GPCRdb

Mutant Browser

Protein name	Generic number	Position	Segment	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

acm1_human	3.52x52	125	TM3	F => A	N/A	N/A		Moro O et al (1993)
acm1_human	3.54x54	127	TM3	V => A	N/A	N/A		Moro O et al (1993)
acm1_human	34.50x50	130	ICL2	P => A	N/A	N/A		Moro O et al (1993)
acm1_human	34.51x51	131	ICL2	L => A	N/A	N/A		Moro O et al (1993)
acm1_human	34.51x51	131	ICL2	L => N	N/A	N/A		Moro O et al (1993)
acm1_human	34.51x51	131	ICL2	L => D	N/A	N/A		Moro O et al (1993)
acm1_human	34.51x51	131	ICL2	L => F	N/A	N/A		Moro O et al (1993)
acm1_human	34.51x51	131	ICL2	L => M	N/A	N/A		Moro O et al (1993)
acm1_human	34.53x53	133	ICL2	Y => A	N/A	N/A		Moro O et al (1993)
acm1_human	34.56x56	136	ICL2	K => A	N/A	N/A		Moro O et al (1993)
acm1_human	6.30x30	360	TM6	E => A	N/A	N/A		Hogger P et al (1995)
acm1_human		284	ICL3	S => A	N/A	N/A		Moro O et al (1993)
acm1_human	2.61x60	82	TM2	Y => F	N/A	N/A		Drubbisch V et al (1992)
acm1_human	2.50x50	71	TM2	D => N	N/A	N/A		Lameh J et al (1992)
acm1_human	5.65x65	215	TM5	T => A	N/A	N/A		Lameh J et al (1992)
acm1_human		228	ICL3	S => A	N/A	N/A		Lameh J et al (1992)
acm1_human		322	ICL3	S => A	N/A	N/A		Lameh J et al (1992)
acm1_human		330	ICL3	T => A	N/A	N/A		Lameh J et al (1992)
acm1_human	6.24x24	354	TM6	T => A	N/A	N/A		Lameh J et al (1992)
acm1_human	6.26x26	356	TM6	S => A	N/A	N/A		Lameh J et al (1992)
acm1_human	6.38x38	368	TM6	S => A	N/A	N/A		Lameh J et al (1992)
acm1_human	8.53x53	428	H8	T => A	N/A	N/A		Lameh J et al (1992)
acm1_human	5.61x61	211	TM5	I => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.59x59	209	TM5	W => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.62x62	212	TM5	Y => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.32x32	362	TM6	K => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.36x36	366	TM6	T => A	N/A	N/A		Hogger P et al (1995)
acm1_human	3.49x49	122	TM3	D => N	N/A	N/A		Moro O et al (1994)
acm1_human	3.52x52	125	TM3	F => A	N/A	N/A		Moro O et al (1994)
acm1_human	3.54x54	127	TM3	V => A	N/A	N/A		Moro O et al (1994)
acm1_human	34.50x50	130	ICL2	P => A	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => A	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => N	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => D	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => F	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => M	N/A	N/A		Moro O et al (1994)
acm1_human	34.53x53	133	ICL2	Y => A	N/A	N/A		Moro O et al (1994)
acm1_human	34.56x56	136	ICL2	K => A	N/A	N/A		Moro O et al (1994)
acm1_human	2.62x61	83	TM2	T => A	N/A	N/A		Matsui H et al (1995)
acm1_human	2.64x63	85	TM2	Y => A	N/A	N/A		Matsui H et al (1995)
acm1_human	23.50x50	91	ECL1	W => A	N/A	N/A		Matsui H et al (1995)
acm1_human	23.50x50	91	ECL1	W => F	N/A	N/A		Matsui H et al (1995)
acm1_human	3.21x21	94	TM3	G => A	N/A	N/A		Matsui H et al (1995)
acm1_human	3.28x28	101	TM3	W => A	N/A	N/A		Matsui H et al (1995)
acm1_human	3.28x28	101	TM3	W => F	N/A	N/A		Matsui H et al (1995)
acm1_human	4.64x64	164	TM4	W => A	N/A	N/A		Matsui H et al (1995)
acm1_human	4.65x65	165	TM4	Q => A	N/A	N/A		Matsui H et al (1995)
acm1_human	4.69x69	169	TM4	G => A	N/A	N/A		Matsui H et al (1995)
acm1_human		171	ECL2	R => A	N/A	N/A		Matsui H et al (1995)
acm1_human		172	ECL2	T => A	N/A	N/A		Matsui H et al (1995)
acm1_human		181	ECL2	Q => A	N/A	N/A		Matsui H et al (1995)
acm1_human		182	ECL2	F => A	N/A	N/A		Matsui H et al (1995)
acm1_human		184	ECL2	S => A	N/A	N/A		Matsui H et al (1995)
acm1_human	6.59x59	389	TM6	T => A	N/A	N/A		Matsui H et al (1995)
acm1_human	6.60x60	390	TM6	F => A	N/A	N/A		Matsui H et al (1995)
acm1_human	6.61x61	391	TM6	C => A	N/A	N/A		Matsui H et al (1995)
acm1_human		394	ECL3	C => A	N/A	N/A		Matsui H et al (1995)
acm1_human	7.31x30	396	TM7	P => A	N/A	N/A		Matsui H et al (1995)
acm1_human	7.33x32	398	TM7	T => A	N/A	N/A		Matsui H et al (1995)
acm1_human	7.35x34	400	TM7	W => A	N/A	N/A		Matsui H et al (1995)
acm1_human	7.35x34	400	TM7	W => F	N/A	N/A		Matsui H et al (1995)
acm1_human	7.39x38	404	TM7	Y => A	N/A	N/A		Matsui H et al (1995)
acm1_human	7.39x38	404	TM7	Y => F	N/A	N/A		Matsui H et al (1995)
acm1_human	3.54x54	127	TM3	V => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	34.51x51	131	ICL2	L => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	5.61x61	211	TM5	I => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	6.30x30	360	TM6	E => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	6.32x32	362	TM6	K => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	5.42x43	192	TM5	T => A	N/A	N/A		Huang XP et al (1999)
acm1_human	6.52x52	382	TM6	N => A	N/A	N/A		Huang XP et al (1999)
acm1_human		284	ICL3	S => A	N/A	N/A		Moro O et al (1993)
acm1_human	6.58x58	388	TM6	S => Y	N/A	N/A		Huang XP et al (1999)
acm1_human	6.59x59	389	TM6	T => P	N/A	N/A		Huang XP et al (1999)
acm1_human	2.50x50	71	TM2	D => N	N/A	N/A		Lameh J et al (1992)
acm1_human	2.61x60	82	TM2	Y => F	N/A	N/A		Drubbisch V et al (1992)
acm1_human	3.54x54	127	TM3	V => A	N/A	N/A		Moro O et al (1994)
acm1_human	3.54x54	127	TM3	V => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	34.51x51	131	ICL2	L => A	N/A	N/A		Moro O et al (1994)
acm1_human	34.51x51	131	ICL2	L => D	N/A	N/A		Moro O et al (1993)
acm1_human		173	ECL2	V => M	N/A	N/A		Lucas JL et al (2001)
acm1_human	5.42x43	192	TM5	T => A	N/A	N/A		Huang XP et al (1999)
acm1_human	5.59x59	209	TM5	W => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.61x61	211	TM5	I => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.61x61	211	TM5	I => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	5.62x62	212	TM5	Y => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.64x64	214	TM5	E => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.66x66	216	TM5	E => A	N/A	N/A		Hogger P et al (1995)
acm1_human	5.71x71	221	TM5	E => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.29x29	359	TM6	K => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.30x30	360	TM6	E => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.30x30	360	TM6	E => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	6.31x31	361	TM6	K => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.32x32	362	TM6	K => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.32x32	362	TM6	K => A	N/A	N/A		Shockley MS et al (1997)
acm1_human	6.36x36	366	TM6	T => A	N/A	N/A		Hogger P et al (1995)
acm1_human	6.52x52	382	TM6	N => A	N/A	N/A		Huang XP et al (1999)
acm1_human	6.58x58	388	TM6	S => Y	N/A	N/A		Huang XP et al (1999)
acm1_human	6.58x58	388	TM6	S => Y	N/A	N/A		Huang XP et al (1998)
acm1_human	6.59x59	389	TM6	T => P	N/A	N/A		Huang XP et al (1999)
acm1_human	6.59x59	389	TM6	T => P	N/A	N/A		Huang XP et al (1998)
acm1_human	6.59x59	389	TM6	T => Y	N/A	N/A		Huang XP et al (1998)
acm1_human	7.51x51	416	TM7	M => A	N/A	N/A		Schlador ML et al (2000)
acm1_human	7.52x52	417	TM7	C => R	N/A	N/A		Lucas JL et al (2001)
acm1_human	7.52x52	417	TM7	C => S	N/A	N/A		Lucas JL et al (2001)
acm1_human	3.28x28	101	TM3	W => A	N/A	N/A		Leach K et al (2011)
