Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL144397 5ht1b_human Human No 10.1 EC50 = 0.1 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
507 14 6 6 1.5 C1=CC2=C(C=C1OCC(=O)NCCCNC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL342323 5ht1b_human Human No 10.0 EC50 = 0.1 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
829 25 6 10 6.6 C1=CC(=CC=C1C2=CC=C(C=C2)S(=O)(=O)NCCCCCCOC3=CC4=C(C=C3)NC=C4CCN)S(=O)(=O)NCCCCCCOC5=CC6=C(C=C5)NC=C6CCN
CHEMBL144128 5ht1b_human Human No 9.7 EC50 = 0.2 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
491 12 4 6 2.3 C1CN(CCN1CCOC2=CC3=C(C=C2)NC=C3CCN)CCOC4=CC5=C(C=C4)NC=C5CCN
CHEMBL147851 5ht1b_human Human No 9.7 EC50 = 0.2 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
505 11 4 6 1.8 C1CN(CCN1CCOC2=CC3=C(C=C2)NC=C3CCN)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL357830 5ht1b_human Human No 9.6 EC50 = 0.3 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
601 11 4 6 3.0 C1CN(CCC1C2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL146720 5ht1b_human Human No 9.6 EC50 = 0.3 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
519 10 4 6 1.3 C1CN(CCN1C(=O)COC2=CC3=C(C=C2)NC=C3CCN)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL356277 5ht1b_human Human No 9.5 EC50 = 0.3 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
541 12 6 6 2.6 C1=CC(=CC=C1NC(=O)COC2=CC3=C(C=C2)NC=C3CCN)NC(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL357478 5ht1b_human Human No 9.4 EC50 = 0.4 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
610 12 5 7 2.8 C1CN(CCN1C2=CC=C(C=C2)NC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL147901 5ht1b_human Human No 9.4 EC50 = 0.4 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
436 11 5 5 1.8 C1=CC2=C(C=C1OCCNC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL158941 5ht1b_human Human No 9.2 EC50 = 0.6 Funct
Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell linesEffective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell lines
693 16 2 8 3.9 CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N(C)CC3=CC=C(C=C3)CN(C)S(=O)(=O)CC4=CC5=C(C=C4)NC=C5CCN(C)C
CHEMBL424128 5ht1b_human Human No 9.2 EC50 = 0.6 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
435 13 4 4 3.9 C1=CC2=C(C=C1OCCCCCCOC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL148022 5ht1b_human Human No 9.1 EC50 = 0.9 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
455 10 4 4 3.7 C1=CC(=CC(=C1)COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL147677 5ht1b_human Human No 8.8 EC50 = 1.6 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
465 12 6 5 1.6 C1=CC2=C(C=C1OCCNC(=O)NCCOC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL63258 5ht1b_human Human No 5.0 EC50 = 10000 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
452 8 1 6 4.1 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL294547 5ht1b_human Human No 6.9 EC50 = 120 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1b_human Human No 5.9 EC50 = 1400 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1185 5ht1b_human Human Yes 7.8 EC50 = 15.7 Funct
Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell linesEffective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell lines
287 5 2 3 2.2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
CHEMBL470849 5ht1b_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
417 5 1 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL470849 5ht1b_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
417 5 1 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL65321 5ht1b_human Human No 5.8 EC50 = 1500 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC(=CC=C5)F
CHEMBL64004 5ht1b_human Human No 5.8 EC50 = 1700 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=C(C=C5)F
CHEMBL1290596 5ht1b_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
415 4 1 4 4.0 CC1=C(C2=C(C=C1)NC(=O)CC2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL1290596 5ht1b_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
415 4 1 4 4.0 CC1=C(C2=C(C=C1)NC(=O)CC2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL148314 5ht1b_human Human No 8.7 EC50 = 2.1 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
455 10 4 4 3.7 C1=CC=C(C(=C1)COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL129813 5ht1b_human Human No 7.6 EC50 = 25 Funct
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formationAgonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation
503 5 0 7 3.9 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=C6C(=CC=C5)OCCO6
CHEMBL128699 5ht1b_human Human No 7.6 EC50 = 25 Funct
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formationAgonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation
487 5 0 5 5.3 CC1=CC(=C(C(=C1)C)N2CCN(CC2)C(=O)COC3=CC4=C(C=CC=C4N5CCN(CC5)C)C=C3)C
CHEMBL469376 5ht1b_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
445 5 0 5 4.4 CC1CN(CCN1CCCC2=C3C(=CC=C2)N(C(=O)CO3)C)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL469376 5ht1b_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
445 5 0 5 4.4 CC1CN(CCN1CCCC2=C3C(=CC=C2)N(C(=O)CO3)C)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL56 5ht1b_human Human Yes 6.6 EC50 = 260 Funct
The intrinsic activity was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryptamine 1B receptor in CHO cell lineThe intrinsic activity was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryptamine 1B receptor in CHO cell line
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL2112660 5ht1b_human Human No 7.6 EC50 = 28 Funct
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formationAgonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation
470 5 0 6 3.9 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=CC=CC=C5C#N
CHEMBL63167 5ht1b_human Human No 6.5 EC50 = 290 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
486 7 1 7 5.4 C1CN(CCC1(CC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL144030 5ht1b_human Human No 8.5 EC50 = 3 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL338015 5ht1b_human Human No 7.5 EC50 = 30 Funct
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formationAgonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation
505 7 0 7 4.1 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=C(C(=CC=C5)OC)OC
CHEMBL1289164 5ht1b_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
447 4 0 4 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C(C=CC5=C4C=CC(=O)N5C)Cl
CHEMBL1289164 5ht1b_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
447 4 0 4 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C(C=CC5=C4C=CC(=O)N5C)Cl
CHEMBL128 5ht1b_human Human Yes 7.4 EC50 = 38.3 Funct
Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell linesEffective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell lines
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL1290597 5ht1b_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
429 4 0 4 4.2 CC1=C(C2=C(C=C1)N(C(=O)CC2)C)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL1290597 5ht1b_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
429 4 0 4 4.2 CC1=C(C2=C(C=C1)N(C(=O)CC2)C)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL343196 5ht1b_human Human No 8.4 EC50 = 4 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
378 9 4 4 2.5 C1=CC2=C(C=C1OCCOC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL292779 5ht1b_human Human No 6.4 EC50 = 430 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL63799 5ht1b_human Human No 6.4 EC50 = 440 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL29951 5ht1b_human Human No 7.3 EC50 = 50 Funct
The intrinsic activity was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryptamine 1B receptor in CHO cell lineThe intrinsic activity was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryptamine 1B receptor in CHO cell line
577 19 0 4 10.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)OCCCCCCOC3=CC=CC4=C3CC(CC4)N(CCC)CCC
CHEMBL1289047 5ht1b_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 1 4 4.3 CC1=C(C2=C(C=C1)NC(=O)C=C2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL1289047 5ht1b_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 1 4 4.3 CC1=C(C2=C(C=C1)NC(=O)C=C2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL67684 5ht1b_human Human No 6.3 EC50 = 510 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
446 8 1 4 5.2 CC(CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5
CHEMBL433108 5ht1b_human Human No 5.3 EC50 = 5100 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
465 8 1 6 4.3 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=CC=C5
CHEMBL472289 5ht1b_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)N(C(=O)CO5)C
CHEMBL472289 5ht1b_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)N(C(=O)CO5)C
CHEMBL1289048 5ht1b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
427 4 0 4 4.4 CC1=C(C2=C(C=C1)N(C(=O)C=C2)C)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL469375 5ht1b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
431 5 0 5 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCCC4=C5C(=CC=C4)N(C(=O)CO5)C
CHEMBL1289048 5ht1b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
427 4 0 4 4.4 CC1=C(C2=C(C=C1)N(C(=O)C=C2)C)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL469375 5ht1b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay
431 5 0 5 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCCC4=C5C(=CC=C4)N(C(=O)CO5)C
CHEMBL294732 5ht1b_human Human No 7.2 EC50 = 66 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1b_human Human Yes 7.1 EC50 = 77 Funct
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsInhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL63432 5ht1b_human Human No 6.1 EC50 = 810 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL194837 5ht1b_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration against 5-hydroxytryptamine 1B receptorInhibitory concentration against 5-hydroxytryptamine 1B receptor
448 8 1 5 5.0 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=C(C=C(C=C3)Cl)Cl)OCCN(C)C
CHEMBL194837 5ht1b_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration against 5-hydroxytryptamine 1B receptorInhibitory concentration against 5-hydroxytryptamine 1B receptor
448 8 1 5 5.0 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=C(C=C(C=C3)Cl)Cl)OCCN(C)C
CHEMBL159396 5ht1b_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
388 6 1 6 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=NC=CC=N5
CHEMBL147503 5ht1b_rat Rat Yes 9.3 IC50 = 0.5 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
458 6 3 5 3.6 CC1=C(C=CC(=C1)C(=N)N)C2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)OC)N4CCN(CC4)C
CHEMBL128 5ht1b_human Human Yes 9.3 IC50 = 0.5 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL26379 5ht1b_rat Rat Yes 9.1 IC50 = 0.8 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
223 1 2 2 1.5 C1CNCC=C1C2=CNC3=C2C=C(C=C3)C#N
CHEMBL146735 5ht1b_rat Rat Yes 9.0 IC50 = 0.9 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
498 6 1 7 4.5 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL26378 5ht1b_rat Rat Yes 8.9 IC50 = 1.2 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
214 1 3 2 1.4 C1CNCC=C1C2=CNC3=C2C=C(C=C3)O
CHEMBL296161 5ht1b_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL296161 5ht1b_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL147071 5ht1b_rat Rat Yes 8.9 IC50 = 1.3 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
459 6 2 5 3.5 CC1=C(C=CC(=C1)C(=O)N)C2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)OC)N4CCN(CC4)C
CHEMBL296161 5ht1b_human Human No 8.9 IC50 = 1.4 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL15928 5ht1b_rat Rat Yes 8.8 IC50 = 1.6 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL15928 5ht1b_rat Rat Yes 8.8 IC50 = 1.6 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL26906 5ht1b_rat Rat Yes 8.7 IC50 = 1.9 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
216 1 2 2 1.9 C1CNCC=C1C2=CNC3=C2C=C(C=C3)F
CHEMBL128 5ht1b_human Human Yes 8.0 IC50 = 10 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL357634 5ht1b_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
479 8 1 6 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)S(=O)(=O)C5=CC=CC=C5
CHEMBL151420 5ht1b_rat Rat No 8.0 IC50 = 10 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
530 8 1 8 5.3 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OCCF)N5CCN(CC5)C
CHEMBL147853 5ht1b_human Human No 7.0 IC50 = 100 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL149488 5ht1b_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
486 9 2 5 3.1 CC(=O)NC1=CC=C(C=C1)CN(C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL116031 5ht1b_human Human No 7.0 IC50 = 100 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL3608450 5ht1b_human Human No 6.0 IC50 = 1000 Funct
Agonist activity at 5HT1B receptor (unknown origin)Agonist activity at 5HT1B receptor (unknown origin)
415 3 0 5 4.7 CN1CC(C2=CC(=C(C3=C2C1CC4=CC5=C(C=C43)OCO5)OC)OC)C6=CC=CC=C6
CHEMBL61818 5ht1b_rat Rat No 6.0 IC50 = 1000 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
450 6 0 7 5.4 CN1C2=C(C=C(C=C2)CCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F)SC1=O
CHEMBL3608450 5ht1b_human Human No 6.0 IC50 = 1000 Funct
Agonist activity at 5HT1B receptor (unknown origin)Agonist activity at 5HT1B receptor (unknown origin)
415 3 0 5 4.7 CN1CC(C2=CC(=C(C3=C2C1CC4=CC5=C(C=C43)OCO5)OC)OC)C6=CC=CC=C6
CHEMBL28312 5ht1b_rat Rat No 6.0 IC50 = 1000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL48925 5ht1b_rat Rat No 6.0 IC50 = 1000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL65215 5ht1b_human Human No 6.0 IC50 = 1000 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
483 8 1 7 4.4 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=C(C=C5)F
CHEMBL63258 5ht1b_human Human No 6.0 IC50 = 1000 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
452 8 1 6 4.1 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL1911194 5ht1b_human Human No 5.0 IC50 = 10000 Funct
Inhibition of 5-HT1BInhibition of 5-HT1B
374 2 2 4 3.1 CC1=C(C=C(C=C1)C2=NNC(=N2)C)C3=CC4=C(C=C3)C5(CCOCC5)C(=O)N4
CHEMBL26975 5ht1b_rat Rat No 5.0 IC50 = 10000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
417 9 0 5 3.7 CCCN(CCCCN1C(=O)CC(CC1=O)(C)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL52485 5ht1b_rat Rat No 5.0 IC50 = 10000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
417 9 0 5 3.7 CCCN(CCCCN1C(=O)CC(CC1=O)(C)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL11592 5ht1b_rat Rat Yes 5.0 IC50 = 10000 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
443 9 0 5 4.6 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL300692 5ht1b_rat Rat No 5.0 IC50 = 10000 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
374 3 0 4 5.1 CC1=CC2=C(C=C1)N3C=CC=C3C(=N2)N4CCN(CC4)CC5=CC=C(C=C5)F
CHEMBL1911194 5ht1b_human Human No 5.0 IC50 = 10000 Funct
Inhibition of 5-HT1BInhibition of 5-HT1B
374 2 2 4 3.1 CC1=C(C=C(C=C1)C2=NNC(=N2)C)C3=CC4=C(C=C3)C5(CCOCC5)C(=O)N4
CHEMBL285010 5ht1b_rat Rat No 4.0 IC50 = 100000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
233 2 0 3 2.5 COC1=CC=CC2=C1CC(CO2)N3CCCC3
CHEMBL164035 5ht1b_human Human No 7.0 IC50 = 102 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
472 8 1 5 2.9 CN(C)C(=O)C(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL54720 5ht1b_rat Rat Yes 6.0 IC50 = 1023.3 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
348 3 0 4 4.6 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL54720 5ht1b_rat Rat Yes 6.0 IC50 = 1023.3 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
348 3 0 4 4.6 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL65736 5ht1b_rat Rat No 5.0 IC50 = 10232.9 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
312 3 0 4 3.9 C1CC1CN2CCN(CC2)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL331304 5ht1b_rat Rat No 7.0 IC50 = 106 Funct
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptorInhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor
270 1 1 4 2.8 C1CN(CCN1)C2=NC3=C(C(=CC=C3)F)N4C2=CC=C4
CHEMBL64948 5ht1b_rat Rat No 6.0 IC50 = 1096.5 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
300 3 0 4 4.0 CCCN1CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL65367 5ht1b_human Human No 8.0 IC50 = 11 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1b_human Human No 8.0 IC50 = 11 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL128 5ht1b_human Human Yes 8.0 IC50 = 11 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL65367 5ht1b_human Human No 8.0 IC50 = 11 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL128 5ht1b_human Human Yes 8.0 IC50 = 11 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL423599 5ht1b_human Human No 8.0 IC50 = 11 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
443 8 1 4 2.9 CC(=O)N(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1b_human Human No 8.0 IC50 = 11 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL128 5ht1b_rat Rat Yes 7.0 IC50 = 110 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL364005 5ht1b_human Human Yes 7.0 IC50 = 110 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in calfInhibitory activity against 5-hydroxytryptamine 1B receptor in calf
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL118012 5ht1b_human Human No 7.0 IC50 = 110 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1b_rat Rat Yes 7.0 IC50 = 110 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL161066 5ht1b_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CC=NC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147907 5ht1b_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
428 8 2 3 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=CN=C5
CHEMBL364005 5ht1b_human Human Yes 7.0 IC50 = 110 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in calfInhibitory activity against 5-hydroxytryptamine 1B receptor in calf
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL3645480 5ht1b_rat Rat No 6.0 IC50 = 1100 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
308 3 2 3 2.4 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N
CHEMBL3645480 5ht1b_rat Rat No 6.0 IC50 = 1100 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
308 3 2 3 2.4 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N
CHEMBL422453 5ht1b_rat Rat No 5.0 IC50 = 11000 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
261 3 0 3 3.2 CCCN1CCCC12CC3=C(C=CC=C3OC)OC2
CHEMBL334498 5ht1b_rat Rat No 5.0 IC50 = 11200 Funct
Compound was evaluated for binding affinity on 5-HT1B receptors using rat cortex+striatum+ globus pallidus,[ 3H]-5-OH-tryptamine, and serotonin for NSB.Compound was evaluated for binding affinity on 5-HT1B receptors using rat cortex+striatum+ globus pallidus,[ 3H]-5-OH-tryptamine, and serotonin for NSB.
