Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
10696930 | 36098 | None | 0 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL144397 | 36098 | None | 0 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
9897637 | 118996 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL342323 | 118996 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | |||
10791244 | 35806 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL144128 | 35806 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
10720301 | 39997 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL147851 | 39997 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
10531639 | 121336 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL357830 | 121336 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | |||
9984109 | 38888 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL146720 | 38888 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
11800592 | 121049 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL356277 | 121049 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
10008868 | 121189 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL357478 | 121189 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | |||
11797158 | 40053 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL147901 | 40053 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
9832057 | 52331 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
CHEMBL158941 | 52331 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
10836606 | 165628 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL424128 | 165628 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
10647387 | 40204 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | |||
CHEMBL148022 | 40204 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | |||
10837858 | 39819 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL147677 | 39819 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
10671315 | 205469 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | -186 | 2 | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL63258 | 205469 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | -186 | 2 | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
125181385 | 195322 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@@H](C)Cc1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5400905 | 195322 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@@H](C)Cc1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
40 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
77993 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
77993.0 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
995 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
CHEMBL1510 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
DB00216 | 1547 | None | 36 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | |||
18975369 | 101083 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -120 | 2 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
CHEMBL294547 | 101083 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -120 | 2 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
4806 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
71768094 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
71768094.0 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
7351 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
9966051 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
9966051.0 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
CHEMBL2104993 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
DB09068 | 4008 | None | 55 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
163585306 | 195142 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5397369 | 195142 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
11796806 | 102772 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -169 | 2 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL304857 | 102772 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -169 | 2 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
125181384 | 196110 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@H](C)Cc1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5417081 | 196110 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@H](C)Cc1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
2869 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
60 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
60857 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
60857.0 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
CHEMBL1185 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
DB00315 | 4152 | None | 54 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -3 | 5 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
44592371 | 179100 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL470849 | 179100 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
10766570 | 205838 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -501 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
CHEMBL65321 | 205838 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -501 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
121493472 | 195370 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@@H](C)Cc1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5402187 | 195370 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@@H](C)Cc1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
10600213 | 205567 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -575 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
CHEMBL64004 | 205567 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -575 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
163757283 | 195169 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CC[C@@H](Cc1ccc2ccoc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5397993 | 195169 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CC[C@@H](Cc1ccc2ccoc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
145975946 | 164015 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
CHEMBL4207355 | 164015 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
163757284 | 195497 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CCC(Cc1ccc2ccoc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5404902 | 195497 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CCC(Cc1ccc2ccoc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
24762221 | 19326 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -39 | 2 | ChEMBL | 414 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290596 | 19326 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -39 | 2 | ChEMBL | 414 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
11797999 | 40538 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL148314 | 40538 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
10385855 | 14430 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL120055 | 14430 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL321818 | 14430 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
10791125 | 18968 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
CHEMBL128699 | 18968 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
10649124 | 19477 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
CHEMBL129813 | 19477 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
44592333 | 178943 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469376 | 178943 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
1220 | 187 | None | 44 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -95 | 9 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
31 | 187 | None | 44 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -95 | 9 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
7 | 187 | None | 44 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -95 | 9 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL56 | 187 | None | 44 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -95 | 9 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
10838063 | 78807 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
CHEMBL2112660 | 78807 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
163982955 | 195154 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5397645 | 195154 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
145964150 | 164401 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
CHEMBL4212246 | 164401 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
10719687 | 205457 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -257 | 2 | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL63167 | 205457 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -257 | 2 | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
11797998 | 35701 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL144030 | 35701 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
10601619 | 116900 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
CHEMBL338015 | 116900 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
121490990 | 196954 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CC[C@@H](Cc1ccc2occc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5435545 | 196954 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CC[C@@H](Cc1ccc2occc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
52946290 | 19109 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 446 | 4 | 0 | 5 | 4.4 | Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289164 | 19109 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 446 | 4 | 0 | 5 | 4.4 | Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
2543 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
5358 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
5358.0 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
54 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
CHEMBL128 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
DB00669 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
24804774 | 19327 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 428 | 4 | 0 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290597 | 19327 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 428 | 4 | 0 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
10809674 | 119260 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL343196 | 119260 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
114 | 2254 | None | 15 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -169 | 6 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
6426760 | 2254 | None | 15 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -169 | 6 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
CHEMBL292779 | 2254 | None | 15 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -169 | 6 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
10503687 | 205535 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -50 | 2 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL63799 | 205535 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -50 | 2 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
10341917 | 168152 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -97 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL432332 | 168152 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -97 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
10076876 | 101767 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL29951 | 101767 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | |||
52943811 | 19089 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 412 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289047 | 19089 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 412 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
10551328 | 206179 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -97 | 2 | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
CHEMBL67684 | 206179 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -97 | 2 | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
10837853 | 168261 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -309 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
CHEMBL433108 | 168261 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -309 | 2 | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
163982955 | 195154 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5397645 | 195154 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2ccoc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
11 | 1187 | None | 17 | Rat | Functional | pEC50 | = | 7.3 | 7.3 | 75 | 4 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
124007 | 1187 | None | 17 | Rat | Functional | pEC50 | = | 7.3 | 7.3 | 75 | 4 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
CHEMBL304008 | 1187 | None | 17 | Rat | Functional | pEC50 | = | 7.3 | 7.3 | 75 | 4 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
139033209 | 197173 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CCC(Cc1ccc2occc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5440408 | 197173 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 203 | 4 | 1 | 2 | 3.0 | CCC(Cc1ccc2occc2c1)NC | 10.1021/acsmedchemlett.3c00358 | |||
44592208 | 179285 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL472289 | 179285 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
52948697 | 19090 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289048 | 19090 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44592332 | 178942 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469375 | 178942 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
9844873 | 101112 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -48 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL294732 | 101112 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -48 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
163585306 | 195142 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5397369 | 195142 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 203 | 3 | 1 | 3 | 2.2 | CNC(C)C(=O)c1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
2543 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
5358 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
5358.0 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
54 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
CHEMBL128 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
DB00669 | 3707 | None | 46 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
10575553 | 205497 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -245 | 2 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL63432 | 205497 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -245 | 2 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
121493473 | 196775 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@H](C)Cc1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
CHEMBL5431933 | 196775 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 189 | 3 | 1 | 2 | 2.6 | CN[C@H](C)Cc1ccc2occc2c1 | 10.1021/acsmedchemlett.3c00358 | |||
10621021 | 205842 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -66 | 2 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | |||
CHEMBL65367 | 205842 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -66 | 2 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | |||
9844873 | 101112 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -48 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.7b01788 | |||
CHEMBL294732 | 101112 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -48 | 2 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.7b01788 | |||
18975369 | 101083 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -120 | 2 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | |||
CHEMBL294547 | 101083 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -120 | 2 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | |||
145975946 | 164015 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
CHEMBL4207355 | 164015 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
145964150 | 164401 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
CHEMBL4212246 | 164401 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | |||
146395245 | 189166 | None | 19 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 4 | 2 | ChEMBL | 400 | 3 | 2 | 3 | 2.8 | CC(=O)N1CCN([C@H]2CCC[C@@H](NC(=O)c3cc4c(F)ccc(C)c4[nH]3)C2)CC1 | 10.1021/acsmedchemlett.2c00167 | |||
CHEMBL5095235 | 189166 | None | 19 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 4 | 2 | ChEMBL | 400 | 3 | 2 | 3 | 2.8 | CC(=O)N1CCN([C@H]2CCC[C@@H](NC(=O)c3cc4c(F)ccc(C)c4[nH]3)C2)CC1 | 10.1021/acsmedchemlett.2c00167 | |||
11568826 | 132866 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 9 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL370110 | 132866 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 9 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
13339 | 1207 | None | 7 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -3311 | 3 | ChEMBL | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 10.1021/acsmedchemlett.3c00514 | |||
146361282 | 1207 | None | 7 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -3311 | 3 | ChEMBL | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 10.1021/acsmedchemlett.3c00514 | |||
CHEMBL5414447 | 1207 | None | 7 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -3311 | 3 | ChEMBL | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 10.1021/acsmedchemlett.3c00514 | |||
11662592 | 72368 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 15 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198463 | 72368 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 15 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
11655728 | 16651 | None | 7 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241913 | 16651 | None | 7 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
10447834 | 1933 | None | 1 | Human | Functional | pKd | = | 4.9 | 4.9 | - | 3 | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
4026 | 1933 | None | 1 | Human | Functional | pKd | = | 4.9 | 4.9 | - | 3 | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
CHEMBL275507 | 1933 | None | 1 | Human | Functional | pKd | = | 4.9 | 4.9 | - | 3 | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
44373817 | 11722 | None | 0 | Human | Functional | pKd | = | 5.7 | 5.7 | - | 0 | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL1181270 | 11722 | None | 0 | Human | Functional | pKd | = | 5.7 | 5.7 | - | 0 | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL161046 | 11722 | None | 0 | Human | Functional | pKd | = | 5.7 | 5.7 | - | 0 | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
44373789 | 11725 | None | 0 | Human | Functional | pKd | = | 6.7 | 6.7 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL1181275 | 11725 | None | 0 | Human | Functional | pKd | = | 6.7 | 6.7 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL161368 | 11725 | None | 0 | Human | Functional | pKd | = | 6.7 | 6.7 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
10403687 | 2511 | None | 2 | Human | Functional | pKd | = | 5.1 | 5.1 | - | 2 | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
1205 | 2511 | None | 2 | Human | Functional | pKd | = | 5.1 | 5.1 | - | 2 | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
CHEMBL275035 | 2511 | None | 2 | Human | Functional | pKd | = | 5.1 | 5.1 | - | 2 | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | |||
44373791 | 12237 | None | 0 | Human | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL1184450 | 12237 | None | 0 | Human | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
CHEMBL349405 | 12237 | None | 0 | Human | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | |||
11797998 | 35701 | None | 0 | Human | Functional | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL144030 | 35701 | None | 0 | Human | Functional | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
44405730 | 169022 | None | 0 | Human | Functional | pKi | = | 10 | 10.0 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL438619 | 169022 | None | 0 | Human | Functional | pKi | = | 10 | 10.0 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
10720301 | 39997 | None | 0 | Human | Functional | pKi | = | 10.0 | 10.0 | - | 1 | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL147851 | 39997 | None | 0 | Human | Functional | pKi | = | 10.0 | 10.0 | - | 1 | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
10008868 | 121189 | None | 0 | Human | Functional | pKi | = | 9.9 | 9.9 | - | 1 | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL357478 | 121189 | None | 0 | Human | Functional | pKi | = | 9.9 | 9.9 | - | 1 | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | |||
11797158 | 40053 | None | 0 | Human | Functional | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL147901 | 40053 | None | 0 | Human | Functional | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
10837858 | 39819 | None | 0 | Human | Functional | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL147677 | 39819 | None | 0 | Human | Functional | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
10531639 | 121336 | None | 0 | Human | Functional | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL357830 | 121336 | None | 0 | Human | Functional | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | |||
10791244 | 35806 | None | 0 | Human | Functional | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL144128 | 35806 | None | 0 | Human | Functional | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
11800592 | 121049 | None | 0 | Human | Functional | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL356277 | 121049 | None | 0 | Human | Functional | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | |||
10696930 | 36098 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL144397 | 36098 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
9868889 | 72654 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL199443 | 72654 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
10647387 | 40204 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | |||
CHEMBL148022 | 40204 | None | 0 | Human | Functional | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | |||
9984109 | 38888 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
CHEMBL146720 | 38888 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | |||
9897637 | 118996 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | |||
CHEMBL342323 | 118996 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | |||
44405669 | 71995 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 0 | ChEMBL | 465 | 4 | 0 | 8 | 3.5 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccsc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197344 | 71995 | None | 0 | Human | Functional | pKi | = | 9.4 | 9.4 | - | 0 | ChEMBL | 465 | 4 | 0 | 8 | 3.5 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccsc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
10836606 | 165628 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL424128 | 165628 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
44405725 | 71859 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1c(Cl)cccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196914 | 71859 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1c(Cl)cccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
22464649 | 72473 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 459 | 4 | 0 | 7 | 3.4 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198836 | 72473 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 459 | 4 | 0 | 7 | 3.4 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
44405666 | 72898 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 451 | 4 | 0 | 8 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6c5OCC6)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL200315 | 72898 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 451 | 4 | 0 | 8 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6c5OCC6)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
9933975 | 133656 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5nccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL371221 | 133656 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5nccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
46900954 | 16659 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 508 | 6 | 1 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242081 | 16659 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 508 | 6 | 1 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900776 | 16646 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 496 | 5 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241824 | 16646 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 496 | 5 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900956 | 16661 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 522 | 6 | 1 | 7 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242167 | 16661 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 522 | 6 | 1 | 7 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
52942551 | 19307 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 400 | 4 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290486 | 19307 | None | 0 | Human | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 400 | 4 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
46900459 | 16645 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241738 | 16645 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
52947615 | 19143 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289394 | 19143 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
52947414 | 19308 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 414 | 4 | 0 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290487 | 19308 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 414 | 4 | 0 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
24804775 | 19350 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 2 | ChEMBL | 412 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290716 | 19350 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 2 | ChEMBL | 412 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44405702 | 72605 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cnccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL199269 | 72605 | None | 0 | Human | Functional | pKi | = | 9.1 | 9.1 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cnccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
46900455 | 16640 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 493 | 4 | 0 | 6 | 5.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241641 | 16640 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 493 | 4 | 0 | 6 | 5.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900457 | 16641 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241642 | 16641 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900612 | 16643 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 467 | 5 | 0 | 7 | 4.2 | CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
CHEMBL1241736 | 16643 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 467 | 5 | 0 | 7 | 4.2 | CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
46899639 | 16676 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 522 | 5 | 0 | 7 | 4.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242533 | 16676 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 522 | 5 | 0 | 7 | 4.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
11720815 | 16691 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 538 | 5 | 0 | 8 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242717 | 16691 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 538 | 5 | 0 | 8 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
44138098 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL513715 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1021/jm100482n | |||
44138098 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL513715 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44138098 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL513715 | 189581 | None | 0 | Human | Functional | pKi | = | 9 | 9.0 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44405573 | 71881 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 485 | 5 | 0 | 7 | 3.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5-c5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197007 | 71881 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 485 | 5 | 0 | 7 | 3.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5-c5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
44405574 | 72459 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 501 | 6 | 0 | 8 | 4.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Oc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198792 | 72459 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 501 | 6 | 0 | 8 | 4.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Oc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
44405575 | 72519 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 515 | 7 | 0 | 8 | 3.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198999 | 72519 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 515 | 7 | 0 | 8 | 3.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
46900610 | 16639 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 497 | 6 | 0 | 8 | 4.2 | CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
CHEMBL1241640 | 16639 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 497 | 6 | 0 | 8 | 4.2 | CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
11712756 | 16650 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 482 | 5 | 1 | 7 | 3.3 | CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
CHEMBL1241912 | 16650 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 482 | 5 | 1 | 7 | 3.3 | CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
22464842 | 71841 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 434 | 4 | 0 | 8 | 2.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5C#N)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196862 | 71841 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 434 | 4 | 0 | 8 | 2.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5C#N)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
9872238 | 72539 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 439 | 5 | 0 | 8 | 2.3 | COc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL199049 | 72539 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 439 | 5 | 0 | 8 | 2.3 | COc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
46900451 | 16633 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 439 | 4 | 0 | 6 | 4.3 | Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
CHEMBL1241547 | 16633 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 439 | 4 | 0 | 6 | 4.3 | Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
46900778 | 16647 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 450 | 4 | 0 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241825 | 16647 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 450 | 4 | 0 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
11655728 | 16651 | None | 7 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241913 | 16651 | None | 7 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46899637 | 16667 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 522 | 7 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242345 | 16667 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 522 | 7 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46899638 | 16671 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 5 | 0 | 7 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242436 | 16671 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 5 | 0 | 7 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46899640 | 16683 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 536 | 5 | 0 | 7 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242623 | 16683 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 536 | 5 | 0 | 7 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900150 | 16703 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242904 | 16703 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
44138104 | 178938 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL469345 | 178938 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
11797999 | 40538 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL148314 | 40538 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
44405701 | 71955 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ncccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197240 | 71955 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ncccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
22464720 | 72425 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 443 | 4 | 0 | 7 | 2.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Cl)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198696 | 72425 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 443 | 4 | 0 | 7 | 2.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Cl)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
46900453 | 16634 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 453 | 4 | 0 | 6 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241548 | 16634 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 453 | 4 | 0 | 6 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900958 | 16666 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 536 | 6 | 1 | 7 | 4.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1242257 | 16666 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 536 | 6 | 1 | 7 | 4.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
9979309 | 193091 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL522257 | 193091 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | |||
52942644 | 19349 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 398 | 4 | 1 | 4 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1290715 | 19349 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 398 | 4 | 1 | 4 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44592297 | 189599 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 448 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL513875 | 189599 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 448 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
9979309 | 193091 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL522257 | 193091 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
14519851 | 116812 | None | 30 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 187 | 3 | 1 | 2 | 2.2 | NCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL337539 | 116812 | None | 30 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 187 | 3 | 1 | 2 | 2.2 | NCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
2261792 | 116511 | None | 3 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 231 | 6 | 2 | 3 | 1.8 | OCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL336092 | 116511 | None | 3 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 231 | 6 | 2 | 3 | 1.8 | OCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
44405655 | 71902 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 453 | 5 | 0 | 8 | 2.6 | COc1ccc(C)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197064 | 71902 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 453 | 5 | 0 | 8 | 2.6 | COc1ccc(C)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
10584924 | 30418 | None | 0 | Human | Functional | pKi | = | 6.0 | 6.0 | - | 0 | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CC(C)NCCOc1cccc2[nH]ccc12 | 10.1021/jm970507t | |||
CHEMBL139230 | 30418 | None | 0 | Human | Functional | pKi | = | 6.0 | 6.0 | - | 0 | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CC(C)NCCOc1cccc2[nH]ccc12 | 10.1021/jm970507t | |||
22464806 | 71868 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 6 | 0 | 8 | 3.9 | COc1ccc(-c2ccccc2)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196961 | 71868 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 6 | 0 | 8 | 3.9 | COc1ccc(-c2ccccc2)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
10775772 | 30115 | None | 1 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 229 | 5 | 1 | 2 | 3.2 | CC(C)NCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL138963 | 30115 | None | 1 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 229 | 5 | 1 | 2 | 3.2 | CC(C)NCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
10588458 | 27619 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 275 | 8 | 0 | 2 | 4.5 | CCCN(C)CCCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | |||
CHEMBL136962 | 27619 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 275 | 8 | 0 | 2 | 4.5 | CCCN(C)CCCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | |||
6422277 | 30044 | None | 2 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL138907 | 30044 | None | 2 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
44592295 | 179115 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL471047 | 179115 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44592252 | 189303 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 6 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL511279 | 189303 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 466 | 6 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44592335 | 179031 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 462 | 5 | 0 | 5 | 4.2 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL470217 | 179031 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 462 | 5 | 0 | 5 | 4.2 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
10518850 | 35202 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143512 | 35202 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
10809674 | 119260 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
CHEMBL343196 | 119260 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | |||
44405586 | 71866 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 467 | 6 | 0 | 8 | 3.1 | CC(C)Oc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196958 | 71866 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 467 | 6 | 0 | 8 | 3.1 | CC(C)Oc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
11568826 | 132866 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | 9 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL370110 | 132866 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | 9 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
46900606 | 16632 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241546 | 16632 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
46900614 | 16644 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 496 | 6 | 0 | 8 | 4.4 | CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
CHEMBL1241737 | 16644 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 496 | 6 | 0 | 8 | 4.4 | CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | |||