acm1_human	3.28x28	101	TM3	W => A	N/A	N/A		Gregory KJ et al (2010)
acm1_human	7.49x49	414	TM7	N => H	N/A	N/A		Ballesteros JA et al (2001)
acm1_human		269	ICL3	L => H	N/A	N/A		Ballesteros JA et al (2001)
acm1_human		272	ICL3	Y => H	N/A	N/A		Ballesteros JA et al (2001)
acm1_human	3.43x43	116	TM3	L => H	N/A	N/A		Ballesteros JA et al (2001)
acm1_human	6.44x44	374	TM6	F => H	N/A	N/A		Ballesteros JA et al (2001)
acm1_human	2.56x551	77	TM2	F => I	1.259↓	pK(A) (Binding - Radioligand competition/displacement)	AC-42	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	24.547↑	pK(A) (Binding - Radioligand competition/displacement)	AC-42	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	2.455↑	pK(A) (Binding - Radioligand competition/displacement)	AC-42	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.783↓	K(i) (Binding - Radioligand competition/displacement)	APE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1.524↑	K(i) (Binding - Radioligand competition/displacement)	APE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	2.754↑	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.175↑	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	5.618↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.862↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.0	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	7.752↓	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	18.182↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	24.39↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	2.137↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	333.333↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	5.0↓	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	34.483↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	1.202↑	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => A	3.39↓	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	2.342↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	1.548↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.318↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.381↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	3.636↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	1.023↑	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	1.072↓	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	2.088↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.412↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.259↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human		395	ECL3	V => A	3.546↓	pK(A) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.862↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.585↓	pK(d) (Binding - Radioligand saturation)	3-quinuclidinyl-benzilate	Keov P et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.387↓	K(i) (Binding - Radioligand competition/displacement)	HYOSCYAMINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	250.0↓	K(i) (Binding - Radioligand competition/displacement)	HYOSCYAMINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.95↓	pK(i) (Binding - Radioligand competition/displacement)	HYOSCYAMINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	4.367↓	pK(i) (Binding - Radioligand competition/displacement)	HYOSCYAMINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.587↑	K(i) (Binding - Radioligand competition/displacement)	trihexyphenidyl	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	N/A	K(i) (Binding - Radioligand competition/displacement)	trihexyphenidyl	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.288↓	pK(i) (Binding - Radioligand competition/displacement)	trihexyphenidyl	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	35.714↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	6.452↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	76.923↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	13.2↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.25↓	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => F	1.3↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	10.4↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => F	131.9↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.3↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.0	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	288.2↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => F	4.8↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	>100.0↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	6.329↓	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.288↑	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	1.096↑	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	9.804↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	6.173↓	pK(i) (Binding - Radioligand competition/displacement)	4-DAMP	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.46x46	411	TM7	S => A	1.1↑	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	7.47x47	412	TM7	T => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	4-DAMP	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.695↓	K(i) (Binding - Radioligand competition/displacement)	otenzepad	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	>58.824↓	K(i) (Binding - Radioligand competition/displacement)	otenzepad	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL1788199	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	1.698↓	pK(i) (Binding - Radioligand competition/displacement)	tiotropium	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	13.889↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	3.891↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.95↑	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	16.949↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	9.804↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	22.727↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	2.237↓	pK(i) (Binding - Radioligand competition/displacement)	Himbacine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.096↑	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	4.082↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	21.739↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	38.462↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	3.165↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	8.696↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	2.513↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.412↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	1.66↑	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.202↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.096↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.23↑	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	xanomeline	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	3.021↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	2.041↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	5.495↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	4.274↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	3.236↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	