Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ada2a_human 3.32x32 128 TM3 D => N N/A N/A Wang CD et al (1991)
ada2a_human 2.50x50 94 TM2 D => N N/A N/A Wang CD et al (1991)
ada2a_human 3.49x49 145 TM3 D => N N/A N/A Wang CD et al (1991)
ada2a_human 5.42x43 215 TM5 S => A N/A N/A Wang CD et al (1991)
ada2a_human 5.46x461 219 TM5 S => A N/A N/A Wang CD et al (1991)
ada2a_human 7.39x38 427 TM7 F => N N/A N/A Suryanarayana S et al (1991)
ada2a_human 7.39x38 427 TM7 F => N N/A N/A Suryanarayana S et al (1993)
ada2a_human 7.39x38 427 TM7 F => N N/A N/A Suryanarayana S et al (1991)
ada2a_human 8.59x59 457 H8 C => F N/A N/A Eason MG et al (1994)
ada2a_human 8.59x59 457 H8 C => A N/A N/A Eason MG et al (1994)
ada2a_human 6.34x34 388 TM6 T => F N/A N/A Ren Q et al (1993)
ada2a_human 6.34x34 388 TM6 T => A N/A N/A Ren Q et al (1993)
ada2a_human 6.34x34 388 TM6 T => C N/A N/A Ren Q et al (1993)
ada2a_human 6.34x34 388 TM6 T => E N/A N/A Ren Q et al (1993)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Ren Q et al (1993)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Betuing S et al (1997)
ada2a_human 4.57x57 180 TM4 S => A N/A N/A Hehr A et al (1997)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Marjamaki A et al (1998)
ada2a_human 8.59x59 457 H8 C => A N/A N/A Jewell-Motz EA et al (1998)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Wurch T et al (1999)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Marjamaki A et al (1999)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Salminen T et al (1999)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Cockcroft V et al (2000)
ada2a_human 2.50x50 94 TM2 D => N N/A N/A Pauwels PJ et al (2000)
ada2a_human 3.32x32 128 TM3 D => S N/A N/A Peltonen JM et al (2003)
ada2a_human 4.57x57 180 TM4 S => A N/A N/A Hehr A et al (1997)
ada2a_human 5.39x40 212 TM5 V => C N/A N/A Marjamaki A et al (1999)
ada2a_human 5.42x43 215 TM5 S => A N/A N/A Rudling JE et al (1999)
ada2a_human 5.42x43 215 TM5 S => A N/A N/A Pauwels PJ et al (2000)
ada2a_human 5.42x43 215 TM5 S => C N/A N/A Marjamaki A et al (1999)
ada2a_human 5.42x43 215 TM5 S => C N/A N/A Peltonen JM et al (2003)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Marjamaki A et al (1999)
ada2a_human 5.43x44 216 TM5 C => S N/A N/A Peltonen JM et al (2003)
ada2a_human 5.46x461 219 TM5 S => A N/A N/A Rudling JE et al (1999)
ada2a_human 5.46x461 219 TM5 S => A N/A N/A Pauwels PJ et al (2000)
ada2a_human 5.46x461 219 TM5 S => C N/A N/A Marjamaki A et al (1999)
ada2a_human 5.69x69 242 TM5 T => A N/A N/A Liang M et al (2002)
ada2a_human 5.74x74 247 TM5 S => A N/A N/A Liang M et al (2002)
ada2a_human 273 ICL3 S => A N/A N/A Liang M et al (2002)
ada2a_human 339 ICL3 S => A N/A N/A Liang M et al (2002)
ada2a_human 375 ICL3 S => A N/A N/A Liang M et al (2002)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Wurch T et al (1999)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Pauwels PJ et al (2000)
ada2a_human 6.34x34 388 TM6 T => K N/A N/A Pauwels PJ et al (2001)
ada2a_human 7.39x38 427 TM7 F => N N/A N/A Mizobe T et al (1996)
ada2a_human 6.32x32 386 TM6 R => A N/A N/A Pao CS et al (2005)
ada2a_human 6.31x31 385 TM6 K => A N/A N/A Pao CS et al (2005)
ada2a_human 368 ICL3 R => A N/A N/A Pao CS et al (2005)
ada2a_human 376 ICL3 R => A N/A N/A Pao CS et al (2005)
ada2a_human 373 ICL3 K => A N/A N/A Pao CS et al (2005)
ada2a_human 337 ICL3 R => A N/A N/A Pao CS et al (2005)
ada2a_human 335 ICL3 K => A N/A N/A Pao CS et al (2005)
ada2a_human 333 ICL3 K => A N/A N/A Pao CS et al (2005)
ada2a_human 258 ICL3 P => A N/A N/A Pao CS et al (2005)
ada2a_human 257 ICL3 P => A N/A N/A Pao CS et al (2005)
ada2a_human 5.68x68 241 TM5 R => A N/A N/A Pao CS et al (2005)
ada2a_human 5.67x67 240 TM5 R => A N/A N/A Pao CS et al (2005)
ada2a_human 5.66x66 239 TM5 K => A N/A N/A Pao CS et al (2005)
ada2a_human 5.60x60 233 TM5 R => A N/A N/A Pao CS et al (2005)
ada2a_human 3.50x50 146 TM3 R => E N/A N/A Rodriguez D et al (2011)
ada2a_human 5.64x64 237 TM5 I => A N/A N/A Chen XP et al (2010)
ada2a_human 2.50x50 94 TM2 D => N 7.812↓ EC50 (Binding - Radioligand competition/displacement) idazoxan Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.585↑ pK(i) (Binding - Radioligand saturation) idazoxan Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.435↓ EC50 (Binding - Radioligand competition/displacement) idazoxan Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) idazoxan Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 14.706↓ pK(i) (Binding - Radioligand competition/displacement) idazoxan Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.175↓ pK(i) (Binding - Radioligand competition/displacement) idazoxan Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.259↑ pK(i) (Binding - Radioligand saturation) idazoxan Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.438↑ EC50 (Binding - Radioligand competition/displacement) idazoxan Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.399↑ pK(d) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 2.291↑ pK(d) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.0↑ K(d) (Binding - Radioligand saturation) RX821002 Marjamaki A et al (1998) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.429↑ K(d) (Binding - Radioligand saturation) RX821002 