46900782 | 16655 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 510 | 6 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241998 | 16655 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 510 | 6 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
44592296 | 178941 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469374 | 178941 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44592294 | 189372 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL511815 | 189372 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
10585509 | 29761 | None | 1 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 229 | 6 | 1 | 2 | 3.2 | CCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL138683 | 29761 | None | 1 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 229 | 6 | 1 | 2 | 3.2 | CCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
2543 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
5358 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
5358.0 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
54 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
CHEMBL128 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
DB00669 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | |||
2543 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
5358 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
5358.0 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
54 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
CHEMBL128 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
DB00669 | 3707 | None | 46 | Human | Functional | pKi | = | 7.6 | 7.6 | 2 | 14 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
9909089 | 187074 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL490417 | 187074 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | |||
9909089 | 187074 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL490417 | 187074 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
23274477 | 29129 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL138136 | 29129 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
2199302 | 30107 | None | 22 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 201 | 4 | 1 | 2 | 2.4 | CNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL138958 | 30107 | None | 22 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 201 | 4 | 1 | 2 | 2.4 | CNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
1328538 | 31592 | None | 7 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 291 | 6 | 0 | 2 | 4.4 | CN(CCOc1cccc2ccccc12)Cc1ccccc1 | 10.1021/jm970507t | |||
CHEMBL140416 | 31592 | None | 7 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 291 | 6 | 0 | 2 | 4.4 | CN(CCOc1cccc2ccccc12)Cc1ccccc1 | 10.1021/jm970507t | |||
2176 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
4828 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
4828.0 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
91 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
CHEMBL500 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
DB00960 | 3127 | None | 40 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 8 | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | |||
14519863 | 115265 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL334465 | 115265 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
9802530 | 35395 | None | 1 | Human | Functional | pKi | = | 7.6 | 7.6 | -11 | 2 | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143767 | 35395 | None | 1 | Human | Functional | pKi | = | 7.6 | 7.6 | -11 | 2 | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
14566707 | 119155 | None | 24 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 201 | 4 | 1 | 2 | 2.6 | NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL342704 | 119155 | None | 24 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 201 | 4 | 1 | 2 | 2.6 | NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
10365683 | 113141 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 435 | 7 | 3 | 5 | 2.4 | CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1 | 10.1021/jm960552l | |||
CHEMBL331240 | 113141 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 435 | 7 | 3 | 5 | 2.4 | CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1 | 10.1021/jm960552l | |||
44405677 | 71869 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1cc(Cl)ccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196962 | 71869 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1cc(Cl)ccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
22464831 | 71907 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 423 | 4 | 0 | 7 | 2.6 | Cc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197078 | 71907 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 423 | 4 | 0 | 7 | 2.6 | Cc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
22464606 | 72031 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1c(Cl)cc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197445 | 72031 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1c(Cl)cc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
44138104 | 178938 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL469345 | 178938 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1021/jm100482n | |||
44138104 | 178938 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469345 | 178938 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44592209 | 179286 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL472290 | 179286 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21 | 10.1016/j.bmcl.2009.02.056 | |||
52943861 | 19108 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289163 | 19108 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44592207 | 189472 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL512724 | 189472 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
10654938 | 78849 | None | 8 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 179 | 4 | 1 | 2 | 1.9 | CNCCOc1cccc(C)c1C | 10.1021/jm970507t | |||
CHEMBL2112766 | 78849 | None | 8 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 179 | 4 | 1 | 2 | 1.9 | CNCCOc1cccc(C)c1C | 10.1021/jm970507t | |||
52947622 | 19160 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1289510 | 19160 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
22464564 | 71856 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 461 | 4 | 0 | 9 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5ncnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL196907 | 71856 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 461 | 4 | 0 | 9 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5ncnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
22067856 | 29548 | None | 38 | Human | Functional | pKi | = | 5.5 | 5.5 | - | 0 | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm970507t | |||
CHEMBL138509 | 29548 | None | 38 | Human | Functional | pKi | = | 5.5 | 5.5 | - | 0 | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm970507t | |||
22464634 | 73048 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccc6ccccc6n5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL200951 | 73048 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccc6ccccc6n5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
10618751 | 35199 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | -25 | 2 | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143510 | 35199 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | -25 | 2 | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
52944840 | 18985 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
CHEMBL1287827 | 18985 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | |||
44405726 | 71989 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1cc(Cl)c(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197338 | 71989 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1cc(Cl)c(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
2303 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
4946 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
564 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
63 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
91536 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
CHEMBL27 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
CHEMBL452861 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
DB00571 | 3187 | None | 44 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 20 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | |||
44405665 | 73046 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.3 | COc1ccc(C(F)(F)F)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL200949 | 73046 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 507 | 5 | 0 | 8 | 3.3 | COc1ccc(C(F)(F)F)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
10635169 | 31590 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 261 | 7 | 0 | 2 | 4.1 | CCCN(C)CCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | |||
CHEMBL140415 | 31590 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 261 | 7 | 0 | 2 | 4.1 | CCCN(C)CCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | |||
13520547 | 27012 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL136470 | 27012 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
44592249 | 178957 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469567 | 178957 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
44592250 | 178958 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 442 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469568 | 178958 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 442 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
22464804 | 73047 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 489 | 5 | 0 | 8 | 3.4 | COc1ccc2ccccc2c1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL200950 | 73047 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 489 | 5 | 0 | 8 | 3.4 | COc1ccc2ccccc2c1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
44405587 | 133634 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 495 | 6 | 0 | 8 | 3.7 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCC(C)(C)C)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL371094 | 133634 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 495 | 6 | 0 | 8 | 3.7 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCC(C)(C)C)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
22464614 | 71882 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 469 | 6 | 0 | 9 | 2.3 | COc1ccc(OC)c(N2CCN(CCn3cnc4sc5c(c4c3=O)CCN(C)C5)CC2)c1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL197011 | 71882 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 469 | 6 | 0 | 9 | 2.3 | COc1ccc(OC)c(N2CCN(CCn3cnc4sc5c(c4c3=O)CCN(C)C5)CC2)c1 | 10.1016/j.bmcl.2005.04.077 | |||
37732 | 26831 | None | 47 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 151 | 4 | 1 | 2 | 1.3 | CNCCOc1ccccc1 | 10.1021/jm970507t | |||
CHEMBL136311 | 26831 | None | 47 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 151 | 4 | 1 | 2 | 1.3 | CNCCOc1ccccc1 | 10.1021/jm970507t | |||
44592251 | 179013 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 456 | 6 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469995 | 179013 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 456 | 6 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
5 | 139 | None | 45 | Human | Functional | pKi | = | 8.2 | 8.2 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
5202 | 139 | None | 45 | Human | Functional | pKi | = | 8.2 | 8.2 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pKi | = | 8.2 | 8.2 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
DB08839 | 139 | None | 45 | Human | Functional | pKi | = | 8.2 | 8.2 | -19 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | |||
10560632 | 26740 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL136236 | 26740 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
46900608 | 16638 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 427 | 4 | 0 | 8 | 2.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241639 | 16638 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 427 | 4 | 0 | 8 | 2.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
22002244 | 72367 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1ccc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198462 | 72367 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1ccc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | |||
14519865 | 31595 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL140417 | 31595 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
10263828 | 30881 | None | 9 | Human | Functional | pKi | = | 5.1 | 5.1 | - | 0 | ChEMBL | 243 | 6 | 1 | 2 | 3.6 | CC(C)NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL139737 | 30881 | None | 9 | Human | Functional | pKi | = | 5.1 | 5.1 | - | 0 | ChEMBL | 243 | 6 | 1 | 2 | 3.6 | CC(C)NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
44592334 | 178963 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 448 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
CHEMBL469589 | 178963 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 448 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | |||
10691904 | 35629 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143967 | 35629 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
11662592 | 72368 | None | 0 | Human | Functional | pKi | = | 8.0 | 8.0 | 15 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198463 | 72368 | None | 0 | Human | Functional | pKi | = | 8.0 | 8.0 | 15 | 2 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
3604129 | 30272 | None | 3 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
CHEMBL139103 | 30272 | None | 3 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | |||
2105 | 3054 | None | 28 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 25 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
47811 | 3054 | None | 28 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 25 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
48 | 3054 | None | 28 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 25 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
CHEMBL531 | 3054 | None | 28 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 25 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
DB01186 | 3054 | None | 28 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 25 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
4223 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
6918314 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
6918314.0 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
7427 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
CHEMBL439849 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
DB06684 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -707 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
1220 | 187 | None | 44 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -95 | 9 | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | |||
31 | 187 | None | 44 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -95 | 9 | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | |||
7 | 187 | None | 44 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -95 | 9 | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | |||
CHEMBL56 | 187 | None | 44 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -95 | 9 | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | |||
137 | 138 | None | 0 | Human | Functional | pIC50 | None | 11.9 | 11.9 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9774213 | |||||
7048565 | 138 | None | 0 | Human | Functional | pIC50 | None | 11.9 | 11.9 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9774213 | |||||
7048566 | 138 | None | 0 | Human | Functional | pIC50 | None | 11.9 | 11.9 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9774213 | |||||
1524 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
1524 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
197 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
197 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
3822 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
3822 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
3822.0 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
3822.0 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
88 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
88 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
CHEMBL51 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
CHEMBL51 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
DB12465 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | |||
DB12465 | 2181 | None | 61 | Human | Functional | pIC50 | None | 5.3 | 5.3 | -125 | 18 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | |||
5074 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | |||
5074 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | |||
97 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | |||
97 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | |||
CHEMBL267777 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | |||
CHEMBL267777 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | |||
DB12693 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | |||
DB12693 | 3332 | None | 53 | Human | Functional | pIC50 | None | 6.3 | 6.3 | -33 | 10 | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | |||
16 | 2253 | None | 10 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -177 | 5 | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | |||
9847194 | 2253 | None | 10 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -177 | 5 | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | |||
CHEMBL313714 | 2253 | None | 10 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -177 | 5 | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | |||
46 | 2905 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | |||
71351 | 2905 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | |||
CHEMBL2104619 | 2905 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | |||
DB06229 | 2905 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | |||
110 | 1174 | None | 16 | Human | Functional | pIC50 | None | 7.6 | 7.6 | -1 | 2 | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | |||
132552 | 1174 | None | 16 | Human | Functional | pIC50 | None | 7.6 | 7.6 | -1 | 2 | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | |||
CHEMBL159332 | 1174 | None | 16 | Human | Functional | pIC50 | None | 7.6 | 7.6 | -1 | 2 | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | |||
113 | 1852 | None | 12 | Human | Functional | pKB | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 | |||
128018 | 1852 | None | 12 | Human | Functional | pKB | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 | |||
CHEMBL119264 | 1852 | None | 12 | Human | Functional | pKB | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
19066203 | 12093 | None | 0 | Human | Binding | pEC50 | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1183904 | 12093 | None | 0 | Human | Binding | pEC50 | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL323986 | 12093 | None | 0 | Human | Binding | pEC50 | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
19066163 | 11390 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL111302 | 11390 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1180017 | 11390 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
5 | 139 | None | 45 | Rat | Binding | pEC50 | = | 7.6 | 7.6 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
5202 | 139 | None | 45 | Rat | Binding | pEC50 | = | 7.6 | 7.6 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pEC50 | = | 7.6 | 7.6 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
DB08839 | 139 | None | 45 | Rat | Binding | pEC50 | = | 7.6 | 7.6 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
CHEMBL5078078 | 217023 | None | 9 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | None | None | None | CC(C)(O)c1ccc(N2Cc3c(ccnc3-c3ccc(F)cc3OCC(F)(F)F)C2=O)cc1 | 10.6019/CHEMBL5303768 | |||||
5 | 139 | None | 45 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
5202 | 139 | None | 45 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
DB08839 | 139 | None | 45 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
137634921 | 156341 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 586 | 3 | 2 | 9 | 4.5 | O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | 10.1021/acs.jmedchem.7b00359 | |||
CHEMBL4064865 | 156341 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 586 | 3 | 2 | 9 | 4.5 | O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | 10.1021/acs.jmedchem.7b00359 | |||
11539632 | 70585 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
CHEMBL194837 | 70585 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
1043 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
149 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
8223 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
8223.0 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
CHEMBL442 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
DB00696 | 1582 | None | 6 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
9952249 | 52688 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 388 | 6 | 1 | 7 | 2.3 | c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
CHEMBL159396 | 52688 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 388 | 6 | 1 | 7 | 2.3 | c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
9846928 | 39691 | None | 14 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 457 | 6 | 3 | 5 | 4.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
CHEMBL147503 | 39691 | None | 14 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 457 | 6 | 3 | 5 | 4.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
11333554 | 96714 | None | 18 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 223 | 1 | 2 | 2 | 2.4 | N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL26379 | 96714 | None | 18 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 223 | 1 | 2 | 2 | 2.4 | N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
10531 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
10531.0 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
121 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
888 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
CHEMBL1732 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
DB00320 | 1420 | None | 13 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
10323598 | 38910 | None | 18 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
CHEMBL146735 | 38910 | None | 18 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
15646678 | 96712 | None | 14 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 214 | 1 | 3 | 2 | 2.3 | Oc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL26378 | 96712 | None | 14 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 214 | 1 | 3 | 2 | 2.3 | Oc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
9881526 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
CHEMBL296161 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
9881526 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
CHEMBL296161 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
10718709 | 39295 | None | 16 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 458 | 6 | 2 | 5 | 3.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
CHEMBL147071 | 39295 | None | 16 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 458 | 6 | 2 | 5 | 3.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
9881526 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9704558 | |||
CHEMBL296161 | 101302 | None | 1 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9704558 | |||
107780 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
14 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
CHEMBL15928 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
107780 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
14 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
CHEMBL15928 | 1844 | None | 35 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | -4 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
11344959 | 97346 | None | 33 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 216 | 1 | 2 | 1 | 2.7 | Fc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL26906 | 97346 | None | 33 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 216 | 1 | 2 | 1 | 2.7 | Fc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
1588 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
28864 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
28864.0 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
43 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
CHEMBL157138 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
DB00589 | 2325 | None | 21 | Rat | Binding | pIC50 | = | 8 | 8.0 | -58 | 43 | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
10552663 | 121203 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 478 | 8 | 1 | 6 | 3.5 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL357634 | 121203 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 478 | 8 | 1 | 6 | 3.5 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
10578117 | 44055 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 529 | 8 | 1 | 7 | 5.4 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
CHEMBL151420 | 44055 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 529 | 8 | 1 | 7 | 5.4 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
10790076 | 40001 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL147853 | 40001 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10076176 | 106491 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
CHEMBL3126382 | 106491 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
CHEMBL3139683 | 106491 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
10576874 | 41990 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 485 | 9 | 2 | 6 | 4.2 | CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL149488 | 41990 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 485 | 9 | 2 | 6 | 4.2 | CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10836986 | 168410 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 443 | 9 | 3 | 5 | 4.1 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL434125 | 168410 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 443 | 9 | 3 | 5 | 4.1 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10526736 | 10224 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
CHEMBL116031 | 10224 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
10671211 | 205184 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 449 | 6 | 0 | 5 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL61818 | 205184 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 449 | 6 | 0 | 5 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
122186880 | 123046 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 5 | ChEMBL | 415 | 3 | 0 | 5 | 4.8 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
CHEMBL3608450 | 123046 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 5 | ChEMBL | 415 | 3 | 0 | 5 | 4.8 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
2470 | 3653 | None | 40 | Rat | Binding | pIC50 | = | 6 | 6.0 | -43651 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
3300 | 3653 | None | 40 | Rat | Binding | pIC50 | = | 6 | 6.0 | -43651 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
5265 | 3653 | None | 40 | Rat | Binding | pIC50 | = | 6 | 6.0 | -43651 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
99 | 3653 | None | 40 | Rat | Binding | pIC50 | = | 6 | 6.0 | -43651 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
CHEMBL267930 | 3653 | None | 40 | Rat | Binding | pIC50 | = | 6 | 6.0 | -43651 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
10476735 | 13736 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1195096 | 13736 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL553833 | 13736 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10342423 | 99523 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL28312 | 99523 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL48925 | 99523 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
3082597 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL283606 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10072866 | 199931 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL51561 | 199931 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL56990 | 199931 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10671315 | 205469 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL63258 | 205469 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
10575553 | 205497 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL63432 | 205497 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
10767140 | 205828 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 482 | 8 | 1 | 5 | 4.5 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
CHEMBL65215 | 205828 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 482 | 8 | 1 | 5 | 4.5 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10251234 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1178932 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL50530 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10024943 | 97443 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL26975 | 97443 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL52485 | 97443 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
10571450 | 101926 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 374 | 3 | 0 | 4 | 4.3 | Cc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL300692 | 101926 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 374 | 3 | 0 | 4 | 4.3 | Cc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
57397383 | 67974 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 374 | 2 | 2 | 4 | 3.8 | Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 | 10.1016/j.bmcl.2011.09.006 | |||
CHEMBL1911194 | 67974 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 374 | 2 | 2 | 4 | 3.8 | Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 | 10.1016/j.bmcl.2011.09.006 | |||
10014217 | 99802 | None | 0 | Rat | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 233 | 2 | 0 | 3 | 2.1 | COc1cccc2c1CC(N1CCCC1)CO2 | 10.1021/jm00038a007 | |||
CHEMBL285010 | 99802 | None | 0 | Rat | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 233 | 2 | 0 | 3 | 2.1 | COc1cccc2c1CC(N1CCCC1)CO2 | 10.1021/jm00038a007 | |||
10719202 | 56573 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 6 | 3.1 | CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL164035 | 56573 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 6 | 3.1 | CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
9863146 | 197236 | None | 1 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL54720 | 197236 | None | 1 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
9863146 | 197236 | None | 1 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL54720 | 197236 | None | 1 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
10852612 | 205890 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 312 | 3 | 0 | 5 | 3.1 | c1cc2c(N3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
CHEMBL65736 | 205890 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 312 | 3 | 0 | 5 | 3.1 | c1cc2c(N3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
31101 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
31101.0 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
35 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
403 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
CHEMBL493 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
DB01200 | 729 | None | 28 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -48 | 35 | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
10849641 | 113153 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm970376w | |||
CHEMBL331304 | 113153 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm970376w | |||
10590360 | 205794 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 300 | 3 | 0 | 5 | 3.1 | CCCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL64948 | 205794 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 300 | 3 | 0 | 5 | 3.1 | CCCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10621021 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL65367 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
10621021 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL65367 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
10789334 | 165436 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 442 | 8 | 1 | 5 | 3.7 | CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL423599 | 165436 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 442 | 8 | 1 | 5 | 3.7 | CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
10621021 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
CHEMBL65367 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
2543 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
5358 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
5358.0 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
54 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
CHEMBL128 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
DB00669 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
10646958 | 11411 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL118012 | 11411 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10787241 | 54608 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1 | 10.1021/jm9805687 | |||
CHEMBL161066 | 54608 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1 | 10.1021/jm9805687 | |||
10788620 | 40060 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 427 | 8 | 2 | 4 | 5.1 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL147907 | 40060 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 427 | 8 | 2 | 4 | 5.1 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10131112 | 1552 | None | 18 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
8428 | 1552 | None | 18 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL364005 | 1552 | None | 18 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
15951404 | 125456 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 308 | 3 | 2 | 3 | 3.2 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4ccco4)cc23)C1 | nan | |||
CHEMBL3645480 | 125456 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 308 | 3 | 2 | 3 | 3.2 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4ccco4)cc23)C1 | nan | |||
10635163 | 165022 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 261 | 3 | 0 | 3 | 2.9 | CCCN1CCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
CHEMBL422453 | 165022 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 261 | 3 | 0 | 3 | 2.9 | CCCN1CCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
18366015 | 78403 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2110300 | 78403 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
10550367 | 115271 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 426 | 7 | 1 | 4 | 4.2 | COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2 | 10.1021/jm950861w | |||
CHEMBL334498 | 115271 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 426 | 7 | 1 | 4 | 4.2 | COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2 | 10.1021/jm950861w | |||
10664878 | 89304 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 340 | 4 | 3 | 3 | 2.2 | CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O | 10.1021/jm000956k | |||
CHEMBL2368255 | 89304 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 340 | 4 | 3 | 3 | 2.2 | CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O | 10.1021/jm000956k | |||
10516340 | 205924 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 272 | 1 | 0 | 5 | 2.3 | CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL65974 | 205924 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 272 | 1 | 0 | 5 | 2.3 | CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10529106 | 98367 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 490 | 5 | 3 | 5 | 3.4 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL274922 | 98367 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 490 | 5 | 3 | 5 | 3.4 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10646958 | 11411 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
CHEMBL118012 | 11411 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
73356443 | 89735 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376490 | 89735 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
11794750 | 119968 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1 | 10.1021/jm9805687 | |||
CHEMBL349185 | 119968 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1 | 10.1021/jm9805687 | |||
10838684 | 119204 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 487 | 10 | 3 | 7 | 3.6 | NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL342805 | 119204 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 487 | 10 | 3 | 7 | 3.6 | NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10814424 | 99058 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 475 | 6 | 2 | 4 | 4.8 | COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL280000 | 99058 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 475 | 6 | 2 | 4 | 4.8 | COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10574762 | 10145 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL115750 | 10145 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
10597901 | 10656 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL117046 | 10656 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10574762 | 10145 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
CHEMBL115750 | 10145 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
10601144 | 119452 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 490 | 11 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
CHEMBL344537 | 119452 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 490 | 11 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
9803620 | 162555 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL416688 | 162555 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
10575553 | 205497 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL63432 | 205497 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
10714071 | 89311 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 368 | 5 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368262 | 89311 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 368 | 5 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
10597901 | 10656 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704558 | |||
CHEMBL117046 | 10656 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704558 | |||
10740531 | 119930 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 9 | 2 | 5 | 3.4 | c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL348815 | 119930 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 414 | 9 | 2 | 5 | 3.4 | c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