1.072↑	pK(i) (Binding - Radioligand competition/displacement)	methoctramine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.318↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.175↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.755↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.175↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	3.636↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	1.82↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	1.047↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	2.089↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.21x21	94	TM3	G => A	3.086↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.21x21	94	TM3	G => A	2.288↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	26.316↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	11.765↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	5.618↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.381↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.64x64	164	TM4	W => A	1.122↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.64x64	164	TM4	W => A	1.514↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.65x65	165	TM4	Q => A	1.698↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.65x65	165	TM4	Q => A	1.318↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.69x69	169	TM4	G => A	3.984↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.69x69	169	TM4	G => A	1.318↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	1.23↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	3.02↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		172	ECL2	T => A	1.122↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		172	ECL2	T => A	1.024↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.35↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.047↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.047↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.148↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.047↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.023↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => A	1.698↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => A	1.445↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.60x60	390	TM6	F => A	1.479↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.60x60	390	TM6	F => A	1.23↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.61x61	391	TM6	C => A	3.236↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.61x61	391	TM6	C => A	1.096↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		394	ECL3	C => A	1.513↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		394	ECL3	C => A	1.445↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.31x30	396	TM7	P => A	1.585↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.31x30	396	TM7	P => A	1.202↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.33x32	398	TM7	T => A	1.122↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.33x32	398	TM7	T => A	1.175↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	18.182↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	9.804↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	10.0↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	5.128↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	1.318↑	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	1.148↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	4.673↓	pK(i) (Binding - Other)	gallamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	5.464↓	K(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	N/A	K(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	11.494↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.50x50	71	TM2	D => N	1.655↑	Single-point (Binding - Radioligand saturation)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.574↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	1.905↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	1.445↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	2.951↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.047↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.23↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.779↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.658↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.259↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => F	1.318↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	7.937↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	6.173↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.21x21	94	TM3	G => A	1.412↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	8.929↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.23↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	9.7↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.4↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	4.785↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	4.367↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	7.407↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => F	2.8↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	7.2↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	1.349↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => F	96.7↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.64x64	164	TM4	W => A	1.479↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.65x65	165	TM4	Q => A	1.202↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.69x69	169	TM4	G => A	2.398↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	3.311↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		172	ECL2	T => A	1.175↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.096↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.202↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	1.072↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => W	1.175↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	1.23↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.096↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.318↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	3.021↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	3.311↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	5.376↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.202↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.0	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.39x40	189	TM5	T => A	3.021↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.25↓	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.905↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.65x65	215	TM5	T => A	1.0	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human		228	ICL3	S => A	1.058↓	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human		252	ICL3	P => A	2.188↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Sawyer GW et al (2008)	Vass M et al (2019)
acm1_human		254	ICL3	T => A	2.632↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Sawyer GW et al (2008)	Vass M et al (2019)
