affinity towards Alpha-2C adrenergic receptor
202 1 2 2 1.5 COC1=CC2=C(C=C1)C3=C(N2)CNCC3
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 Funct
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 Funct
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 Funct
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
230 5 1 2 2.4 CC(C1=NCCN1)OC2=CC=CC=C2CC=C
CHEMBL2205829 ada2c_human Human No 5.8 Ki = 1783 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
309 2 1 4 2.2 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC8=C(C=C7)OCO8)O
CHEMBL2205829 ada2c_human Human No 5.8 Ki = 1783 Funct
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
309 2 1 4 2.2 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC8=C(C=C7)OCO8)O
CHEMBL246852 ada2c_human Human No 7.8 Ki = 18 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
498 6 0 8 6.1 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5C(F)(F)F
CHEMBL654 ada2c_human Human Yes 7.8 Ki = 18 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
265 0 0 3 3.3 CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
CHEMBL246852 ada2c_human Human No 7.8 Ki = 18 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
498 6 0 8 6.1 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5C(F)(F)F
CHEMBL654 ada2c_human Human Yes 7.8 Ki = 18 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
265 0 0 3 3.3 CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
CHEMBL3417586 ada2c_human Human No 5.8 Ki = 1800 Funct
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 CC1CCCN1CCCOC2=CC=C(C=C2)C3=NNC(=O)C4C3C4
CHEMBL3417586 ada2c_human Human No 5.8 Ki = 1800 Funct
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 CC1CCCN1CCCOC2=CC=C(C=C2)C3=NNC(=O)C4C3C4
CHEMBL467094 ada2c_human Human Yes 6.7 Ki = 181 Funct
Displacement of [3H]Clonidine from human adrenergic Alpha-2C receptorDisplacement of [3H]Clonidine from human adrenergic Alpha-2C receptor
339 2 0 5 3.2 CN1CCC2=CC(=C(C3=C2C1CC4=CC5=C(C=C43)OCO5)OC)OC
CHEMBL467094 ada2c_human Human Yes 6.7 Ki = 181 Funct
Displacement of [3H]Clonidine from human adrenergic Alpha-2C receptorDisplacement of [3H]Clonidine from human adrenergic Alpha-2C receptor
339 2 0 5 3.2 CN1CCC2=CC(=C(C3=C2C1CC4=CC5=C(C=C43)OCO5)OC)OC
CHEMBL2205816 ada2c_human Human No 5.7 Ki = 1835 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
280 3 1 3 1.8 C1C2C3C4C1C5C2C6C3C4C5(N6CCC7=CC=CC=N7)O
CHEMBL2205816 ada2c_human Human No 5.7 Ki = 1835 Funct
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
280 3 1 3 1.8 C1C2C3C4C1C5C2C6C3C4C5(N6CCC7=CC=CC=N7)O
CHEMBL2205814 ada2c_human Human No 5.7 Ki = 1874 Funct
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
339 5 1 4 2.8 COC1=C(C=C(C=C1)CCN2C3C4C5CC6C4C2(C7C6C5C73)O)OC
CHEMBL246639 ada2c_human Human No 7.7 Ki = 19 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
460 7 0 6 5.2 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC(=CC=C5)OC
CHEMBL246228 ada2c_human Human No 7.7 Ki = 19 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
406 5 1 8 1.8 COC1=C(C=C2CN(CCC2=C1)CC3=CN=C(N4C3=NC(=N4)C5=CC=CO5)N)OC
CHEMBL382310 ada2c_human Human No 7.7 Ki = 19 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
340 1 3 4 0.3 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)O)O
CHEMBL246639 ada2c_human Human No 7.7 Ki = 19 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
460 7 0 6 5.2 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC(=CC=C5)OC
CHEMBL246228 ada2c_human Human No 7.7 Ki = 19 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
406 5 1 8 1.8 COC1=C(C=C2CN(CCC2=C1)CC3=CN=C(N4C3=NC(=N4)C5=CC=CO5)N)OC
CHEMBL308570 ada2c_human Human No 7.7 Ki = 19 Funct