427 7 1 5 4.5 COC1=CC=CC2=C1CC3(CCCCN3CCCCNC(=O)C4=CC=C(C=C4)F)CO2
CHEMBL2368255 5ht1b_human Human No 6.0 IC50 = 1122.0 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
340 4 3 3 1.5 CC1(C(=O)N(C(=O)N1)CCC2=CC3=C(C=C2)NC=C3C4CC(C4)N)C
CHEMBL65974 5ht1b_rat Rat No 5.0 IC50 = 11220.2 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
272 1 0 4 3.1 CN1CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL274922 5ht1b_rat Rat No 7.0 IC50 = 113 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
491 5 3 5 2.3 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)C(=O)N)OC
CHEMBL118012 5ht1b_human Human No 6.9 IC50 = 114 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2376490 5ht1b_rat Rat No 7.9 IC50 = 12 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
294 2 2 2 3.5 CC1=C(C2=C(N1)C=CC(=C2)C3=CSC=C3)C4=CCNCC4
CHEMBL349185 5ht1b_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
390 8 2 5 2.0 C1CN(CC1CNCC2=COC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL342805 5ht1b_human Human No 6.9 IC50 = 120 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
488 11 3 6 2.8 C1CN(CCC1NC(COC(=O)N)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL280000 5ht1b_rat Rat No 6.9 IC50 = 120 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
476 6 2 4 4.4 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)CCC4=CNC5=CC=CC=C54)OC
CHEMBL115750 5ht1b_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL117046 5ht1b_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL115750 5ht1b_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL344537 5ht1b_human Human No 5.9 IC50 = 1200 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
491 11 2 6 4.0 COCC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL416688 5ht1b_human Human No 5.9 IC50 = 1200 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL63432 5ht1b_human Human No 5.9 IC50 = 1200 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL2368262 5ht1b_human Human No 5.9 IC50 = 1202.3 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
368 5 2 3 2.5 CC1(C(=O)N(C(=O)N1)CCC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C)C
CHEMBL117046 5ht1b_human Human No 6.9 IC50 = 125 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL348815 5ht1b_human Human No 6.9 IC50 = 125 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 9 2 4 3.4 C1CN(CC1CNCCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL49 5ht1b_rat Rat Yes 4.9 IC50 = 12589.3 Funct
Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandBinding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligand
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL53416 5ht1b_rat Rat No 4.9 IC50 = 12882.5 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
342 3 0 3 4.6 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=CC=CC=C4N5C3=CC=C5
CHEMBL162463 5ht1b_human Human No 7.9 IC50 = 13 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
387 6 1 4 3.5 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=CC=CC=C5
CHEMBL163462 5ht1b_human Human No 7.9 IC50 = 13 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
444 8 2 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(C5=CC=CC=C5)C(=O)N
CHEMBL351346 5ht1b_human Human No 7.9 IC50 = 13 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
415 7 1 4 3.6 CC(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147818 5ht1b_human Human No 7.9 IC50 = 13 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
472 10 2 5 3.6 CN(C)CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114040 5ht1b_human Human No 7.9 IC50 = 13 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL301765 5ht1b_rat Rat No 7.9 IC50 = 13.8 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
258 1 1 4 2.7 C1CN(CCN1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL301765 5ht1b_rat Rat No 7.9 IC50 = 13.8 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
258 1 1 4 2.7 C1CN(CCN1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL347665 5ht1b_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
426 7 1 5 2.9 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C#N
CHEMBL341854 5ht1b_human Human No 5.9 IC50 = 1300 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
459 10 3 5 3.3 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL64003 5ht1b_human Human No 5.9 IC50 = 1300 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
436 7 1 5 4.9 C1CN(CCC1CC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL53573 5ht1b_rat Rat No 4.9 IC50 = 13182.6 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
343 3 0 4 3.9 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(N=CC=C4)N5C3=CC=C5
CHEMBL349824 5ht1b_rat Rat No 5.9 IC50 = 1320 Funct
Concentration necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol, binds to 5-hydroxytryptamine 1B receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol, binds to 5-hydroxytryptamine 1B receptor at 1 uM
259 3 0 3 2.8 CCCN1CCC=C2C1COC3=C2C(=CC=C3)OC
CHEMBL279320 5ht1b_rat Rat No 6.9 IC50 = 133 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
498 10 3 6 3.4 CN(C)CCOC1=C(C=CC(=C1)NC(=O)NCCN2CCC(CC2)C3=CNC4=C3C=CC(=C4)F)OC
CHEMBL348811 5ht1b_human Human No 5.9 IC50 = 1349.0 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
271 4 2 2 1.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC(=O)N
CHEMBL295698 5ht1b_rat Rat Yes 4.9 IC50 = 13539 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
531 7 0 6 4.3 CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL621 5ht1b_rat Rat Yes 5.9 IC50 = 1356 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL296419 5ht1b_rat Rat Yes 5.9 IC50 = 1387 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL296419 5ht1b_rat Rat Yes 5.9 IC50 = 1387 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL343648 5ht1b_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
443 9 2 4 4.1 CC(C1=CC=CC=C1)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63167 5ht1b_human Human No 7.9 IC50 = 14 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
486 7 1 7 5.4 C1CN(CCC1(CC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159332 5ht1b_human Human Yes 7.8 IC50 = 14.5 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
321 5 2 4 1.5 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CC3CCCN3C
CHEMBL146131 5ht1b_human Human No 6.9 IC50 = 140 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2376491 5ht1b_rat Rat No 6.9 IC50 = 140 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
288 2 2 1 3.8 CC1=C(C2=C(N1)C=CC(=C2)C3=CC=CC=C3)C4=CCNCC4
CHEMBL146891 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
416 8 2 5 2.4 C1CN(CCC1NCC2=CN=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146729 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
416 8 2 5 2.4 C1CN(CCC1NCC2=CC=NC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148325 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
458 7 2 4 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(=O)NC5=CC=CC=C5
CHEMBL147555 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
507 9 1 6 3.2 CN(CC1=CC=C(C=C1)S(=O)(=O)C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL423212 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
435 8 1 5 3.7 CN(CC1=CC=CS1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1b_human Human No 6.9 IC50 = 140 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL154787 5ht1b_rat Rat No 5.9 IC50 = 1400 Funct
In vitro inhibitory concentration against radioligand [3H]5-HT binding to 5-hydroxytryptamine 1B receptor in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]5-HT binding to 5-hydroxytryptamine 1B receptor in rat striatal membrane
459 7 1 7 4.5 CC1=C(SC2=C1C(=O)N(C(=N2)SCCCN3CCC(CC3)C4=CC=CC=C4OC)N)C
CHEMBL3084967 5ht1b_human Human No 6.9 IC50 = 141.3 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
327 5 2 3 3.0 CN(C)C1CC(C1)CC2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL418678 5ht1b_rat Rat No 4.8 IC50 = 14454.4 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
366 3 0 5 4.7 C1CN(CCN1CC2=CC=C(C=C2)F)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL416662 5ht1b_rat Rat No 4.8 IC50 = 14454.4 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
421 3 0 5 5.1 C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC5=C(C=CC(=C5)Cl)N6C4=CC=C6
CHEMBL304857 5ht1b_human Human No 6.8 IC50 = 145 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL274001 5ht1b_human Human No 6.8 IC50 = 145 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
310 5 2 4 1.2 C1CN(CCN1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL420874 5ht1b_human Human No 6.8 IC50 = 145 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420874 5ht1b_human Human No 6.8 IC50 = 146 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL62366 5ht1b_rat Rat No 4.8 IC50 = 14791.1 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
348 2 0 4 4.8 CN1CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC(=C3)C5=CC=CC=C5
CHEMBL1201356 5ht1b_rat Rat Yes 7.8 IC50 = 15 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
339 4 3 3 2.3 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL294732 5ht1b_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331612 5ht1b_human Human No 7.8 IC50 = 15 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
309 5 1 3 2.7 C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL294732 5ht1b_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331612 5ht1b_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
309 5 1 3 2.7 C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL159683 5ht1b_human Human No 7.8 IC50 = 15 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 8 1 4 3.6 CN(CC1CCCN1CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL294732 5ht1b_human Human No 7.8 IC50 = 15 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146628 5ht1b_human Human No 6.8 IC50 = 150 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.7 C1CN(CCC1NC(CCO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1b_human Human Yes 6.8 IC50 = 150 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL356315 5ht1b_human Human No 6.8 IC50 = 150 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL27403 5ht1b_rat Rat Yes 6.8 IC50 = 150 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
334 1 0 6 4.0 CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL53490 5ht1b_rat Rat No 6.8 IC50 = 151.4 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
253 1 1 4 1.9 C1CN(CCN1)C2=NC3=C(N=CC=C3)N4C2=CC=C4
CHEMBL161694 5ht1b_human Human No 5.8 IC50 = 1513.6 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
310 4 1 4 3.3 CC1=NOC(=N1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL11409 5ht1b_human Human No 5.8 IC50 = 1584.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
498 8 0 6 4.2 CCCN1CCN(CC12CC3=C(C=CC=C3OC)OC2)CCCCN4C(=O)CC5(CCCC5)CC4=O
CHEMBL128 5ht1b_human Human Yes 7.8 IC50 = 16 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL128 5ht1b_human Human Yes 7.8 IC50 = 16 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL67460 5ht1b_human Human No 7.8 IC50 = 16 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC=CC=C2F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1963527 5ht1b_rat Rat No 6.8 IC50 = 160 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
336 3 2 3 3.0 CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL146132 5ht1b_human Human No 6.8 IC50 = 160 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1963527 5ht1b_rat Rat No 6.8 IC50 = 160 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
336 3 2 3 3.0 CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL305301 5ht1b_human Human No 5.8 IC50 = 1600 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
469 8 1 7 4.0 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL349390 5ht1b_human Human No 6.8 IC50 = 165 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
458 9 3 5 2.1 CC(=O)NC1=CC=C(C=C1)CNCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL351303 5ht1b_human Human No 6.8 IC50 = 165 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117633 5ht1b_human Human No 6.8 IC50 = 166 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL120216 5ht1b_rat Rat Yes 6.8 IC50 = 167 Funct
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptorInhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor
270 1 1 4 2.8 C1CN(CCN1)C2=NC3=C(C=CC(=C3)F)N4C2=CC=C4
CHEMBL348962 5ht1b_human Human No 7.8 IC50 = 17 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
444 9 2 5 2.8 CNCC(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146502 5ht1b_human Human No 6.8 IC50 = 170 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
443 9 2 4 4.4 CC(CC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146023 5ht1b_human Human No 6.8 IC50 = 170 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
486 10 3 5 3.1 CC(=O)NC1=CC=C(C=C1)CCNC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117633 5ht1b_human Human No 6.8 IC50 = 170 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL333089 5ht1b_human Human No 6.8 IC50 = 170 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
472 9 2 5 2.8 CC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114038 5ht1b_human Human No 6.8 IC50 = 170 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
501 8 2 8 4.4 C1CN(CC(C1NCC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1b_rat Rat Yes 7.8 IC50 = 18 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL128 5ht1b_rat Rat Yes 7.8 IC50 = 18 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL163573 5ht1b_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=N5
CHEMBL162805 5ht1b_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
390 7 1 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CO5
CHEMBL352159 5ht1b_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
431 7 1 4 3.3 C1CN(C(=S)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL145982 5ht1b_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
493 9 1 6 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)S(=O)(=O)C5=CC=CC=C5
CHEMBL2110299 5ht1b_human Human No 7.7 IC50 = 18.2 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