acm1_human		263	ICL3	C => A	2.088↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Sawyer GW et al (2008)	Vass M et al (2019)
acm1_human		284	ICL3	S => A	1.196↓	Single-point (Binding - Other)	N-methyl scopolamine	Moro O et al (1993)	Vass M et al (2019)
acm1_human		322	ICL3	S => A	1.058↓	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human		330	ICL3	T => A	1.018↑	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	6.24x24	354	TM6	T => A	1.127↑	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	6.26x26	356	TM6	S => A	1.091↑	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	6.38x38	368	TM6	S => A	1.055↑	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	6.44x44	374	TM6	F => A	5.618↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	115.0↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => F	1.8↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	105.0↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => A	1.148↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.60x60	390	TM6	F => A	1.412↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.61x61	391	TM6	C => A	1.047↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.445↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		394	ECL3	C => A	1.318↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.31x30	396	TM7	P => A	1.349↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.32x31	397	TM7	E => A	1.658↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.33x32	398	TM7	T => A	1.047↑	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.479↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	1.202↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.23↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.072↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	1.318↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => Y	2.455↑	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.175↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	52.632↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	7.246↓	pK(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.40x39	405	TM7	W => A	1.23↓	pK(A) (Binding - Radioligand saturation)	N-methyl scopolamine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.46x46	411	TM7	S => A	1.6↑	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	7.47x47	412	TM7	T => A	1.429↓	K(d) (Binding - Radioligand saturation)	N-methyl scopolamine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	8.53x53	428	H8	T => A	1.037↓	Single-point (Binding - Other)	N-methyl scopolamine	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.047↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	9.804↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	8.547↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	35.714↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Suga H et al (2010)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	31.25↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Suga H et al (2013)	Vass M et al (2019)
acm1_human	4.66x66	166	TM4	Y => A	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	4.67x67	167	TM4	L => F	1.949↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		170	ECL2	E => A	1.047↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		170	ECL2	E => K	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		174	ECL2	L => A	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		174	ECL2	L => P	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		177	ECL2	Q => E	1.381↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	2.342↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.658↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	5.35x36	185	TM5	Q => A	1.096↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.047↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.818↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.32x31	397	TM7	E => A	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	N-methyl scopolamine	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.429↓	K(i) (Binding - Radioligand competition/displacement)	McN-A-343	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	10.204↓	pK(i) (Binding - Radioligand competition/displacement)	McN-A-343	Suga H et al (2010)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	11.765↓	pK(i) (Binding - Radioligand competition/displacement)	McN-A-343	Suga H et al (2013)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	1.429↓	K(i) (Binding - Radioligand competition/displacement)	McN-A-343	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	3.333↓	K(i) (Binding - Radioligand competition/displacement)	McN-A-343	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	10.0↓	K(i) (Binding - Radioligand competition/displacement)	McN-A-343	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	19.1↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	1.667↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => F	2.3↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	31.7↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => F	7.4↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.7↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.447↑	K(h) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	4.545↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.833↑	K(l) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	1.25↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => F	10.0↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	>100.0↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	2.545↓	K(h) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	8.197↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	2.786↓	K(l) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	16.923↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.895↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	27.5↑	K(l) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	1.938↓	K(l) (Binding - Radioligand competition/displacement)	oxotremorine-M	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	7.46x46	411	TM7	S => A	2.1↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	7.47x47	412	TM7	T => A	1.0	K(i) (Binding - Radioligand competition/displacement)	oxotremorine-M	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.048↑	IC50 (Binding - Radioligand competition/displacement)	atropine	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.072↓	IC50 (Binding - Radioligand competition/displacement)	atropine	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	4.673↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	5.618↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	17.857↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	1.122↑	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	27.778↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	3.236↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	1.621↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	3.165↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	3.717↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	