2477 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
2477.0 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
36 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
437 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
CHEMBL49 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
DB00490 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
10617292 | 194821 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 342 | 3 | 0 | 4 | 3.8 | c1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL53416 | 194821 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 342 | 3 | 0 | 4 | 3.8 | c1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
2585 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
2585.0 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
522 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
551 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
CHEMBL723 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
DB01136 | 803 | None | 59 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -120 | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
10667886 | 56031 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 386 | 6 | 1 | 5 | 3.5 | c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL162463 | 56031 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 386 | 6 | 1 | 5 | 3.5 | c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
44214559 | 56514 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL163462 | 56514 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
10573843 | 120211 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 4.1 | CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL351346 | 120211 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 4.1 | CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
10504600 | 39961 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 471 | 10 | 2 | 6 | 4.0 | CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL147818 | 39961 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 471 | 10 | 2 | 6 | 4.0 | CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
71459969 | 79561 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
CHEMBL2114040 | 79561 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
15226949 | 102082 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
CHEMBL301765 | 102082 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
15226949 | 102082 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm960501o | |||
CHEMBL301765 | 102082 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm960501o | |||
10764869 | 119801 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 425 | 7 | 1 | 6 | 3.4 | N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL347665 | 119801 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 425 | 7 | 1 | 6 | 3.4 | N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
9911120 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
CHEMBL11265 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
10837591 | 118825 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL341854 | 118825 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10694177 | 205566 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL64003 | 205566 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
9841032 | 194849 | None | 1 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 343 | 3 | 0 | 5 | 3.2 | c1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL53573 | 194849 | None | 1 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 343 | 3 | 0 | 5 | 3.2 | c1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
14450355 | 120032 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 259 | 3 | 0 | 3 | 3.0 | CCCN1CCC=C2c3c(OC)cccc3OCC21 | 10.1021/jm00123a039 | |||
CHEMBL349824 | 120032 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 259 | 3 | 0 | 3 | 3.0 | CCCN1CCC=C2c3c(OC)cccc3OCC21 | 10.1021/jm00123a039 | |||
10696635 | 98963 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 497 | 10 | 3 | 5 | 4.3 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
CHEMBL279320 | 98963 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 497 | 10 | 3 | 5 | 4.3 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
10612178 | 119929 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 271 | 4 | 2 | 2 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL348811 | 119929 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 271 | 4 | 2 | 2 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1 | 10.1021/jm000956k | |||
3823 | 50235 | None | 31 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -38 | 11 | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
76973198 | 50235 | None | 31 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -38 | 11 | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
CHEMBL157101 | 50235 | None | 31 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | -38 | 11 | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
213 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
2717 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
5533 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
5533.0 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
CHEMBL621 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
DB00656 | 3853 | None | 34 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -3 | 43 | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
2247 | 505 | None | 55 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -35 | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
249 | 505 | None | 55 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -35 | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
2603 | 505 | None | 55 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -35 | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
CHEMBL296419 | 505 | None | 55 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -35 | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
DB00637 | 505 | None | 55 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | -35 | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
72548703 | 161661 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
CHEMBL4128926 | 161661 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
10551206 | 119322 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL343648 | 119322 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10719687 | 205457 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL63167 | 205457 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
110 | 1174 | None | 16 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
132552 | 1174 | None | 16 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
CHEMBL159332 | 1174 | None | 16 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
10718714 | 38153 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL146131 | 38153 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
73351905 | 89736 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376491 | 89736 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
10835665 | 38902 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm9910021 | |||
CHEMBL146729 | 38902 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm9910021 | |||
10549785 | 39096 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9910021 | |||
CHEMBL146891 | 39096 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9910021 | |||
10625408 | 39732 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 9 | 1 | 7 | 3.7 | CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL147555 | 39732 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 9 | 1 | 7 | 3.7 | CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10766277 | 40550 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 457 | 7 | 2 | 5 | 4.3 | CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL148325 | 40550 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 457 | 7 | 2 | 5 | 4.3 | CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
11796806 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL304857 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10717709 | 165377 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL423212 | 165377 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
11796806 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL304857 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
10504100 | 47754 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 8 | 4.2 | COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
CHEMBL154787 | 47754 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 7 | 1 | 8 | 4.2 | COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
10592324 | 103517 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 327 | 5 | 2 | 3 | 2.7 | CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1 | 10.1021/jm000956k | |||
CHEMBL3084967 | 103517 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 327 | 5 | 2 | 3 | 2.7 | CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1 | 10.1021/jm000956k | |||
11793287 | 163372 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 366 | 3 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL418678 | 163372 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 366 | 3 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
19978059 | 162542 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 420 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL416662 | 162542 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 420 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
11796806 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
CHEMBL304857 | 102772 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
10614907 | 98238 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 310 | 5 | 2 | 5 | 1.6 | c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
CHEMBL274001 | 98238 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 310 | 5 | 2 | 5 | 1.6 | c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
9930155 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL420874 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
9930155 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
CHEMBL420874 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
11792032 | 205279 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 348 | 2 | 0 | 5 | 4.0 | CN1CCN(c2nc3cc(-c4ccccc4)sc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL62366 | 205279 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 348 | 2 | 0 | 5 | 4.0 | CN1CCN(c2nc3cc(-c4ccccc4)sc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10733696 | 113391 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
CHEMBL331612 | 113391 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
150 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
1764 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
8226 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
8226.0 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
CHEMBL1201356 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
DB00353 | 2509 | None | 14 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -6 | 15 | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
9844873 | 101112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL294732 | 101112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.5b00258 | |||
10733696 | 113391 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
CHEMBL331612 | 113391 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
10597902 | 53016 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.9 | CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
CHEMBL159683 | 53016 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.9 | CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
9844873 | 101112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL294732 | 101112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
11 | 1187 | None | 17 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
124007 | 1187 | None | 17 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
CHEMBL304008 | 1187 | None | 17 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
10766319 | 38769 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.9 | OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL146628 | 38769 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.9 | OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
16 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
9847194 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
CHEMBL313714 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
10813769 | 121053 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL356315 | 121053 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
109 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
2689 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
CHEMBL27403 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
10753377 | 194835 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 253 | 1 | 1 | 5 | 1.3 | c1cnc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL53490 | 194835 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 253 | 1 | 1 | 5 | 1.3 | c1cnc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm960501o | |||
10757342 | 55123 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 310 | 4 | 1 | 4 | 3.3 | Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
CHEMBL161694 | 55123 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 310 | 4 | 1 | 4 | 3.3 | Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
44267168 | 9857 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 497 | 8 | 0 | 6 | 3.9 | CCCN1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11409 | 9857 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 497 | 8 | 0 | 6 | 3.9 | CCCN1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
10813413 | 206139 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL67460 | 206139 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
15951194 | 71662 | None | 11 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | CN1CC=C(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)CC1 | nan | |||
CHEMBL1963527 | 71662 | None | 11 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | CN1CC=C(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)CC1 | nan | |||
11797562 | 38154 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL146132 | 38154 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10695596 | 102848 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 468 | 8 | 1 | 5 | 3.9 | Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL305301 | 102848 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 468 | 8 | 1 | 5 | 3.9 | Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
18366015 | 78403 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2110300 | 78403 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
10718668 | 119983 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 9 | 3 | 6 | 3.4 | CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL349390 | 119983 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 457 | 9 | 3 | 6 | 3.4 | CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10502763 | 120206 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL351303 | 120206 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10645471 | 11046 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL117633 | 11046 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
10516184 | 14535 | None | 5 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm970376w | |||
CHEMBL120216 | 14535 | None | 5 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm970376w | |||
10789399 | 119938 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 443 | 9 | 2 | 6 | 3.3 | CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL348962 | 119938 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 443 | 9 | 2 | 6 | 3.3 | CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
10551207 | 38609 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.4 | C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL146502 | 38609 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.4 | C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10696275 | 38020 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 485 | 10 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL146023 | 38020 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 485 | 10 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10645471 | 11046 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
CHEMBL117633 | 11046 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
10814273 | 114416 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
CHEMBL333089 | 114416 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
67650695 | 79558 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
CHEMBL2114038 | 79558 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
134 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
1775 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
9681 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
9681.0 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
CHEMBL1065 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
DB00247 | 2514 | None | 19 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
2543 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
5358 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
5358.0 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
54 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
CHEMBL128 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
DB00669 | 3707 | None | 46 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | -17 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
10620429 | 56280 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
CHEMBL162805 | 56280 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
10644750 | 56528 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
CHEMBL163573 | 56528 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
10574671 | 120289 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 430 | 7 | 1 | 5 | 3.8 | S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
CHEMBL352159 | 120289 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 430 | 7 | 1 | 5 | 3.8 | S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
10719938 | 37971 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 492 | 9 | 1 | 6 | 3.7 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL145982 | 37971 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 492 | 9 | 1 | 6 | 3.7 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
18691541 | 78402 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 285 | 3 | 3 | 3 | 2.0 | N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2110299 | 78402 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 285 | 3 | 3 | 3 | 2.0 | N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
10809876 | 102708 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 381 | 5 | 0 | 5 | 2.4 | COc1ccccc1N1CCN(CCc2ccc3c(c2)OCC(=O)N3C)CC1 | 10.1021/jm970298c | |||
CHEMBL304438 | 102708 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 381 | 5 | 0 | 5 | 2.4 | COc1ccccc1N1CCN(CCc2ccc3c(c2)OCC(=O)N3C)CC1 | 10.1021/jm970298c | |||
10131112 | 1552 | None | 18 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
8428 | 1552 | None | 18 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL364005 | 1552 | None | 18 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
10837853 | 168261 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
CHEMBL433108 | 168261 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
7059581 | 167141 | None | 1 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
CHEMBL428892 | 167141 | None | 1 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
16 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
9847194 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
CHEMBL313714 | 2253 | None | 10 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
2351 | 3286 | None | 44 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -10 | 21 | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
2820 | 3286 | None | 44 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -10 | 21 | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
5035 | 3286 | None | 44 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -10 | 21 | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
CHEMBL81 | 3286 | None | 44 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -10 | 21 | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
DB00481 | 3286 | None | 44 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -10 | 21 | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
10717512 | 205526 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 4.9 | FC(F)(F)c1ccccc1CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL63713 | 205526 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 430 | 4 | 0 | 5 | 4.9 | FC(F)(F)c1ccccc1CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
15516682 | 10292 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 450 | 7 | 2 | 6 | 3.6 | CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL116161 | 10292 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 450 | 7 | 2 | 6 | 3.6 | CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1 | 10.1016/s0960-894x(99)00614-9 | |||
133 | 2496 | None | 39 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
1723 | 2496 | None | 39 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
28693 | 2496 | None | 39 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
CHEMBL19215 | 2496 | None | 39 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
DB13520 | 2496 | None | 39 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
18975369 | 101083 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
CHEMBL294547 | 101083 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
18975369 | 101083 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
CHEMBL294547 | 101083 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
10576618 | 205398 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 478 | 3 | 0 | 5 | 6.6 | FC(F)(F)c1cccc(N2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
CHEMBL62902 | 205398 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 478 | 3 | 0 | 5 | 6.6 | FC(F)(F)c1cccc(N2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
10738329 | 101789 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL299634 | 101789 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
1212 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
204 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
3372 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
3372.0 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
CHEMBL726 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
DB00623 | 1662 | None | 37 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -144 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
44305547 | 205788 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 4 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(Cc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL64903 | 205788 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 4 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(Cc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
10569395 | 101703 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 343 | 3 | 0 | 5 | 3.3 | C=CCN1CCN(c2nc3ccc4ncccc4c3n3cccc23)CC1 | 10.1021/jm960501o | |||
CHEMBL299097 | 101703 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 343 | 3 | 0 | 5 | 3.3 | C=CCN1CCN(c2nc3ccc4ncccc4c3n3cccc23)CC1 | 10.1021/jm960501o | |||
141 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
6089 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
CHEMBL12420 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
DB01488 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
124 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
2032 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
4636 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
4636.0 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
CHEMBL762 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
DB00935 | 2981 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
130 | 3500 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -8 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
3378093 | 3500 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -8 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
CHEMBL281350 | 3500 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -8 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
108029 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
23 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
CHEMBL18785 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
10838923 | 52651 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 3 | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm9811054 | |||
CHEMBL15933 | 52651 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 3 | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm9811054 | |||
11798094 | 54735 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
CHEMBL161176 | 54735 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
10787240 | 119870 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
CHEMBL348304 | 119870 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
1042 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
148 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
443884 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
443884.0 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
CHEMBL119443 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
DB01253 | 1581 | None | 13 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
196129 | 67820 | None | 12 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | -1 | 15 | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
CHEMBL1909065 | 67820 | None | 12 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | -1 | 15 | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
10547091 | 204555 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 369 | 5 | 1 | 6 | 3.4 | COc1ccccc1N1CCN(CCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
CHEMBL60885 | 204555 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 369 | 5 | 1 | 6 | 3.4 | COc1ccccc1N1CCN(CCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
10716915 | 55161 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 7 | 1 | 5 | 3.6 | Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL161723 | 55161 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 7 | 1 | 5 | 3.6 | Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
10572483 | 119951 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
CHEMBL349041 | 119951 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
10522029 | 205607 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 353 | 4 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL64167 | 205607 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 353 | 4 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4)CC3)ccc21 | 10.1021/jm970298c | |||
10524876 | 205783 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 397 | 7 | 1 | 6 | 4.2 | COc1ccccc1N1CCN(CCCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
CHEMBL64878 | 205783 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 397 | 7 | 1 | 6 | 4.2 | COc1ccccc1N1CCN(CCCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
10504095 | 165356 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL423022 | 165356 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
73347306 | 89728 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376483 | 89728 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
10645715 | 40276 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL148085 | 40276 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
9980269 | 99137 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL280586 | 99137 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL54266 | 99137 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10251234 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1178932 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL50530 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
9978353 | 11257 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
CHEMBL1178987 | 11257 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
CHEMBL52785 | 11257 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
10095594 | 12372 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1185501 | 12372 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL417550 | 12372 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
9981024 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL26018 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL300735 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10252000 | 98600 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL27650 | 98600 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL50188 | 98600 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
3082597 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL283606 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
3082597 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL283606 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
18691565 | 89306 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
CHEMBL2368257 | 89306 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
10643940 | 89310 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368261 | 89310 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1 | 10.1021/jm000956k | |||
10637485 | 101720 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 293 | 3 | 0 | 5 | 2.2 | C=CCN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
CHEMBL299231 | 101720 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 293 | 3 | 0 | 5 | 2.2 | C=CCN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
4189 | 209380 | None | 58 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -41 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
CHEMBL1559 | 209380 | None | 58 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -41 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
CHEMBL91 | 209380 | None | 58 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -41 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
10621020 | 110441 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL324287 | 110441 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
10805623 | 99306 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 320 | 1 | 1 | 4 | 2.9 | FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm00170a007 | |||
CHEMBL28178 | 99306 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 320 | 1 | 1 | 4 | 2.9 | FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm00170a007 | |||
10575878 | 35537 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL143890 | 35537 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
10766318 | 37784 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 10 | 2 | 6 | 4.1 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL145815 | 37784 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 10 | 2 | 6 | 4.1 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10551857 | 165467 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL423749 | 165467 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
10621020 | 110441 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
CHEMBL324287 | 110441 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
10766235 | 78891 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL2112862 | 78891 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10624003 | 206121 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.5 | CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL67367 | 206121 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.5 | CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
135398737 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
135398737.0 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
38 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
722 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
CHEMBL42 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
DB00363 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
146420029 | 184868 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
CHEMBL4851044 | 184868 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
10834909 | 165015 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
CHEMBL422366 | 165015 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
10503687 | 205535 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL63799 | 205535 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
67650716 | 79559 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
CHEMBL2114039 | 79559 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
71450983 | 79680 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
CHEMBL2115112 | 79680 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
44323506 | 209480 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
CHEMBL91534 | 209480 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
25014630 | 83572 | None | 1 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 326 | 3 | 3 | 4 | 3.3 | N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 | 10.1016/j.ejmech.2012.07.006 | |||
CHEMBL2203713 | 83572 | None | 1 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 326 | 3 | 3 | 4 | 3.3 | N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 | 10.1016/j.ejmech.2012.07.006 | |||
3198 | 207971 | None | 50 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
CHEMBL1201049 | 207971 | None | 50 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
CHEMBL808 | 207971 | None | 50 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
11744707 | 165004 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 454 | 6 | 0 | 5 | 4.3 | COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
CHEMBL422283 | 165004 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 454 | 6 | 0 | 5 | 4.3 | COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
10696986 | 52979 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 508 | 7 | 3 | 5 | 4.1 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15965 | 52979 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 508 | 7 | 3 | 5 | 4.1 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
44267181 | 9613 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 277 | 7 | 0 | 3 | 3.4 | CCCN(CCC)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11262 | 9613 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 277 | 7 | 0 | 3 | 3.4 | CCCN(CCC)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
10552023 | 98656 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 462 | 2 | 2 | 3 | 5.1 | CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12 | 10.1021/jm9811054 | |||
CHEMBL276928 | 98656 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 462 | 2 | 2 | 3 | 5.1 | CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12 | 10.1021/jm9811054 | |||
11795333 | 56287 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm980569z | |||
CHEMBL162858 | 56287 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm980569z | |||
10813272 | 38330 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 446 | 8 | 2 | 5 | 4.6 | CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
CHEMBL146285 | 38330 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 446 | 8 | 2 | 5 | 4.6 | CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
3191 | 102913 | None | 65 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
3191.0 | 102913 | None | 65 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
CHEMBL305660 | 102913 | None | 65 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
DB11742 | 102913 | None | 65 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
10378253 | 111460 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 266 | 1 | 0 | 4 | 2.2 | CN1CCN(c2nc3ccccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
CHEMBL327197 | 111460 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 266 | 1 | 0 | 4 | 2.2 | CN1CCN(c2nc3ccccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
10647243 | 99003 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 451 | 4 | 2 | 4 | 4.1 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL279646 | 99003 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 451 | 4 | 2 | 4 | 4.1 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10622257 | 102187 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 424 | 4 | 0 | 5 | 5.5 | c1ccc(CN2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL302447 | 102187 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 424 | 4 | 0 | 5 | 5.5 | c1ccc(CN2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
107715 | 203402 | None | 16 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
CHEMBL1255837 | 203402 | None | 16 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
CHEMBL601773 | 203402 | None | 16 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
10577311 | 39805 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 499 | 10 | 2 | 6 | 4.5 | CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL147660 | 39805 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 499 | 10 | 2 | 6 | 4.5 | CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10835928 | 121135 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 420 | 9 | 1 | 5 | 4.4 | CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL357007 | 121135 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 420 | 9 | 1 | 5 | 4.4 | CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
25060119 | 104370 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -32359 | 7 | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
CHEMBL3099899 | 104370 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -32359 | 7 | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
141 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.6 | 5.6 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
6089 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.6 | 5.6 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
CHEMBL12420 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.6 | 5.6 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
DB01488 | 1427 | None | 18 | Human | Binding | pIC50 | = | 5.6 | 5.6 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
19978038 | 197266 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
CHEMBL54914 | 197266 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
10623614 | 121114 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 454 | 8 | 2 | 5 | 4.7 | c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL356808 | 121114 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 454 | 8 | 2 | 5 | 4.7 | c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10647181 | 100920 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
CHEMBL293614 | 100920 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