285 3 3 3 1.5 C1C(CC1N)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL364005 5ht1b_rat Rat Yes 6.8 IC50 = 180 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in ratInhibitory activity against 5-hydroxytryptamine 1B receptor in rat
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL304438 5ht1b_rat Rat No 6.8 IC50 = 180 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
381 5 0 5 2.9 CN1C(=O)COC2=C1C=CC(=C2)CCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL364005 5ht1b_rat Rat Yes 6.8 IC50 = 180 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in ratInhibitory activity against 5-hydroxytryptamine 1B receptor in rat
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL433108 5ht1b_human Human No 5.8 IC50 = 1800 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
465 8 1 6 4.3 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=CC=C5
CHEMBL428892 5ht1b_rat Rat No 6.7 IC50 = 182.0 Funct
Binding affinity towards 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity towards 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL313714 5ht1b_human Human Yes 6.7 IC50 = 185 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL81 5ht1b_rat Rat Yes 5.7 IC50 = 1861 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL63713 5ht1b_rat Rat No 4.7 IC50 = 18620.9 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
430 4 0 7 6.0 C1CN(CCN1CCC2=CC=CC=C2C(F)(F)F)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL294547 5ht1b_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL116161 5ht1b_human Human No 7.7 IC50 = 19 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
451 7 2 5 3.3 CC1(CCCN(C1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O)C
CHEMBL294547 5ht1b_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL294547 5ht1b_human Human No 7.7 IC50 = 19 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL62902 5ht1b_rat Rat No 4.7 IC50 = 19054.6 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
479 3 0 7 7.4 C1CN(CCN1C2=CC=CC(=C2)C(F)(F)F)C3=NC4=C(C(=CS4)C5=CC=CC=C5)N6C3=CC=C6
CHEMBL299634 5ht1b_rat Rat No 4.7 IC50 = 19054.6 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
377 3 0 3 5.2 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(C=CC(=C4)Cl)N5C3=CC=C5
CHEMBL64903 5ht1b_rat Rat No 4.7 IC50 = 19498.5 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
380 4 0 5 4.1 C1CN(CCN1CC2=CC=C(C=C2)F)CC3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL299097 5ht1b_rat Rat No 4.7 IC50 = 19498.5 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
343 3 0 4 4.0 C=CCN1CCN(CC1)C2=NC3=C(C4=C(C=C3)N=CC=C4)N5C2=CC=C5
CHEMBL281350 5ht1b_rat Rat Yes 8.7 IC50 = 2 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
521 3 0 6 5.6 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=C4C=C6C(=C5)OCC67CCN(CC7)C
CHEMBL18785 5ht1b_rat Rat Yes 8.7 IC50 = 2 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
228 2 2 2 1.8 COC1=CC2=C(C=C1)NC=C2C3=CCNCC3
CHEMBL15933 5ht1b_rat Rat No 8.7 IC50 = 2.1 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
495 4 1 6 5.4 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC5=C(C=C4)OCC56CCN(CC6)C
CHEMBL161176 5ht1b_human Human No 8.6 IC50 = 2.4 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
458 8 2 5 2.3 CC(=O)NC1=CC=CC(=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL348304 5ht1b_human Human No 8.6 IC50 = 2.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 1 4 3.4 C1CC(N(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)COCC5=CC=CC=C5
CHEMBL119443 5ht1b_rat Rat Yes 8.6 IC50 = 2.8 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
325 3 3 3 1.8 CC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL1909065 5ht1b_rat Rat No 8.5 IC50 = 3.0 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL1909065 5ht1b_rat Rat No 8.5 IC50 = 3.0 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL60885 5ht1b_rat Rat No 7.7 IC50 = 20 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
369 5 1 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL161723 5ht1b_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
419 7 1 5 3.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)F
CHEMBL349041 5ht1b_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
390 8 2 5 2.1 C1CN(CC1CNCC2=CC=CO2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL64878 5ht1b_rat Rat No 6.7 IC50 = 200 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
398 7 1 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL64167 5ht1b_rat Rat No 6.7 IC50 = 200 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
353 4 0 4 3.8 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4)SC1=O
CHEMBL423022 5ht1b_human Human No 6.7 IC50 = 200 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)O)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2376483 5ht1b_rat Rat Yes 6.7 IC50 = 200 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
230 1 2 2 2.3 CC1=C(C2=C(N1)C=CC(=C2)F)C3=CCNCC3
CHEMBL148085 5ht1b_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
419 8 1 5 3.0 CN(CC1=COC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL27650 5ht1b_rat Rat No 4.7 IC50 = 20000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
429 8 0 5 4.2 CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL50188 5ht1b_rat Rat No 4.7 IC50 = 20000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
429 8 0 5 4.2 CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL283606 5ht1b_rat Rat Yes 4.7 IC50 = 20000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
263 6 0 3 3.8 CCCN(CCC)C1CC2=C(C=CC=C2OC)OC1
CHEMBL283606 5ht1b_rat Rat Yes 4.7 IC50 = 20000 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
263 6 0 3 3.8 CCCN(CCC)C1CC2=C(C=CC=C2OC)OC1
CHEMBL2368261 5ht1b_human Human No 6.7 IC50 = 204.2 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
387 5 1 3 3.6 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CCN4C(=O)C5=CC=CC=C5C4=O
CHEMBL2368257 5ht1b_human Human No 6.7 IC50 = 204.2 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
327 4 1 3 2.7 CN1C(COC1=O)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL299231 5ht1b_rat Rat No 6.7 IC50 = 204.2 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
293 3 0 4 3.0 C=CCN1CCN(CC1)C2=NC3=C(N=CC=C3)N4C2=CC=C4
CHEMBL91 5ht1b_rat Rat Yes 4.7 IC50 = 20600 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL91 5ht1b_rat Rat Yes 4.7 IC50 = 20600 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL324287 5ht1b_human Human No 6.7 IC50 = 209 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
401 7 1 4 3.2 CN(CC1=CC=CC=C1)C2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL28178 5ht1b_rat Rat No 7.7 IC50 = 21 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
320 1 1 6 3.5 C1CN(CCN1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL143890 5ht1b_human Human No 6.7 IC50 = 210 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)O)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL145815 5ht1b_human Human No 6.7 IC50 = 210 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 2 5 3.4 COCC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL423749 5ht1b_human Human No 6.7 IC50 = 210 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 2 5 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL324287 5ht1b_human Human No 6.7 IC50 = 210 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
401 7 1 4 3.2 CN(CC1=CC=CC=C1)C2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2112862 5ht1b_human Human No 6.7 IC50 = 210 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
457 7 3 5 2.9 C1CN(CCC1NC2C(CC3=CC=CC=C23)O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL67367 5ht1b_human Human No 5.7 IC50 = 2100 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
465 8 1 6 4.3 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL42 5ht1b_rat Rat Yes 5.7 IC50 = 2109 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 5ht1b_rat Rat Yes 5.7 IC50 = 2109 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL422366 5ht1b_human Human No 7.7 IC50 = 22 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CN=CC=C5
CHEMBL63799 5ht1b_human Human No 7.7 IC50 = 22 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114039 5ht1b_human Human No 6.7 IC50 = 220 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
515 8 1 8 4.9 CN(CC1=CC=CC=C1C(F)(F)F)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2115112 5ht1b_human Human No 6.7 IC50 = 220 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
515 8 1 8 4.9 CN(CC1=CC=CC=C1C(F)(F)F)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL91534 5ht1b_human Human No 6.7 IC50 = 220 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2203713 5ht1b_human Human No 5.7 IC50 = 2200 Funct
Inhibition of 5HT1B receptorInhibition of 5HT1B receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL808 5ht1b_rat Rat Yes 4.7 IC50 = 22034 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL808 5ht1b_rat Rat Yes 4.7 IC50 = 22034 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL422283 5ht1b_rat Rat No 5.7 IC50 = 2210 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
455 6 0 5 4.4 COC1=CC=CC2=C1CC3(CCCCN3CCCCN4C(=O)CC5(CCCC5)CC4=O)CO2
CHEMBL15965 5ht1b_rat Rat No 6.7 IC50 = 223 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
509 7 3 6 3.3 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCN3CCC(CC3)C4=CNC5=C4C=CC(=C5)F)OC
CHEMBL11262 5ht1b_human Human No 4.6 IC50 = 22908.7 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
277 7 0 3 4.0 CCCN(CCC)CC1CC2=C(C=CC=C2OC)OC1
CHEMBL276928 5ht1b_rat Rat No 7.6 IC50 = 23 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
463 2 2 4 3.9 CN1CCC2(CC1)COC3=C2C=C(C=C3)NC(=O)N4CCC(CC4)C5=CNC6=C5C=C(C=C6)F
CHEMBL162858 5ht1b_human Human No 7.6 IC50 = 23 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=NC=C5
CHEMBL146285 5ht1b_human Human No 6.6 IC50 = 230 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
447 8 2 5 4.0 CC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL305660 5ht1b_rat Rat Yes 5.6 IC50 = 2314 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL327197 5ht1b_rat Rat No 6.6 IC50 = 232 Funct
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptorInhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor
266 1 0 3 3.1 CN1CCN(CC1)C2=NC3=CC=CC=C3N4C2=CC=C4
CHEMBL279646 5ht1b_rat Rat No 6.6 IC50 = 233 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
452 4 2 5 3.1 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(C3)C4=CNC5=C4C=C(C=C5)F)OC
CHEMBL302447 5ht1b_rat Rat No 4.6 IC50 = 23988.3 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
425 4 0 4 6.3 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(C(=CS4)C5=CC=CC=C5)N6C3=CC=C6
CHEMBL357007 5ht1b_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
421 9 1 4 4.4 CC(=CCCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C
CHEMBL147660 5ht1b_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
500 10 2 5 3.3 CC(=O)NC1=CC=C(C=C1)CN(C)CC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL54914 5ht1b_rat Rat No 6.6 IC50 = 245.5 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
267 1 0 4 2.4 CN1CCN(CC1)C2=NC3=C(N=CC=C3)N4C2=CC=C4
CHEMBL356808 5ht1b_human Human No 7.6 IC50 = 25 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
455 8 2 4 4.1 C1CC2=CC=CC=C2C1NCC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL293614 5ht1b_human Human No 7.6 IC50 = 25 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC=C(C=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL42 5ht1b_rat Rat Yes 5.6 IC50 = 2500 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL119785 5ht1b_human Human No 6.6 IC50 = 251 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL61869 5ht1b_rat Rat No 6.6 IC50 = 260 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
355 4 2 5 3.2 C1CN(CCN1CCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC=C4O
CHEMBL119785 5ht1b_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161192 5ht1b_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 9 2 4 3.5 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL147786 5ht1b_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
393 8 1 4 3.2 CN(CC1CC1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL341897 5ht1b_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
469 10 3 5 3.3 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)CS(=O)(=O)NC
CHEMBL49 5ht1b_rat Rat Yes 4.6 IC50 = 26000 Funct
Binding affinity towards 5-HT1B was determinedBinding affinity towards 5-HT1B was determined
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL8412 5ht1b_rat Rat Yes 4.6 IC50 = 26000 Funct
Binding affinity towards 5-HT1B was determinedBinding affinity towards 5-HT1B was determined
401 6 0 7 1.5 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4
CHEMBL350277 5ht1b_human Human No 6.6 IC50 = 263.0 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
361 6 2 2 3.4 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC(=O)NCC4=CC=CC=C4
CHEMBL52612 5ht1b_rat Rat No 4.6 IC50 = 26302.7 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
318 4 0 3 3.0 C1CN(CCN1CC2=CC=CC=C2)C3=C(C=CC=N3)N4C=CC=C4
CHEMBL728 5ht1b_rat Rat Yes 5.6 IC50 = 2651 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL430122 5ht1b_rat Rat No 6.6 IC50 = 267 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
473 4 2 5 3.1 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)C#N)OC
CHEMBL334923 5ht1b_human Human No 5.6 IC50 = 2691.5 Funct
Compound was tested for binding affinity against 5-hydroxytryptamine 1B receptorCompound was tested for binding affinity against 5-hydroxytryptamine 1B receptor
275 4 0 4 3.2 CC1=CSC2=C1N3C=CC=C3C2=NOCCN(C)C
CHEMBL111899 5ht1b_human Human No 7.6 IC50 = 27 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
465 9 2 5 4.0 CN(CC1CCCCC1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL115989 5ht1b_human Human No 7.6 IC50 = 27 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
423 9 2 5 2.3 CN(CC1CC1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL128 5ht1b_human Human Yes 7.6 IC50 = 27 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1B receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1B receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL164111 5ht1b_human Human No 7.6 IC50 = 27 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