125.0↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.289↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	atropine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	12.346↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	5.882↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.047↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	32.359↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	3.09↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	4.566↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	8.128↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	3.311↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.738↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.318↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.862↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	19.953↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.739↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	7.407↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.862↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL522460	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.175↓	pK(A) (Binding - Radioligand competition/displacement)	pilocarpine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.667↓	K(i) (Binding - Radioligand competition/displacement)	pilocarpine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	3.236↓	pK(A) (Binding - Radioligand competition/displacement)	pilocarpine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	3.2↑	K(i) (Binding - Radioligand competition/displacement)	pilocarpine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.25↓	K(i) (Binding - Radioligand competition/displacement)	pilocarpine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	4.8↑	K(i) (Binding - Radioligand competition/displacement)	pilocarpine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	34.483↓	pK(A) (Binding - Radioligand competition/displacement)	pilocarpine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.441↑	K(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.174↑	K(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	9.709↓	K(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	15.625↓	K(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.188↓	pK(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	4.367↓	pK(d) (Binding - Radioligand saturation)	CHEMBL558910	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	1.622↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	1.23↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.479↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.259↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.479↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	1.096↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => F	1.445↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.289↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	2.342↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	5.0↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.148↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.381↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	1.259↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => W	1.738↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	3.467↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	4.266↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.202↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.818↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.622↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.39x40	189	TM5	T => A	1.549↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.688↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	6.44x44	374	TM6	F => A	7.762↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.23↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		395	ECL3	V => A	1.349↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.32x31	397	TM7	E => A	1.479↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	2.398↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => Y	3.546↓	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.698↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.40x39	405	TM7	W => A	16.218↑	pK(b) (Binding - Radioligand competition/displacement)	CHEMBL608112	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	2.137↓	pK(A) (Binding - Radioligand competition/displacement)	acetylcholine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.513↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	13.158↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	6.623↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.349↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.096↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	13.158↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => F	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	3.086↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	37.037↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	45.455↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	4.566↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	5.376↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.21x21	94	TM3	G => A	1.38↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.21x21	94	TM3	G => A	2.632↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	21.739↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	23.81↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	3.548↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	2.089↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	13.514↓	pK(A) (Binding - Radioligand competition/displacement)	acetylcholine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	17.241↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	58.824↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	47.619↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Suga H et al (2010)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	55.556↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Suga H et al (2013)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	20.0↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	50.0↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	3.546↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => Q	1.413↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Thal DM et al (2016)	Vass M et al (2019)