135398737 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
135398737.0 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
38 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
722 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
CHEMBL42 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
DB00363 | 958 | None | 57 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -691 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
10838153 | 14106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
CHEMBL119785 | 14106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
10832055 | 205191 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 355 | 4 | 2 | 6 | 3.1 | Oc1nc2ccc(CCN3CCN(c4ccccc4O)CC3)cc2s1 | 10.1021/jm970298c | |||
CHEMBL61869 | 205191 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 355 | 4 | 2 | 6 | 3.1 | Oc1nc2ccc(CCN3CCN(c4ccccc4O)CC3)cc2s1 | 10.1021/jm970298c | |||
10838153 | 14106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL119785 | 14106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
11796081 | 54753 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 414 | 9 | 2 | 5 | 3.5 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL161192 | 54753 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 414 | 9 | 2 | 5 | 3.5 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10691928 | 39937 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 392 | 8 | 1 | 5 | 3.5 | CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL147786 | 39937 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 392 | 8 | 1 | 5 | 3.5 | CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10671996 | 118830 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 468 | 10 | 3 | 4 | 4.0 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1 | 10.1021/jm9910021 | |||
CHEMBL341897 | 118830 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 468 | 10 | 3 | 4 | 4.0 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1 | 10.1021/jm9910021 | |||
2477 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
2477.0 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
36 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
437 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
CHEMBL49 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
DB00490 | 745 | None | 38 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
42 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
56971 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
CHEMBL8412 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
10546537 | 120090 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 2 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL350277 | 120090 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 2 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
10519608 | 193537 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(CN2CCN(c3ncccc3-n3cccc3)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL52612 | 193537 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(CN2CCN(c3ncccc3-n3cccc3)CC2)cc1 | 10.1021/jm960501o | |||
2274 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
4917 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
4917.0 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
7279 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
CHEMBL728 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
DB00433 | 3173 | None | 38 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
10838188 | 167717 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 472 | 4 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL430122 | 167717 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 472 | 4 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10781299 | 11680 | None | 7 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
CHEMBL1181152 | 11680 | None | 7 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
CHEMBL157110 | 11680 | None | 7 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
19956256 | 115362 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | |||
CHEMBL334923 | 115362 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | |||
44341707 | 9466 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 464 | 9 | 2 | 6 | 4.0 | CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL111899 | 9466 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 464 | 9 | 2 | 6 | 4.0 | CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
15516681 | 10204 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 422 | 9 | 2 | 6 | 2.9 | CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL115989 | 10204 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 422 | 9 | 2 | 6 | 2.9 | CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
2543 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
5358 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
54 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
10596566 | 56585 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm980569z | |||
CHEMBL164111 | 56585 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm980569z | |||
10765655 | 114510 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL333341 | 114510 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
115 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
4296 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
CHEMBL274866 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
10526642 | 169376 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL441296 | 169376 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10838030 | 23515 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 468 | 8 | 0 | 5 | 4.7 | CCCN1CCCC12COc1cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c1C2 | 10.1021/jm950861w | |||
CHEMBL133375 | 23515 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 468 | 8 | 0 | 5 | 4.7 | CCCN1CCCC12COc1cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c1C2 | 10.1021/jm950861w | |||
2812 | 4781 | None | 63 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -51 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
CHEMBL104 | 4781 | None | 63 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | -51 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
10596387 | 168562 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL435060 | 168562 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10805740 | 89308 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 321 | 5 | 2 | 3 | 2.0 | CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
CHEMBL2368259 | 89308 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 321 | 5 | 2 | 3 | 2.0 | CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
277 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
2913 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
2913.0 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
765 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
CHEMBL516 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
DB00434 | 1301 | None | 39 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
10765655 | 114510 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
CHEMBL333341 | 114510 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
10468938 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
CHEMBL116092 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
10468938 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
CHEMBL116092 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
10468938 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9910021 | |||
CHEMBL116092 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9910021 | |||
10812465 | 35540 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 9 | 2 | 5 | 4.2 | c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL143893 | 35540 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 9 | 2 | 5 | 4.2 | c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10551328 | 206179 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
CHEMBL67684 | 206179 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
10718277 | 205720 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 447 | 6 | 0 | 4 | 4.2 | CN1C(=O)COc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL64610 | 205720 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 447 | 6 | 0 | 4 | 4.2 | CN1C(=O)COc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
9930155 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
CHEMBL420874 | 164127 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
10836850 | 40290 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 440 | 7 | 2 | 5 | 4.4 | c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL148095 | 40290 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 440 | 7 | 2 | 5 | 4.4 | c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10766570 | 205838 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
CHEMBL65321 | 205838 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
9866484 | 56294 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
CHEMBL162899 | 56294 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
11798502 | 56509 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 4.5 | FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL163376 | 56509 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 4.5 | FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
73351903 | 89729 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376484 | 89729 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 7.5 | 7.5 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
15951337 | 125454 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
CHEMBL3645476 | 125454 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
CHEMBL1200558 | 211058 | None | 19 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](N)C1=N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC)CS1 | nan | |||||
10550857 | 205904 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL65824 | 205904 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
2763724 | 98530 | None | 39 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 276 | 1 | 2 | 1 | 3.3 | Brc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL27592 | 98530 | None | 39 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 276 | 1 | 2 | 1 | 3.3 | Brc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
10573904 | 121372 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.9 | c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
CHEMBL358072 | 121372 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.9 | c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
3050532 | 99501 | None | 3 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 232 | 1 | 2 | 1 | 3.2 | Clc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL282994 | 99501 | None | 3 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 232 | 1 | 2 | 1 | 3.2 | Clc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
53263 | 99549 | None | 14 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 243 | 2 | 2 | 3 | 2.5 | O=[N+]([O-])c1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
CHEMBL283257 | 99549 | None | 14 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 243 | 2 | 2 | 3 | 2.5 | O=[N+]([O-])c1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
2761023 | 98820 | None | 45 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 3 | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
CHEMBL2011570 | 98820 | None | 45 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 3 | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
CHEMBL27811 | 98820 | None | 45 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 3 | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
44341625 | 111380 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 501 | 10 | 4 | 7 | 3.3 | CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL326723 | 111380 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 501 | 10 | 4 | 7 | 3.3 | CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1016/s0960-894x(99)00614-9 | |||
10477461 | 113456 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 424 | 9 | 2 | 6 | 3.1 | CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL331819 | 113456 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 424 | 9 | 2 | 6 | 3.1 | CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
73453 | 29624 | None | 14 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | -26 | 17 | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
CHEMBL1385840 | 29624 | None | 14 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | -26 | 17 | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
10468938 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
CHEMBL116092 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
10468938 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704560 | |||
CHEMBL116092 | 10246 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704560 | |||
9821397 | 100975 | None | 22 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 383 | 5 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(CCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
CHEMBL293923 | 100975 | None | 22 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 383 | 5 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(CCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
10759541 | 202610 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 339 | 4 | 1 | 5 | 3.4 | Oc1nc2ccc(CCN3CCN(c4ccccc4)CC3)cc2s1 | 10.1021/jm970298c | |||
CHEMBL59637 | 202610 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 339 | 4 | 1 | 5 | 3.4 | Oc1nc2ccc(CCN3CCN(c4ccccc4)CC3)cc2s1 | 10.1021/jm970298c | |||
10501785 | 205185 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 411 | 7 | 0 | 6 | 3.8 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
CHEMBL61819 | 205185 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 411 | 7 | 0 | 6 | 3.8 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
10625376 | 52467 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 505 | 5 | 3 | 4 | 4.7 | CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12 | 10.1021/jm9811054 | |||
CHEMBL15909 | 52467 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 505 | 5 | 3 | 4 | 4.7 | CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12 | 10.1021/jm9811054 | |||
44364110 | 35544 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL143894 | 35544 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
71461714 | 79679 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
CHEMBL2115111 | 79679 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
10809238 | 203598 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 371 | 4 | 0 | 5 | 3.1 | Cn1c(=O)sc2cc(CCN3CCN(c4ccc(F)cc4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL60318 | 203598 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 371 | 4 | 0 | 5 | 3.1 | Cn1c(=O)sc2cc(CCN3CCN(c4ccc(F)cc4)CC3)ccc21 | 10.1021/jm970298c | |||
10319624 | 99041 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL27991 | 99041 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL298534 | 99041 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10070029 | 165512 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL423841 | 165512 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL54089 | 165512 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10812693 | 102808 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 433 | 8 | 1 | 5 | 4.3 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL305062 | 102808 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 433 | 8 | 1 | 5 | 4.3 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
10251234 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1178932 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL50530 | 11249 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10092409 | 12050 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL1183479 | 12050 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL299561 | 12050 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10047322 | 97193 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
CHEMBL26783 | 97193 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
CHEMBL50993 | 97193 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
11743327 | 98756 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 428 | 8 | 1 | 5 | 3.9 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL27763 | 98756 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 428 | 8 | 1 | 5 | 3.9 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1 | 10.1021/jm00038a007 | |||
10265863 | 193433 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 283 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1COc2ccc3ccccc3c2C1 | 10.1021/jm00038a007 | |||
CHEMBL52438 | 193433 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 283 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1COc2ccc3ccccc3c2C1 | 10.1021/jm00038a007 | |||
6761 | 67821 | None | 11 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -43 | 18 | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
CHEMBL1909072 | 67821 | None | 11 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -43 | 18 | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
10409556 | 162466 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.3 | COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL416523 | 162466 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.3 | COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
10614906 | 110568 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL324931 | 110568 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
11796807 | 165638 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 428 | 9 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL424154 | 165638 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 428 | 9 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
9949172 | 10877 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL117249 | 10877 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
11794853 | 205533 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
CHEMBL63790 | 205533 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
10499348 | 203821 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 369 | 4 | 1 | 6 | 2.7 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4O)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL60447 | 203821 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 369 | 4 | 1 | 6 | 2.7 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4O)CC3)ccc21 | 10.1021/jm970298c | |||
15951272 | 125453 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
CHEMBL3645475 | 125453 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
10614906 | 110568 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
CHEMBL324931 | 110568 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
10600213 | 205567 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
CHEMBL64004 | 205567 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
3066250 | 70310 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL194305 | 70310 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
9911120 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
CHEMBL11265 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
10617665 | 52778 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 347 | 5 | 2 | 2 | 3.9 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL159470 | 52778 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 347 | 5 | 2 | 2 | 3.9 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
44267852 | 11199 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2c(ccc3ccccc23)O1 | 10.1021/jm00401a007 | |||
CHEMBL11787 | 11199 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2c(ccc3ccccc23)O1 | 10.1021/jm00401a007 | |||
10714457 | 101771 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 374 | 4 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(Cc3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL299524 | 101771 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 374 | 4 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(Cc3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
1971 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
2404 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
4543 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
4543.0 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
CHEMBL445 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
DB00540 | 2866 | None | 32 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
11668825 | 9593 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 415 | 7 | 2 | 5 | 3.8 | OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL112507 | 9593 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 415 | 7 | 2 | 5 | 3.8 | OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
10501944 | 11041 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL117579 | 11041 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
18691566 | 89305 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 299 | 4 | 3 | 3 | 2.3 | CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368256 | 89305 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 299 | 4 | 3 | 3 | 2.3 | CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
10571716 | 40507 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 378 | 8 | 1 | 5 | 3.3 | C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL148286 | 40507 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 378 | 8 | 1 | 5 | 3.3 | C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
969502 | 98164 | None | 3 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
CHEMBL1314789 | 98164 | None | 3 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
CHEMBL273490 | 98164 | None | 3 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
10689227 | 55833 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 350 | 8 | 2 | 5 | 2.4 | C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL162296 | 55833 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 350 | 8 | 2 | 5 | 2.4 | C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
10501944 | 11041 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
CHEMBL117579 | 11041 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
10693206 | 55178 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 415 | 9 | 1 | 5 | 4.2 | c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL161735 | 55178 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 415 | 9 | 1 | 5 | 4.2 | c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
109 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
2689 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
CHEMBL27403 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
109 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
2689 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
CHEMBL27403 | 902 | None | 26 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 7 | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
11796209 | 205846 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
CHEMBL65413 | 205846 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
10766320 | 38304 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL146265 | 38304 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
44341783 | 10101 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 454 | 7 | 3 | 7 | 3.0 | CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL115496 | 10101 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 454 | 7 | 3 | 7 | 3.0 | CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
49836386 | 18557 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 253 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 | 10.1021/jm100515z | |||
CHEMBL1275709 | 18557 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 253 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 | 10.1021/jm100515z | |||
31703 | 194829 | None | 40 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
CHEMBL359744 | 194829 | None | 40 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
CHEMBL53463 | 194829 | None | 40 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
10764998 | 113553 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
CHEMBL331970 | 113553 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
10502988 | 38023 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL146024 | 38023 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10764998 | 113553 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL331970 | 113553 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10838622 | 38175 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 485 | 9 | 3 | 6 | 4.5 | CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL146150 | 38175 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 485 | 9 | 3 | 6 | 4.5 | CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
44296810 | 162088 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 404 | 7 | 0 | 7 | 3.3 | COc1ccc2c(c1)nc(N1CCN(CCCCn3cccn3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL415933 | 162088 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 404 | 7 | 0 | 7 | 3.3 | COc1ccc2c(c1)nc(N1CCN(CCCCn3cccn3)CC1)c1cccn12 | 10.1021/jm960501o | |||
44267205 | 98462 | None | 0 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 366 | 5 | 0 | 4 | 3.6 | CCCN1CCN(Cc2ccccc2)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL275481 | 98462 | None | 0 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 366 | 5 | 0 | 4 | 3.6 | CCCN1CCN(Cc2ccccc2)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
11005810 | 10469 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL116463 | 10469 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
26987 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
26987.0 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
6063 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
671 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
CHEMBL1626 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
DB00283 | 949 | None | 27 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | -138 | 21 | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
10548444 | 56929 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 390 | 7 | 2 | 6 | 2.2 | c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1 | 10.1021/jm980569z | |||
CHEMBL164413 | 56929 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 390 | 7 | 2 | 6 | 2.2 | c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1 | 10.1021/jm980569z | |||
10644514 | 101111 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 397 | 6 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
CHEMBL294730 | 101111 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 397 | 6 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
18975338 | 102672 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 416 | 7 | 2 | 6 | 2.5 | OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL304197 | 102672 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 416 | 7 | 2 | 6 | 2.5 | OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
10386282 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm980569z | |||
CHEMBL420965 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm980569z | |||
376254 | 118568 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 284 | 1 | 0 | 4 | 2.4 | CN1CCN(c2nc3cc(F)ccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
CHEMBL341474 | 118568 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 284 | 1 | 0 | 4 | 2.4 | CN1CCN(c2nc3cc(F)ccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
180 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
200 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
2160 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
2160.0 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
CHEMBL629 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
DB00321 | 401 | None | 38 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
10600212 | 102768 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F | 10.1021/jm981133m | |||
CHEMBL304833 | 102768 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F | 10.1021/jm981133m | |||
173 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
5011 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
CHEMBL18772 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
9911120 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
CHEMBL11265 | 9625 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
10835403 | 26424 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 410 | 5 | 0 | 4 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC12COc1ccccc1C2 | 10.1021/jm950861w | |||
CHEMBL135952 | 26424 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 410 | 5 | 0 | 4 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC12COc1ccccc1C2 | 10.1021/jm950861w | |||
1220 | 187 | None | 44 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -7413 | 43 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
31 | 187 | None | 44 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -7413 | 43 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
7 | 187 | None | 44 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -7413 | 43 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
CHEMBL56 | 187 | None | 44 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -7413 | 43 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
10665840 | 89309 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 354 | 4 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368260 | 89309 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 354 | 4 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
9911120 | 9625 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11265 | 9625 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
10546440 | 195880 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 360 | 3 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL54125 | 195880 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 360 | 3 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
10852406 | 52856 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 309 | 4 | 2 | 3 | 3.0 | Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1 | 10.1021/jm000956k | |||
CHEMBL159536 | 52856 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 309 | 4 | 2 | 3 | 3.0 | Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1 | 10.1021/jm000956k | |||
10502669 | 56577 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.1 | CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL164046 | 56577 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.1 | CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10764284 | 55450 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
CHEMBL161969 | 55450 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
13673326 | 16421 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccc3ccccc3c2O1 | 10.1021/jm00401a007 | |||
CHEMBL12311 | 16421 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccc3ccccc3c2O1 | 10.1021/jm00401a007 | |||
23374587 | 54588 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 267 | 4 | 1 | 4 | 2.0 | c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
CHEMBL161045 | 54588 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 267 | 4 | 1 | 4 | 2.0 | c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
5 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
5202 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
DB08839 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
5 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
5202 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
DB08839 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
5 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
5202 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
DB08839 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
10768115 | 119789 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 513 | 9 | 2 | 6 | 4.1 | CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL347570 | 119789 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 513 | 9 | 2 | 6 | 4.1 | CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10789000 | 205776 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 435 | 6 | 1 | 5 | 5.2 | Oc1nc2ccc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
CHEMBL64845 | 205776 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 435 | 6 | 1 | 5 | 5.2 | Oc1nc2ccc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
10251673 | 99544 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL283207 | 99544 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL52396 | 99544 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10646959 | 40128 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL147961 | 40128 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10321248 | 99480 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL28287 | 99480 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL50722 | 99480 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
2726 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
2726.0 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
621 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
83 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
CHEMBL71 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
DB00477 | 919 | None | 48 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | -147 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
10719857 | 205401 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 363 | 3 | 0 | 4 | 4.0 | C[N+]1(Cc2ccccc2)CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL62911 | 205401 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 363 | 3 | 0 | 4 | 4.0 | C[N+]1(Cc2ccccc2)CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
2393 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
5078 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
5078.0 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
51 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
CHEMBL905 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
DB00953 | 3334 | None | 46 | Human | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
10693140 | 53095 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL159759 | 53095 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
11795644 | 40446 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 406 | 8 | 1 | 5 | 4.0 | CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL148233 | 40446 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 406 | 8 | 1 | 5 | 4.0 | CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10552243 | 39982 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 5.4 | c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL147838 | 39982 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 468 | 7 | 1 | 5 | 5.4 | c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10756517 | 189282 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL51118 | 189282 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10756517 | 189282 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm960501o | |||
CHEMBL51118 | 189282 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm960501o | |||
10550488 | 35664 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL144002 | 35664 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
161 | 754 | None | 4 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -16 | 6 | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
4284720 | 754 | None | 4 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -16 | 6 | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
CHEMBL1255834 | 754 | None | 4 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | -16 | 6 | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
10811876 | 102183 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
CHEMBL302431 | 102183 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
9949172 | 10877 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
CHEMBL117249 | 10877 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
10498554 | 196468 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 357 | 3 | 0 | 5 | 3.5 | Cc1ccnc2c1nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL54246 | 196468 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 357 | 3 | 0 | 5 | 3.5 | Cc1ccnc2c1nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
10539089 | 51973 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 257 | 3 | 2 | 2 | 2.1 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL158638 | 51973 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 257 | 3 | 2 | 2 | 2.1 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1 | 10.1021/jm000956k | |||
15222791 | 28568 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 219 | 1 | 1 | 3 | 1.8 | COc1cccc2c1CC1(CCCN1)CO2 | 10.1021/jm950861w | |||
CHEMBL137643 | 28568 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 219 | 1 | 1 | 3 | 1.8 | COc1cccc2c1CC1(CCCN1)CO2 | 10.1021/jm950861w | |||
10574570 | 56248 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.1 | CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm980569z | |||
CHEMBL162722 | 56248 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 4.1 | CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm980569z | |||
10719203 | 38390 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 471 | 9 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL146335 | 38390 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 471 | 9 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10505438 | 56371 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 496 | 9 | 1 | 8 | 3.9 | Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1 | 10.1021/jm980569z | |||
CHEMBL163114 | 56371 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 496 | 9 | 1 | 8 | 3.9 | Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1 | 10.1021/jm980569z | |||
10788207 | 203223 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 419 | 4 | 0 | 4 | 3.4 | CN1C(=O)COc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL60047 | 203223 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 419 | 4 | 0 | 4 | 3.4 | CN1C(=O)COc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
10552573 | 38152 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 476 | 10 | 4 | 5 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1 | 10.1021/jm9910021 | |||
CHEMBL146129 | 38152 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 476 | 10 | 4 | 5 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1 | 10.1021/jm9910021 | |||
10764757 | 44041 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 423 | 6 | 4 | 5 | 3.0 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15139 | 44041 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 423 | 6 | 4 | 5 | 3.0 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10645615 | 101055 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
CHEMBL294368 | 101055 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