390 7 1 5 2.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=COC=C5
CHEMBL333341 5ht1b_human Human No 7.6 IC50 = 27 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL441296 5ht1b_human Human No 6.6 IC50 = 270 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL133375 5ht1b_rat Rat No 5.6 IC50 = 2700 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
469 8 0 5 4.9 CCCN1CCCC12CC3=C(C=CC=C3OCCCCN4C(=O)CC5(CCCC5)CC4=O)OC2
CHEMBL104 5ht1b_rat Rat Yes 4.6 IC50 = 27310 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL104 5ht1b_rat Rat Yes 4.6 IC50 = 27310 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL435060 5ht1b_human Human No 6.6 IC50 = 275 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2368259 5ht1b_human Human No 6.6 IC50 = 275.4 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
321 5 2 4 1.3 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2C3CC(C3)N(C)C
CHEMBL333341 5ht1b_human Human No 7.6 IC50 = 28 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL116092 5ht1b_human Human Yes 7.6 IC50 = 28 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1b_human Human Yes 7.6 IC50 = 28 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1b_human Human Yes 7.6 IC50 = 28 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL143893 5ht1b_human Human No 7.6 IC50 = 28 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 9 2 4 3.7 C1CN(CCC1CNCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL67684 5ht1b_human Human No 7.6 IC50 = 28 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
446 8 1 4 5.2 CC(CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5
CHEMBL64610 5ht1b_rat Rat No 6.6 IC50 = 280 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
448 6 0 7 4.5 CN1C(=O)COC2=C1C=CC(=C2)CCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL148095 5ht1b_human Human No 6.6 IC50 = 280 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
441 7 2 4 3.9 C1CC2=CC=CC=C2C1NC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL65321 5ht1b_human Human No 6.6 IC50 = 280 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC(=CC=C5)F
CHEMBL163376 5ht1b_human Human No 6.6 IC50 = 282 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
469 7 1 7 4.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL162899 5ht1b_human Human No 6.6 IC50 = 282 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
415 7 1 4 2.7 C1CN(C(=O)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL2376484 5ht1b_rat Rat No 7.5 IC50 = 29 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
360 3 2 7 2.9 CC1=C(C2=C(N1)C=CC(=C2)OS(=O)(=O)C(F)(F)F)C3=CCNCC3
CHEMBL3645476 5ht1b_rat Rat No 6.5 IC50 = 290 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
338 4 2 3 3.6 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL3645476 5ht1b_rat Rat No 6.5 IC50 = 290 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
338 4 2 3 3.6 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL1200558 5ht1b_rat Rat Yes 5.5 IC50 = 2978 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
1423 31 17 21 -4.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4
CHEMBL1200558 5ht1b_rat Rat Yes 5.5 IC50 = 2978 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
1423 31 17 21 -4.1 CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4
CHEMBL65824 5ht1b_human Human No 8.5 IC50 = 3.1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
436 7 1 5 4.6 C1CN(CCC1(CC2=CC=CC=C2F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL27592 5ht1b_rat Rat Yes 8.5 IC50 = 3.2 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
277 1 2 1 2.5 C1CNCC=C1C2=CNC3=C2C=C(C=C3)Br
CHEMBL358072 5ht1b_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
416 8 2 5 3.6 C1CN(CCC1CNC2=CC=CC=N2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL282994 5ht1b_rat Rat Yes 8.5 IC50 = 3.3 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
233 1 2 1 2.4 C1CNCC=C1C2=CNC3=C2C=C(C=C3)Cl
CHEMBL283257 5ht1b_rat Rat Yes 8.5 IC50 = 3.5 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTInhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
243 1 2 3 1.6 C1CNCC=C1C2=CNC3=C2C=C(C=C3)[N+](=O)[O-]
CHEMBL27811 5ht1b_rat Rat Yes 8.4 IC50 = 3.7 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT as the radioligand.Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT as the radioligand.
198 1 2 1 1.8 C1CNCC=C1C2=CNC3=CC=CC=C32
CHEMBL326723 5ht1b_human Human No 7.5 IC50 = 30 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
502 10 4 6 1.8 CC(=O)NC1=CC=C(C=C1)CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL331819 5ht1b_human Human No 7.5 IC50 = 30 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
425 9 2 5 2.9 CC(C)CN(C)CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL116092 5ht1b_human Human Yes 7.5 IC50 = 30.2 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1b_human Human Yes 7.5 IC50 = 30.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL293923 5ht1b_rat Rat No 6.5 IC50 = 300 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
384 5 0 5 3.7 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL59637 5ht1b_rat Rat No 6.5 IC50 = 300 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
339 4 1 4 3.6 C1CN(CCN1CCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC=C4
CHEMBL61819 5ht1b_rat Rat No 6.5 IC50 = 300 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
412 7 0 5 4.4 CN1C2=C(C=C(C=C2)CCCCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL15909 5ht1b_rat Rat No 6.5 IC50 = 300 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
506 5 3 5 3.8 CN1CCC2(CC1)COC3=C2C=C(C=C3)NC(=O)NCCN4CCC(CC4)C5=CNC6=C5C=CC(=C6)F
CHEMBL143894 5ht1b_human Human No 6.5 IC50 = 300 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
457 7 3 5 2.9 C1CN(CCC1NC2C(CC3=CC=CC=C23)O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL2115111 5ht1b_human Human No 6.5 IC50 = 300 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
501 8 2 8 4.4 C1CN(CC(C1NCC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL60318 5ht1b_rat Rat No 5.5 IC50 = 3000 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
371 4 0 5 3.9 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=C(C=C4)F)SC1=O
CHEMBL27991 5ht1b_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL298534 5ht1b_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL423841 5ht1b_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
408 8 0 5 3.9 CCCN(CCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL54089 5ht1b_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
408 8 0 5 3.9 CCCN(CCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL305062 5ht1b_human Human No 5.5 IC50 = 3000 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
434 8 1 5 3.8 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL27763 5ht1b_rat Rat No 4.5 IC50 = 30000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
429 8 1 5 4.3 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4O)OC3
CHEMBL26783 5ht1b_rat Rat No 4.5 IC50 = 30000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
413 8 0 4 4.6 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=CC=CC=C4OC3
CHEMBL50993 5ht1b_rat Rat No 4.5 IC50 = 30000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
413 8 0 4 4.6 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=CC=CC=C4OC3
CHEMBL52438 5ht1b_rat Rat No 4.5 IC50 = 30000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
283 5 0 2 5.1 CCCN(CCC)C1CC2=C(C=CC3=CC=CC=C23)OC1
CHEMBL1909072 5ht1b_rat Rat Yes 5.5 IC50 = 3007 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL416523 5ht1b_human Human No 5.5 IC50 = 3020.0 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
415 8 1 5 3.4 COC1=CC=CC2=C1CC(CO2)CNCCCCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL324931 5ht1b_human Human No 6.5 IC50 = 304 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL424154 5ht1b_human Human No 6.5 IC50 = 305 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 9 2 4 3.9 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL117249 5ht1b_human Human No 6.5 IC50 = 309 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL63790 5ht1b_rat Rat No 5.5 IC50 = 3090.3 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
392 3 0 6 4.4 C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC5=C(N6C4=CC=C6)SC=C5
CHEMBL60447 5ht1b_rat Rat No 7.5 IC50 = 31 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
369 4 1 5 3.4 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4O)SC1=O
CHEMBL3645475 5ht1b_rat Rat No 6.5 IC50 = 310 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
338 4 2 3 3.6 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL194305 5ht1b_rat Rat Yes 6.5 IC50 = 310 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in ratInhibitory activity against 5-hydroxytryptamine 1B receptor in rat
242 2 2 2 2.2 CC1=C(C2=C(N1)C=CC(=C2)OC)C3=CCNCC3
CHEMBL3645475 5ht1b_rat Rat No 6.5 IC50 = 310 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
338 4 2 3 3.6 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL324931 5ht1b_human Human No 6.5 IC50 = 310 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL64004 5ht1b_human Human No 6.5 IC50 = 310 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=C(C=C5)F
CHEMBL194305 5ht1b_rat Rat Yes 6.5 IC50 = 310 Funct
Inhibitory activity against 5-hydroxytryptamine 1B receptor in ratInhibitory activity against 5-hydroxytryptamine 1B receptor in rat
242 2 2 2 2.2 CC1=C(C2=C(N1)C=CC(=C2)OC)C3=CCNCC3
CHEMBL11265 5ht1b_rat Rat No 4.5 IC50 = 31100 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
441 6 0 5 4.0 COC1=CC=CC2=C1CC3(CCCN3CCCCN4C(=O)CC5(CCCC5)CC4=O)CO2
CHEMBL159470 5ht1b_human Human No 6.5 IC50 = 316.2 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
347 5 2 2 3.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)C(=O)NCC4=CC=CC=C4
CHEMBL11787 5ht1b_rat Rat No 5.5 IC50 = 3162.3 Funct
Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
437 7 1 5 4.2 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=C(O3)C=CC5=CC=CC=C54
CHEMBL299524 5ht1b_rat Rat No 4.5 IC50 = 31622.8 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
374 4 0 4 4.1 C1CN(CCN1CC2=CC=C(C=C2)F)CC3=NC4=CC=CC=C4N5C3=CC=C5
CHEMBL445 5ht1b_rat Rat Yes 5.5 IC50 = 3199 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL112507 5ht1b_human Human No 7.5 IC50 = 32 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
416 7 2 4 3.5 C1CN(CCC1(CC2=CC=CC=C2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117579 5ht1b_human Human No 7.5 IC50 = 32 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL2368256 5ht1b_human Human No 7.5 IC50 = 32.4 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
299 4 3 3 2.0 CNC1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL148286 5ht1b_human Human No 6.5 IC50 = 320 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
379 8 1 4 3.1 CN(CC=C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL273490 5ht1b_rat Rat No 5.5 IC50 = 3235.9 Funct
Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandBinding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligand
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL162296 5ht1b_human Human No 6.5 IC50 = 325 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
350 8 2 4 2.1 C=CCNCC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL117579 5ht1b_human Human No 7.5 IC50 = 33 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL161735 5ht1b_human Human No 7.5 IC50 = 33 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
416 9 1 4 3.6 C1CN(CC1COCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL27403 5ht1b_rat Rat Yes 6.5 IC50 = 338.8 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
334 1 0 6 4.0 CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL27403 5ht1b_rat Rat Yes 6.5 IC50 = 338.8 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
334 1 0 6 4.0 CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL65413 5ht1b_rat Rat No 4.5 IC50 = 33884.4 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
417 3 0 4 5.9 C1CN(CCN1CC2=CC(=C(C=C2)Cl)Cl)C3=NC4=C(C=CS4)N5C3=CC=C5
CHEMBL146265 5ht1b_human Human No 7.5 IC50 = 34 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
459 10 3 5 3.0 C1CN(CCC1CNC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1275709 5ht1b_human Human No 6.5 IC50 = 340 Funct
Binding affinity to 5HT1B receptorBinding affinity to 5HT1B receptor
253 2 1 2 2.8 CN(C)C1CCC(C1)C2=CNC3=C2C=C(C=C3)C#N
CHEMBL115496 5ht1b_human Human No 6.5 IC50 = 340 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
455 9 3 6 2.3 CC(C)(C)OC(=O)NCC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL1275709 5ht1b_human Human No 6.5 IC50 = 340 Funct
Binding affinity to 5HT1B receptorBinding affinity to 5HT1B receptor
253 2 1 2 2.8 CN(C)C1CCC(C1)C2=CNC3=C2C=C(C=C3)C#N
CHEMBL53463 5ht1b_rat Rat Yes 4.5 IC50 = 34464 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
544 5 6 12 1.3 CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
CHEMBL53463 5ht1b_rat Rat Yes 4.5 IC50 = 34464 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
544 5 6 12 1.3 CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
CHEMBL370110 5ht1b_human Human No 7.5 IC50 = 35 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.6 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CN=CC6=CC=CC=C65
CHEMBL331970 5ht1b_human Human No 7.5 IC50 = 35 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146024 5ht1b_human Human No 7.5 IC50 = 35 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
435 8 1 5 3.6 CN(CC1=CSC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331970 5ht1b_human Human No 7.5 IC50 = 35 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL370110 5ht1b_human Human No 7.5 IC50 = 35 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.6 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CN=CC6=CC=CC=C65
CHEMBL146150 5ht1b_human Human No 6.5 IC50 = 350 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