acm1_human	4.64x64	164	TM4	W => A	6.623↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.64x64	164	TM4	W => A	5.495↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.65x65	165	TM4	Q => A	1.202↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.65x65	165	TM4	Q => A	1.412↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.69x69	169	TM4	G => A	4.367↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	4.69x69	169	TM4	G => A	6.329↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	3.717↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	4.167↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		172	ECL2	T => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		172	ECL2	T => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	4.673↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	1.349↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => W	1.072↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	7.246↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	2.692↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	2.042↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.23↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.739↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.739↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	3.39↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	2.95↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	2.398↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	2.513↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	14.167↑	K(h) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	37.037↓	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	83.333↓	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.128↓	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	111.111↓	pK(A) (Binding - Radioligand competition/displacement)	acetylcholine	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	43.478↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	7.727↑	K(h) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	9.009↓	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	23.256↓	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1.667↓	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	12.143↑	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	107.143↑	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	1.845↓	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	52.632↓	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => A	1.658↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	1.235↓	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	1.071↑	K(i) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	78.0↑	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	56.522↑	K(l) (Binding - Radioligand competition/displacement)	acetylcholine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.60x60	390	TM6	F => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.60x60	390	TM6	F => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.61x61	391	TM6	C => A	1.905↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	6.61x61	391	TM6	C => A	2.042↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	2.817↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.739↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human		394	ECL3	C => A	3.631↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human		394	ECL3	C => A	2.138↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.31x30	396	TM7	P => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.31x30	396	TM7	P => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.33x32	398	TM7	T => A	1.412↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.33x32	398	TM7	T => A	1.412↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	9.091↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	8.13↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	6.329↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	17.857↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	3.086↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	1.949↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => Y	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	3.636↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	45.455↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	58.824↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	22.727↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	25.641↓	pK(i) (Binding - Radioligand competition/displacement)	acetylcholine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.429↓	K(i) (Binding - Radioligand competition/displacement)	arecoline	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	3.8↑	K(i) (Binding - Radioligand competition/displacement)	arecoline	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	arecoline	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.285↓	K(i) (Binding - Radioligand competition/displacement)	arecoline	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	1.667↓	K(i) (Binding - Radioligand competition/displacement)	arecoline	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1.024↑	K(i) (Binding - Radioligand competition/displacement)	arecoline	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	19.091↑	K(i) (Binding - Radioligand competition/displacement)	arecoline	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	11.053↑	K(i) (Binding - Radioligand competition/displacement)	arecoline	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.25↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	13.3↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.0	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.89↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	1.6↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	62.5↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.725↓	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	3.103↑	K(i) (Binding - Radioligand competition/displacement)	oxotremorine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	1.149↓	K(i) (Binding - Radioligand competition/displacement)	CHOLINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	3.096↓	K(i) (Binding - Radioligand competition/displacement)	CHOLINE	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.50x50	71	TM2	D => N	No effect	IC50 (Binding - Radioligand competition/displacement)	carbachol	Lameh J et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.464↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.864↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	1.87↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	4.673↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.62x61	83	TM2	T => A	1.148↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	5.236↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	1.111↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	3.333↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	8.333↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	22.222↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	29.412↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => F	3.6↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	1000.0↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	8.3↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => F	6.0↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => A	500.0↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.175↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	3.086↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	7.244↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.318↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	