Mutant Browser

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Protein nameGeneric numberPositionSegmentMutationFoldChange or QualExp TypeLigandReferenceReview
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Protein name
Generic number
Position
Segment
Mutation
FoldChange or Qual
Exp Type
Ligand
Reference
Review
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Protein name
Generic number
Segment
Position
Mutation
FoldChange or Qual
Exp Type
Ligand
Reference
Review
5ht1d_human 7.39x38 342 TM7 T => N N/A N/A Adham N et al (1994)
5ht1d_human 5.37x38 196 TM5 S => L N/A N/A Wurch T et al (1998)
5ht1d_human 5.40x41 199 TM5 I => V N/A N/A Wurch T et al (1998)
5ht1d_human 5.44x45 203 TM5 C => V N/A N/A Wurch T et al (1998)
5ht1d_human 5.49x49 208 TM5 I => F N/A N/A Wurch T et al (1998)
5ht1d_human 45.51x51 189 ECL2 L => Q N/A N/A Wurch T et al (2000)
5ht1d_human 193 ECL2 S => D N/A N/A Wurch T et al (1998)
5ht1d_human 5.37x38 196 TM5 S => L N/A N/A Wurch T et al (1998)
5ht1d_human 5.40x41 199 TM5 I => V N/A N/A Wurch T et al (1998)
5ht1d_human 5.44x45 203 TM5 C => V N/A N/A Wurch T et al (1998)
5ht1d_human 5.49x49 208 TM5 I => F N/A N/A Wurch T et al (1998)
5ht1d_human 5.51x51 210 TM5 S => E N/A N/A Wurch T et al (1998)
5ht1d_human 5.51x51 210 TM5 S => T N/A N/A Wurch T et al (1998)
5ht1d_human 5.52x52 211 TM5 V => L N/A N/A Wurch T et al (1998)
5ht1d_human 5.56x56 215 TM5 I => A N/A N/A Wurch T et al (1998)
5ht1d_human 7.39x38 342 TM7 T => N Increased effect K(i) (Binding - Radioligand competition/displacement) (-)-propranolol Adham N et al (1994) Vass M et al (2019)
5ht1d_human 45.51x51 189 ECL2 L => Q 1.372↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Wurch T et al (2000) Vass M et al (2019)
5ht1d_human 7.39x38 342 TM7 T => N Increased effect K(i) (Binding - Radioligand competition/displacement) pindolol Adham N et al (1994) Vass M et al (2019)
5ht1d_human 45.51x51 189 ECL2 L => Q 5.917↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (2000) Vass M et al (2019)
5ht1d_human 5.37x38 196 TM5 S => L 7.246↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.37x38 196 TM5 S => L 2.793↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.40x41 199 TM5 I => V 2.155↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.40x41 199 TM5 I => V 1.046↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.44x45 203 TM5 C => V 4.132↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.44x45 203 TM5 C => V 1.629↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.49x49 208 TM5 I => F 2.933↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 5.49x49 208 TM5 I => F 1.326↓ K(i) (Binding - Radioligand competition/displacement) ketanserin Wurch T et al (1998) Vass M et al (2019)
5ht1d_human 7.39x38 342 TM7 T => N Gain of effect (wt had no effect) K(d) (Binding - Radioligand saturation) [125I]iodocyanopindolol Adham N et al (1994) Vass M et al (2019)
5ht1d_human 3.29x29 115 TM3 L => A 1.818↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 3.32x32 118 TM3 D => A N/A pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 3.33x33 119 TM3 I => A 32.258↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 3.36x36 122 TM3 C => A 19.231↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 3.37x37 123 TM3 T => A 333.333↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 191 ECL2 N => A 1.0 pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 5.38x39 197 TM5 Y => A 2.288↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 5.42x43 201 TM5 S => A 2.632↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 5.43x44 202 TM5 T => A 7.246↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 5.46x461 205 TM5 A => F 1000.0↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 5.46x461 205 TM5 A => S 1.862↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 6.48x48 314 TM6 W => A 250.0↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 6.51x51 317 TM6 F => A 111.111↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 6.52x52 318 TM6 F => A 1.778↑ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 6.55x55 321 TM6 S => A 2.95↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 7.39x38 342 TM7 T => A 5.0↓ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 7.43x42 346 TM7 Y => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 7.43x42 346 TM7 Y => F Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 191 ECL2 N => A 1.38↑ pEC50 (Functional - Other) 5-hydroxytryptamine Xu P et al (2021)
5ht1d_human 6.55x55 321 TM6 S => E 3.981↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht1d_human 6.55x55 321 TM6 S => A 1.0 pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
Protein nameGeneric numberSegmentPositionMutationFoldChange or QualExp TypeLigandReferenceReview
Showing 1 to 49 of 49 entries


Residue

Diagrams

ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term L Q A L K I S L A V V L S V I T L A T V L S N A F V L T T I L L T T P A N Y L I G S L A T T D L L V S I L V M P I S I A Y T I T H G Q I L C D I W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T A G H A A T M I A I V W A I S I C I S I P P L F W R Q I S Y T I Y S T C G A F Y I P S V L L I I L Y G R I Y R A A R N R I L N P P S R I S A A R E R K A T K I L G I I L G A F I I C W L P F F V V S L V L P I C H P A L F D F F T W L G Y L N S L I N P I I Y T V F N E E F Q K F R Q A I V
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N S L V T A L T I V S L V V A L S I K 1 G S L A T T D L L V S L I V M P I S I A Y 2 V C L H L I S A T C C T I D S S L W I D 3 A A T M I A I V W A I S I C I S I P P L 4 Y L I I L L V S P I Y F A G C T S Y I T Y 5 G I I L G A F I I C W L P F F V V S L V 6 I P N I L S N L Y G L W T F F D F L A 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1D receptor
TM3
3x29 3.29x29 L115
3x32 3.32x32 D118
3x33 3.33x33 I119
3x36 3.36x36 C122
3x37 3.37x37 T123
TM5
5x38 5.37x38 S196
5x39 5.38x39 Y197
5x41 5.40x41 I199
5x43 5.42x43 S201
5x44 5.43x44 T202
5x45 5.44x45 C203
5x461 5.46x461 A205
5x49 5.49x49 I208
5x51 5.51x51 S210
5x52 5.52x52 V211
5x56 5.56x56 I215
TM6
6x48 6.48x48 W314
6x51 6.51x51 F317
6x52 6.52x52 F318
6x55 6.55x55 S321
TM7
7x38 7.39x38 T342
7x42 7.43x42 Y346