486 9 3 5 3.1 CC(C1=CC=C(C=C1)NC(=O)C)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL415933 5ht1b_rat Rat No 5.5 IC50 = 3548.1 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
405 7 0 5 3.7 COC1=CC2=C(C=C1)N3C=CC=C3C(=N2)N4CCN(CC4)CCCCN5C=CC=N5
CHEMBL275481 5ht1b_human Human No 4.5 IC50 = 35481.3 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
367 5 0 4 4.0 CCCN1CCN(CC12CC3=C(C=CC=C3OC)OC2)CC4=CC=CC=C4
CHEMBL116463 5ht1b_human Human No 5.5 IC50 = 3580 Funct
Binding affinity against 5-hydroxytryptamine 1B receptorBinding affinity against 5-hydroxytryptamine 1B receptor
518 11 1 6 6.5 C1CN(CCC1NC(=O)OCCC2=CC=C(C=C2)C#N)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL1626 5ht1b_rat Rat Yes 6.5 IC50 = 359 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL164413 5ht1b_human Human No 7.4 IC50 = 36 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
390 7 2 5 1.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=NC=CN5
CHEMBL294730 5ht1b_rat Rat No 6.4 IC50 = 360 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
398 6 0 5 4.1 CN1C2=C(C=C(C=C2)CCCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL304197 5ht1b_human Human No 6.4 IC50 = 360 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
417 7 2 5 2.2 C1CN(CCN1CC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL420965 5ht1b_human Human Yes 7.4 IC50 = 37 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL341474 5ht1b_rat Rat Yes 6.4 IC50 = 371 Funct
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptorInhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor
284 1 0 4 3.2 CN1CCN(CC1)C2=NC3=C(C=CC(=C3)F)N4C2=CC=C4
CHEMBL304833 5ht1b_human Human No 6.4 IC50 = 380 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5F
CHEMBL135952 5ht1b_rat Rat No 5.4 IC50 = 3800 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
411 5 0 4 4.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCCC34CC5=CC=CC=C5OC4
CHEMBL56 5ht1b_rat Rat Yes 5.4 IC50 = 3801.9 Funct
Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandBinding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligand
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL2368260 5ht1b_human Human No 5.4 IC50 = 3801.9 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
354 4 2 3 2.0 CC1(C(=O)N(C(=O)N1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C)C
CHEMBL11265 5ht1b_human Human No 5.4 IC50 = 3801.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
441 6 0 5 4.0 COC1=CC=CC2=C1CC3(CCCN3CCCCN4C(=O)CC5(CCCC5)CC4=O)CO2
CHEMBL54125 5ht1b_rat Rat No 4.4 IC50 = 38018.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
360 3 0 4 4.7 C1CN(CCN1CC2=CC=C(C=C2)F)C3=NC4=CC=CC=C4N5C3=CC=C5
CHEMBL159536 5ht1b_human Human No 5.4 IC50 = 3890.5 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
309 4 2 3 3.1 CC1=NC(=NN1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL164046 5ht1b_human Human No 7.4 IC50 = 39 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 8 2 4 3.6 CC(C)(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161969 5ht1b_human Human No 5.4 IC50 = 3900 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
415 7 1 4 2.7 C1CN(C(=O)CN1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL12311 5ht1b_rat Rat No 6.4 IC50 = 398.1 Funct
Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
437 7 1 5 4.2 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=C(O3)C5=CC=CC=C5C=C4
CHEMBL161045 5ht1b_human Human No 8.4 IC50 = 4.4 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
267 4 1 3 0.8 C1CN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL347570 5ht1b_human Human No 7.4 IC50 = 40 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
514 9 2 5 2.9 CC(=O)NC1=CC=C(C=C1)C(=O)N(C)CC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL64845 5ht1b_rat Rat No 6.4 IC50 = 400 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
436 6 1 7 5.2 C1CN(CCN1CCCCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL283207 5ht1b_rat Rat No 6.4 IC50 = 400 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
423 9 0 5 4.3 CCCN(CCCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL52396 5ht1b_rat Rat No 6.4 IC50 = 400 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
423 9 0 5 4.3 CCCN(CCCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL147961 5ht1b_human Human No 6.4 IC50 = 400 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
445 9 3 5 3.4 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL28287 5ht1b_rat Rat No 4.4 IC50 = 40000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
445 9 0 6 4.3 CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL50722 5ht1b_rat Rat No 4.4 IC50 = 40000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
445 9 0 6 4.3 CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL71 5ht1b_rat Rat Yes 5.4 IC50 = 4041 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL62911 5ht1b_rat Rat No 4.4 IC50 = 40738.0 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
364 3 0 3 4.6 C[N+]1(CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC=C3)CC5=CC=CC=C5
CHEMBL905 5ht1b_human Human Yes 7.4 IC50 = 41 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
269 5 1 3 1.7 CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
CHEMBL159759 5ht1b_human Human No 7.4 IC50 = 41 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148233 5ht1b_human Human No 7.4 IC50 = 41 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
407 8 1 4 4.0 CC(=CCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C
CHEMBL147838 5ht1b_human Human No 6.4 IC50 = 410 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
469 7 1 4 4.8 C1CCN(C(C1)C2=CC=CC=C2)C3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL51118 5ht1b_rat Rat No 6.4 IC50 = 416.9 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
298 3 0 4 3.8 C=CCN1CCN(CC1)C2=NC3=C(C=CS3)N4C2=CC=C4
CHEMBL51118 5ht1b_rat Rat No 6.4 IC50 = 416.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
298 3 0 4 3.8 C=CCN1CCN(CC1)C2=NC3=C(C=CS3)N4C2=CC=C4
CHEMBL144002 5ht1b_human Human No 6.4 IC50 = 420 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 8 2 4 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL1255834 5ht1b_rat Rat Yes 6.4 IC50 = 421.1 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
286 5 2 3 3.0 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N
CHEMBL1255834 5ht1b_rat Rat Yes 6.4 IC50 = 421.1 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
286 5 2 3 3.0 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N
CHEMBL302431 5ht1b_rat Rat No 5.4 IC50 = 4265.8 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
417 3 0 4 5.9 C1CN(CCN1CC2=CC(=C(C=C2)Cl)Cl)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL117249 5ht1b_human Human No 6.4 IC50 = 430 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL54246 5ht1b_rat Rat No 4.4 IC50 = 43651.6 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
357 3 0 4 4.2 CC1=C2C(=NC=C1)N3C=CC=C3C(=N2)N4CCN(CC4)CC5=CC=CC=C5
CHEMBL158638 5ht1b_human Human No 7.4 IC50 = 44.7 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
257 3 2 2 1.6 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)C(=O)N
CHEMBL137643 5ht1b_rat Rat No 5.4 IC50 = 4400 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
219 1 1 3 1.8 COC1=CC=CC2=C1CC3(CCCN3)CO2
CHEMBL162722 5ht1b_human Human No 7.4 IC50 = 45 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
429 8 1 4 4.0 CC(CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=CC=CC=C5
CHEMBL146335 5ht1b_human Human No 7.4 IC50 = 45 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
472 9 3 5 2.7 CC(=O)NC1=CC=C(C=C1)CNC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163114 5ht1b_human Human No 7.3 IC50 = 46 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
497 9 1 7 3.9 CC1=NOC(=N1)C2=CC=C(C=C2)CCN3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL60047 5ht1b_rat Rat No 6.3 IC50 = 460 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
419 4 0 7 3.8 CN1C(=O)COC2=C1C=CC(=C2)CCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL146129 5ht1b_human Human No 6.3 IC50 = 460 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
477 10 4 5 3.5 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL15139 5ht1b_rat Rat No 6.3 IC50 = 467 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
424 6 4 5 2.6 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCC3=CNC4=C3C=C(C=C4)O)OC
CHEMBL294368 5ht1b_rat Rat No 5.3 IC50 = 4677.4 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
417 3 0 4 5.9 C1CN(CCN1CC2=C(C=C(C=C2)Cl)Cl)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL326125 5ht1b_human Human No 7.3 IC50 = 47 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
445 9 3 5 2.6 C1CN(CCC1(CNCC2=CC=CC=C2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1b_human Human Yes 7.3 IC50 = 47 Funct
Affinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding technique
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1b_human Human Yes 7.3 IC50 = 47 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159819 5ht1b_human Human No 7.3 IC50 = 47 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1b_human Human Yes 7.3 IC50 = 47 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL116153 5ht1b_human Human No 7.3 IC50 = 47 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC(=C5)F)F
CHEMBL964 5ht1b_rat Rat Yes 5.3 IC50 = 4720 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
297 7 0 4 3.9 CCN(CC)C(=S)SSC(=S)N(CC)CC
CHEMBL349893 5ht1b_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CC=CC=N2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143947 5ht1b_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL49932 5ht1b_rat Rat No 4.3 IC50 = 48977.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
387 3 0 6 3.7 C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC5=C(N=CC=C5)N6C4=CC=C6
CHEMBL159483 5ht1b_human Human No 7.3 IC50 = 49 Funct
Affinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding technique
433 9 3 4 3.6 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL159483 5ht1b_human Human No 7.3 IC50 = 49 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
433 9 3 4 3.6 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL160070 5ht1b_human Human No 7.3 IC50 = 49 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
447 9 3 4 4.0 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL293678 5ht1b_human Human No 7.3 IC50 = 49 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
432 8 1 4 4.9 C1CN(CCC1(CCC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL3645479 5ht1b_rat Rat No 6.3 IC50 = 490 Funct
Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).Binding Assay: 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
324 3 2 3 3.0 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL3645479 5ht1b_rat Rat No 6.3 IC50 = 490 Funct
BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12). BindingDB_Patents: Binding Assay. 5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosci 1987, 7: 894-903). 5-HT1B (rat cerebral cortex) binding assays (agonist radioligand) were performed according to the method of Hoyer et. al. (Eur. J. Pharmacol. 1995, 118: 1-12).
324 3 2 3 3.0 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N
CHEMBL65765 5ht1b_human Human No 8.3 IC50 = 5.3 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
436 7 1 5 4.6 C1CN(CCC1(CC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL160070 5ht1b_human Human No 7.3 IC50 = 50 Funct
Affinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding technique
447 9 3 4 4.0 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL159819 5ht1b_human Human No 7.3 IC50 = 50 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL15855 5ht1b_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
448 4 2 4 3.4 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=CC=CC=C54)OC
CHEMBL15961 5ht1b_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C(=CC=C5)F)OC
CHEMBL1275791 5ht1b_human Human No 6.3 IC50 = 500 Funct
Binding affinity to 5HT1B receptorBinding affinity to 5HT1B receptor
246 2 1 2 3.2 CN(C)C1CCC(C1)C2=CNC3=C2C=C(C=C3)F
CHEMBL1275791 5ht1b_human Human No 6.3 IC50 = 500 Funct
Binding affinity to 5HT1B receptorBinding affinity to 5HT1B receptor
246 2 1 2 3.2 CN(C)C1CCC(C1)C2=CNC3=C2C=C(C=C3)F
CHEMBL439849 5ht1b_rat Rat Yes 5.3 IC50 = 5000 Funct
Inhibition of rat hydroxytryptamine 1B receptorInhibition of rat hydroxytryptamine 1B receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL439849 5ht1b_rat Rat Yes 5.3 IC50 = 5000 Funct
Inhibition of rat hydroxytryptamine 1B receptorInhibition of rat hydroxytryptamine 1B receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL416747 5ht1b_rat Rat No 4.3 IC50 = 50000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
361 9 0 4 4.5 CCCN(CCCCN1CCCCC1)C2CC3=C(C=CC=C3OC)OC2
CHEMBL8412 5ht1b_rat Rat Yes 4.3 IC50 = 50000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
401 6 0 7 1.5 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4
CHEMBL8412 5ht1b_rat Rat Yes 4.3 IC50 = 50000 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
401 6 0 7 1.5 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4
CHEMBL12124 5ht1b_rat Rat Yes 5.3 IC50 = 5011.9 Funct
Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
386 7 1 5 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=CC=CC=C4O3
CHEMBL11592 5ht1b_human Human Yes 5.3 IC50 = 5011.9 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
443 9 0 5 4.6 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL422191 5ht1b_human Human No 5.3 IC50 = 5100 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
338 6 1 4 2.0 CN1CCN(CC1)CCCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL137486 5ht1b_rat Rat No 4.3 IC50 = 51100 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
459 8 1 6 4.4 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2CCCCC23CC4=C(C=CC=C4OC)OC3
CHEMBL292262 5ht1b_human Human No 6.3 IC50 = 520 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC=CC=C2F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL143510 5ht1b_human Human No 6.3 IC50 = 530 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.