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
231 2 2 4 2.0 CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3
CHEMBL382310 ada2c_human Human No 7.7 Ki = 19 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
340 1 3 4 0.3 C1CC(C(C2C1CN3CCC4=C(C3C2)NC5=CC=CC=C45)C(=O)O)O
CHEMBL90997 ada2c_human Human Yes 7.7 Ki = 19 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
218 2 1 2 2.0 C1C(CC2=C1C=CC(=C2)F)CC3CN=CN3
CHEMBL90997 ada2c_human Human Yes 7.7 Ki = 19 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
218 2 1 2 2.0 C1C(CC2=C1C=CC(=C2)F)CC3CN=CN3
CHEMBL179648 ada2c_human Human Yes 7.7 Ki = 19.6 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
322 4 0 3 3.7 C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
CHEMBL179648 ada2c_human Human Yes 7.7 Ki = 19.6 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
322 4 0 3 3.7 C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
CHEMBL3409256 ada2c_human Human No 6.7 Ki = 190 Funct
Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cellsDisplacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cells
519 9 1 6 4.1 C1CN(CCN1CCCOC2=CC=CC=C2C(=O)N)C3=CC=CC4=C3C=CN4S(=O)(=O)C5=CC=CC=C5
CHEMBL3409256 ada2c_human Human No 6.7 Ki = 190 Funct
Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cellsDisplacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cells
519 9 1 6 4.1 C1CN(CCN1CCCOC2=CC=CC=C2C(=O)N)C3=CC=CC4=C3C=CN4S(=O)(=O)C5=CC=CC=C5
CHEMBL91550 ada2c_human Human No 6.7 Ki = 190.6 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
622 11 3 6 6.0 CCC1=C(C(C(=C(N1)CC)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL295395 ada2c_human Human No 5.7 Ki = 1905 Funct
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
543 7 1 8 3.4 CC1=C(C(CC(=O)N1C)C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC(CC3)(C#N)C4=C(C=C(C=C4)F)F
CHEMBL127257 ada2c_human Human Yes 5.7 Ki = 1912 Funct
Inhibition of alpha2C adrenergic receptor (unknown origin)Inhibition of alpha2C adrenergic receptor (unknown origin)
320 3 1 3 3.7 CC1=C(C=C(C=C1)N2CCN(CC2)CC3=NC4=CC=CC=C4N3)C
CHEMBL1940420 ada2c_human Human Yes 6.7 Ki = 194.5 Funct
Displacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation countingDisplacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation counting
315 6 0 5 3.7 C1CN(CCN1CCCOC2=CC=C(C=C2)F)C3=CC=CC=N3
CHEMBL1940420 ada2c_human Human Yes 6.7 Ki = 194.5 Funct
Displacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation countingDisplacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation counting
315 6 0 5 3.7 C1CN(CCN1CCCOC2=CC=C(C=C2)F)C3=CC=CC=N3
CHEMBL1256503 ada2c_human Human No 6.7 Ki = 195.0 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
226 2 1 2 1.5 COC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL72753 ada2c_human Human Yes 6.7 Ki = 195.0 Funct
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
248 2 2 3 0.5 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Cl
CHEMBL1256503 ada2c_human Human No 6.7 Ki = 195.0 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
226 2 1 2 1.5 COC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL72441 ada2c_human Human No 6.7 Ki = 199.5 Funct
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
235 4 2 3 1.8 CC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL128168 ada2c_human Human No 6.7 Ki = 199.5 Funct
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 2 2.9 CC(C1=NCCN1)OC2=CC=CC=C2C3=CC=CC=C3
CHEMBL295001 ada2c_human Human No 5.7 Ki = 1995 Funct
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
529 7 2 8 3.3 CC1=C(C(CC(=O)N1)C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC(CC3)(C#N)C4=C(C=C(C=C4)F)F