Marjamaki A et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.066↑ K(d) (Binding - Radioligand saturation) RX821002 Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.488↓ K(d) (Binding - Radioligand saturation) RX821002 Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.119↑ K(d) (Binding - Radioligand saturation) RX821002 Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 9.091↓ pK(d) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.083↑ K(d) (Binding - Radioligand saturation) RX821002 Betuing S et al (1997) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 2.344↑ pK(d) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.63↑ pK(i) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.23↑ pK(i) (Binding - Radioligand competition/displacement) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 10.0↓ pK(i) (Binding - Radioligand competition/displacement) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.585↓ pK(i) (Binding - Radioligand competition/displacement) RX821002 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.047↑ pK(i) (Binding - Radioligand saturation) RX821002 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.992↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1160703 Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 4.464↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1160703 Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 5.682↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1160703 Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 4.0↓ K(i) (Binding - Radioligand competition/displacement) R-norphenephrine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 16.667↓ K(i) (Binding - Radioligand competition/displacement) R-norphenephrine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 13.158↓ K(i) (Binding - Radioligand competition/displacement) R-norphenephrine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.778↑ pK(i) (Binding - Radioligand saturation) RX 811033 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.047↓ pK(i) (Binding - Radioligand competition/displacement) RX 811033 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 11.236↓ pK(i) (Binding - Radioligand competition/displacement) RX 811033 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 2.882↓ pK(i) (Binding - Radioligand competition/displacement) RX 811033 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 2.342↓ pK(i) (Binding - Radioligand saturation) RX 811033 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 10.417↓ K(i) (Binding - Radioligand competition/displacement) phenylephrine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 4.255↓ K(i) (Binding - Radioligand competition/displacement) phenylephrine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.549↑ pK(i) (Binding - Radioligand saturation) CHEMBL123349 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.23↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL123349 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 8.13↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL123349 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.318↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL123349 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.413↑ pK(i) (Binding - Radioligand saturation) CHEMBL123349 Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.35↓ pK(i) (Binding - Radioligand competition/displacement) MK-912 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.512↑ pK(i) (Binding - Radioligand saturation) clonidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.175↓ pK(i) (Binding - Radioligand competition/displacement) clonidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.054↓ K(i) (Binding - Radioligand competition/displacement) clonidine Salminen T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.372↑ K(i) (Binding - Radioligand competition/displacement) clonidine Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.071↑ K(i) (Binding - Radioligand competition/displacement) clonidine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.054↓ K(i) (Binding - Radioligand competition/displacement) clonidine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 2.342↓ pK(i) (Binding - Radioligand competition/displacement) clonidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 3.548↑ pK(i) (Binding - Radioligand competition/displacement) clonidine Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 5.888↑ pK(i) (Binding - Radioligand saturation) clonidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.622↑ pK(i) (Binding - Radioligand saturation) DEXEFAROXAN Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.047↑ pK(i) (Binding - Radioligand competition/displacement) DEXEFAROXAN Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 12.048↓ pK(i) (Binding - Radioligand competition/displacement) DEXEFAROXAN Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.023↑ pK(i) (Binding - Radioligand competition/displacement) DEXEFAROXAN Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.122↑ pK(i) (Binding - Radioligand saturation) DEXEFAROXAN Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 3.953↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Salminen T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 