364 7 1 7 3.0 CCN(CC)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL303514 5ht1b_human Human No 6.3 IC50 = 540 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC=C(C=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL112558 5ht1b_human Human No 7.3 IC50 = 55 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
446 9 3 6 1.6 C1CN(CCC1(CNCC2=CC=CC=N2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL276175 5ht1b_rat Rat Yes 5.3 IC50 = 5530 Funct
compound was measured for affinity against 5-hydroxytryptamine 1B receptor labelled with [3H]5-HT radioligand in striatum tissuecompound was measured for affinity against 5-hydroxytryptamine 1B receptor labelled with [3H]5-HT radioligand in striatum tissue
443 6 0 7 4.0 C1CCC2(C1)CC(=O)N(C(=O)C2)OCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
CHEMBL163127 5ht1b_human Human No 7.3 IC50 = 56 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
458 8 2 5 2.3 CC(=O)NC1=CC=C(C=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2110300 5ht1b_human Human No 6.3 IC50 = 562.3 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
313 4 2 3 2.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL52625 5ht1b_rat Rat No 4.3 IC50 = 56234.1 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
361 3 0 5 4.0 C1CN(CCN1CC2=CC=C(C=C2)F)C3=NC4=C(N=CC=C4)N5C3=CC=C5
CHEMBL15808 5ht1b_rat Rat No 6.3 IC50 = 567 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
438 3 2 5 2.8 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC4=C(C3)C5=C(N4)C=CC(=C5)F)OC
CHEMBL330803 5ht1b_human Human No 6.3 IC50 = 568 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
295 4 1 3 1.6 C1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL331143 5ht1b_human Human No 7.2 IC50 = 57 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
409 9 3 5 1.9 C1CC1CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL2376487 5ht1b_rat Rat No 6.2 IC50 = 570 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
257 1 2 3 2.0 CC1=C(C2=C(N1)C=CC(=C2)[N+](=O)[O-])C3=CCNCC3
CHEMBL330803 5ht1b_human Human No 6.2 IC50 = 570 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
295 4 1 3 1.6 C1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL159733 5ht1b_human Human No 6.2 IC50 = 575 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 9 1 4 3.9 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)CN4C=NC=N4)CC5=CC=CC=C5
CHEMBL159381 5ht1b_human Human No 6.2 IC50 = 575 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 1 4 3.4 C1CC(N(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)COCC5=CC=CC=C5
CHEMBL62274 5ht1b_rat Rat No 6.2 IC50 = 575.4 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
298 3 0 4 3.8 C=CCN1CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL146391 5ht1b_human Human No 7.2 IC50 = 58 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
443 9 2 4 4.1 CC(C1=CC=CC=C1)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL133939 5ht1b_human Human No 5.2 IC50 = 5800 Funct
Binding affinity against 5-hydroxytryptamine 1B receptorBinding affinity against 5-hydroxytryptamine 1B receptor
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL68019 5ht1b_human Human No 5.2 IC50 = 5800 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
450 8 1 5 5.4 C1CN(CCC1CCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL52867 5ht1b_rat Rat No 4.2 IC50 = 58884.4 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
438 3 0 6 4.7 C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC5=C(C6=C(C=C5)N=CC=C6)N7C4=CC=C7
CHEMBL161696 5ht1b_human Human No 7.2 IC50 = 59 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
435 7 1 4 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)Cl
CHEMBL159650 5ht1b_human Human No 7.2 IC50 = 59 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
429 9 1 4 3.8 CN(CC1CCN(C1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL18785 5ht1b_rat Rat Yes 8.2 IC50 = 6 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
228 2 2 2 1.8 COC1=CC2=C(C=C1)NC=C2C3=CCNCC3
CHEMBL1185 5ht1b_human Human Yes 8.2 IC50 = 6.2 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
287 5 2 3 2.2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
CHEMBL147148 5ht1b_human Human No 8.2 IC50 = 6.2 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
472 8 2 4 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(=O)NC5=CC=CC=C5
CHEMBL359447 5ht1b_rat Rat Yes 8.2 IC50 = 6.3 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
484 5 2 7 4.2 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)O)N5CCN(CC5)C
CHEMBL143952 5ht1b_human Human No 7.2 IC50 = 60 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
479 9 2 6 3.3 C1CN(CCC1CNS(=O)(=O)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL151894 5ht1b_rat Rat No 7.2 IC50 = 60 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
534 7 1 9 4.2 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)S(=O)(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL59741 5ht1b_rat Rat No 6.2 IC50 = 600 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
407 4 1 7 4.5 C1CN(CCN1CCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL264027 5ht1b_rat Rat No 4.2 IC50 = 60000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
306 7 1 4 2.2 CCCN(CCNC(=O)C)C1CC2=C(C=CC=C2OC)OC1
CHEMBL26715 5ht1b_rat Rat No 4.2 IC50 = 60000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
306 7 1 4 2.2 CCCN(CCNC(=O)C)C1CC2=C(C=CC=C2OC)OC1
CHEMBL115352 5ht1b_human Human No 7.2 IC50 = 61 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
439 9 2 5 3.3 CC(C)(C)CN(C)CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL292935 5ht1b_rat Rat No 7.2 IC50 = 61 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
384 6 1 5 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL3286557 5ht1b_human Human No 6.2 IC50 = 610 Funct
Binding affinity to 5HT1B receptor (unknown origin)Binding affinity to 5HT1B receptor (unknown origin)
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL3286557 5ht1b_human Human No 6.2 IC50 = 610 Funct
Binding affinity to 5HT1B receptor (unknown origin)Binding affinity to 5HT1B receptor (unknown origin)
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL161780 5ht1b_human Human No 7.2 IC50 = 62 Funct
Affinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding technique
441 10 3 5 2.4 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN3CCC(C3)CNCC4=CC=CC=C4
CHEMBL345657 5ht1b_human Human No 7.2 IC50 = 62 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CN=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161780 5ht1b_human Human No 7.2 IC50 = 62 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
441 10 3 5 2.4 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN3CCC(C3)CNCC4=CC=CC=C4
CHEMBL16035 5ht1b_rat Rat No 7.2 IC50 = 63 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
426 6 3 5 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCC3=CNC4=C3C=C(C=C4)F)OC
CHEMBL143951 5ht1b_human Human No 7.2 IC50 = 63 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
324 5 2 4 1.5 C1CN(CCC1N)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL12152 5ht1b_rat Rat Yes 6.2 IC50 = 631.0 Funct
Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
386 7 1 5 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=CC=CC=C4O3
CHEMBL2368258 5ht1b_human Human No 5.2 IC50 = 6309.6 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
326 4 2 3 1.4 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CN4C(=O)CNC4=O
CHEMBL64727 5ht1b_rat Rat No 4.2 IC50 = 63095.7 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
417 3 0 4 5.9 C1CN(CCN1CC2=C(C=C(C=C2)Cl)Cl)C3=NC4=C(C=CS4)N5C3=CC=C5
CHEMBL280314 5ht1b_rat Rat No 6.2 IC50 = 633 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
455 7 2 5 3.6 CN(C)CCOC1=C(C=CC(=C1)NC(=O)N2CCC(CC2)C3=CNC4=C3C=C(C=C4)F)OC
CHEMBL261977 5ht1b_rat Rat No 6.2 IC50 = 645.7 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
375 4 0 4 5.3 C1CN(CCN1CC=CC2=CC=CC=C2)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL147546 5ht1b_human Human No 7.2 IC50 = 66 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
500 10 2 5 3.6 CC(=O)NC1=CC=C(C=C1)CCN(C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL343667 5ht1b_human Human No 7.2 IC50 = 66 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
521 10 1 6 3.4 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)S(=O)(=O)C
CHEMBL143967 5ht1b_human Human No 6.2 IC50 = 660 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.
392 9 1 7 4.1 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL11265 5ht1b_human Human No 5.2 IC50 = 6606.9 Funct
Compound was evaluated for the binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]ketanserin.Compound was evaluated for the binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]ketanserin.
441 6 0 5 4.0 COC1=CC=CC2=C1CC3(CCCN3CCCCN4C(=O)CC5(CCCC5)CC4=O)CO2
CHEMBL293879 5ht1b_rat Rat No 6.2 IC50 = 676.1 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
344 5 0 6 3.4 CCOC(=O)CN1CCN(CC1)C2=NC3=C(N4C2=CC=C4)SC=C3
CHEMBL2114036 5ht1b_human Human No 6.2 IC50 = 680 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL350153 5ht1b_human Human No 7.2 IC50 = 69 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
461 9 1 4 4.3 CN1C(COC1=O)CC2=CC3=C(C=C2)NC=C3CCN4CCC(C4)CN(C)CC5=CC=CC=C5
CHEMBL137478 5ht1b_rat Rat No 4.2 IC50 = 69100 Funct
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBBinding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
275 3 0 3 3.6 CCCN1CCCCC12CC3=C(C=CC=C3OC)OC2
CHEMBL11425 5ht1b_human Human No 5.2 IC50 = 6918.3 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
385 7 1 4 3.4 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3CC4=CC=CC=C4OC3
CHEMBL53662 5ht1b_rat Rat No 4.2 IC50 = 69183.1 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
390 4 0 5 4.7 COC1=CC2=C(C=C1)N3C=CC=C3C(=N2)N4CCN(CC4)CC5=CC=C(C=C5)F
CHEMBL422504 5ht1b_rat Rat No 8.1 IC50 = 7.3 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
484 5 2 7 4.6 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)O)N5CCN(CC5)C
CHEMBL162930 5ht1b_human Human No 8.1 IC50 = 7.4 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
311 5 1 4 1.5 C1COCCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL418499 5ht1b_rat Rat No 7.2 IC50 = 70 Funct
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HTAffinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]5-HT
421 4 0 7 4.6 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F)SC1=O
CHEMBL443762 5ht1b_rat Rat Yes 7.2 IC50 = 70 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
562 7 1 9 4.1 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OS(=O)(=O)C)N5CCN(CC5)C
CHEMBL12028 5ht1b_rat Rat No 6.2 IC50 = 700 Funct
In vitro inhibitory concentration against radioligand [3H]5-HT binding to 5-hydroxytryptamine 1B receptor in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]5-HT binding to 5-hydroxytryptamine 1B receptor in rat striatal membrane
460 7 1 8 3.8 CC1=C(SC2=C1C(=O)N(C(=N2)SCCCN3CCN(CC3)C4=CC=CC=C4OC)N)C
CHEMBL151695 5ht1b_rat Rat No 6.2 IC50 = 700 Funct
Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayInhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assay
616 7 1 12 5.7 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OS(=O)(=O)C(F)(F)F)N5CCN(CC5)C
CHEMBL715 5ht1b_rat Rat Yes 6.2 IC50 = 707 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL715 5ht1b_rat Rat Yes 6.2 IC50 = 707 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL292725 5ht1b_rat Rat No 5.2 IC50 = 7079.5 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
392 3 0 6 4.4 C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC5=C(C=CS5)N6C4=CC=C6
CHEMBL63905 5ht1b_rat Rat No 4.2 IC50 = 70794.6 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
352 2 0 5 5.0 C1CN(CCN1C2=CC=C(C=C2)F)C3=NC4=C(N5C3=CC=C5)SC=C4
CHEMBL298649 5ht1b_rat Rat No 4.2 IC50 = 70794.6 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
375 3 0 5 4.3 CC1=C2C(=NC=C1)N3C=CC=C3C(=N2)N4CCN(CC4)CC5=CC=C(C=C5)F
CHEMBL115444 5ht1b_human Human No 6.2 IC50 = 708 Funct
Binding affinity against 5-hydroxytryptamine 1B receptorBinding affinity against 5-hydroxytryptamine 1B receptor
430 4 1 5 3.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)OCC4=CC5=C(C=C4Cl)OCO5
CHEMBL342330 5ht1b_human Human No 7.2 IC50 = 71 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 2 5 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL292779 5ht1b_human Human No 7.1 IC50 = 72 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1b_human Human No 7.1 IC50 = 72 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL303997 5ht1b_human Human No 5.1 IC50 = 7200 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
452 8 1 6 4.6 C1CN(CCC1COC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL161410 5ht1b_human Human No 7.1 IC50 = 74 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146991 5ht1b_human Human No 7.1 IC50 = 74 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
442 6 2 4 2.9 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL63845 5ht1b_rat Rat No 5.1 IC50 = 7413.1 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
402 2 0 7 5.8 C1CN(CCN1C2=CC=CC(=C2)C(F)(F)F)C3=NC4=C(C=CS4)N5C3=CC=C5
CHEMBL417608 5ht1b_human Human No 5.1 IC50 = 7413.1 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.