CHEMBL217299 ada2c_human Human Yes 8.7 Ki = 2 Funct
Binding affinity to human cloned adrenergic alpha 2C receptor receptorBinding affinity to human cloned adrenergic alpha 2C receptor receptor
269 0 3 4 1.9 C1C2C(C3=CC=CC=C3CN2)C4=CC(=C(C=C4O1)O)O
CHEMBL217299 ada2c_human Human Yes 8.7 Ki = 2 Funct
Binding affinity to human cloned adrenergic alpha 2C receptor receptorBinding affinity to human cloned adrenergic alpha 2C receptor receptor
269 0 3 4 1.9 C1C2C(C3=CC=CC=C3CN2)C4=CC(=C(C=C4O1)O)O
CHEMBL98889 ada2c_human Human No 8.7 Ki = 2.1 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
465 7 0 8 3.1 CC(=CC1=CN=CC=C1)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC
CHEMBL268258 ada2c_human Human Yes 8.7 Ki = 2.1 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
349 6 0 3 5.3 CN(CCC1=CC2=C(C=C1)C=CO2)CC3CCCC4=C3C=CC=C4OC
CHEMBL268258 ada2c_human Human Yes 8.7 Ki = 2.1 Funct
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
349 6 0 3 5.3 CN(CCC1=CC2=C(C=C1)C=CO2)CC3CCCC4=C3C=CC=C4OC
CHEMBL1255617 ada2c_human Human No 8.7 Ki = 2.1 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.7 C1CC12C3=CC=CC=C3C4C2(C4)C5=CN=CN5
CHEMBL1255617 ada2c_human Human No 8.7 Ki = 2.1 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.7 C1CC12C3=CC=CC=C3C4C2(C4)C5=CN=CN5
CHEMBL761 ada2c_human Human Yes 8.6 Ki = 2.3 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL761 ada2c_human Human Yes 8.6 Ki = 2.3 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
387 3 1 4 5.3 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)N4CCN5CCCCC5C4
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
387 3 1 4 5.3 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)N4CCN5CCCCC5C4
CHEMBL422597 ada2c_human Human No 8.6 Ki = 2.3 Funct
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
420 6 0 6 3.6 COC1=CC2=C(C=C1)OCC3C2=NOC3CN4CCN(CC4)CC=CC5=CC=CC=C5
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
387 3 1 4 5.3 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)N4CCN5CCCCC5C4
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
387 3 1 4 5.3 CC1=C(C2=CC=CC=C2N=C1C)NC3=CC=C(C=C3)N4CCN5CCCCC5C4
CHEMBL1627 ada2c_human Human Yes 8.6 Ki = 2.4 Funct
Displacement of [125I]HEAT from adrenergic Alpha-2C receptorDisplacement of [125I]HEAT from adrenergic Alpha-2C receptor
463 7 2 3 4.8 CNC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1627 ada2c_human Human Yes 8.6 Ki = 2.4 Funct
Displacement of [125I]HEAT from adrenergic Alpha-2C receptorDisplacement of [125I]HEAT from adrenergic Alpha-2C receptor
463 7 2 3 4.8 CNC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL491419 ada2c_human Human No 8.6 Ki = 2.5 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
476 9 0 7 4.0 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCOCC4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL491419 ada2c_human Human No 8.6 Ki = 2.5 Funct
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
476 9 0 7 4.0 C1CN(CCN(C1)CC2COC3=CC=CC=C3O2)CCOCC4=C(N=CC=C4)OC5=CC=CC=C5
CHEMBL1255617 ada2c_human Human No 8.6 Ki = 2.7 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.7 C1CC12C3=CC=CC=C3C4C2(C4)C5=CN=CN5
CHEMBL2112973 ada2c_human Human No 8.6 Ki = 2.7 Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
460 6 1 5 3.2 CCNC(=O)N1CC2C(ON=C2C3=CC=CC=C31)CN4CCN(CC4)CC=CC5=CC=CC=C5
CHEMBL196064 ada2c_human Human No 8.6 Ki = 2.8 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
497 7 4 5 3.4 CC(C)(C)OC(=O)NCCCNC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
CHEMBL196064 ada2c_human Human No 8.6 Ki = 2.8 Funct
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