11.236↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		184	ECL2	S => A	1.621↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.39x40	189	TM5	T => A	7.407↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.5↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.063↓	K(h) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	9.524↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	3.861↓	K(l) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	21.739↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.59x59	209	TM5	W => A	1.179↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	5.61x61	211	TM5	I => A	1.757↓	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	5.62x62	212	TM5	Y => A	1.453↓	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	6.30x30	360	TM6	E => A	11.0↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	6.32x32	362	TM6	K => A	4.854↓	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	6.36x36	366	TM6	T => A	2.75↑	IC50 (Binding - Radioligand competition/displacement)	carbachol	Hogger P et al (1995)	Vass M et al (2019)
acm1_human	6.44x44	374	TM6	F => A	7.413↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	5.0↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => F	1.111↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	166.667↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	>100.0↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	3.745↓	K(h) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	3.704↓	K(i) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	3.378↓	K(l) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	86.957↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	4.329↓	K(l) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	4.651↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	1.0	K(i) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	29.643↑	K(l) (Binding - Radioligand competition/displacement)	carbachol	Huang XP et al (1999)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human		395	ECL3	V => A	500.0↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.32x31	397	TM7	E => A	1.202↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	2.398↓	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.096↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.40x39	405	TM7	W => A	6.918↑	pK(i) (Binding - Radioligand competition/displacement)	carbachol	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.46x46	411	TM7	S => A	1.5↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	7.47x47	412	TM7	T => A	1.3↑	K(i) (Binding - Radioligand competition/displacement)	carbachol	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	3.003↓	IC50 (Binding - Radioligand competition/displacement)	pirenzepine	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	2.564↓	IC50 (Binding - Radioligand competition/displacement)	pirenzepine	Drubbisch V et al (1992)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	7.752↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => F	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	166.667↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	28.9↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => F	2.2↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => F	1.25↓	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	3.37x37	110	TM3	N => A	6.4↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	4.57x57	157	TM4	W => F	66.1↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.667↓	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.318↓	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => A	34.6↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.48x48	378	TM6	W => F	1.2↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	>100.0↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1000.0↓	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.58x58	388	TM6	S => Y	2.398↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.59x59	389	TM6	T => P	6.897↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	3.546↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	3.717↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => A	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.39x38	404	TM7	Y => F	1.122↑	pK(i) (Binding - Radioligand competition/displacement)	pirenzepine	Matsui H et al (1995)	Vass M et al (2019)
acm1_human	7.46x46	411	TM7	S => A	1.5↑	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	7.47x47	412	TM7	T => A	1.111↓	K(i) (Binding - Radioligand competition/displacement)	pirenzepine	Bourdon H et al (1997)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.549↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	23.50x50	91	ECL1	W => A	14.706↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	4.785↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	4.66x66	166	TM4	Y => A	1.381↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	4.67x67	167	TM4	L => F	1.023↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		170	ECL2	E => A	1.862↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		170	ECL2	E => K	14.493↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		171	ECL2	R => A	9.346↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		174	ECL2	L => A	1.096↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		174	ECL2	L => P	12.658↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		177	ECL2	Q => E	1.288↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	16.667↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.072↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	5.35x36	185	TM5	Q => A	1.318↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.259↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.072↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.32x31	397	TM7	E => A	1.175↑	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	10.989↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.862↓	pKx (Binding - Radioligand competition/displacement)	muscarinic toxin 7	Marquer C et al (2011)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.0	K(i) (Binding - Radioligand competition/displacement)	p-F-HHSiD	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	41.667↓	K(i) (Binding - Radioligand competition/displacement)	p-F-HHSiD	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.412↓	K(i) (Binding - Radioligand competition/displacement)	scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	83.333↓	K(i) (Binding - Radioligand competition/displacement)	scopolamine	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	3.26x26	99	TM3	D => N	2.841↓	Single-point (Binding - Radioligand competition/displacement)	BR-384	Suga H et al (2010)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => N	3.51↑	Single-point (Binding - Radioligand competition/displacement)	BR-384	Suga H et al (2010)	Vass M et al (2019)