457 10 0 5 4.8 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC3CC4=C(C=CC=C4OC)OC3
CHEMBL292779 5ht1b_human Human No 7.1 IC50 = 75 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1B receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1B receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL2376482 5ht1b_rat Rat Yes 7.1 IC50 = 75 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
291 1 2 1 2.9 CC1=C(C2=C(N1)C=CC(=C2)Br)C3=CCNCC3
CHEMBL292779 5ht1b_human Human No 7.1 IC50 = 75 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL145997 5ht1b_human Human No 7.1 IC50 = 76 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
416 8 2 5 2.5 C1CN(CCC1NCC2=CC=CC=N2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL15837 5ht1b_rat Rat No 7.1 IC50 = 77 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
523 8 2 6 3.7 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)F)OC
CHEMBL50456 5ht1b_rat Rat No 4.1 IC50 = 77624.7 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
412 3 0 4 5.1 C1CN(CCN1CC2=C(C=C(C=C2)Cl)Cl)C3=NC4=C(N=CC=C4)N5C3=CC=C5
CHEMBL148071 5ht1b_human Human No 7.1 IC50 = 78 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
522 11 3 7 2.6 CS(=O)(=O)NCC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161970 5ht1b_human Human No 7.1 IC50 = 78 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
429 8 1 4 3.1 C1CN(C(=O)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL357408 5ht1b_human Human No 7.1 IC50 = 78 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
405 8 2 5 2.6 C1CN(CCC1NCC2=COC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147979 5ht1b_human Human No 7.1 IC50 = 79 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
459 10 3 5 3.0 C1CN(CCC1CNC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL12129 5ht1b_rat Rat Yes 6.1 IC50 = 794.3 Funct
Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
386 7 1 5 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=CC=CC=C4O3
CHEMBL65367 5ht1b_human Human No 8.1 IC50 = 8.1 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL1403281 5ht1b_rat Rat Yes 8.1 IC50 = 8.2 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL1403281 5ht1b_rat Rat Yes 8.1 IC50 = 8.2 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL146338 5ht1b_human Human No 8.1 IC50 = 8.9 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
500 10 3 5 3.3 CC(C1=CC=C(C=C1)NC(=O)C)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147940 5ht1b_human Human No 8.1 IC50 = 8.9 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
486 10 3 5 2.9 CC(=O)NC1=CC=C(C=C1)CNCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL278917 5ht1b_rat Rat No 7.1 IC50 = 80 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=CC(=C5)F)OC
CHEMBL189118 5ht1b_human Human No 6.1 IC50 = 800 Funct
Inhibitory concentration against 5-hydroxytryptamine 1B receptorInhibitory concentration against 5-hydroxytryptamine 1B receptor
473 8 1 8 5.5 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)OC(F)(F)F)N(C)CCN(C)C
CHEMBL189118 5ht1b_human Human No 6.1 IC50 = 800 Funct
Inhibitory concentration against 5-hydroxytryptamine 1B receptorInhibitory concentration against 5-hydroxytryptamine 1B receptor
473 8 1 8 5.5 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)OC(F)(F)F)N(C)CCN(C)C
CHEMBL26018 5ht1b_rat Rat No 5.1 IC50 = 8000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
447 11 1 6 4.6 CCCN(CCCCNS(=O)(=O)C1=CC=C(C=C1)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL300735 5ht1b_rat Rat No 5.1 IC50 = 8000 Funct
Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidusBinding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus
447 11 1 6 4.6 CCCN(CCCCNS(=O)(=O)C1=CC=C(C=C1)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL146396 5ht1b_human Human No 7.1 IC50 = 81 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
391 7 1 4 3.1 CC#CCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL162449 5ht1b_rat Rat No 6.1 IC50 = 825 Funct
Concentration necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol binding to 5-hydroxytryptamine 1B receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol binding to 5-hydroxytryptamine 1B receptor at 1 uM
247 1 0 3 2.6 CC1=CC2=C(C3CCCN(C3CO2)C)C(=C1)OC
CHEMBL324751 5ht1b_human Human No 7.1 IC50 = 83 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
459 9 3 5 3.0 CC1=CC=CC=C1CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL119668 5ht1b_human Human No 7.1 IC50 = 83 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL137485 5ht1b_human Human No 6.1 IC50 = 830 Funct
Binding affinity against 5-hydroxytryptamine 1B receptorBinding affinity against 5-hydroxytryptamine 1B receptor
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL350637 5ht1b_human Human No 6.1 IC50 = 831.8 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
296 3 1 4 3.0 CC1=NOC(=N1)C2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL198463 5ht1b_human Human No 7.1 IC50 = 85 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=NC6=CC=CC=C65
CHEMBL113831 5ht1b_human Human No 7.1 IC50 = 85 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
425 9 3 5 2.9 CC(C)(C)CNCC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL148110 5ht1b_human Human No 7.1 IC50 = 85 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
472 9 3 5 3.3 CC(C(=O)NC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2079627 5ht1b_rat Rat No 7.1 IC50 = 85 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)F)OC
CHEMBL352123 5ht1b_human Human No 7.1 IC50 = 85 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
429 9 1 4 4.0 C1CN(CCN1CCCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL326371 5ht1b_human Human No 7.1 IC50 = 85 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL145849 5ht1b_human Human No 7.1 IC50 = 85 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
473 10 2 5 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL198463 5ht1b_human Human No 7.1 IC50 = 85 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=NC6=CC=CC=C65
CHEMBL633 5ht1b_rat Rat Yes 4.1 IC50 = 86167 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL159493 5ht1b_human Human No 7.1 IC50 = 87 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
387 7 2 4 3.6 C1CN(CC1CNC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL348864 5ht1b_human Human No 7.1 IC50 = 87 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
443 9 1 4 4.3 CC(C1=CC=CC=C1)N(C)CC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL326371 5ht1b_human Human No 7.1 IC50 = 88 Funct
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL114303 5ht1b_human Human No 7.1 IC50 = 89 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
473 9 2 5 3.5 CC1=CC=CC=C1CN(C)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL434315 5ht1b_human Human No 7.1 IC50 = 89 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
419 8 1 5 3.1 CN(CC1=CC=CO1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL343217 5ht1b_human Human No 7.1 IC50 = 89 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
477 10 2 6 3.5 COCC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1550957 5ht1b_rat Rat Yes 6.1 IC50 = 890 Funct
Displacement of [125I]-iodocyanopindolol from rat 5HT1B receptorDisplacement of [125I]-iodocyanopindolol from rat 5HT1B receptor
212 1 2 1 2.2 CC1=C(C2=CC=CC=C2N1)C3=CCNCC3
CHEMBL1306 5ht1b_rat Rat Yes 4.1 IC50 = 89897 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL1306 5ht1b_rat Rat Yes 4.1 IC50 = 89897 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL146483 5ht1b_human Human No 8.0 IC50 = 9.3 Funct
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
500 10 3 5 3.3 CC(C1=CC=C(C=C1)NC(=O)C)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163386 5ht1b_human Human No 8.0 IC50 = 9.5 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
431 8 2 5 2.5 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL2368254 5ht1b_human Human No 8.0 IC50 = 9.6 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
278 3 2 2 3.2 C1C(CC1N)C2=CNC3=C2C=C(C=C3)OC4=CC=CC=C4
CHEMBL65710 5ht1b_rat Rat No 4.0 IC50 = 91201.1 Funct
Binding affinity for 5-hydroxytryptamine 1B receptorBinding affinity for 5-hydroxytryptamine 1B receptor
348 3 0 4 4.6 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(C=CS4)N5C3=CC=C5
CHEMBL351311 5ht1b_human Human No 7.0 IC50 = 93 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
416 8 1 5 2.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CN=CC=C5
CHEMBL349528 5ht1b_human Human No 7.0 IC50 = 93 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
297 4 2 4 1.0 C1CN(CC1O)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL159627 5ht1b_human Human No 7.0 IC50 = 93 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
311 5 2 4 1.2 C1CN(CC1CO)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL304993 5ht1b_human Human No 6.0 IC50 = 930 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL148087 5ht1b_human Human No 7.0 IC50 = 95 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL114877 5ht1b_human Human No 7.0 IC50 = 96 Funct
Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro
459 9 2 5 3.1 CN(CC1=CC=CC=C1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL2368253 5ht1b_human Human No 7.0 IC50 = 97.7 Funct
Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorBinding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor
306 4 1 2 4.2 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)OC4=CC=CC=C4
CHEMBL50740 5ht1b_rat Rat No 4.0 IC50 = 97723.7 Funct
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand
393 3 0 4 4.9 C1CN(CCN1CC2=CC=CC=C2)C3=NC4=C(C5=C(C=C4)N=CC=C5)N6C3=CC=C6
CHEMBL148194 5ht1b_human Human No 7.0 IC50 = 98 Funct
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.0 CC(CO)(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143767 5ht1b_human Human No 7.0 IC50 = 98 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor beta clones expressed in human embryonic kidney (HEK 293) cells line.
336 5 1 7 2.3 CN(C)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL116031 5ht1b_human Human No 7.0 IC50 = 98 Funct
Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL119668 5ht1b_human Human No 7.0 IC50 = 98 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL1241913 5ht1b_human Human No 8.9 Kd = 1.2 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL1241913 5ht1b_human Human No 8.9 Kd = 1.2 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL1185 5ht1b_human Human Yes 8.8 Kd = 1.5 Funct
Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.
287 5 2 3 2.2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
CHEMBL374973 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
667 16 4 4 7.8 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL144030 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL438619 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.6 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5C=NC=C6
CHEMBL144030 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL374973 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
667 16 4 4 7.8 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL144030 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL438619 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.6 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5C=NC=C6
CHEMBL147851 5ht1b_human Human No 10.0 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
505 11 4 6 1.8 C1CN(CCN1CCOC2=CC3=C(C=C2)NC=C3CCN)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL15928 5ht1b_human Human Yes 9.9 Ki = 0.1 Funct
Affinity for 5-hydroxytryptamine 1B receptor subtypeAffinity for 5-hydroxytryptamine 1B receptor subtype
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL15928 5ht1b_human Human Yes 9.9 Ki = 0.1 Funct
Affinity towards cloned human 5-hydroxytryptamine 1B receptorAffinity towards cloned human 5-hydroxytryptamine 1B receptor
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL357478 5ht1b_human Human No 9.9 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
610 12 5 7 2.8 C1CN(CCN1C2=CC=C(C=C2)NC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL15928 5ht1b_human Human Yes 9.9 Ki = 0.1 Funct
Affinity for 5-hydroxytryptamine 1B receptor subtypeAffinity for 5-hydroxytryptamine 1B receptor subtype
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL15928 5ht1b_human Human Yes 9.9 Ki = 0.1 Funct
Affinity towards cloned human 5-hydroxytryptamine 1B receptorAffinity towards cloned human 5-hydroxytryptamine 1B receptor
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL339308 5ht1b_human Human No 9.9 Ki = 0.1 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
500 6 2 6 4.2 CC1N=C(NO1)C2=CC(=C(C=C2)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C)C
CHEMBL147901 5ht1b_human Human No 9.8 Ki = 0.2 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
436 11 5 5 1.8 C1=CC2=C(C=C1OCCNC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL247428 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1B receptor expressed in CHO cells
465 6 0 7 3.1 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC5=C(C(=C4)F)OCC(=O)N5C
CHEMBL490417 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL147677 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
465 12 6 5 1.6 C1=CC2=C(C=C1OCCNC(=O)NCCOC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL344127 5ht1b_human Human Yes 9.7 Ki = 0.2 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.
