Mutant Browser

Download
Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ccr2_human 1.39x39 49 TM1 Y => F 1.479↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 1.548↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 1.096↑ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 1.95↑ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 1.412↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 2.513↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 1.202↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q 14.493↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 1.23↓ pK(d) (Binding - Radioligand saturation) CCL2 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 6.026↑ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 5.618↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 25.0↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 1.658↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 2.288↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 1.698↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 1.289↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 7.246↓ pK(i) (Binding - Radioligand competition/displacement) SB-282241 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 3.715↑ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 11.494↓ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 2.041↓ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 3.891↓ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 2.398↓ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 28.571↓ pK(i) (Binding - Radioligand competition/displacement) RS-504393 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 2.188↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 37.037↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 4.367↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 2.884↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 8.547↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 3.311↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 1.513↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q 29.412↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 10.989↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL131243 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 3.984↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 15.152↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.571↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 2.63↑ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 1.818↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 1.412↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 3.086↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q 21.277↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 4.167↓ pK(i) (Binding - Radioligand competition/displacement) TAK-779 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 1.072↑ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 5.376↓ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 7.576↓ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => F 1.949↓ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.32x31 284 TM7 D => A 2.342↓ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.36x35 288 TM7 Q => A 1.072↑ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A Abolished pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => A 22.727↓ pK(i) (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Berkhout TA et al (2003) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.297↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 3.019↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => V 1.046↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.477↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 3.837↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => V 13.514↓ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.778↓ IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 1.942↓ IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => F 10.87↓ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 2.57x57 95 TM2 L => A 3.891↓ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 3.29x29 117 TM3 T => A 4.098↓ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A 1.522↓ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.26x25 278 TM7 E => A 1.571↑ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.26x25 278 TM7 E => K 5.946↑ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.34x33 286 TM7 A => V 1.76↑ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.38x37 290 TM7 T => A 6.769↑ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => A 1.227↓ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => K N/A Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.45x45 297 TM7 H => A 3.385↑ Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 7.45x45 297 TM7 H => D N/A Kd (Binding - Radioligand competition/displacement) CCL2 Gavrilin MA et al (2005) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.297↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 3.019↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => V 1.046↑ IC50 (Binding - Radioligand competition/displacement) CCL2 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.477↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 3.837↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.40x39 292 TM7 T => V 13.514↓ IC50 (Binding - Radioligand competition/displacement) TAK-779 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 1.39x39 49 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 2.60x60 98 TM2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.32x32 120 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.33x33 121 TM3 H => A 2.778↓ IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 6.55x55 263 TM6 I => A 1.942↓ IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 7.39x38 291 TM7 E => Q Abolished IC50 (Binding - Radioligand competition/displacement) Teijin-lead_cmp_5 Hall SE et al (2009) Salam W et al (2025)
ccr2_human 3.51x51 139 TM3 Y => F N/A N/A Rodriguez-Frade JM et al (1999)
ccr2_human 3.51x51 139 TM3 Y => F N/A N/A Mellado M et al (1998)