11647963 | 110961 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.3 | OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL326125 | 110961 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 444 | 9 | 3 | 6 | 3.3 | OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
10386282 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL420965 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10386282 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
CHEMBL420965 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
10811007 | 53161 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL159819 | 53161 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10386282 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL420965 | 164195 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10503731 | 10291 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
CHEMBL116153 | 10291 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
3117 | 210300 | None | 60 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | -3 | 16 | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
CHEMBL964 | 210300 | None | 60 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | -3 | 16 | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
10644749 | 120048 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1 | 10.1021/jm9805687 | |||
CHEMBL349893 | 120048 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1 | 10.1021/jm9805687 | |||
10527882 | 35602 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL143947 | 35602 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
21138 | 98504 | None | 30 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | -162 | 7 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | 10.1021/jm00401a007 | |||
CHEMBL275742 | 98504 | None | 30 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | -162 | 7 | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | 10.1021/jm00401a007 | |||
10548259 | 188329 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 387 | 3 | 0 | 7 | 2.9 | c1cnc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL49932 | 188329 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 387 | 3 | 0 | 7 | 2.9 | c1cnc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
10252256 | 52793 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
CHEMBL159483 | 52793 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
10252256 | 52793 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
CHEMBL159483 | 52793 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
11797644 | 53439 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL160070 | 53439 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10812592 | 100938 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 431 | 8 | 1 | 4 | 5.1 | FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL293678 | 100938 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 431 | 8 | 1 | 4 | 5.1 | FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
15951342 | 125455 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 324 | 3 | 2 | 3 | 3.7 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)C1 | nan | |||
CHEMBL3645479 | 125455 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 324 | 3 | 2 | 3 | 3.7 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)C1 | nan | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.3 | 8.3 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.3 | 8.3 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.3 | 8.3 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.3 | 8.3 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
5 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
5202 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
DB08839 | 139 | None | 45 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
10670534 | 205894 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL65765 | 205894 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
11797644 | 53439 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL160070 | 53439 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10811007 | 53161 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
CHEMBL159819 | 53161 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
9824884 | 51874 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 447 | 4 | 2 | 4 | 4.3 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15855 | 51874 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 447 | 4 | 2 | 4 | 4.3 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10412190 | 52934 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15961 | 52934 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
49836496 | 18562 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 246 | 2 | 1 | 1 | 3.5 | CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 | 10.1021/jm100515z | |||
CHEMBL1275791 | 18562 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 246 | 2 | 1 | 1 | 3.5 | CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 | 10.1021/jm100515z | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
4223 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
6918314 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
6918314.0 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
7427 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
CHEMBL439849 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
DB06684 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
42 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
56971 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
CHEMBL8412 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
10338595 | 162594 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 360 | 9 | 0 | 4 | 4.0 | CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL416747 | 162594 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 360 | 9 | 0 | 4 | 4.0 | CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
42 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
56971 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
CHEMBL8412 | 2063 | None | 41 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | -1778 | 17 | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
23786480 | 15269 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
CHEMBL12124 | 15269 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
121852 | 10168 | None | 5 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11592 | 10168 | None | 5 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL301060 | 10168 | None | 5 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
115 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
4296 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
CHEMBL274866 | 3791 | None | 36 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
3082597 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL283606 | 99613 | None | 5 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10759465 | 164990 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 338 | 6 | 1 | 5 | 2.3 | CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL422191 | 164990 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 338 | 6 | 1 | 5 | 2.3 | CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
10527884 | 28382 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 458 | 8 | 1 | 5 | 3.9 | COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2 | 10.1021/jm950861w | |||
CHEMBL137486 | 28382 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 458 | 8 | 1 | 5 | 3.9 | COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2 | 10.1021/jm950861w | |||
10551525 | 100724 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
CHEMBL292262 | 100724 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
10618751 | 35199 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -4 | 4 | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143510 | 35199 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -4 | 4 | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
10623434 | 102367 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
CHEMBL303514 | 102367 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
44341637 | 9603 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 445 | 9 | 3 | 7 | 2.7 | OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL112558 | 9603 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 445 | 9 | 3 | 7 | 2.7 | OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
44214559 | 56514 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL163462 | 56514 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
145 | 140 | None | 16 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -8 | 29 | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
1832 | 140 | None | 16 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -8 | 29 | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
CHEMBL7257 | 140 | None | 16 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -8 | 29 | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
DB14010 | 140 | None | 16 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -8 | 29 | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
3081681 | 98567 | None | 1 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 442 | 6 | 0 | 7 | 3.4 | O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1021/jm00107a028 | |||
CHEMBL276175 | 98567 | None | 1 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 442 | 6 | 0 | 7 | 3.4 | O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1021/jm00107a028 | |||
9890331 | 56383 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL163127 | 56383 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
18366015 | 78403 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2110300 | 78403 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
10666301 | 193545 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 361 | 3 | 0 | 5 | 3.3 | Fc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL52625 | 193545 | None | 0 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 361 | 3 | 0 | 5 | 3.3 | Fc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
10646633 | 51297 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 437 | 3 | 2 | 4 | 3.7 | COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15808 | 51297 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 437 | 3 | 2 | 4 | 3.7 | COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
44344504 | 112895 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
CHEMBL330803 | 112895 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
44341657 | 113120 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 408 | 9 | 3 | 6 | 2.5 | OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL331143 | 113120 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 408 | 9 | 3 | 6 | 2.5 | OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
73347307 | 89732 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 257 | 2 | 2 | 3 | 2.8 | Cc1[nH]c2ccc([N+](=O)[O-])cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376487 | 89732 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 257 | 2 | 2 | 3 | 2.8 | Cc1[nH]c2ccc([N+](=O)[O-])cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
44344504 | 112895 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
CHEMBL330803 | 112895 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
10834908 | 52681 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
CHEMBL159381 | 52681 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
11796808 | 53069 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 3.8 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL159733 | 53069 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 3.8 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
10590206 | 205261 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL62274 | 205261 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10646873 | 38459 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL146391 | 38459 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10105889 | 24191 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
CHEMBL133939 | 24191 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
10694810 | 206225 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL68019 | 206225 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
11797241 | 194462 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 437 | 3 | 0 | 7 | 4.1 | c1cnc2ccc3nc(N4CCN(Cc5ccc6c(c5)OCO6)CC4)c4cccn4c3c2c1 | 10.1021/jm960501o | |||
CHEMBL52867 | 194462 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 437 | 3 | 0 | 7 | 4.1 | c1cnc2ccc3nc(N4CCN(Cc5ccc6c(c5)OCO6)CC4)c4cccn4c3c2c1 | 10.1021/jm960501o | |||
10741528 | 55127 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 434 | 7 | 1 | 5 | 4.2 | Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL161696 | 55127 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 434 | 7 | 1 | 5 | 4.2 | Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
10836301 | 52980 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 4.1 | CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL159650 | 52980 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 4.1 | CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
108029 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
23 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL18785 | 3414 | None | 45 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | -3 | 13 | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
2869 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
60 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
60857 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
60857.0 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
CHEMBL1185 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
DB00315 | 4152 | None | 54 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
10528410 | 39393 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 471 | 8 | 2 | 5 | 4.6 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL147148 | 39393 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 471 | 8 | 2 | 5 | 4.6 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
10624680 | 122084 | None | 13 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
CHEMBL359447 | 122084 | None | 13 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.2 | 8.2 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
10719448 | 35612 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 478 | 9 | 2 | 6 | 3.4 | O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL143952 | 35612 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 478 | 9 | 2 | 6 | 3.4 | O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10673854 | 44466 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 533 | 7 | 1 | 8 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
CHEMBL151894 | 44466 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 533 | 7 | 1 | 8 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
10645076 | 202766 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 407 | 4 | 1 | 5 | 4.4 | Oc1nc2ccc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
CHEMBL59741 | 202766 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 407 | 4 | 1 | 5 | 4.4 | Oc1nc2ccc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
121852 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL11592 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
CHEMBL301060 | 10168 | None | 5 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
10040815 | 97113 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL264027 | 97113 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL26715 | 97113 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
15516683 | 10074 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 438 | 8 | 2 | 6 | 3.5 | CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL115352 | 10074 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 438 | 8 | 2 | 6 | 3.5 | CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
10691383 | 100829 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 383 | 6 | 1 | 6 | 3.8 | COc1ccccc1N1CCN(CCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
CHEMBL292935 | 100829 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 383 | 6 | 1 | 6 | 3.8 | COc1ccccc1N1CCN(CCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
25070577 | 111729 | None | 5 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 304 | 3 | 2 | 4 | 2.3 | CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2 | 10.1021/jm5003292 | |||
CHEMBL3286557 | 111729 | None | 5 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 304 | 3 | 2 | 4 | 2.3 | CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2 | 10.1021/jm5003292 | |||
9867902 | 55235 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
CHEMBL161780 | 55235 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
9867902 | 55235 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
CHEMBL161780 | 55235 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
10525100 | 119585 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
CHEMBL345657 | 119585 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
10341917 | 168152 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL432332 | 168152 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
10502495 | 53731 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 425 | 6 | 3 | 4 | 3.4 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL16035 | 53731 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 425 | 6 | 3 | 4 | 3.4 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10592083 | 35610 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 324 | 5 | 2 | 5 | 2.1 | NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL143951 | 35610 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 324 | 5 | 2 | 5 | 2.1 | NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
182585 | 15453 | None | 12 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -1 | 3 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
CHEMBL12152 | 15453 | None | 12 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -1 | 3 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
10782381 | 89307 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 326 | 4 | 2 | 3 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368258 | 89307 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 326 | 4 | 2 | 3 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1 | 10.1021/jm000956k | |||
10598044 | 205752 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
CHEMBL64727 | 205752 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
10551680 | 99098 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 454 | 7 | 2 | 4 | 4.7 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
CHEMBL280314 | 99098 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 454 | 7 | 2 | 4 | 4.7 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
10833258 | 96471 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 374 | 4 | 0 | 5 | 4.4 | C(=C/c1ccccc1)\CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL261977 | 96471 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 374 | 4 | 0 | 5 | 4.4 | C(=C/c1ccccc1)\CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
1524 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
197 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
3822 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
3822.0 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
88 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
CHEMBL51 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
DB12465 | 2181 | None | 61 | Human | Binding | pIC50 | = | 5.2 | 5.2 | -2344 | 51 | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
10839082 | 39725 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 499 | 10 | 2 | 6 | 4.3 | CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL147546 | 39725 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 499 | 10 | 2 | 6 | 4.3 | CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10602052 | 119329 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 520 | 10 | 1 | 7 | 3.9 | CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL343667 | 119329 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 520 | 10 | 1 | 7 | 3.9 | CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10691904 | 35629 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | -6 | 4 | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143967 | 35629 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | -6 | 4 | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
9911120 | 9625 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11265 | 9625 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
10569470 | 100966 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 344 | 4 | 0 | 7 | 2.2 | CCOC(=O)CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
CHEMBL293879 | 100966 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 344 | 4 | 0 | 7 | 2.2 | CCOC(=O)CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
10789717 | 79557 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
CHEMBL2114036 | 79557 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
10600063 | 120075 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 460 | 9 | 1 | 4 | 4.2 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL350153 | 120075 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 460 | 9 | 1 | 4 | 4.2 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1 | 10.1021/jm9805687 | |||
10707563 | 28363 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 275 | 3 | 0 | 3 | 3.3 | CCCN1CCCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
CHEMBL137478 | 28363 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 275 | 3 | 0 | 3 | 3.3 | CCCN1CCCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
10091430 | 9883 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 384 | 7 | 1 | 4 | 3.3 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL11425 | 9883 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 384 | 7 | 1 | 4 | 3.3 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1 | 10.1016/0960-894X(96)00174-6 | |||
10452995 | 194858 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 390 | 4 | 0 | 5 | 4.0 | COc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL53662 | 194858 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 390 | 4 | 0 | 5 | 4.0 | COc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
10600871 | 165045 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
CHEMBL422504 | 165045 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
10733823 | 56296 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 311 | 5 | 1 | 5 | 2.0 | c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
CHEMBL162930 | 56296 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 311 | 5 | 1 | 5 | 2.0 | c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
10717072 | 163338 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 421 | 4 | 0 | 5 | 4.0 | Cn1c(=O)sc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
CHEMBL418499 | 163338 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 421 | 4 | 0 | 5 | 4.0 | Cn1c(=O)sc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
10530932 | 169781 | None | 14 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 561 | 7 | 1 | 9 | 4.4 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(C)(=O)=O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
CHEMBL443762 | 169781 | None | 14 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 561 | 7 | 1 | 9 | 4.4 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(C)(=O)=O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
9981671 | 14547 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 459 | 7 | 1 | 9 | 3.1 | COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
CHEMBL12028 | 14547 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 459 | 7 | 1 | 9 | 3.1 | COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
10627612 | 44259 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 615 | 7 | 1 | 9 | 5.3 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(=O)(=O)C(F)(F)F)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
CHEMBL151695 | 44259 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 615 | 7 | 1 | 9 | 5.3 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(=O)(=O)C(F)(F)F)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
10429859 | 12046 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
CHEMBL1183429 | 12046 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
CHEMBL296395 | 12046 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
135398745 | 2914 | None | 65 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -162 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
135398745.0 | 2914 | None | 65 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -162 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
47 | 2914 | None | 65 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -162 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
CHEMBL715 | 2914 | None | 65 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -162 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
DB00334 | 2914 | None | 65 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | -162 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
173 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
5011 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
CHEMBL18772 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
10739272 | 100793 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3sccc3n2c1 | 10.1021/jm950543x | |||
CHEMBL292725 | 100793 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3sccc3n2c1 | 10.1021/jm950543x | |||
173 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
5011 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
CHEMBL18772 | 3262 | None | 58 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | -2 | 22 | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
10689339 | 205549 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 352 | 2 | 0 | 5 | 4.0 | Fc1ccc(N2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL63905 | 205549 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 352 | 2 | 0 | 5 | 4.0 | Fc1ccc(N2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
10714509 | 101644 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 375 | 3 | 0 | 5 | 3.7 | Cc1ccnc2c1nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
CHEMBL298649 | 101644 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 375 | 3 | 0 | 5 | 3.7 | Cc1ccnc2c1nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
11059058 | 10093 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
CHEMBL115444 | 10093 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
10504096 | 118999 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL342330 | 118999 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
114 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
6426760 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
CHEMBL292779 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
114 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
6426760 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
CHEMBL292779 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
10694895 | 102500 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 4.7 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL303997 | 102500 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 4.7 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1 | 10.1021/jm981133m | |||
10501945 | 54950 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
CHEMBL161410 | 54950 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
10741826 | 39210 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL146991 | 39210 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
10573164 | 205542 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 402 | 2 | 0 | 5 | 4.9 | FC(F)(F)c1cccc(N2CCN(c3nc4sccc4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
CHEMBL63845 | 205542 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 402 | 2 | 0 | 5 | 4.9 | FC(F)(F)c1cccc(N2CCN(c3nc4sccc4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
44267161 | 163137 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 456 | 10 | 0 | 5 | 4.4 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
CHEMBL417608 | 163137 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 456 | 10 | 0 | 5 | 4.4 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
114 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
6426760 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
CHEMBL292779 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
73354882 | 89727 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376482 | 89727 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
114 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
6426760 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
CHEMBL292779 | 2254 | None | 15 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
10693207 | 37992 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
CHEMBL145997 | 37992 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
10530035 | 51647 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 522 | 8 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL15837 | 51647 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 522 | 8 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10645335 | 188820 | None | 0 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 411 | 3 | 0 | 5 | 4.5 | Clc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm960501o | |||
CHEMBL50456 | 188820 | None | 0 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 411 | 3 | 0 | 5 | 4.5 | Clc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm960501o | |||
10768329 | 40261 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 521 | 11 | 3 | 7 | 3.0 | CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL148071 | 40261 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 521 | 11 | 3 | 7 | 3.0 | CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10836290 | 55453 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 3.1 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1 | 10.1021/jm980569z | |||
CHEMBL161970 | 55453 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 428 | 8 | 1 | 5 | 3.1 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1 | 10.1021/jm980569z | |||
11795525 | 121180 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 404 | 8 | 2 | 6 | 3.5 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm9910021 | |||
CHEMBL357408 | 121180 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 404 | 8 | 2 | 6 | 3.5 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm9910021 | |||
10766321 | 40155 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL147979 | 40155 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
6604720 | 15279 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
CHEMBL12129 | 15279 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
10621021 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
CHEMBL65367 | 205842 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
134551 | 358 | None | 18 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | -5 | 21 | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
271 | 358 | None | 18 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | -5 | 21 | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
885 | 358 | None | 18 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | -5 | 21 | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
CHEMBL1403281 | 358 | None | 18 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | -5 | 21 | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
10505525 | 38393 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL146338 | 38393 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10767244 | 40102 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 485 | 10 | 3 | 6 | 4.1 | CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL147940 | 40102 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 485 | 10 | 3 | 6 | 4.1 | CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10096048 | 98909 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL278917 | 98909 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
9804849 | 67477 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 472 | 8 | 1 | 5 | 5.1 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
CHEMBL189118 | 67477 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 472 | 8 | 1 | 5 | 5.1 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
9981024 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL26018 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL300735 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10786628 | 38466 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 390 | 7 | 1 | 5 | 3.1 | CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL146396 | 38466 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 390 | 7 | 1 | 5 | 3.1 | CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
14450364 | 56019 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 247 | 1 | 0 | 3 | 2.6 | COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2 | 10.1021/jm00123a039 | |||
CHEMBL162449 | 56019 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 247 | 1 | 0 | 3 | 2.6 | COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2 | 10.1021/jm00123a039 | |||
11626724 | 110539 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL324751 | 110539 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
6426761 | 13962 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm980569z | |||
CHEMBL119668 | 13962 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm980569z | |||
9881324 | 28380 | None | 3 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
CHEMBL137485 | 28380 | None | 3 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
10709057 | 120132 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 296 | 3 | 1 | 4 | 3.3 | Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
CHEMBL350637 | 120132 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 296 | 3 | 1 | 4 | 3.3 | Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
44341798 | 9818 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 424 | 8 | 3 | 6 | 3.1 | CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL113831 | 9818 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 424 | 8 | 3 | 6 | 3.1 | CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
11798621 | 40312 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 471 | 9 | 3 | 6 | 3.8 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL148110 | 40312 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 471 | 9 | 3 | 6 | 3.8 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
10412189 | 77282 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
CHEMBL2079627 | 77282 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
10670211 | 120284 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 3.9 | c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
CHEMBL352123 | 120284 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 428 | 9 | 1 | 5 | 3.9 | c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
10739818 | 111206 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL326371 | 111206 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10719245 | 37819 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 472 | 10 | 2 | 6 | 4.1 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL145849 | 37819 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 472 | 10 | 2 | 6 | 4.1 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
176 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2157 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2157.0 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2566 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
CHEMBL633 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
DB01118 | 398 | None | 47 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -10 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2105 | 3054 | None | 28 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | -27 | 33 | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
47811 | 3054 | None | 28 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | -27 | 33 | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
48 | 3054 | None | 28 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | -27 | 33 | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
CHEMBL531 | 3054 | None | 28 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | -27 | 33 | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
DB01186 | 3054 | None | 28 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | -27 | 33 | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
10500370 | 52806 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 386 | 7 | 2 | 5 | 3.7 | c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
CHEMBL159493 | 52806 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 386 | 7 | 2 | 5 | 3.7 | c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
10670879 | 119932 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.4 | C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL348864 | 119932 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 442 | 9 | 1 | 5 | 4.4 | C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
10739818 | 111206 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
CHEMBL326371 | 111206 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
44341609 | 9897 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 472 | 9 | 2 | 6 | 3.9 | Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL114303 | 9897 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 472 | 9 | 2 | 6 | 3.9 | Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
10600678 | 119261 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 476 | 10 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
CHEMBL343217 | 119261 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 476 | 10 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
10811964 | 168437 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
CHEMBL434315 | 168437 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
3245407 | 48119 | None | 21 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL1550957 | 48119 | None | 21 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
441383 | 20340 | None | 41 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -74 | 17 | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
CHEMBL1306 | 20340 | None | 41 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | -74 | 17 | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
10720175 | 38581 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
CHEMBL146483 | 38581 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
10788768 | 56511 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 430 | 8 | 2 | 6 | 3.0 | OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL163386 | 56511 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 430 | 8 | 2 | 6 | 3.0 | OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