377 8 2 3 3.2 CN(C)CCC1=CNC2=C1C=C(C=C2)C=CC(=O)NCC3=CC=C(C=C3)OC
CHEMBL247428 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1B receptor expressed in CHO cells
465 6 0 7 3.1 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC5=C(C(=C4)F)OCC(=O)N5C
CHEMBL490417 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL2112662 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
473 6 0 5 4.3 CC1=CC=CC=C1CN2CCN(CC2)C(=O)COC3=CC4=C(C=CC=C4N5CCN(CC5)C)C=C3
CHEMBL357830 5ht1b_human Human No 9.7 Ki = 0.2 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
601 11 4 6 3.0 C1CN(CCC1C2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL199088 5ht1b_human Human No 9.6 Ki = 0.3 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
441 2 0 8 3.3 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CN=C(C=C5)C(F)(F)F
CHEMBL199088 5ht1b_human Human No 9.6 Ki = 0.3 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
441 2 0 8 3.3 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CN=C(C=C5)C(F)(F)F
CHEMBL144128 5ht1b_human Human No 9.6 Ki = 0.3 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
491 12 4 6 2.3 C1CN(CCN1CCOC2=CC3=C(C=C2)NC=C3CCN)CCOC4=CC5=C(C=C4)NC=C5CCN
CHEMBL356277 5ht1b_human Human No 9.6 Ki = 0.3 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
541 12 6 6 2.6 C1=CC(=CC=C1NC(=O)COC2=CC3=C(C=C2)NC=C3CCN)NC(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL3647266 5ht1b_crigr Chinese hamster No 9.6 Ki = 0.3 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
545 7 1 7 5.1 C1CN(CCC1NC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5)C6=C(C=CC=N6)Cl
CHEMBL3647266 5ht1b_crigr Chinese hamster No 9.6 Ki = 0.3 Funct
BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
545 7 1 7 5.1 C1CN(CCC1NC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5)C6=C(C=CC=N6)Cl
CHEMBL199443 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5N=CC=C6
CHEMBL144397 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
507 14 6 6 1.5 C1=CC2=C(C=C1OCC(=O)NCCCNC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL199443 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 2.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5N=CC=C6
CHEMBL340786 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
459 5 0 5 4.6 CC1=CC=CC=C1N2CCN(CC2)C(=O)COC3=CC4=C(C=CC=C4N5CCN(CC5)C)C=C3
CHEMBL473186 5ht1b_human Human Yes 9.5 Ki = 0.3 Funct
Binding affinity to 5HT1B receptor (unknown origin)Binding affinity to 5HT1B receptor (unknown origin)
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL484059 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
465 5 1 5 4.7 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=CC=CC5=C4C=CC(=N5)C6=CC=CC=C6
CHEMBL370852 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
407 2 0 4 4.0 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CC=C(C=C5)Cl
CHEMBL473186 5ht1b_human Human Yes 9.5 Ki = 0.3 Funct
Binding affinity to 5HT1B receptor (unknown origin)Binding affinity to 5HT1B receptor (unknown origin)
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL484059 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
465 5 1 5 4.7 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=CC=CC5=C4C=CC(=N5)C6=CC=CC=C6
CHEMBL370852 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
407 2 0 4 4.0 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CC=C(C=C5)Cl
CHEMBL148022 5ht1b_human Human No 9.5 Ki = 0.3 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
455 10 4 4 3.7 C1=CC(=CC(=C1)COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL146720 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
519 10 4 6 1.3 C1CN(CCN1C(=O)COC2=CC3=C(C=C2)NC=C3CCN)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL342323 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
829 25 6 10 6.6 C1=CC(=CC=C1C2=CC=C(C=C2)S(=O)(=O)NCCCCCCOC3=CC4=C(C=C3)NC=C4CCN)S(=O)(=O)NCCCCCCOC5=CC6=C(C=C5)NC=C6CCN
CHEMBL2112660 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
470 5 0 6 3.9 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=CC=CC=C5C#N
CHEMBL444398 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
390 4 2 4 3.3 CC1=CC2=C(N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL496520 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C(C5=C(C=C4)OCC(=O)N5)F
CHEMBL444398 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
390 4 2 4 3.3 CC1=CC2=C(N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL496520 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C(C5=C(C=C4)OCC(=O)N5)F
CHEMBL197344 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
466 4 0 7 3.5 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5SC=C6
CHEMBL197344 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
466 4 0 7 3.5 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5SC=C6
CHEMBL605785 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Binding affinity to 5HT1B receptor expressed in CHO cellsBinding affinity to 5HT1B receptor expressed in CHO cells
507 5 1 8 2.2 CC1=C(C(=NN1C)C)C2=C3C(=CC(=C2)F)C(=O)C=C(O3)C(=O)NC4=CN=C(C=C4)C5(CCOCC5)OC
CHEMBL605785 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Binding affinity to 5HT1B receptor expressed in CHO cellsBinding affinity to 5HT1B receptor expressed in CHO cells
507 5 1 8 2.2 CC1=C(C(=NN1C)C)C2=C3C(=CC(=C2)F)C(=O)C=C(O3)C(=O)NC4=CN=C(C=C4)C5(CCOCC5)OC
CHEMBL605785 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Binding affinity to 5HT1B receptor expressed in CHO cellsBinding affinity to 5HT1B receptor expressed in CHO cells
507 5 1 8 2.2 CC1=C(C(=NN1C)C)C2=C3C(=CC(=C2)F)C(=O)C=C(O3)C(=O)NC4=CN=C(C=C4)C5(CCOCC5)OC
CHEMBL129813 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
503 5 0 7 3.9 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=C6C(=CC=C5)OCCO6
CHEMBL2112661 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
495 5 0 5 5.4 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=CC=CC6=CC=CC=C65
CHEMBL338015 5ht1b_human Human No 9.4 Ki = 0.4 Funct
Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cells
505 7 0 7 4.1 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)N4CCN(CC4)C5=C(C(=CC=C5)OC)OC
CHEMBL3650029 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.5 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
484 7 0 7 3.4 C1CN(CCN1CCC2=CC=CC=N2)C3=CC=CC4=C3OC(=C4)C(=O)N5CC(C5)OC6=CN=CC=C6
CHEMBL3650029 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.5 Funct
BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
484 7 0 7 3.4 C1CN(CCN1CCC2=CC=CC=N2)C3=CC=CC4=C3OC(=C4)C(=O)N5CC(C5)OC6=CN=CC=C6
CHEMBL502138 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
681 17 4 4 8.3 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL196914 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
474 5 0 7 3.0 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=C(C(=CC=C5)Cl)OC
CHEMBL200315 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
452 4 0 7 2.4 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5OCC6
CHEMBL198836 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
460 4 0 6 3.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=CC=CC=C65
CHEMBL371221 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 3.0 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=NC=CC6=CC=CC=C65
CHEMBL424128 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cells
435 13 4 4 3.9 C1=CC2=C(C=C1OCCCCCCOC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL502138 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
681 17 4 4 8.3 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL196914 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
474 5 0 7 3.0 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=C(C(=CC=C5)Cl)OC
CHEMBL200315 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
452 4 0 7 2.4 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=C5OCC6
CHEMBL198836 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
460 4 0 6 3.7 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=CC=CC6=CC=CC=C65
CHEMBL371221 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRInhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR
461 4 0 7 3.0 CN1CCC2=C(C1)SC3=C2C(=O)N(C=N3)CCN4CCN(CC4)C5=NC=CC6=CC=CC=C65
CHEMBL1242081 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 6 1 6 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CC7
CHEMBL282229 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Binding affinity for human 5-hydroxytryptamine 1B receptorBinding affinity for human 5-hydroxytryptamine 1B receptor
513 8 0 7 5.2 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC(=C(C=C54)OCCN(C)C)OC
CHEMBL490417 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL1631532 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
405 6 1 5 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)OC
CHEMBL1632206 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
389 5 1 4 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C
CHEMBL522257 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL497980 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=C(C=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL521506 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL490417 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL194647 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
397 2 0 5 3.1 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CC=C(C=C5)C#N
CHEMBL1242081 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 6 1 6 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CC7
CHEMBL490417 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL1631532 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
405 6 1 5 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)OC
CHEMBL1632206 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
389 5 1 4 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C
CHEMBL522257 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL497980 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=C(C=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL521506 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL490417 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL194647 5ht1b_human Human No 9.3 Ki = 0.5 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
397 2 0 5 3.1 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=CC=C(C=C5)C#N
CHEMBL3647261 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.5 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
510 7 1 6 5.2 C1CN(CCC1NC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5)C6=CC=CC=C6
CHEMBL3647261 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.5 Funct
BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
510 7 1 6 5.2 C1CN(CCC1NC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5)C6=CC=CC=C6
CHEMBL3647282 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.6 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
541 8 1 8 4.4 COC1=C(N=CC=C1)N2CCC(CC2)NC(=O)C3=CC4=C(O3)C(=CC=C4)N5CCN(CC5)CCC6=CC=CC=N6
CHEMBL3647282 5ht1b_crigr Chinese hamster No 9.3 Ki = 0.6 Funct
BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
541 8 1 8 4.4 COC1=C(N=CC=C1)N2CCC(CC2)NC(=O)C3=CC4=C(O3)C(=CC=C4)N5CCN(CC5)CCC6=CC=CC=N6
CHEMBL500284 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
695 18 4 4 8.8 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL500284 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
695 18 4 4 8.8 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL1242167 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 6 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCC7
CHEMBL1241824 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
497 5 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N(C)C
CHEMBL1242167 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 6 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCC7
CHEMBL1241824 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
497 5 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N(C)C
CHEMBL1290486 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
401 4 1 4 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)NC5=CC=C4
CHEMBL1290486 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
401 4 1 4 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)NC5=CC=C4
CHEMBL196848 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Binding affinity against cloned human 5-hydroxytryptamine 1B receptorBinding affinity against cloned human 5-hydroxytryptamine 1B receptor
470 4 0 4 5.7 CC1CN(CC(N1C)C)C2=C(C=C3CCN(C3=C2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5C)OC
CHEMBL196848 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Binding affinity against cloned human 5-hydroxytryptamine 1B receptorBinding affinity against cloned human 5-hydroxytryptamine 1B receptor
470 4 0 4 5.7 CC1CN(CC(N1C)C)C2=C(C=C3CCN(C3=C2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5C)OC
CHEMBL484260 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
417 4 1 5 3.8 CC1=NC2=C(C=C1)C(=CC(=C2)C)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL491839 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
408 4 1 5 3.4 CC1(CC2=C(O1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)C
CHEMBL489195 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
403 4 1 6 2.8 CC1=NC=C2C(=N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL484260 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
417 4 1 5 3.8 CC1=NC2=C(C=C1)C(=CC(=C2)C)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL491839 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
408 4 1 5 3.4 CC1(CC2=C(O1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)C
CHEMBL489195 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
403 4 1 6 2.8 CC1=NC=C2C(=N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL198975 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
453 3 0 5 3.8 CC1=C(C=NN1C2=CC=CC=C2)C(=O)N3CCC4=C3C=C5C(=C4)C=CN=C5N6CCN(CC6)C
CHEMBL198975 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
453 3 0 5 3.8 CC1=C(C=NN1C2=CC=CC=C2)C(=O)N3CCC4=C3C=C5C(=C4)C=CN=C5N6CCN(CC6)C
CHEMBL158941 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
693 16 2 8 3.9 CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N(C)CC3=CC=C(C=C3)CN(C)S(=O)(=O)CC4=CC5=C(C=C4)NC=C5CCN(C)C
CHEMBL158941 5ht1b_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
693 16 2 8 3.9 CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N(C)CC3=CC=C(C=C3)CN(C)S(=O)(=O)CC4=CC5=C(C=C4)NC=C5CCN(C)C
CHEMBL158941 5ht1b_human Human No 9.2 Ki = 0.6 Funct
In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1B receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1B receptor using [3H]5-CT radioligand
693 16 2 8 3.9 CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N(C)CC3=CC=C(C=C3)CN(C)S(=O)(=O)CC4=CC5=C(C=C4)NC=C5CCN(C)C
CHEMBL3647276 5ht1b_crigr Chinese hamster No 9.2 Ki = 0.7 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
485 9 1 6 4.7 COC1=CC=CC(=C1)CCNC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5
CHEMBL282950 5ht1b_human Human No 9.2 Ki = 0.7 Funct
Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]5-CT as radioligand
607 11 4 7 4.3 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCC(=O)NC4=CC=C(C=C4)NC(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL3647276 5ht1b_crigr Chinese hamster No 9.2 Ki = 0.7 Funct
BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.BindingDB_Patents: Inhibition Assay. Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
485 9 1 6 4.7 COC1=CC=CC(=C1)CCNC(=O)C2=CC3=C(O2)C(=CC=C3)N4CCN(CC4)CCC5=CC=CC=N5
CHEMBL444404 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
555 8 4 4 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL31217 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
445 8 2 5 4.2 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCCOC4=CC5=C(C=C4)NC=C5CCN
CHEMBL31217 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]5-CT as radioligand
445 8 2 5 4.2 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCCOC4=CC5=C(C=C4)NC=C5CCN
CHEMBL444404 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
555 8 4 4 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL31217 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
445 8 2 5 4.2 CN1CCN(CC1)C2=CC=CC3=C2C=C(C=C3)OCCOC4=CC5=C(C=C4)NC=C5CCN
CHEMBL452387 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
625 13 4 4 6.1 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL452387 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
625 13 4 4 6.1 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL1241738 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=C6CO5)C
CHEMBL1289394 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
445 4 0 5 4.6 CC1CN(CCN1CCC2=C3C=CC(=O)N(C3=CC=C2)C)C4=C5C=CC(=NC5=CC(=C4)F)C
CHEMBL1290716 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL1290487 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
415 4 0 4 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)N(C5=CC=C4)C
CHEMBL1241913 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]-5-HT from human recombinant 5HT1B receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1B receptor expressed in CHO cells after 45 mins by scintillation counting
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL241463 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cells
450 6 1 6 4.4 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC5=C(C(=C4)F)OCC(=O)N5
CHEMBL1631535 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
425 6 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL489393 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
431 5 0 5 4.0 CCN1C(=O)COC2=C1C=C(C=C2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL490211 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
388 4 1 5 3.3 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=NC=CC5=CC=CC=C54
CHEMBL523064 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
415 4 1 5 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CC4CC3CN4CCC5=CC6=C(C=C5)OCC(=O)N6
CHEMBL370625 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
424 2 0 5 3.7 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=C6C=CC=NC6=CC=C5
CHEMBL1241738 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1B receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=C6CO5)C
CHEMBL1289394 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
445 4 0 5 4.6 CC1CN(CCN1CCC2=C3C=CC(=O)N(C3=CC=C2)C)C4=C5C=CC(=NC5=CC(=C4)F)C
CHEMBL1290716 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL1290487 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
415 4 0 4 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)N(C5=CC=C4)C
CHEMBL1241913 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]-5-HT from human recombinant 5HT1B receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1B receptor expressed in CHO cells after 45 mins by scintillation counting
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL241463 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cells
450 6 1 6 4.4 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC5=C(C(=C4)F)OCC(=O)N5
CHEMBL1631535 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1B receptor expressed in CHO cells
425 6 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL489393 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
431 5 0 5 4.0 CCN1C(=O)COC2=C1C=C(C=C2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL490211 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
388 4 1 5 3.3 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=NC=CC5=CC=CC=C54
CHEMBL523064 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1B receptor expressed in CHO cells
415 4 1 5 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CC4CC3CN4CCC5=CC6=C(C=C5)OCC(=O)N6
CHEMBL370625 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand
424 2 0 5 3.7 CN1CCN(CC1)C2=NC=CC3=CC4=C(C=C32)N(CC4)C(=O)C5=C6C=CC=NC6=CC=C5
CHEMBL500488 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
709 19 4 4 9.4 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL500488 5ht1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting
709 19 4 4 9.4 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)CCCCCCCCCCCCCCC(=O)NC4=CC5=C(C=C4)NC=C5C6CCN(CC6)C
CHEMBL3647270 5ht1b_crigr Chinese hamster No 9.1 Ki = 0.9 Funct
Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.Inhibition Assay: Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal Transduct. Res. 22:483-495 (2002) and Naunyn-Schmiedeberg's Arch Pharmacol. 356:328-334 (1997) and incorporated by reference herein. These assays were be used with some modifications:For the binding assay stably transfected chinese hamster ovary (CHO) cell lines expressing 5-HT1A receptors or 5-HT1B receptors were harvested by centrifugation at 300x g for 10 min and resuspended in 10 mM Tris-HCl, 5 mM EDTA at pH 7.4. The cells were pooled, recentrifuged and resuspended before homogenisation using a Dounce homogeniser ("type B"). Cell membranes were centrifuged at 48 000x g for 10 min and then resuspended in harvesting buffer using an Ultra-Turrax T8 (IKA Labortechnik, Germany), aliquots were stored frozen in -70 C.Frozen membrane preparations were thawed, homogenized with an Ultra-Turrax and mixed with SPA beads.
364 5 1 5 2.8 CNC(=O)C1=CC2=C(O1)C(=CC=C2)N3CCN(CC3)CCC4=CC=CC=N4