497 7 4 5 3.4 CC(C)(C)OC(=O)NCCCNC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
CHEMBL319573 ada2c_human Human No 8.6 Ki = 2.8 Funct
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
468 7 0 8 3.7 COC1=C(C=C2C(=C1)C3=NOC(C3CO2)CN4CCN(CC4)CC=CC5=CC=CC=C5F)OC
CHEMBL1255771 ada2c_human Human No 8.6 Ki = 2.8 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.6 CC12CC1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL1255771 ada2c_human Human No 8.6 Ki = 2.8 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.6 CC12CC1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL42 ada2c_human Human Yes 8.5 Ki = 2.9 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 ada2c_human Human Yes 8.5 Ki = 2.9 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL590615 ada2c_human Human No 7.7 Ki = 20 Funct
Binding affinity to Alpha2C adrenoceptor receptorBinding affinity to Alpha2C adrenoceptor receptor
297 4 1 3 3.0 C1C2C3C4C1C5C2C6C3C4C5(O6)NCCC7=CC(=CC=C7)F
CHEMBL392992 ada2c_human Human No 7.7 Ki = 20 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
430 6 0 5 5.3 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5
CHEMBL590615 ada2c_human Human No 7.7 Ki = 20 Funct
Binding affinity to Alpha2C adrenoceptor receptorBinding affinity to Alpha2C adrenoceptor receptor
297 4 1 3 3.0 C1C2C3C4C1C5C2C6C3C4C5(O6)NCCC7=CC(=CC=C7)F
CHEMBL392992 ada2c_human Human No 7.7 Ki = 20 Funct
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
430 6 0 5 5.3 COC1=C2C(=C(C=C1)CN3CCC4=CC(=C(C=C4C3)OC)OC)C=C(O2)C5=CC=CC=C5
CHEMBL1255617 ada2c_human Human No 7.7 Ki = 20.4 Funct
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.7 C1CC12C3=CC=CC=C3C4C2(C4)C5=CN=CN5
CHEMBL194659 ada2c_human Human No 6.7 Ki = 200 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 4 3.3 CN(C)CC1CC2C(O1)C3=C(C=CC(=C3)F)OC4=CC=CC=C24
CHEMBL194659 ada2c_human Human No 6.7 Ki = 200 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 4 3.3 CN(C)CC1CC2C(O1)C3=C(C=CC(=C3)F)OC4=CC=CC=C24
CHEMBL19236 ada2c_human Human Yes 5.7 Ki = 2000 Funct
Binding affinity for human Alpha-2C adrenergic receptorBinding affinity for human Alpha-2C adrenergic receptor
242 3 2 4 0.6 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
CHEMBL323579 ada2c_human Human No 6.7 Ki = 204 Funct
Binding affinity against human Alpha-2c adrenergic receptorBinding affinity against human Alpha-2c adrenergic receptor
667 14 4 8 3.9 CCC1=C(C(C(=C(N1)COCCN)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL523048 ada2c_human Human No 6.7 Ki = 204.2 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
328 5 1 2 4.2 C1CN=C(N1)C(C2=CC=CC=C2)OC3=CC=CC=C3C4=CC=CC=C4
CHEMBL523048 ada2c_human Human No 6.7 Ki = 204.2 Funct
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
328 5 1 2 4.2 C1CN=C(N1)C(C2=CC=CC=C2)OC3=CC=CC=C3C4=CC=CC=C4
CHEMBL415 ada2c_human Human Yes 6.7 Ki = 205 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
348 4 3 5 3.3 CC1CN(CCN1)C2=CC=C(C=C2)NC3=C(C=NC4=CC=CC=C43)CO
CHEMBL30739 ada2c_human Human No 6.7 Ki = 205 Funct
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
232 1 1 2 3.2 CC1=C2CCCC(C2=C(S1)C)C3=CN=CN3
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205 Funct
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
348 4 3 5 3.3 CC1CN(CCN1)C2=CC=C(C=C2)NC3=C(C=NC4=CC=CC=C43)CO
CHEMBL30739 ada2c_rat Rat No 6.7 Ki = 205 Funct
in vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
232 1 1 2 3.2 CC1=C2CCCC(C2=C(S1)C)C3=CN=CN3
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205.1 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
348 4 3 5 3.3 CC1CN(CCN1)C2=CC=C(C=C2)NC3=C(C=NC4=CC=CC=C43)CO