10588665 | 89303 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 278 | 3 | 2 | 2 | 4.2 | N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368254 | 89303 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 278 | 3 | 2 | 2 | 4.2 | N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
9981024 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL26018 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
CHEMBL300735 | 96150 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
10247171 | 205885 | None | 0 | Rat | Binding | pIC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
CHEMBL65710 | 205885 | None | 0 | Rat | Binding | pIC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
10811801 | 120208 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 415 | 8 | 1 | 6 | 2.9 | c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
CHEMBL351311 | 120208 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 415 | 8 | 1 | 6 | 2.9 | c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
10519108 | 52960 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 311 | 5 | 2 | 5 | 1.6 | OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL159627 | 52960 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 311 | 5 | 2 | 5 | 1.6 | OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
10780344 | 120000 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 297 | 4 | 2 | 5 | 1.4 | O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
CHEMBL349528 | 120000 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 297 | 4 | 2 | 5 | 1.4 | O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
10526737 | 102797 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.5 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
CHEMBL304993 | 102797 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.5 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
10526567 | 40281 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL148087 | 40281 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
10456869 | 9994 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.6 | CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
CHEMBL114877 | 9994 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 458 | 9 | 2 | 6 | 3.6 | CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
10494885 | 89302 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 306 | 4 | 1 | 2 | 4.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
CHEMBL2368253 | 89302 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 306 | 4 | 1 | 2 | 4.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
18691565 | 89306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
CHEMBL2368257 | 89306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
10834414 | 189002 | None | 0 | Rat | Binding | pIC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.4 | c1ccc(CN2CCN(c3nc4ccc5ncccc5c4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
CHEMBL50740 | 189002 | None | 0 | Rat | Binding | pIC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.4 | c1ccc(CN2CCN(c3nc4ccc5ncccc5c4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
10504097 | 40406 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
CHEMBL148194 | 40406 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
9802530 | 35395 | None | 1 | Human | Binding | pIC50 | = | 7.0 | 7.0 | -2 | 4 | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143767 | 35395 | None | 1 | Human | Binding | pIC50 | = | 7.0 | 7.0 | -2 | 4 | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
10526736 | 10224 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
CHEMBL116031 | 10224 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
6426761 | 13962 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm9704560 | |||
CHEMBL119668 | 13962 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm9704560 | |||
23533297 | 193134 | None | 2 | Guinea pig | Binding | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5209320 | 193134 | None | 2 | Guinea pig | Binding | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5222828 | 193134 | None | 2 | Guinea pig | Binding | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
2869 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
60 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
60857 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
60857.0 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
CHEMBL1185 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
DB00315 | 4152 | None | 54 | Human | Binding | pKd | = | 8.8 | 8.8 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
23533297 | 193134 | None | 2 | Guinea pig | Binding | pKi | = | 11 | 11.0 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5209320 | 193134 | None | 2 | Guinea pig | Binding | pKi | = | 11 | 11.0 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5222828 | 193134 | None | 2 | Guinea pig | Binding | pKi | = | 11 | 11.0 | - | 1 | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
1043 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
149 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
8223 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
8223.0 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
CHEMBL442 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
DB00696 | 1582 | None | 6 | Rat | Binding | pKi | = | 10.0 | 10.0 | 4 | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
11797998 | 35701 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 1 | 3 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
CHEMBL144030 | 35701 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 1 | 3 | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
24881753 | 137289 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 14 | 2 | ChEMBL | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL374973 | 137289 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 14 | 2 | ChEMBL | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
107780 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
14 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL15928 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
107780 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
14 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL15928 | 1844 | None | 35 | Human | Binding | pKi | = | 9.9 | 9.9 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
44351656 | 117162 | None | 0 | Human | Binding | pKi | = | 9.9 | 9.9 | 5 | 3 | ChEMBL | 499 | 6 | 2 | 7 | 4.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm9703552 | |||
CHEMBL339308 | 117162 | None | 0 | Human | Binding | pKi | = | 9.9 | 9.9 | 5 | 3 | ChEMBL | 499 | 6 | 2 | 7 | 4.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm9703552 | |||
44443130 | 93822 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
CHEMBL247428 | 93822 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
9909089 | 187074 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL490417 | 187074 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
6160690 | 119385 | None | 30 | Human | Binding | pKi | = | 9.7 | 9.7 | 6 | 3 | ChEMBL | 377 | 8 | 2 | 3 | 3.6 | COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1 | 10.1021/jm9604890 | |||
CHEMBL344127 | 119385 | None | 30 | Human | Binding | pKi | = | 9.7 | 9.7 | 6 | 3 | ChEMBL | 377 | 8 | 2 | 3 | 3.6 | COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1 | 10.1021/jm9604890 | |||
71461632 | 78809 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 2 | 3 | ChEMBL | 472 | 6 | 0 | 5 | 3.6 | Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
CHEMBL2112662 | 78809 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 2 | 3 | ChEMBL | 472 | 6 | 0 | 5 | 3.6 | Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
44404240 | 72552 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 3 | ChEMBL | 441 | 2 | 0 | 5 | 3.6 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL199088 | 72552 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 3 | ChEMBL | 441 | 2 | 0 | 5 | 3.6 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
59636728 | 125751 | None | 0 | Chinese hamster | Binding | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 544 | 7 | 1 | 7 | 4.6 | O=C(NC1CCN(c2ncccc2Cl)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647266 | 125751 | None | 0 | Chinese hamster | Binding | pKi | = | 9.6 | 9.6 | - | 1 | ChEMBL | 544 | 7 | 1 | 7 | 4.6 | O=C(NC1CCN(c2ncccc2Cl)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
124 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
2032 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
4636 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
4636.0 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
CHEMBL762 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
DB00935 | 2981 | None | 32 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
9955819 | 118208 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 3 | ChEMBL | 458 | 5 | 0 | 5 | 3.6 | Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
CHEMBL340786 | 118208 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 3 | ChEMBL | 458 | 5 | 0 | 5 | 3.6 | Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
188 | 3391 | None | 49 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 6 | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
196968 | 3391 | None | 49 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 6 | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
CHEMBL473186 | 3391 | None | 49 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 6 | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
10073139 | 184402 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 464 | 5 | 1 | 5 | 4.6 | O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL484059 | 184402 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 464 | 5 | 1 | 5 | 4.6 | O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
44404225 | 133602 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL370852 | 133602 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 3 | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
10838063 | 78807 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
CHEMBL2112660 | 78807 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
10531 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
10531.0 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
121 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
888 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
CHEMBL1732 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
DB00320 | 1420 | None | 13 | Rat | Binding | pKi | = | 9.4 | 9.4 | -5 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
9977716 | 170233 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 390 | 4 | 2 | 4 | 3.2 | Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL444398 | 170233 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 390 | 4 | 2 | 4 | 3.2 | Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2008.08.084 | |||
10454806 | 187991 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL496520 | 187991 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
2869 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
60 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
60857 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
60857.0 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
CHEMBL1185 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
DB00315 | 4152 | None | 54 | Human | Binding | pKi | = | 9.4 | 9.4 | -5 | 7 | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1039/d3md00677h | |||
45104767 | 204067 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
CHEMBL605785 | 204067 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
45104767 | 204067 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
CHEMBL605785 | 204067 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
10649124 | 19477 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
CHEMBL129813 | 19477 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
10672840 | 78808 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 2 | 3 | ChEMBL | 494 | 5 | 0 | 5 | 4.5 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
CHEMBL2112661 | 78808 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 2 | 3 | ChEMBL | 494 | 5 | 0 | 5 | 4.5 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
10601619 | 116900 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
CHEMBL338015 | 116900 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 3 | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
59636724 | 126276 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 483 | 7 | 0 | 7 | 3.5 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CC(Oc2cccnc2)C1 | nan | |||
CHEMBL3650029 | 126276 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 483 | 7 | 0 | 7 | 3.5 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CC(Oc2cccnc2)C1 | nan | |||
10434550 | 12103 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 52 | 3 | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1183948 | 12103 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 52 | 3 | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL325359 | 12103 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 52 | 3 | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
2543 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
5358 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
5358.0 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
54 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
DB00669 | 3707 | None | 46 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1039/d3md00677h | |||
24881204 | 188529 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 2 | ChEMBL | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL502138 | 188529 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 2 | ChEMBL | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
10673329 | 99386 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 10 | 3 | ChEMBL | 512 | 8 | 0 | 7 | 5.2 | COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1021/jm970457s | |||
CHEMBL282229 | 99386 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 10 | 3 | ChEMBL | 512 | 8 | 0 | 7 | 5.2 | COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1021/jm970457s | |||
49850672 | 56402 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -1 | 9 | ChEMBL | 404 | 5 | 1 | 5 | 4.1 | COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1631532 | 56402 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -1 | 9 | ChEMBL | 404 | 5 | 1 | 5 | 4.1 | COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
49850872 | 56474 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -1 | 9 | ChEMBL | 388 | 5 | 1 | 4 | 3.9 | CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1632206 | 56474 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -1 | 9 | ChEMBL | 388 | 5 | 1 | 4 | 3.9 | CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
9909089 | 187074 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL490417 | 187074 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100714c | |||
10478217 | 188193 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -2 | 3 | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL497980 | 188193 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -2 | 3 | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
10071738 | 192708 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 3 | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL521506 | 192708 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 3 | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
9979309 | 193091 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -5 | 3 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL522257 | 193091 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -5 | 3 | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
9909089 | 187074 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
CHEMBL490417 | 187074 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | -23 | 7 | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
44404229 | 70510 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 1 | 3 | ChEMBL | 397 | 2 | 0 | 5 | 3.1 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL194647 | 70510 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 1 | 3 | ChEMBL | 397 | 2 | 0 | 5 | 3.1 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
59636723 | 125746 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | O=C(NC1CCN(c2ccccc2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647261 | 125746 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | O=C(NC1CCN(c2ccccc2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
59636782 | 125767 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 540 | 8 | 1 | 8 | 4.0 | COc1cccnc1N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
CHEMBL3647282 | 125767 | None | 0 | Chinese hamster | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 540 | 8 | 1 | 8 | 4.0 | COc1cccnc1N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
24881754 | 188399 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 2 | ChEMBL | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL500284 | 188399 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 2 | ChEMBL | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
44402885 | 71838 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 25 | 2 | ChEMBL | 469 | 4 | 0 | 4 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL196848 | 71838 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 25 | 2 | ChEMBL | 469 | 4 | 0 | 4 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
10001971 | 184430 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -5 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.5 | Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL484260 | 184430 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -5 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.5 | Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1 | 10.1016/j.bmcl.2008.08.084 | |||
10341129 | 186904 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 403 | 4 | 1 | 6 | 2.6 | Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL489195 | 186904 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 403 | 4 | 1 | 6 | 2.6 | Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
10319235 | 187243 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 3 | ChEMBL | 407 | 4 | 1 | 5 | 3.1 | CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL491839 | 187243 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 3 | ChEMBL | 407 | 4 | 1 | 5 | 3.1 | CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1 | 10.1016/j.bmcl.2008.08.084 | |||
9955522 | 72514 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 452 | 3 | 0 | 6 | 3.7 | Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL198975 | 72514 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 452 | 3 | 0 | 6 | 3.7 | Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1 | 10.1016/j.bmcl.2005.06.042 | |||
9832057 | 52331 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
CHEMBL158941 | 52331 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
9832057 | 52331 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
CHEMBL158941 | 52331 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 3 | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
44279549 | 99494 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 606 | 11 | 4 | 7 | 4.6 | CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL282950 | 99494 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 3 | ChEMBL | 606 | 11 | 4 | 7 | 4.6 | CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
59636764 | 125761 | None | 0 | Chinese hamster | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 484 | 9 | 1 | 6 | 4.2 | COc1cccc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
CHEMBL3647276 | 125761 | None | 0 | Chinese hamster | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 484 | 9 | 1 | 6 | 4.2 | COc1cccc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
44279525 | 105568 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL31217 | 105568 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
44279525 | 105568 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL31217 | 105568 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
24881689 | 170235 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL444404 | 170235 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
24881203 | 173334 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL452387 | 173334 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
11655728 | 16651 | None | 7 | Human | Binding | pKi | = | 9.1 | 9.1 | -16 | 6 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
CHEMBL1241913 | 16651 | None | 7 | Human | Binding | pKi | = | 9.1 | 9.1 | -16 | 6 | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
10275633 | 91988 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL241463 | 91988 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
49850870 | 56405 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -6 | 9 | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1631535 | 56405 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -6 | 9 | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
10048342 | 186938 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL489393 | 186938 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2008.08.084 | |||
10023176 | 187052 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 3 | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL490211 | 187052 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 3 | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
44580783 | 193269 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 31 | 3 | ChEMBL | 414 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL523064 | 193269 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 31 | 3 | ChEMBL | 414 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
44404241 | 133512 | None | 1 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 3 | ChEMBL | 423 | 2 | 0 | 5 | 3.7 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL370625 | 133512 | None | 1 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 3 | ChEMBL | 423 | 2 | 0 | 5 | 3.7 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
10385855 | 14430 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL120055 | 14430 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL321818 | 14430 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 3 | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
24881264 | 188414 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 13 | 2 | ChEMBL | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL500488 | 188414 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 13 | 2 | ChEMBL | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
59636727 | 125755 | None | 0 | Chinese hamster | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 364 | 5 | 1 | 5 | 2.6 | CNC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647270 | 125755 | None | 0 | Chinese hamster | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 364 | 5 | 1 | 5 | 2.6 | CNC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
59636707 | 125753 | None | 0 | Chinese hamster | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 484 | 7 | 1 | 7 | 3.9 | O=C(NCc1ccc2c(c1)OCO2)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647268 | 125753 | None | 0 | Chinese hamster | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 484 | 7 | 1 | 7 | 3.9 | O=C(NCc1ccc2c(c1)OCO2)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
22184652 | 85086 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 5 | 2 | 7 | 2.8 | COc1cc(N2CCCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
CHEMBL224195 | 85086 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 491 | 5 | 2 | 7 | 2.8 | COc1cc(N2CCCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
124 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
2032 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
4636 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
4636.0 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
CHEMBL762 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
DB00935 | 2981 | None | 32 | Rat | Binding | pKi | = | 9.0 | 9.0 | -2 | 32 | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
45104862 | 203291 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
CHEMBL601013 | 203291 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
45104862 | 203291 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
CHEMBL601013 | 203291 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
107780 | 1844 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
14 | 1844 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
CHEMBL15928 | 1844 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 17 | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
28 | 3496 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
3292447 | 3496 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
CHEMBL20963 | 3496 | None | 35 | Human | Binding | pKi | = | 9 | 9.0 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
10802304 | 108592 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 4 | 3 | ChEMBL | 274 | 9 | 2 | 2 | 4.0 | CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
CHEMBL320079 | 108592 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 4 | 3 | ChEMBL | 274 | 9 | 2 | 2 | 4.0 | CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
10613373 | 111368 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 3 | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
CHEMBL326667 | 111368 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 3 | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
49850669 | 56403 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -5 | 3 | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1631533 | 56403 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -5 | 3 | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
10454807 | 186939 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -5 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL489394 | 186939 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -5 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
59636767 | 125771 | None | 0 | Chinese hamster | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
CHEMBL3647286 | 125771 | None | 0 | Chinese hamster | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
44404268 | 72177 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 3 | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL197947 | 72177 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 3 | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
9957274 | 135370 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 3 | ChEMBL | 491 | 4 | 0 | 7 | 3.8 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL372743 | 135370 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 3 | ChEMBL | 491 | 4 | 0 | 7 | 3.8 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
44404249 | 140448 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -3 | 3 | ChEMBL | 412 | 2 | 0 | 6 | 2.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL380812 | 140448 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -3 | 3 | ChEMBL | 412 | 2 | 0 | 6 | 2.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
5 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
5202 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
DB08839 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
5 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
5202 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
DB08839 | 139 | None | 45 | Rat | Binding | pKi | = | 9.0 | 9.0 | -13 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
10665156 | 109035 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 8 | 2 | ChEMBL | 344 | 11 | 1 | 3 | 4.9 | CCCCCCCCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
CHEMBL321190 | 109035 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 8 | 2 | ChEMBL | 344 | 11 | 1 | 3 | 4.9 | CCCCCCCCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.0 | 9.0 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.0 | 9.0 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.0 | 9.0 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.0 | 9.0 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
59636758 | 125745 | None | 0 | Chinese hamster | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 511 | 7 | 1 | 7 | 4.3 | O=C(Nc1ccc(N2CCOCC2)cc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647260 | 125745 | None | 0 | Chinese hamster | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 511 | 7 | 1 | 7 | 4.3 | O=C(Nc1ccc(N2CCOCC2)cc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
28 | 3496 | None | 35 | Human | Binding | pKi | = | 8.9 | 8.9 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
3292447 | 3496 | None | 35 | Human | Binding | pKi | = | 8.9 | 8.9 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
CHEMBL20963 | 3496 | None | 35 | Human | Binding | pKi | = | 8.9 | 8.9 | 13 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
106 | 148 | None | 19 | Human | Binding | pKi | = | 8.9 | 8.9 | 4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
1797 | 148 | None | 19 | Human | Binding | pKi | = | 8.9 | 8.9 | 4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
CHEMBL97450 | 148 | None | 19 | Human | Binding | pKi | = | 8.9 | 8.9 | 4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
49850673 | 56408 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -10 | 3 | ChEMBL | 418 | 6 | 1 | 5 | 4.5 | CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1631538 | 56408 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -10 | 3 | ChEMBL | 418 | 6 | 1 | 5 | 4.5 | CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
49852001 | 56475 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -6 | 3 | ChEMBL | 402 | 6 | 1 | 4 | 4.3 | CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1632207 | 56475 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -6 | 3 | ChEMBL | 402 | 6 | 1 | 4 | 4.3 | CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
49850567 | 56485 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -6 | 9 | ChEMBL | 452 | 6 | 1 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1632217 | 56485 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -6 | 9 | ChEMBL | 452 | 6 | 1 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49850570 | 56488 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -7 | 9 | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1632220 | 56488 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -7 | 9 | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
44580740 | 187868 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL495703 | 187868 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
10174199 | 187799 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 3 | ChEMBL | 481 | 9 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
CHEMBL495213 | 187799 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 3 | ChEMBL | 481 | 9 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
44404236 | 70580 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL194809 | 70580 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
1042 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
148 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
443884 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
443884.0 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
CHEMBL119443 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
DB01253 | 1581 | None | 13 | Rat | Binding | pKi | = | 8.9 | 8.9 | -5 | 16 | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
19066163 | 11390 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL111302 | 11390 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1180017 | 11390 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 28 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
24881752 | 171862 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL446745 | 171862 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
24881202 | 172689 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL448902 | 172689 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
59636755 | 126280 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 5 | 0 | 5 | 3.2 | Cc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
CHEMBL3650033 | 126280 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 5 | 0 | 5 | 3.2 | Cc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
196129 | 67820 | None | 12 | Rat | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
CHEMBL1909065 | 67820 | None | 12 | Rat | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
59636746 | 125766 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 502 | 6 | 0 | 8 | 3.6 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCN(c2nccs2)CC1 | nan | |||
CHEMBL3647281 | 125766 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 502 | 6 | 0 | 8 | 3.6 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCN(c2nccs2)CC1 | nan | |||
59636781 | 126286 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)n1 | nan | |||
CHEMBL3650039 | 126286 | None | 0 | Chinese hamster | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)n1 | nan | |||
10791125 | 18968 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
CHEMBL128699 | 18968 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
1884 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
4440 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
4440.0 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
45 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
CHEMBL1278 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
DB00952 | 2735 | None | 40 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 5 | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1039/d3md00677h | |||
44342784 | 9829 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 2 | ChEMBL | 444 | 4 | 2 | 2 | 5.8 | Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL113950 | 9829 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 2 | ChEMBL | 444 | 4 | 2 | 2 | 5.8 | Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
44342506 | 10127 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 2 | ChEMBL | 464 | 4 | 2 | 2 | 6.2 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL115663 | 10127 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 2 | ChEMBL | 464 | 4 | 2 | 2 | 6.2 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
44402887 | 71758 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 79 | 2 | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL196600 | 71758 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 79 | 2 | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
10577268 | 82421 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 15 | 3 | ChEMBL | 498 | 8 | 1 | 7 | 5.1 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
CHEMBL21724 | 82421 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 15 | 3 | ChEMBL | 498 | 8 | 1 | 7 | 5.1 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
49850772 | 56415 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 9 | ChEMBL | 397 | 5 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1631545 | 56415 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 9 | ChEMBL | 397 | 5 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49852002 | 56476 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 3 | ChEMBL | 416 | 6 | 1 | 4 | 4.5 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1632208 | 56476 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 3 | ChEMBL | 416 | 6 | 1 | 4 | 4.5 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49850984 | 56483 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 3 | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1 | 10.1021/jm100714c | |||
CHEMBL1632215 | 56483 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -10 | 3 | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1 | 10.1021/jm100714c | |||
44443131 | 93863 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 3 | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
CHEMBL247609 | 93863 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 3 | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
44443132 | 169587 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 478 | 7 | 0 | 6 | 3.6 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21 | 10.1016/j.bmcl.2007.06.078 | |||
CHEMBL443060 | 169587 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 478 | 7 | 0 | 6 | 3.6 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21 | 10.1016/j.bmcl.2007.06.078 | |||
10387420 | 187960 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -6 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL496317 | 187960 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -6 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
44404258 | 166254 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 505 | 5 | 0 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL426285 | 166254 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 505 | 5 | 0 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
10848041 | 9376 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 246 | 7 | 2 | 2 | 3.2 | CCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
CHEMBL111376 | 9376 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 3 | ChEMBL | 246 | 7 | 2 | 2 | 3.2 | CCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
49836002 | 126278 | None | 0 | Chinese hamster | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 460 | 5 | 0 | 5 | 3.4 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
CHEMBL3650031 | 126278 | None | 0 | Chinese hamster | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 460 | 5 | 0 | 5 | 3.4 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
9830790 | 203517 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
CHEMBL602674 | 203517 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
9830790 | 203517 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
CHEMBL602674 | 203517 | None | 1 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
19066203 | 12093 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1183904 | 12093 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL323986 | 12093 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 47 | 3 | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
59636750 | 125747 | None | 0 | Chinese hamster | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 518 | 8 | 1 | 7 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
CHEMBL3647262 | 125747 | None | 0 | Chinese hamster | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 518 | 8 | 1 | 7 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
59636703 | 125752 | None | 0 | Chinese hamster | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
CHEMBL3647267 | 125752 | None | 0 | Chinese hamster | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