3.831↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 4.016↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.326↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 10.989↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 3.953↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 4.132↓ K(i) (Binding - Radioligand competition/displacement) (-)-noradrenaline Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 3.36x36 132 TM3 C => V 1.19↓ K(d) (Binding - Radioligand saturation) [3H]RS-79948-197 Frang H et al (2001) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.961↓ K(d) (Binding - Radioligand saturation) yohimbine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 4.739↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.608↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.883↓ K(d) (Binding - Radioligand saturation) yohimbine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.333↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.488↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.133↑ K(d) (Binding - Radioligand saturation) yohimbine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 2.353↓ K(d) (Binding - Radioligand saturation) yohimbine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.74x74 247 TM5 S => A 1.2↑ K(d) (Binding - Radioligand saturation) yohimbine Liang M et al (2001) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.488↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 2.825↓ K(d) (Binding - Radioligand saturation) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 4.292↓ EC50 (Binding - Radioligand competition/displacement) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.901↓ EC50 (Binding - Radioligand competition/displacement) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.037↓ K(i) (Binding - Radioligand competition/displacement) yohimbine Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.149↑ EC50 (Binding - Radioligand competition/displacement) yohimbine Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.779↓ pK(i) (Binding - Radioligand competition/displacement) RS-15385 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.217↓ K(i) (Binding - Radioligand competition/displacement) L-NOREPINEPHRINE Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 20.0↓ K(i) (Binding - Radioligand competition/displacement) L-NOREPINEPHRINE Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.497↓ K(i) (Binding - Radioligand competition/displacement) R-2-amino-1-phenylethanol Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 5.714↓ K(i) (Binding - Radioligand competition/displacement) R-2-amino-1-phenylethanol Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 10.526↓ K(i) (Binding - Radioligand competition/displacement) R-2-amino-1-phenylethanol Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.105↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.105↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.0 EC50 (Binding - Radioligand competition/displacement) prazosin Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.527↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.527↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.0 EC50 (Binding - Radioligand competition/displacement) prazosin Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 3.155↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 3.155↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 3.69↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 3.69↓ K(i) (Binding - Radioligand competition/displacement) prazosin Wang CD et al (1991) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.0 EC50 (Binding - Radioligand competition/displacement) prazosin Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.445↓ pK(i) (Binding - Radioligand competition/displacement) BRL 44408 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 2.755↓ pK(i) (Binding - Radioligand competition/displacement) WB 4101 Wurch T et al (1999) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.778↑ pK(i) (Binding - Radioligand competition/displacement) TALIPEXOLE Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 1.288↑ pK(i) (Binding - Radioligand competition/displacement) TALIPEXOLE Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.223↑ K(i) (Binding - Radioligand competition/displacement) CHLOROETHYLCLONIDINE Marjamaki A et al (1998) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.223↑ K(i) (Binding - Radioligand competition/displacement) CHLOROETHYLCLONIDINE Marjamaki A et al (1999) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.429↓ K(i) (Binding - Radioligand competition/displacement) OXEDRINE Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 1.072↓ K(i) (Binding - Radioligand competition/displacement) OXEDRINE Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.089↑ pK(i) (Binding - Radioligand saturation) atipamezole Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.622↑ pK(i) (Binding - Radioligand competition/displacement) atipamezole Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 5.747↓ pK(i) (Binding - Radioligand competition/displacement) atipamezole Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.35↓ pK(i) (Binding - Radioligand competition/displacement) atipamezole Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.047↑ pK(i) (Binding - Radioligand saturation) atipamezole Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 12.5↓ K(i) (Binding - Radioligand competition/displacement) Norphenephrine Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 2.809↓ K(i) (Binding - Radioligand competition/displacement) Norphenephrine Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.326↓ K(i) (Binding - Radioligand competition/displacement) PI-CLONIDINE Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 3.236↑ pK(i) (Binding - Radioligand competition/displacement) guanabenz Wurch T et al (1999) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.421↑ K(i) (Binding - Radioligand competition/displacement) (+)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 6.667↓ K(i) (Binding - Radioligand competition/displacement) (+)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 19.608↓ K(i) (Binding - Radioligand competition/displacement) (+)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 17.857↓ K(i) (Binding - Radioligand competition/displacement) (+)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.952↑ K(i) (Binding - Radioligand competition/displacement) octopamine Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 1.208↓ K(i) (Binding - Radioligand competition/displacement) octopamine Rudling JE et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 3.623↓ K(i) (Binding - Radioligand competition/displacement) dopamine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 7.143↓ K(i) (Binding - Radioligand competition/displacement) dopamine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 27.778↓ K(i) (Binding - Radioligand competition/displacement) dopamine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 4.138↑ K(i) (Binding - Radioligand competition/displacement) phentolamine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.36x36 132 TM3 C => V 45.455↓ K(i) (Binding - Radioligand competition/displacement) phentolamine Frang H et al (2001) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.751↓ K(i) (Binding - Radioligand competition/displacement) phentolamine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 2.165↓ K(i) (Binding - Radioligand competition/displacement) phentolamine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 2.5↑ K(i) (Binding - Radioligand competition/displacement) phentolamine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.318↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.597↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.658↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Salminen T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.721↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.222↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.658↓ K(i) (Binding - Radioligand competition/displacement) apraclonidine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 10.667↑ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.288↓ EC50 (Binding - Radioligand competition/displacement) (-)-adrenaline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 15.136↑ pK(i) (Binding - Radioligand saturation) (-)-adrenaline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 2.5↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.894↓ EC50 (Binding - Radioligand competition/displacement) (-)-adrenaline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 27.778↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A <3.984↓ pK(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.717↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 17.857↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 43.478↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 13.158↓ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A <3.984↓ pK(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.74x74 247 TM5 S => A 1.099↑ K(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Liang M et al (2001) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 19.953↑ pK(i) (Binding - Radioligand competition/displacement) (-)-adrenaline Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 20.893↑ pK(i) (Binding - Radioligand saturation) (-)-adrenaline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.652↑ EC50 (Binding - Radioligand competition/displacement) (-)-adrenaline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.259↓ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 3.36x36 132 TM3 C => V 17.544↓ K(i) (Binding - Radioligand competition/displacement) phenoxybenzamine Frang H et al (2001) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 5.051↓ K(i) (Binding - Radioligand competition/displacement) oxymetazoline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.667↓ K(i) (Binding - Radioligand competition/displacement) oxymetazoline Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.141↓ EC50 (Binding - Radioligand competition/displacement) oxymetazoline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 3.802↑ pK(i) (Binding - Radioligand saturation) oxymetazoline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.25↑ EC50 (Binding - Radioligand competition/displacement) oxymetazoline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 2.63↑ pK(i) (Binding - Radioligand