acm1_human	7.42x41	407	TM7	C => A	13.158↓	Single-point (Binding - Radioligand competition/displacement)	BR-384	Suga H et al (2010)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	2.137↓	pK(A) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.862↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	2.95↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	4.274↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	79.433↑	pK(A) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	54.954↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	3.546↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	3.984↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	2.138↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	5.129↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.479↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.622↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	2.63↑	pK(A) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Avlani VA et al (2010)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	4.786↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.381↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	9.091↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL3354065	Keov P et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	2.0↓	K(h) (Binding - Radioligand competition/displacement)	CHEMBL1183042	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	3.003↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1183042	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.852↓	K(l) (Binding - Radioligand competition/displacement)	CHEMBL1183042	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1.034↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1183042	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.149↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1185481	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	1.667↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1185481	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	1.815↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1190710	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	3.0↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1190710	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	1.047↑	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	4.566↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	2.755↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	1.202↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	3.39↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	2.882↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	1.349↑	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	1.479↑	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	2.088↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	2.817↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.818↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	1.995↑	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	1.289↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	2.088↓	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	1.148↑	pK(i) (Binding - Radioligand competition/displacement)	VCP813	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	18.519↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => F	7.576↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	15.152↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => F	4.902↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	100.0↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => F	2.513↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => W	1.38↑	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => F	21.277↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => Y	16.129↓	pK(b) (Binding - Radioligand competition/displacement)	Benzoquinazolinone 12	Abdul-Ridha A et al (2014)	Vass M et al (2019)
acm1_human	5.42x43	192	TM5	T => A	3.584↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1189286	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	6.52x52	382	TM6	N => A	10.833↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL1189286	Huang XP et al (1999)	Vass M et al (2019)
acm1_human	2.56x551	77	TM2	F => I	4.082↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.61x60	82	TM2	Y => A	28.571↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	2.64x63	85	TM2	Y => A	23.81↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	23.49x49	90	ECL1	H => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.28x28	101	TM3	W => A	50.119↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.29x29	102	TM3	L => A	8.547↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.32x32	105	TM3	D => E	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	3.33x33	106	TM3	Y => A	4.367↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.51x51	179	ECL2	Y => A	1.202↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	45.52x52	180	ECL2	I => A	4.365↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human		181	ECL2	Q => A	1.122↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human		182	ECL2	F => A	1.148↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human		183	ECL2	L => A	1.549↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	6.51x51	381	TM6	Y => A	2.884↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human		392	ECL3	K => A	2.817↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human		393	ECL3	D => A	2.342↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.35x34	400	TM7	W => A	13.889↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
acm1_human	7.36x35	401	TM7	E => A	2.571↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL2146597	Keov P et al (2014)	Vass M et al (2019)
Protein name	Generic number	Segment	Position	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

Residue

Diagrams

Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

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Residue Table

GPCRdb(A)	GPCRdb(A)	M₁ receptor
TM2
2x50	2.50x50	D71
2x551	2.56x551	F77
2x60	2.61x60	Y82
2x61	2.62x61	T83
2x63	2.64x63	Y85
TM3
3x21	3.21x21	G94
3x26	3.26x26	D99
3x28	3.28x28	W101
3x29	3.29x29	L102
3x32	3.32x32	D105
3x33	3.33x33	Y106
3x37	3.37x37	N110
3x43	3.43x43	L116
3x49	3.49x49	D122
3x52	3.52x52	F125
3x54	3.54x54	V127
TM4
4x57	4.57x57	W157
4x64	4.64x64	W164
4x65	4.65x65	Q165
4x66	4.66x66	Y166
4x67	4.67x67	L167
4x69	4.69x69	G169
TM5
5x36	5.35x36	Q185
5x40	5.39x40	T189
5x43	5.42x43	T192
5x59	5.59x59	W209
5x61	5.61x61	I211
5x62	5.62x62	Y212
5x64	5.64x64	E214
5x65	5.65x65	T215
5x66	5.66x66	E216
5x71	5.71x71	E221
TM6
6x24	6.24x24	T354
6x26	6.26x26	S356
6x29	6.29x29	K359
6x30	6.30x30	E360
6x31	6.31x31	K361
6x32	6.32x32	K362
6x36	6.36x36	T366
6x38	6.38x38	S368
6x44	6.44x44	F374
6x48	6.48x48	W378
6x51	6.51x51	Y381
6x52	6.52x52	N382
6x58	6.58x58	S388
6x59	6.59x59	T389
6x60	6.60x60	F390
6x61	6.61x61	C391
TM7
7x30	7.31x30	P396
7x31	7.32x31	E397
7x32	7.33x32	T398
7x34	7.35x34	W400
7x35	7.36x35	E401
7x38	7.39x38	Y404
7x39	7.40x39	W405
7x41	7.42x41	C407
7x46	7.46x46	S411
7x47	7.47x47	T412
7x49	7.49x49	N414
7x51	7.51x51	M416
7x52	7.52x52	C417
H8
8x53	8.53x53	T428

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