44403095 | 135303 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 3 | 6 | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL372453 | 135303 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 3 | 6 | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
10376578 | 121143 | None | 1 | Human | Binding | pKi | = | 8.7 | 8.7 | -4 | 3 | ChEMBL | 230 | 3 | 2 | 1 | 3.2 | CNCCc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1021/jm9805945 | |||
CHEMBL357034 | 121143 | None | 1 | Human | Binding | pKi | = | 8.7 | 8.7 | -4 | 3 | ChEMBL | 230 | 3 | 2 | 1 | 3.2 | CNCCc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1021/jm9805945 | |||
44402876 | 70912 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 6 | 3 | ChEMBL | 492 | 4 | 0 | 5 | 5.2 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL195114 | 70912 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 6 | 3 | ChEMBL | 492 | 4 | 0 | 5 | 5.2 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
44402879 | 71432 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 50 | 2 | ChEMBL | 445 | 4 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL195898 | 71432 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 50 | 2 | ChEMBL | 445 | 4 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
11304596 | 56412 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -12 | 9 | ChEMBL | 416 | 5 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1631542 | 56412 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -12 | 9 | ChEMBL | 416 | 5 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49852000 | 56416 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 452 | 8 | 1 | 5 | 4.1 | CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1631548 | 56416 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 452 | 8 | 1 | 5 | 4.1 | CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
49852003 | 56477 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -6 | 3 | ChEMBL | 430 | 5 | 1 | 4 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1632209 | 56477 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -6 | 3 | ChEMBL | 430 | 5 | 1 | 4 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49850569 | 56487 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -7 | 3 | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1632219 | 56487 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -7 | 3 | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
49850571 | 56489 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -12 | 3 | ChEMBL | 431 | 7 | 2 | 4 | 4.4 | CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1632221 | 56489 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -12 | 3 | ChEMBL | 431 | 7 | 2 | 4 | 4.4 | CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
24865725 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL497963 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
10127424 | 176159 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 443 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL459061 | 176159 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 443 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
10319737 | 187869 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -6 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL495705 | 187869 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -6 | 3 | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
24865725 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL497963 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
10238566 | 190137 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL517170 | 190137 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 3 | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
24865725 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
CHEMBL497963 | 188190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
44404244 | 72576 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 3 | ChEMBL | 444 | 2 | 0 | 5 | 4.1 | Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL199175 | 72576 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 3 | ChEMBL | 444 | 2 | 0 | 5 | 4.1 | Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1 | 10.1016/j.bmcl.2005.06.042 | |||
44404272 | 140978 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL382078 | 140978 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
130 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
3378093 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL281350 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -91 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
2543 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
5358 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
5358.0 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
54 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
DB00669 | 3707 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
127036 | 9362 | None | 10 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 229 | 1 | 3 | 2 | 1.1 | NC(=O)c1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
CHEMBL111316 | 9362 | None | 10 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 229 | 1 | 3 | 2 | 1.1 | NC(=O)c1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
10296414 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
76 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
CHEMBL183460 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
10296414 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
76 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL183460 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
10296414 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
76 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
CHEMBL183460 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
10296414 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
76 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
CHEMBL183460 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
10296414 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
76 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
CHEMBL183460 | 3531 | None | 14 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 9 | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
130 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
3378093 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL281350 | 3500 | None | 32 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
59636719 | 125762 | None | 0 | Chinese hamster | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 532 | 8 | 0 | 7 | 3.9 | CN(Cc1cccc(S(C)(=O)=O)c1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3647277 | 125762 | None | 0 | Chinese hamster | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 532 | 8 | 0 | 7 | 3.9 | CN(Cc1cccc(S(C)(=O)=O)c1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
2393 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
5078 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
5078.0 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
51 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
CHEMBL905 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
DB00953 | 3334 | None | 46 | Human | Binding | pKi | = | 8 | 8.0 | -1 | 5 | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
1342 | 35 | None | 37 | Human | Binding | pKi | = | 8 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
3 | 35 | None | 37 | Human | Binding | pKi | = | 8 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
CHEMBL277120 | 35 | None | 37 | Human | Binding | pKi | = | 8 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.6019/CHEMBL5442175 | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.6019/CHEMBL5442175 | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.6019/CHEMBL5442175 | |||
1251 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
7191 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
77992 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
77992.0 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
CHEMBL1279 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
DB00998 | 1692 | None | 20 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 8 | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
44292375 | 169277 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -36 | 2 | ChEMBL | 256 | 3 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
CHEMBL44054 | 169277 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -36 | 2 | ChEMBL | 256 | 3 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
1342 | 35 | None | 37 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
3 | 35 | None | 37 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
CHEMBL277120 | 35 | None | 37 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 18 | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
11071135 | 210467 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -45 | 7 | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | |||
CHEMBL97333 | 210467 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -45 | 7 | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | |||
22132503 | 102035 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -25 | 4 | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
CHEMBL301475 | 102035 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -25 | 4 | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
CHEMBL552599 | 102035 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -25 | 4 | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
44400359 | 68707 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -10 | 3 | ChEMBL | 432 | 6 | 0 | 7 | 3.0 | Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1 | 10.1021/jm049039v | |||
CHEMBL192176 | 68707 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -10 | 3 | ChEMBL | 432 | 6 | 0 | 7 | 3.0 | Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1 | 10.1021/jm049039v | |||
10159927 | 94023 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -10 | 3 | ChEMBL | 432 | 6 | 1 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
CHEMBL248457 | 94023 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -10 | 3 | ChEMBL | 432 | 6 | 1 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
24881617 | 188433 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -165 | 2 | ChEMBL | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
CHEMBL500737 | 188433 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -165 | 2 | ChEMBL | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
44593711 | 184429 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 3 | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
CHEMBL484216 | 184429 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 3 | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
24865724 | 188070 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -63 | 3 | ChEMBL | 445 | 8 | 0 | 4 | 5.3 | CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
CHEMBL497127 | 188070 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -63 | 3 | ChEMBL | 445 | 8 | 0 | 4 | 5.3 | CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
181743 | 178677 | None | 4 | Human | Binding | pKi | = | 7 | 7.0 | -50 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
CHEMBL467094 | 178677 | None | 4 | Human | Binding | pKi | = | 7 | 7.0 | -50 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
181743 | 178677 | None | 4 | Human | Binding | pKi | = | 7 | 7.0 | -50 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
CHEMBL467094 | 178677 | None | 4 | Human | Binding | pKi | = | 7 | 7.0 | -50 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
15124074 | 119761 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -14 | 3 | ChEMBL | 394 | 6 | 0 | 4 | 3.4 | CCc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
CHEMBL347334 | 119761 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -14 | 3 | ChEMBL | 394 | 6 | 0 | 4 | 3.4 | CCc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
10811696 | 102537 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -316 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
CHEMBL2368612 | 102537 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -316 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
CHEMBL3040263 | 102537 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -316 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
152 | 364 | None | 24 | Rat | Binding | pKi | = | 6 | 6.0 | -57 | 18 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
2107 | 364 | None | 24 | Rat | Binding | pKi | = | 6 | 6.0 | -57 | 18 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
CHEMBL275854 | 364 | None | 24 | Rat | Binding | pKi | = | 6 | 6.0 | -57 | 18 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
5475158 | 67234 | None | 25 | Rat | Binding | pKi | = | 6 | 6.0 | -1023 | 13 | ChEMBL | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | 10.1021/jm00384a001 | |||
CHEMBL18786 | 67234 | None | 25 | Rat | Binding | pKi | = | 6 | 6.0 | -1023 | 13 | ChEMBL | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | 10.1021/jm00384a001 | |||
10257042 | 206819 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -25 | 7 | ChEMBL | 551 | 6 | 3 | 3 | 7.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1 | 10.1016/s0960-894x(01)00397-3 | |||
CHEMBL71707 | 206819 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -25 | 7 | ChEMBL | 551 | 6 | 3 | 3 | 7.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1 | 10.1016/s0960-894x(01)00397-3 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 6 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -151 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
135398745 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
47 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
DB00334 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 6 | 6.0 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 6 | 6.0 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 6 | 6.0 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 6 | 6.0 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 6 | 6.0 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
10573876 | 10465 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -501 | 7 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
CHEMBL116448 | 10465 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -501 | 7 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
9934284 | 90330 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -2511 | 10 | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL238520 | 90330 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -2511 | 10 | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
22326660 | 90805 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -50 | 3 | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL239167 | 90805 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -50 | 3 | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL4558518 | 216481 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -45 | 14 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N1CCCC1CNC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1 | 10.6019/CHEMBL4507288 | |||||
11046087 | 4949 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -134 | 4 | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
CHEMBL104753 | 4949 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -134 | 4 | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
11110452 | 5132 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -158 | 4 | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
CHEMBL105722 | 5132 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -158 | 4 | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
13520547 | 27012 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -2 | 3 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
CHEMBL136470 | 27012 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -2 | 3 | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
23274477 | 29129 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -3 | 3 | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
CHEMBL138136 | 29129 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -3 | 3 | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
3198 | 207971 | None | 50 | Rat | Binding | pKi | = | 5 | 5.0 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
CHEMBL1201049 | 207971 | None | 50 | Rat | Binding | pKi | = | 5 | 5.0 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
CHEMBL808 | 207971 | None | 50 | Rat | Binding | pKi | = | 5 | 5.0 | -44 | 34 | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
117209971 | 186591 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -20 | 5 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4877051 | 186591 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -20 | 5 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
1150 | 3878 | None | 72 | Rat | Binding | pKi | = | 5.0 | 5.0 | -204 | 24 | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
125 | 3878 | None | 72 | Rat | Binding | pKi | = | 5.0 | 5.0 | -204 | 24 | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
CHEMBL6640 | 3878 | None | 72 | Rat | Binding | pKi | = | 5.0 | 5.0 | -204 | 24 | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
DB08653 | 3878 | None | 72 | Rat | Binding | pKi | = | 5.0 | 5.0 | -204 | 24 | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
20255884 | 66084 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -30 | 2 | ChEMBL | 234 | 2 | 2 | 5 | 1.6 | Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
CHEMBL183704 | 66084 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -30 | 2 | ChEMBL | 234 | 2 | 2 | 5 | 1.6 | Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
24881550 | 172849 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 726 | 10 | 4 | 4 | 9.0 | O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
CHEMBL450852 | 172849 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 726 | 10 | 4 | 4 | 9.0 | O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
44431532 | 145325 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -14 | 4 | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
CHEMBL391271 | 145325 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -14 | 4 | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
9893924 | 4750 | None | 24 | Human | Binding | pKi | = | 6.0 | 6.0 | -42 | 22 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442175 | |||
CHEMBL103769 | 4750 | None | 24 | Human | Binding | pKi | = | 6.0 | 6.0 | -42 | 22 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442175 | |||
11297 | 67366 | None | 11 | Rat | Binding | pKi | = | 6.0 | 6.0 | -26 | 5 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | 10.1021/jm00384a001 | |||
CHEMBL18855 | 67366 | None | 11 | Rat | Binding | pKi | = | 6.0 | 6.0 | -26 | 5 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | 10.1021/jm00384a001 | |||
44352308 | 117551 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -131 | 12 | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
CHEMBL339980 | 117551 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -131 | 12 | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
44383729 | 59947 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -23 | 2 | ChEMBL | 294 | 4 | 1 | 2 | 4.3 | C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1 | 10.1016/s0960-894x(00)00133-5 | |||
CHEMBL173162 | 59947 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -23 | 2 | ChEMBL | 294 | 4 | 1 | 2 | 4.3 | C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1 | 10.1016/s0960-894x(00)00133-5 | |||
10531 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
10531.0 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
121 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
888 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
CHEMBL1732 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
DB00320 | 1420 | None | 13 | Human | Binding | pKi | = | 7.0 | 7.0 | -35 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
4431 | 2729 | None | 18 | Rat | Binding | pKi | = | 6.0 | 6.0 | -3090 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
73 | 2729 | None | 18 | Rat | Binding | pKi | = | 6.0 | 6.0 | -3090 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
CHEMBL8618 | 2729 | None | 18 | Rat | Binding | pKi | = | 6.0 | 6.0 | -3090 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
134 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
1775 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
9681 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
9681.0 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
CHEMBL1065 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
DB00247 | 2514 | None | 19 | Rat | Binding | pKi | = | 7.0 | 7.0 | -251 | 67 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
10015980 | 206775 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -154 | 5 | ChEMBL | 270 | 4 | 1 | 2 | 3.2 | CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL71469 | 206775 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -154 | 5 | ChEMBL | 270 | 4 | 1 | 2 | 3.2 | CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
10065919 | 103145 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -22 | 3 | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
CHEMBL307521 | 103145 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -22 | 3 | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
10250307 | 22615 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | -295 | 2 | ChEMBL | 398 | 5 | 0 | 4 | 4.4 | Clc1cccc2c1CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
CHEMBL132657 | 22615 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | -295 | 2 | ChEMBL | 398 | 5 | 0 | 4 | 4.4 | Clc1cccc2c1CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
10896220 | 107586 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -3 | 4 | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
CHEMBL318735 | 107586 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -3 | 4 | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
44337731 | 11383 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 21 | 2 | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL106807 | 11383 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 21 | 2 | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1179968 | 11383 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 21 | 2 | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
9862256 | 209578 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -7 | 9 | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
CHEMBL92139 | 209578 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -7 | 9 | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
44342823 | 113873 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 472 | 4 | 2 | 2 | 5.6 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL332484 | 113873 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 472 | 4 | 2 | 2 | 5.6 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
133 | 2496 | None | 39 | Rat | Binding | pKi | = | 8.0 | 8.0 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
1723 | 2496 | None | 39 | Rat | Binding | pKi | = | 8.0 | 8.0 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
28693 | 2496 | None | 39 | Rat | Binding | pKi | = | 8.0 | 8.0 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
CHEMBL19215 | 2496 | None | 39 | Rat | Binding | pKi | = | 8.0 | 8.0 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
DB13520 | 2496 | None | 39 | Rat | Binding | pKi | = | 8.0 | 8.0 | -40 | 42 | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
107715 | 203402 | None | 16 | Rat | Binding | pKi | = | 8.0 | 8.0 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
CHEMBL1255837 | 203402 | None | 16 | Rat | Binding | pKi | = | 8.0 | 8.0 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
CHEMBL601773 | 203402 | None | 16 | Rat | Binding | pKi | = | 8.0 | 8.0 | -22 | 21 | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
10069802 | 102933 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -9 | 5 | ChEMBL | 404 | 9 | 1 | 3 | 5.2 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL305837 | 102933 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -9 | 5 | ChEMBL | 404 | 9 | 1 | 3 | 5.2 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
10044965 | 206626 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -18 | 5 | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL70680 | 206626 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -18 | 5 | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
59636718 | 126294 | None | 0 | Chinese hamster | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 456 | 5 | 0 | 5 | 3.7 | CN(C)C(=O)c1cc2c(Br)ccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
CHEMBL3650046 | 126294 | None | 0 | Chinese hamster | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 456 | 5 | 0 | 5 | 3.7 | CN(C)C(=O)c1cc2c(Br)ccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 8.0 | 8.0 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 8.0 | 8.0 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 8.0 | 8.0 | -18 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
44404394 | 132883 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 7 | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL370128 | 132883 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 7 | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
415628 | 210651 | None | 52 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 5 | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
CHEMBL9841 | 210651 | None | 52 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 5 | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
11049209 | 209864 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -223 | 8 | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
CHEMBL93923 | 209864 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -223 | 8 | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
44376492 | 120050 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -11 | 2 | ChEMBL | 469 | 6 | 1 | 3 | 4.9 | O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
CHEMBL349903 | 120050 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -11 | 2 | ChEMBL | 469 | 6 | 1 | 3 | 4.9 | O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
10198756 | 4872 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 3 | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
CHEMBL104374 | 4872 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 3 | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
10925382 | 5018 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -85 | 4 | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
CHEMBL105091 | 5018 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -85 | 4 | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
6422277 | 30044 | None | 2 | Rat | Binding | pKi | = | 6.0 | 6.0 | -28 | 4 | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
CHEMBL138907 | 30044 | None | 2 | Rat | Binding | pKi | = | 6.0 | 6.0 | -28 | 4 | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
44383738 | 60286 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -13 | 2 | ChEMBL | 326 | 5 | 2 | 3 | 3.9 | OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
CHEMBL174141 | 60286 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -13 | 2 | ChEMBL | 326 | 5 | 2 | 3 | 3.9 | OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
122197403 | 133542 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -8 | 4 | ChEMBL | 433 | 5 | 1 | 4 | 4.3 | C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
CHEMBL3706923 | 133542 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -8 | 4 | ChEMBL | 433 | 5 | 1 | 4 | 4.3 | C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
9981270 | 165369 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -40 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL423127 | 165369 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -40 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
42611190 | 3156 | None | 14 | Human | Binding | pKi | = | 5.9 | 5.9 | -2884 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
5802 | 3156 | None | 14 | Human | Binding | pKi | = | 5.9 | 5.9 | -2884 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pKi | = | 5.9 | 5.9 | -2884 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
115 | 3791 | None | 36 | Rat | Binding | pKi | = | 6.9 | 6.9 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
4296 | 3791 | None | 36 | Rat | Binding | pKi | = | 6.9 | 6.9 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
CHEMBL274866 | 3791 | None | 36 | Rat | Binding | pKi | = | 6.9 | 6.9 | 1 | 26 | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
11662592 | 72368 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -97 | 9 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
CHEMBL198463 | 72368 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -97 | 9 | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
44292367 | 101924 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -33 | 2 | ChEMBL | 228 | 2 | 1 | 1 | 3.1 | Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
CHEMBL300686 | 101924 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -33 | 2 | ChEMBL | 228 | 2 | 1 | 1 | 3.1 | Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
10003971 | 63053 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -199 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL1788198 | 63053 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -199 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL5083607 | 217362 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 9 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
25067561 | 203549 | None | 5 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
CHEMBL602875 | 203549 | None | 5 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
44394222 | 127621 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -39 | 2 | ChEMBL | 245 | 1 | 2 | 3 | 3.0 | Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
CHEMBL366322 | 127621 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -39 | 2 | ChEMBL | 245 | 1 | 2 | 3 | 3.0 | Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
113 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
128018 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
CHEMBL119264 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
25067561 | 203549 | None | 5 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
CHEMBL602875 | 203549 | None | 5 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
10478367 | 71694 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 19 | 7 | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL196370 | 71694 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 19 | 7 | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL430500 | 71694 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 19 | 7 | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
44402874 | 133615 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 19 | 2 | ChEMBL | 447 | 3 | 0 | 4 | 4.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL370896 | 133615 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 19 | 2 | ChEMBL | 447 | 3 | 0 | 4 | 4.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
44444556 | 94455 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
CHEMBL250973 | 94455 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
10436045 | 3516 | None | 4 | Human | Binding | pKi | = | 7.9 | 7.9 | -3 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
782 | 3516 | None | 4 | Human | Binding | pKi | = | 7.9 | 7.9 | -3 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Binding | pKi | = | 7.9 | 7.9 | -3 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
10597210 | 77160 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 3 | ChEMBL | 401 | 3 | 1 | 3 | 4.1 | Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
CHEMBL20771 | 77160 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 3 | ChEMBL | 401 | 3 | 1 | 3 | 4.1 | Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
49850768 | 56409 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -39 | 3 | ChEMBL | 402 | 5 | 0 | 4 | 3.9 | CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
CHEMBL1631539 | 56409 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -39 | 3 | ChEMBL | 402 | 5 | 0 | 4 | 3.9 | CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
10310285 | 190034 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL516997 | 190034 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 3 | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
24865726 | 187762 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 467 | 8 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
CHEMBL495046 | 187762 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 467 | 8 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
24865727 | 193222 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 11 | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
CHEMBL522708 | 193222 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 11 | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
56935645 | 67939 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 553 | 5 | 1 | 6 | 5.1 | COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2011.09.046 | |||
CHEMBL1910792 | 67939 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 553 | 5 | 1 | 6 | 5.1 | COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2011.09.046 | |||
14083218 | 63071 | None | 5 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
CHEMBL1788239 | 63071 | None | 5 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
92042876 | 151425 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -229 | 10 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -229 | 10 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
10020895 | 4707 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -158 | 8 | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
CHEMBL103479 | 4707 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -158 | 8 | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
10926112 | 172734 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -208 | 4 | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
CHEMBL449406 | 172734 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -208 | 4 | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
2274 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
4917 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
4917.0 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
7279 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
CHEMBL728 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
DB00433 | 3173 | None | 38 | Rat | Binding | pKi | = | 5.9 | 5.9 | -39 | 32 | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
145990586 | 166939 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -93 | 11 | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
CHEMBL4285281 | 166939 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -93 | 11 | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
10358224 | 206778 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -52 | 5 | ChEMBL | 313 | 5 | 1 | 2 | 4.2 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
CHEMBL71474 | 206778 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -52 | 5 | ChEMBL | 313 | 5 | 1 | 2 | 4.2 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
53248361 | 62102 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -77 | 7 | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | |||
CHEMBL1774991 | 62102 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -77 | 7 | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | |||
73213196 | 104516 | None | 3 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 13 | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104093 | 104516 | None | 3 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 13 | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
73213196 | 104516 | None | 3 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 13 | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104093 | 104516 | None | 3 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 13 | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
2812 | 4781 | None | 63 | Rat | Binding | pKi | = | 4.9 | 4.9 | -51 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
CHEMBL104 | 4781 | None | 63 | Rat | Binding | pKi | = | 4.9 | 4.9 | -51 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
4223 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
6918314 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
6918314.0 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
7427 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
CHEMBL439849 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
DB06684 | 3992 | None | 57 | Human | Binding | pKi | = | 5.9 | 5.9 | -457 | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.6019/CHEMBL5442175 | |||
62597539 | 106268 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
CHEMBL2260923 | 106268 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
CHEMBL3138772 | 106268 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
11794624 | 80243 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 387 | 3 | 1 | 3 | 3.8 | Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
CHEMBL21369 | 80243 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 387 | 3 | 1 | 3 | 3.8 | Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
10310423 | 175600 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -50 | 3 | ChEMBL | 445 | 7 | 0 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL457765 | 175600 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -50 | 3 | ChEMBL | 445 | 7 | 0 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
10238763 | 175798 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 3 | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL458200 | 175798 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 3 | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
44580784 | 188192 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -501 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
CHEMBL497979 | 188192 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -501 | 3 | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
9891617 | 210441 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1000 | 5 | ChEMBL | 486 | 4 | 2 | 6 | 4.9 | Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1 | 10.1016/s0960-894x(01)00558-3 | |||
CHEMBL97211 | 210441 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1000 | 5 | ChEMBL | 486 | 4 | 2 | 6 | 4.9 | Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1 | 10.1016/s0960-894x(01)00558-3 | |||
10413595 | 161935 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -3981 | 11 | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
CHEMBL414628 | 161935 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -3981 | 11 | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