competition/displacement) oxymetazoline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 22.727↓ K(i) (Binding - Radioligand competition/displacement) oxymetazoline Salminen T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 9.346↓ K(i) (Binding - Radioligand competition/displacement) oxymetazoline Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 3.388↑ pK(i) (Binding - Radioligand competition/displacement) oxymetazoline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.862↑ pK(i) (Binding - Radioligand competition/displacement) oxymetazoline Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.862↑ pK(i) (Binding - Radioligand saturation) oxymetazoline Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 2.096↓ EC50 (Binding - Radioligand competition/displacement) oxymetazoline Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 13.183↑ pK(i) (Binding - Radioligand saturation) dexmedetomidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 2.344↑ pK(i) (Binding - Radioligand competition/displacement) dexmedetomidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.092↓ K(i) (Binding - Radioligand competition/displacement) dexmedetomidine Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 1.047↑ pK(i) (Binding - Radioligand competition/displacement) dexmedetomidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 8.128↑ pK(i) (Binding - Radioligand saturation) dexmedetomidine Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 1.761↓ K(d) (Binding - Radioligand saturation) brimonidine (UK14304) Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.0↓ K(d) (Binding - Radioligand saturation) brimonidine (UK14304) Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 1.499↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 2.611↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Wang CD et al (1991) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 4.386↓ EC50 (Binding - Radioligand competition/displacement) brimonidine (UK14304) Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 2.50x50 94 TM2 D => N 3.02↑ pK(i) (Binding - Radioligand saturation) brimonidine (UK14304) Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 3.49x49 145 TM3 D => N 1.171↓ EC50 (Binding - Radioligand competition/displacement) brimonidine (UK14304) Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.42x43 215 TM5 S => A 1.739↓ pK(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 200.0↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Salminen T et al (1999) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 200.0↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Cockcroft V et al (2000) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 3.937↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 6.211↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 200.0↓ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.46x461 219 TM5 S => A 3.09↑ pK(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => A 2.234↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Ren Q et al (1993) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => C 5.385↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Ren Q et al (1993) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => E 5.0↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Ren Q et al (1993) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => F 1.312↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Ren Q et al (1993) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 10.5↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Ren Q et al (1993) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 1.571↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Betuing S et al (1997) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 3.646↑ K(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Betuing S et al (1997) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 8.71↑ pK(i) (Binding - Radioligand competition/displacement) brimonidine (UK14304) Wurch T et al (1999) Vass M et al (2019)
ada2a_human 6.34x34 388 TM6 T => K 13.804↑ pK(i) (Binding - Radioligand saturation) brimonidine (UK14304) Pauwels PJ et al (2000) Vass M et al (2019)
ada2a_human 8.49x49 447 H8 D => N 1.139↑ EC50 (Binding - Radioligand competition/displacement) brimonidine (UK14304) Horstman DA et al (1990) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 21.739↓ K(i) (Binding - Radioligand competition/displacement) (+)-Octopamine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 2.088↓ K(i) (Binding - Radioligand competition/displacement) S-norphenephrine Peltonen JM et al (2003) Vass M et al (2019)
ada2a_human 5.43x44 216 TM5 C => S 15.385↓ K(i) (Binding - Radioligand competition/displacement) S-norphenephrine Peltonen JM et al (2003) Vass M et al (2019)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM2
2x50 2.50x50 D94
TM3
3x32 3.32x32 D128
3x36 3.36x36 C132
3x49 3.49x49 D145
3x50 3.50x50 R146
TM4
4x57 4.57x57 S180
TM5
5x40 5.39x40 V212
5x43 5.42x43 S215
5x44 5.43x44 C216
5x461 5.46x461 S219
5x60 5.60x60 R233
5x64 5.64x64 I237
5x66 5.66x66 K239
5x67 5.67x67 R240
5x68 5.68x68 R241
5x69 5.69x69 T242
5x74 5.74x74 S247
TM6
6x31 6.31x31 K385
6x32 6.32x32 R386
6x34 6.34x34 T388
TM7
7x38 7.39x38 F427
H8
8x49 8.49x49 D447
8x59 8.59x59 C457