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205.1 Funct
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
348 4 3 5 3.3 CC1CN(CCN1)C2=CC=C(C=C2)NC3=C(C=NC4=CC=CC=C43)CO
CHEMBL195437 ada2c_human Human Yes 5.7 Ki = 2068 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL1643902 ada2c_human Human No 5.7 Ki = 2071 Funct
Inhibition of Alpha-2C adrenergic receptorInhibition of Alpha-2C adrenergic receptor
297 4 0 2 4.4 CN(CCC1=CC(=CC=C1)F)C2C3C4CC5C2C6C3CC4C56
CHEMBL1643902 ada2c_human Human No 5.7 Ki = 2071 Funct
Inhibition of Alpha-2C adrenergic receptorInhibition of Alpha-2C adrenergic receptor
297 4 0 2 4.4 CN(CCC1=CC(=CC=C1)F)C2C3C4CC5C2C6C3CC4C56
CHEMBL1643902 ada2c_human Human No 5.7 Ki = 2071 Funct
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
297 4 0 2 4.4 CN(CCC1=CC(=CC=C1)F)C2C3C4CC5C2C6C3CC4C56
CHEMBL25467 ada2c_human Human Yes 7.7 Ki = 21 Funct
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
264 1 0 2 4.2 CN1CCC2=C(C=CC3=C2C(=C(S3)C=C)C1)Cl
CHEMBL179648 ada2c_human Human Yes 7.7 Ki = 21.1 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
322 4 0 3 3.7 C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
CHEMBL179648 ada2c_human Human Yes 7.7 Ki = 21.1 Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
322 4 0 3 3.7 C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
CHEMBL611 ada2c_human Human Yes 6.7 Ki = 213 Funct
The compound was tested for binding affinity against alpha-2C-adrenoceptor, from human clones.The compound was tested for binding affinity against alpha-2C-adrenoceptor, from human clones.
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL74283 ada2c_human Human Yes 6.7 Ki = 213.8 Funct
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
296 2 4 3 1.0 C1CNC2=C(N1)C=CC(=C2Br)NC3=NCCN3
CHEMBL954 ada2c_human Human Yes 6.7 Ki = 215 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL306792 ada2c_human Human No 6.7 Ki = 218.8 Funct
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 1.5 CSC1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL70692 ada2c_human Human No 6.7 Ki = 218.8 Funct
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 1.5 CSC1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL195706 ada2c_human Human No 6.7 Ki = 219 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 4 3.3 CN(C)CC1CC2C(O1)C3=C(C=CC(=C3)F)OC4=CC=CC=C24
CHEMBL195706 ada2c_human Human No 6.7 Ki = 219 Funct
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 4 3.3 CN(C)CC1CC2C(O1)C3=C(C=CC(=C3)F)OC4=CC=CC=C24
CHEMBL411 ada2c_human Human Yes 5.7 Ki = 2201 Funct
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL1626 ada2c_human Human Yes 6.7 Ki = 223.9 Funct
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL611 ada2c_human Human Yes 6.7 Ki = 223.9 Funct
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL3588911 ada2c_human Human Yes 4.7 Ki = 22387.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
243 5 1 2 2.2 CC1=CC=CC=C1CN2C=CN=C2CNC(C)C
CHEMBL3588911 ada2c_human Human Yes 4.7 Ki = 22387.2 Funct
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
243 5 1 2 2.2 CC1=CC=CC=C1CN2C=CN=C2CNC(C)C
CHEMBL98063 ada2c_human Human No 6.7 Ki = 224 Funct
Binding affinity against human Alpha-2C adrenergic receptorBinding affinity against human Alpha-2C adrenergic receptor
693 15 3 9 5.8 CCC1=C(C(C(=C(N1)COCCN=[N+]=[N-])C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL147077 ada2c_human Human No 5.7 Ki = 2244 Funct
Binding affinity for recombinant human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand.
590 10 3 8 3.5 CC1=C(C(C(=C(N1)C)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C(=O)OC)C4=CC=C(C=C4)[N+](=O)[O-])C(=O)NC