10115848 | 90804 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -794 | 3 | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL239166 | 90804 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -794 | 3 | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
24865540 | 187782 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -7 | 3 | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
CHEMBL495160 | 187782 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -7 | 3 | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
24881618 | 188895 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -125 | 2 | ChEMBL | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
CHEMBL505750 | 188895 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -125 | 2 | ChEMBL | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
24881619 | 189146 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -9 | 2 | ChEMBL | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
CHEMBL509314 | 189146 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -9 | 2 | ChEMBL | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
277 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
2913 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
2913.0 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
765 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
CHEMBL516 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
DB00434 | 1301 | None | 39 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 49 | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
11154555 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
11154555.0 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
5037 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
7671 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
CHEMBL2028019 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
CHEMBL3085826 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
DB06016 | 800 | None | 50 | Human | Binding | pKi | = | 6.9 | 6.9 | -457 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.6019/CHEMBL5442175 | |||
50878551 | 90779 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 18 | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
CHEMBL2391541 | 90779 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 18 | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
50878551 | 90779 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 18 | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
CHEMBL2391541 | 90779 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 18 | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
44342783 | 9821 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 2 | ChEMBL | 436 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL113868 | 9821 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 2 | ChEMBL | 436 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
3658 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
517 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
5709 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
5709.0 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
CHEMBL312448 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
DB06694 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
106 | 148 | None | 19 | Rat | Binding | pKi | = | 7.9 | 7.9 | -4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
1797 | 148 | None | 19 | Rat | Binding | pKi | = | 7.9 | 7.9 | -4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
CHEMBL97450 | 148 | None | 19 | Rat | Binding | pKi | = | 7.9 | 7.9 | -4 | 6 | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
52942395 | 17928 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -24 | 5 | ChEMBL | 386 | 3 | 0 | 4 | 5.0 | CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1016/j.bmc.2012.10.049 | |||
CHEMBL1259203 | 17928 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -24 | 5 | ChEMBL | 386 | 3 | 0 | 4 | 5.0 | CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1016/j.bmc.2012.10.049 | |||
10643939 | 14116 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 35 | 2 | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
CHEMBL119800 | 14116 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 35 | 2 | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
44403101 | 72021 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 6 | ChEMBL | 485 | 5 | 1 | 5 | 4.5 | COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL197408 | 72021 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 6 | ChEMBL | 485 | 5 | 1 | 5 | 4.5 | COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
83357 | 98225 | None | 38 | Rat | Binding | pKi | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | 206 | 3 | 1 | 3 | 1.5 | CCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
CHEMBL273923 | 98225 | None | 38 | Rat | Binding | pKi | = | 7.9 | 7.9 | -1 | 3 | ChEMBL | 206 | 3 | 1 | 3 | 1.5 | CCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
44376494 | 56278 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -4 | 2 | ChEMBL | 420 | 6 | 2 | 3 | 4.5 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
CHEMBL162771 | 56278 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -4 | 2 | ChEMBL | 420 | 6 | 2 | 3 | 4.5 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
10163458 | 85216 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 3.1 | CNc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(OC)cc12 | 10.1016/j.bmc.2006.10.037 | |||
CHEMBL225364 | 85216 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 3.1 | CNc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(OC)cc12 | 10.1016/j.bmc.2006.10.037 | |||
10089261 | 102529 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 350 | 4 | 0 | 4 | 4.5 | CN(C)CCSc1nc2ccccc2c2c1CCOc1ccccc1-2 | 10.1021/jm00014a021 | |||
CHEMBL304016 | 102529 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 350 | 4 | 0 | 4 | 4.5 | CN(C)CCSc1nc2ccccc2c2c1CCOc1ccccc1-2 | 10.1021/jm00014a021 | |||
206 | 2493 | None | 10 | Rat | Binding | pKi | = | 4.9 | 4.9 | -7585 | 24 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
68848 | 2493 | None | 10 | Rat | Binding | pKi | = | 4.9 | 4.9 | -7585 | 24 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
CHEMBL12314 | 2493 | None | 10 | Rat | Binding | pKi | = | 4.9 | 4.9 | -7585 | 24 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
72550642 | 114142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 8 | ChEMBL | 491 | 10 | 1 | 4 | 5.6 | COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
CHEMBL3326982 | 114142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 8 | ChEMBL | 491 | 10 | 1 | 4 | 5.6 | COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
44461249 | 207809 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 3 | ChEMBL | 421 | 5 | 2 | 3 | 4.3 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
CHEMBL79674 | 207809 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -15 | 3 | ChEMBL | 421 | 5 | 2 | 3 | 4.3 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
44269026 | 33752 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -363 | 2 | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
CHEMBL14224 | 33752 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -363 | 2 | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
CHEMBL1743629 | 33752 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -363 | 2 | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
10016747 | 60318 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -40 | 2 | ChEMBL | 284 | 4 | 1 | 2 | 4.3 | Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
CHEMBL174355 | 60318 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -40 | 2 | ChEMBL | 284 | 4 | 1 | 2 | 4.3 | Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
127036186 | 137501 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -42 | 19 | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
CHEMBL3753318 | 137501 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -42 | 19 | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
21509921 | 104514 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -131 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104091 | 104514 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -131 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL4535474 | 216454 | None | 39 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 22 | ChEMBL | None | None | None | CNCc1ccccc1-c1csc([C@@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 | 10.6019/CHEMBL4507273 | |||||
10498633 | 163398 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 358 | 15 | 2 | 2 | 6.2 | CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1 | 10.1021/jm950498t | |||
CHEMBL418823 | 163398 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 1 | 3 | ChEMBL | 358 | 15 | 2 | 2 | 6.2 | CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1 | 10.1021/jm950498t | |||
CHEMBL1200558 | 211058 | None | 19 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](N)C1=N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC)CS1 | nan | |||||
125957 | 120224 | None | 1 | Rat | Binding | pKi | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
CHEMBL351530 | 120224 | None | 1 | Rat | Binding | pKi | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
14975319 | 77263 | None | 0 | Rat | Binding | pKi | = | 4.9 | 4.9 | -245 | 2 | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
CHEMBL2079545 | 77263 | None | 0 | Rat | Binding | pKi | = | 4.9 | 4.9 | -245 | 2 | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
21509921 | 104514 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -131 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104091 | 104514 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -131 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
6761 | 67821 | None | 11 | Rat | Binding | pKi | = | 5.9 | 5.9 | -43 | 18 | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
CHEMBL1909072 | 67821 | None | 11 | Rat | Binding | pKi | = | 5.9 | 5.9 | -43 | 18 | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
117209962 | 184975 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -52 | 7 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4852622 | 184975 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -52 | 7 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
448779 | 63088 | None | 24 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
CHEMBL1788285 | 63088 | None | 24 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
10858566 | 102142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -22 | 5 | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
CHEMBL302172 | 102142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -22 | 5 | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
10858566 | 102142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -22 | 5 | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL302172 | 102142 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -22 | 5 | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
11826976 | 209987 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 483 | 6 | 1 | 4 | 5.0 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cccnc4)cc23)CC1 | 10.1021/jm020938y | |||
CHEMBL94612 | 209987 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 483 | 6 | 1 | 4 | 5.0 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cccnc4)cc23)CC1 | 10.1021/jm020938y | |||
113 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
128018 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
CHEMBL119264 | 1852 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | 39 | 3 | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
44342727 | 10173 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -18 | 2 | ChEMBL | 465 | 6 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL115941 | 10173 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -18 | 2 | ChEMBL | 465 | 6 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
44342705 | 110170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 2 | ChEMBL | 420 | 4 | 2 | 2 | 4.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL323603 | 110170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 2 | ChEMBL | 420 | 4 | 2 | 2 | 4.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
3658 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
517 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
5709 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
5709.0 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
CHEMBL312448 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
DB06694 | 4107 | None | 38 | Human | Binding | pKi | = | 7.9 | 7.9 | -4 | 8 | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
10518850 | 35202 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 4 | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
CHEMBL143512 | 35202 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 4 | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 7.9 | 7.9 | -11 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
10828231 | 9356 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 2 | 3 | ChEMBL | 302 | 10 | 2 | 2 | 4.7 | CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
CHEMBL111283 | 9356 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 2 | 3 | ChEMBL | 302 | 10 | 2 | 2 | 4.7 | CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
11740144 | 63052 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -15 | 4 | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL1788197 | 63052 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -15 | 4 | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
11098166 | 109843 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -5 | 3 | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
CHEMBL323264 | 109843 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -5 | 3 | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
59636721 | 126290 | None | 0 | Chinese hamster | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 472 | 5 | 0 | 5 | 3.6 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N6CCC6)oc45)CC3)ccc21 | nan | |||
CHEMBL3650042 | 126290 | None | 0 | Chinese hamster | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 472 | 5 | 0 | 5 | 3.6 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N6CCC6)oc45)CC3)ccc21 | nan | |||
2762737 | 101905 | None | 9 | Human | Binding | pKi | = | 7.9 | 7.9 | -35 | 2 | ChEMBL | 230 | 4 | 1 | 1 | 3.4 | CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
CHEMBL300519 | 101905 | None | 9 | Human | Binding | pKi | = | 7.9 | 7.9 | -35 | 2 | ChEMBL | 230 | 4 | 1 | 1 | 3.4 | CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
44376280 | 119967 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -11 | 2 | ChEMBL | 449 | 6 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
CHEMBL349174 | 119967 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -11 | 2 | ChEMBL | 449 | 6 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
44376588 | 120016 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -12 | 2 | ChEMBL | 465 | 7 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
CHEMBL349675 | 120016 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -12 | 2 | ChEMBL | 465 | 7 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
59636711 | 126293 | None | 0 | Chinese hamster | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cc(N2CCN(CCc3ccccn3)CC2)c2oc(C(=O)N(C)C)cc2c1 | nan | |||
CHEMBL3650045 | 126293 | None | 0 | Chinese hamster | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cc(N2CCN(CCc3ccccn3)CC2)c2oc(C(=O)N(C)C)cc2c1 | nan | |||
10683472 | 201843 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | N#CC1=Cc2cccc(OCC3CCCNC3)c2OC1 | 10.1021/jm970806i | |||
CHEMBL59102 | 201843 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | N#CC1=Cc2cccc(OCC3CCCNC3)c2OC1 | 10.1021/jm970806i | |||
CHEMBL4535474 | 216454 | None | 39 | Human | Binding | pKi | = | 5.9 | 5.9 | -11 | 22 | ChEMBL | None | None | None | CNCc1ccccc1-c1csc([C@@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 | 10.6019/CHEMBL4507273 | |||||
10066481 | 18483 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -371 | 3 | ChEMBL | 350 | 2 | 0 | 4 | 3.1 | c1ccc2c(c1)CC(N1CCN(c3cccc4c3OCCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
CHEMBL127216 | 18483 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -371 | 3 | ChEMBL | 350 | 2 | 0 | 4 | 3.1 | c1ccc2c(c1)CC(N1CCN(c3cccc4c3OCCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
10247055 | 116204 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 2 | ChEMBL | 346 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
CHEMBL335752 | 116204 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -501 | 2 | ChEMBL | 346 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
3191 | 102913 | None | 65 | Rat | Binding | pKi | = | 5.9 | 5.9 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
3191.0 | 102913 | None | 65 | Rat | Binding | pKi | = | 5.9 | 5.9 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
CHEMBL305660 | 102913 | None | 65 | Rat | Binding | pKi | = | 5.9 | 5.9 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
DB11742 | 102913 | None | 65 | Rat | Binding | pKi | = | 5.9 | 5.9 | -17 | 25 | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
10062659 | 206632 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -93 | 5 | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
CHEMBL70710 | 206632 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -93 | 5 | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
12406830 | 65293 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -26 | 2 | ChEMBL | 267 | 1 | 2 | 1 | 2.2 | Cc1cc(Br)cc(C)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
CHEMBL182837 | 65293 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -26 | 2 | ChEMBL | 267 | 1 | 2 | 1 | 2.2 | Cc1cc(Br)cc(C)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
132060743 | 162330 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 13 | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
CHEMBL4163428 | 162330 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 13 | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
1971 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
2404 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
4543 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
4543.0 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
CHEMBL445 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
DB00540 | 2866 | None | 32 | Rat | Binding | pKi | = | 5.8 | 5.8 | -13 | 29 | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
76326512 | 106306 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
CHEMBL2260924 | 106306 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
CHEMBL3138935 | 106306 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
44438464 | 147228 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 508 | 7 | 1 | 7 | 4.9 | OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CCCC1 | 10.1016/j.bmcl.2006.12.109 | |||
CHEMBL392770 | 147228 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 508 | 7 | 1 | 7 | 4.9 | OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CCCC1 | 10.1016/j.bmcl.2006.12.109 | |||
44431537 | 145329 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 4 | ChEMBL | 440 | 5 | 1 | 5 | 3.6 | N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1 | 10.1016/j.bmcl.2007.03.101 | |||
CHEMBL391273 | 145329 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 4 | ChEMBL | 440 | 5 | 1 | 5 | 3.6 | N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1 | 10.1016/j.bmcl.2007.03.101 | |||
11200511 | 204187 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 8 | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
CHEMBL606547 | 204187 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 8 | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
10068933 | 103856 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 4 | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
CHEMBL309021 | 103856 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 4 | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
44292365 | 188216 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -61 | 2 | ChEMBL | 270 | 2 | 1 | 1 | 4.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1016/s0960-894x(00)00322-x | |||
CHEMBL49826 | 188216 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -61 | 2 | ChEMBL | 270 | 2 | 1 | 1 | 4.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1016/s0960-894x(00)00322-x | |||
69836292 | 79049 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 15 | 3 | ChEMBL | 438 | 5 | 0 | 6 | 3.3 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
CHEMBL2113098 | 79049 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 15 | 3 | ChEMBL | 438 | 5 | 0 | 6 | 3.3 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
10238565 | 191035 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 3 | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL518545 | 191035 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -15 | 3 | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
10194809 | 188232 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -25 | 3 | ChEMBL | 431 | 8 | 1 | 4 | 5.2 | CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
CHEMBL498354 | 188232 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -25 | 3 | ChEMBL | 431 | 8 | 1 | 4 | 5.2 | CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
44404230 | 70543 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 3 | ChEMBL | 440 | 2 | 0 | 4 | 4.2 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL194701 | 70543 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 3 | ChEMBL | 440 | 2 | 0 | 4 | 4.2 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
44404245 | 71932 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -6 | 3 | ChEMBL | 391 | 2 | 0 | 6 | 2.8 | Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1 | 10.1016/j.bmcl.2005.06.042 | |||
CHEMBL197169 | 71932 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -6 | 3 | ChEMBL | 391 | 2 | 0 | 6 | 2.8 | Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1 | 10.1016/j.bmcl.2005.06.042 | |||
10774576 | 210702 | None | 3 | Rat | Binding | pKi | = | 7.8 | 7.8 | 1 | 3 | ChEMBL | 204 | 3 | 1 | 2 | 2.0 | CCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
CHEMBL9870 | 210702 | None | 3 | Rat | Binding | pKi | = | 7.8 | 7.8 | 1 | 3 | ChEMBL | 204 | 3 | 1 | 2 | 2.0 | CCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
10048252 | 11384 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -41 | 2 | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL107772 | 11384 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -41 | 2 | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
CHEMBL1179973 | 11384 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -41 | 2 | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
11035452 | 5006 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 4 | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
CHEMBL105025 | 5006 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 4 | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
10759257 | 100230 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | 7 | 2 | ChEMBL | 335 | 1 | 0 | 4 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2sccc2-3)CC1 | 10.1021/jm981112s | |||
CHEMBL288069 | 100230 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | 7 | 2 | ChEMBL | 335 | 1 | 0 | 4 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2sccc2-3)CC1 | 10.1021/jm981112s | |||
3604129 | 30272 | None | 3 | Rat | Binding | pKi | = | 5.8 | 5.8 | -19 | 3 | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
CHEMBL139103 | 30272 | None | 3 | Rat | Binding | pKi | = | 5.8 | 5.8 | -19 | 3 | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
10398118 | 102176 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -11 | 5 | ChEMBL | 207 | 3 | 1 | 1 | 2.7 | CCCNC1CCc2cc(F)ccc2C1 | 10.1021/jm00012a021 | |||
CHEMBL302373 | 102176 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -11 | 5 | ChEMBL | 207 | 3 | 1 | 1 | 2.7 | CCCNC1CCc2cc(F)ccc2C1 | 10.1021/jm00012a021 | |||
10088157 | 22887 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -1071 | 2 | ChEMBL | 332 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
CHEMBL132878 | 22887 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -1071 | 2 | ChEMBL | 332 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
854157 | 77893 | None | 7 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
CHEMBL2093087 | 77893 | None | 7 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
141 | 1427 | None | 18 | Human | Binding | pKi | = | 5.8 | 5.8 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
6089 | 1427 | None | 18 | Human | Binding | pKi | = | 5.8 | 5.8 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
CHEMBL12420 | 1427 | None | 18 | Human | Binding | pKi | = | 5.8 | 5.8 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
DB01488 | 1427 | None | 18 | Human | Binding | pKi | = | 5.8 | 5.8 | -44 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
10070281 | 208019 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -28 | 3 | ChEMBL | 412 | 5 | 1 | 3 | 4.7 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
CHEMBL81191 | 208019 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -28 | 3 | ChEMBL | 412 | 5 | 1 | 3 | 4.7 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
752521 | 201193 | None | 5 | Human | Binding | pKi | = | 5.8 | 5.8 | -74 | 9 | ChEMBL | 295 | 1 | 3 | 5 | 1.9 | CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 | 10.1021/acs.jmedchem.5b01631 | |||
CHEMBL582877 | 201193 | None | 5 | Human | Binding | pKi | = | 5.8 | 5.8 | -74 | 9 | ChEMBL | 295 | 1 | 3 | 5 | 1.9 | CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 | 10.1021/acs.jmedchem.5b01631 | |||
14083215 | 63087 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
CHEMBL1788284 | 63087 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
44461149 | 207827 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | ChEMBL | 421 | 5 | 1 | 5 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
CHEMBL79853 | 207827 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | ChEMBL | 421 | 5 | 1 | 5 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
44461298 | 208173 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -7 | 3 | ChEMBL | 420 | 5 | 1 | 4 | 4.5 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
CHEMBL82488 | 208173 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -7 | 3 | ChEMBL | 420 | 5 | 1 | 4 | 4.5 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
31703 | 194829 | None | 40 | Rat | Binding | pKi | = | 4.8 | 4.8 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
CHEMBL359744 | 194829 | None | 40 | Rat | Binding | pKi | = | 4.8 | 4.8 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
CHEMBL53463 | 194829 | None | 40 | Rat | Binding | pKi | = | 4.8 | 4.8 | -48 | 3 | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
9795333 | 103130 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -21 | 2 | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
CHEMBL307408 | 103130 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -21 | 2 | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
9795333 | 103130 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -21 | 2 | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
CHEMBL307408 | 103130 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -21 | 2 | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
46945446 | 17769 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 5 | 2 | ChEMBL | 408 | 9 | 0 | 5 | 4.6 | CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1 | 10.1016/j.bmcl.2010.07.135 | |||
CHEMBL1258723 | 17769 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 5 | 2 | ChEMBL | 408 | 9 | 0 | 5 | 4.6 | CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1 | 10.1016/j.bmcl.2010.07.135 | |||
22132555 | 13713 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 4 | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
CHEMBL1194956 | 13713 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 4 | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
CHEMBL553591 | 13713 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 4 | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
10597855 | 84423 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
CHEMBL2113350 | 84423 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
CHEMBL2219579 | 84423 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 4 | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
10194297 | 79020 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -50 | 3 | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
CHEMBL2113061 | 79020 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -50 | 3 | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
10115847 | 92014 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -3 | 3 | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL241500 | 92014 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -3 | 3 | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
44581604 | 176163 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -39 | 3 | ChEMBL | 485 | 7 | 0 | 4 | 5.6 | CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL459068 | 176163 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -39 | 3 | ChEMBL | 485 | 7 | 0 | 4 | 5.6 | CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1 | 10.1016/j.bmcl.2008.11.052 | |||
10174088 | 189607 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -100 | 3 | ChEMBL | 473 | 7 | 0 | 5 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
CHEMBL513955 | 189607 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -100 | 3 | ChEMBL | 473 | 7 | 0 | 5 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
10172853 | 187752 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -63 | 3 | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
CHEMBL494992 | 187752 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -63 | 3 | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
9954121 | 96459 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -2511 | 4 | ChEMBL | 424 | 4 | 2 | 5 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
CHEMBL261917 | 96459 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -2511 | 4 | ChEMBL | 424 | 4 | 2 | 5 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
9863250 | 18002 | None | 4 | Human | Binding | pKi | = | 5.8 | 5.8 | -512 | 7 | ChEMBL | 350 | 5 | 0 | 3 | 3.3 | Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
CHEMBL12624 | 18002 | None | 4 | Human | Binding | pKi | = | 5.8 | 5.8 | -512 | 7 | ChEMBL | 350 | 5 | 0 | 3 | 3.3 | Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
10835110 | 114652 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -398 | 8 | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
CHEMBL333784 | 114652 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -398 | 8 | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
11248705 | 90329 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -630 | 10 | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
CHEMBL238519 | 90329 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -630 | 10 | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
24865541 | 187783 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -316 | 3 | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1 | 10.1021/jm8001444 | |||
CHEMBL495161 | 187783 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -316 | 3 | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1 | 10.1021/jm8001444 | |||
10543269 | 26595 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -3 | 3 | ChEMBL | 314 | 3 | 1 | 5 | 1.7 | OCCN1CCN(c2nc3cccc(F)c3n3cccc23)CC1 | 10.1021/jm990151g | |||
CHEMBL136108 | 26595 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -3 | 3 | ChEMBL | 314 | 3 | 1 | 5 | 1.7 | OCCN1CCN(c2nc3cccc(F)c3n3cccc23)CC1 | 10.1021/jm990151g | |||
24881201 | 186955 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -4 | 2 | ChEMBL | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
CHEMBL489453 | 186955 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -4 | 2 | ChEMBL | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
59636729 | 125758 | None | 0 | Chinese hamster | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 390 | 5 | 0 | 5 | 3.0 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCC1 | nan | |||
CHEMBL3647273 | 125758 | None | 0 | Chinese hamster | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 390 | 5 | 0 | 5 | 3.0 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCC1 | nan | |||
10786335 | 12064 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 63 | 2 | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
CHEMBL118360 | 12064 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 63 | 2 | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
44403105 | 72132 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 19 | 5 | ChEMBL | 455 | 5 | 1 | 6 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL197796 | 72132 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 19 | 5 | ChEMBL | 455 | 5 | 1 | 6 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
CHEMBL5084249 | 217394 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -19 | 8 | ChEMBL | None | None | None | CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5094493 | 217989 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -7 | 7 | ChEMBL | None | None | None | CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
11810310 | 4720 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -144 | 4 | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
CHEMBL103550 | 4720 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -144 | 4 | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
122187375 | 123089 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 2 | ChEMBL | 443 | 5 | 0 | 5 | 5.6 | CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
CHEMBL3609140 | 123089 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 2 | ChEMBL | 443 | 5 | 0 | 5 | 5.6 | CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
10049500 | 77850 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1071 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL2092864 | 77850 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1071 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL2112317 | 77850 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1071 | 5 | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
15870567 | 187079 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -36 | 2 | ChEMBL | 242 | 4 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
CHEMBL49048 | 187079 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -36 | 2 | ChEMBL | 242 | 4 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
14639163 | 206656 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 190 | 3 | 1 | 3 | 1.2 | COc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
CHEMBL70831 | 206656 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 190 | 3 | 1 | 3 | 1.2 | COc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
168268877 | 190079 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -35 | 12 | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
CHEMBL5170784 | 190079 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -35 | 12 | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
10425027 | 206670 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -31 | 5 | ChEMBL | 302 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1 | 10.1021/jm00012a021 | |||
CHEMBL70882 | 206670 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -31 | 5 | ChEMBL | 302 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1 | 10.1021/jm00012a021 | |||
16117151 | 60107 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1659 | 7 | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
CHEMBL1642882 | 60107 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1659 | 7 | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
CHEMBL1739102 | 60107 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1659 | 7 | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
3038495 | 708 | None | 33 | Human | Binding | pKi | = | 6.8 | 6.8 | -107 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
7625 | 708 | None | 33 | Human | Binding | pKi | = | 6.8 | 6.8 | -107 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
CHEMBL25236 | 708 | None | 33 | Human | Binding | pKi | = | 6.8 | 6.8 | -107 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
9901086 | 187737 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -549 | 15 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442175 | |||
CHEMBL4743049 | 187737 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -549 | 15 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442175 | |||
CHEMBL494947 | 187737 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -549 | 15 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442175 | |||
14547415 | 100725 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -10 | 4 | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
CHEMBL292274 | 100725 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -10 | 4 | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 5.8 | 5.8 | -977 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
180 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
200 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
2160 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
2160.0 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
CHEMBL629 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
DB00321 | 401 | None | 38 | Rat | Binding | pKi | = | 5.8 | 5.8 | -389 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
44214329 | 59457 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -33 | 2 | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
CHEMBL171129 | 59457 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -33 | 2 | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
44342969 | 10531 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -21 | 2 | ChEMBL | 449 | 5 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
CHEMBL116876 | 10531 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -21 | 2 | ChEMBL | 449 | 5 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
59636726 | 125773 | None | 0 | Chinese hamster | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 8 | 1 | 7 | 2.9 | Cn1cnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
CHEMBL3647288 | 125773 | None | 0 | Chinese hamster | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 8 | 1 | 7 | 2.9 | Cn1cnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
2477 | 745 | None | 38 | Rat | Binding | pKi | = | 7.8 | 7.8 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
2477.0 | 745 | None | 38 | Rat | Binding | pKi | = | 7.8 | 7.8 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
36 | 745 | None | 38 | Rat | Binding | pKi | = | 7.8 | 7.8 | -16 | 28 | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
437 |