ccr2_human 7.32x31 284 TM7 D => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => N N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => K N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.39x38 291 TM7 E => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.39x38 291 TM7 E => Q N/A N/A Mirzadegan T et al (2000)
ccr2_human 21 N-term T => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 22 N-term T => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 23 N-term F => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 24 N-term F => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 25 N-term D => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 26 N-term Y => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 26 N-term Y => F N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 36 N-term D => A N/A N/A Hemmerich S et al (1999)
ccr2_human 15 N-term E => A N/A N/A Hemmerich S et al (1999)
ccr2_human 18 N-term E => A N/A N/A Hemmerich S et al (1999)
ccr2_human 19 N-term E => A N/A N/A Hemmerich S et al (1999)
ccr2_human 21 N-term T => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 22 N-term T => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 23 N-term F => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 24 N-term F => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 25 N-term D => A N/A N/A Hemmerich S et al (1999)
ccr2_human 25 N-term D => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 26 N-term Y => A N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 26 N-term Y => F N/A N/A Preobrazhensky AA et al (2000)
ccr2_human 27 N-term D => A N/A N/A Hemmerich S et al (1999)
ccr2_human 32 N-term C => A N/A N/A Monteclaro FS et al (1997)
ccr2_human 36 N-term D => A N/A N/A Hemmerich S et al (1999)
ccr2_human 1.28x28 38 TM1 K => D N/A N/A Berkhout TA et al (2003)
ccr2_human 1.37x37 47 TM1 P => L N/A N/A Smith MW et al (1997)
ccr2_human 1.39x39 49 TM1 Y => F N/A N/A Berkhout TA et al (2003)
ccr2_human 1.39x39 49 TM1 Y => L N/A N/A Berkhout TA et al (2003)
ccr2_human 1.39x39 49 TM1 Y => Q N/A N/A Berkhout TA et al (2003)
ccr2_human 1.39x39 49 TM1 Y => R N/A N/A Berkhout TA et al (2003)
ccr2_human 1.54x54 64 TM1 V => I N/A N/A Petersen DC et al (2002)
ccr2_human 1.54x54 64 TM1 V => I N/A N/A Kostrikis LG et al (1998)
ccr2_human 2.49x49 87 TM2 S => A N/A N/A Smith MW et al (1997)
ccr2_human 3.32x32 120 TM3 Y => A N/A N/A Berkhout TA et al (2003)
ccr2_human 3.32x32 120 TM3 Y => H N/A N/A Berkhout TA et al (2003)
ccr2_human 3.33x33 121 TM3 H => A N/A N/A Berkhout TA et al (2003)
ccr2_human 3.33x33 121 TM3 H => F N/A N/A Berkhout TA et al (2003)
ccr2_human 3.33x33 121 TM3 H => R N/A N/A Berkhout TA et al (2003)
ccr2_human 3.51x51 139 TM3 Y => F N/A N/A Rodriguez-Frade JM et al (1999)
ccr2_human 3.51x51 139 TM3 Y => F N/A N/A Mellado M et al (1998)
ccr2_human 5.38x39 202 TM5 H => R N/A N/A Berkhout TA et al (2003)
ccr2_human 6.51x51 259 TM6 Y => H N/A N/A Berkhout TA et al (2003)
ccr2_human 6.52x52 260 TM6 N => N N/A N/A Petersen DC et al (2002)
ccr2_human 6.62x62 270 TM6 E => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 277 ECL3 C => A N/A N/A Monteclaro FS et al (1997)
ccr2_human 7.26x25 278 TM7 E => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => A N/A N/A Hemmerich S et al (1999)
ccr2_human 7.32x31 284 TM7 D => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => A N/A N/A Berkhout TA et al (2003)
ccr2_human 7.32x31 284 TM7 D => K N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => K N/A N/A Berkhout TA et al (2003)
ccr2_human 7.32x31 284 TM7 D => N N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.32x31 284 TM7 D => Q N/A N/A Berkhout TA et al (2003)
ccr2_human 7.36x35 288 TM7 Q => A N/A N/A Berkhout TA et al (2003)
ccr2_human 7.36x35 288 TM7 Q => T N/A N/A Berkhout TA et al (2003)
ccr2_human 7.38x37 290 TM7 T => A N/A N/A Berkhout TA et al (2003)
ccr2_human 7.39x38 291 TM7 E => A N/A N/A Hemmerich S et al (1999)
ccr2_human 7.39x38 291 TM7 E => A N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.39x38 291 TM7 E => A N/A N/A Berkhout TA et al (2003)
ccr2_human 7.39x38 291 TM7 E => K N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.39x38 291 TM7 E => Q N/A N/A Mirzadegan T et al (2000)
ccr2_human 7.39x38 291 TM7 E => Q N/A N/A Berkhout TA et al (2003)
ccr2_human 7.39x38 291 TM7 E => T N/A N/A Berkhout TA et al (2003)
ccr2_human 7.40x39 292 TM7 T => A N/A N/A Berkhout TA et al (2003)
ccr2_human 7.40x39 292 TM7 T => Y N/A N/A Berkhout TA et al (2003)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K K L K ICL1ECL1 E W V F ECL1ICL2 A V F A L K A R ICL2ECL2 K C Q K E D S V Y V C G P Y F ECL2ICL3 R ICL3ECL3 L S N C ECL3N-term M L S T S R S R F I R N T N E S G E E V T T F F D Y D Y G A P C H K F D N-termC-term G C R I A P L Q K P V C G G P G V R P G K N V K V T T Q G L L D G R G K G K S I G R A P E A S L Q D K E G A C-term V K Q I G A Q L L P P L Y S L V F I F G F V G N M L V V L I L I N C C L T D I Y L L N L A I S D L L F L I T L P L W A H S A A N G N A M C K L F T G L Y H I G Y F G G I F F I I L L T I D R Y L A I V H T V T F G V V T S V I T W L V A V F A S V P G I I F T P R G W N N F H T I M R N I L G L V L P L L I M V I C Y S G I L K T L L R C N E K K R H R A V R V I F T I M I V Y F L F W T P Y N I V I L L N T F Q E F F G E S T S Q L D Q A T Q V T E T L G M T H C C I N P I I Y A F V G E K F H I F R S L A L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
M N G V F G F I F V L S Y L P P L L Q A 1 L N L A I S D L L F L I T L P L W A H S 2 L I I F F I G G F Y G I H Y L G T F L K 3 G V V T S V I T W L V A V F A S V P G 4 Y C I V M I L L P L V L G L I N R M I T H 5 F T I M I V Y F L F W T P Y N I V I L L 6 I P N I C C H T M G L T E T V Q T A Q 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
CCR2
TM1
1x28 1.28x28 K38
1x37 1.37x37 P47
1x39 1.39x39 Y49
1x54 1.54x54 V64
TM2
2x49 2.49x49 S87
2x57 2.57x57 L95
2x60 2.60x60 W98
TM3
3x29 3.29x29 T117
3x32 3.32x32 Y120
3x33 3.33x33 H121
3x51 3.51x51 Y139
TM5
5x39 5.38x39 H202
TM6
6x51 6.51x51 Y259
6x52 6.52x52 N260
6x55 6.55x55 I263
6x62 6.62x62 E270
TM7
7x25 7.26x25 E278
7x31 7.32x31 D284
7x33 7.34x33 A286
7x35 7.36x35 Q288
7x37 7.38x37 T290
7x38 7.39x38 E291
7x39 7.40x39 T292
7x45 7.45x45 H297