Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd1_human 2.50x50 70 TM2 D => V N/A N/A Tomic M et al (1993)
drd1_human 2.61x60 81 TM2 K => E N/A N/A Tomic M et al (1993)
drd1_human 5.42x43 198 TM5 S => A N/A N/A Pollock NJ et al (1992)
drd1_human 5.43x44 199 TM5 S => A N/A N/A Pollock NJ et al (1992)
drd1_human 5.46x461 202 TM5 S => A N/A N/A Pollock NJ et al (1992)
drd1_human 6.46x46 283 TM6 C => V N/A N/A Tomic M et al (1993)
drd1_human 7.41x40 319 TM7 F => L N/A N/A Tomic M et al (1993)
drd1_human 7.43x42 321 TM7 W => Y N/A N/A Tomic M et al (1993)
drd1_human 347 C-term C => G N/A N/A Jensen AA et al (1995)
drd1_human 351 C-term C => G N/A N/A Jensen AA et al (1995)
drd1_human 6.27x27 264 TM6 F => I N/A N/A Charpentier S et al (1996)
drd1_human 6.29x29 266 TM6 R => K N/A N/A Charpentier S et al (1996)
drd1_human 5.49x49 205 TM5 I => A N/A N/A Cho W et al (1996)
drd1_human 5.49x49 205 TM5 I => Y N/A N/A Cho W et al (1996)
drd1_human 6.49x49 286 TM6 L => A N/A N/A Cho W et al (1996)
drd1_human 6.49x49 286 TM6 L => Y N/A N/A Cho W et al (1996)
drd1_human 347 C-term C => A N/A N/A Manoach DS et al (1997)
drd1_human 351 C-term C => A N/A N/A Manoach DS et al (1997)
drd1_human 12.52x52 56 ICL1 S => L N/A N/A Jin H et al (1998)
drd1_human 347 C-term C => A N/A N/A Jin H et al (1997)
drd1_human 351 C-term C => A N/A N/A Jin H et al (1997)
drd1_human 412 C-term P => I N/A N/A Demchyshyn LL et al (2000)
drd1_human 412 C-term P => A N/A N/A Demchyshyn LL et al (2000)
drd1_human 5 N-term N => Q N/A N/A Karpa KD et al (1999)
drd1_human 6.27x27 264 TM6 F => I N/A N/A Charpentier S et al (1996)
drd1_human 6.29x29 266 TM6 R => K N/A N/A Charpentier S et al (1996)
drd1_human 347 C-term C => G N/A N/A Jensen AA et al (1995)
drd1_human 351 C-term C => G N/A N/A Jensen AA et al (1995)
drd1_human 428 C-term T => V N/A N/A Rankin ML et al (2006)
drd1_human 431 C-term S => A N/A N/A Rankin ML et al (2006)
drd1_human 347 C-term C => G 1.107↑ K(i) (Binding - Radioligand competition/displacement) (S)-BULBOCAPNINE Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.336↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL157913 Jensen AA et al (1995) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 12.658↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.912↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => A 1.698↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Cho W et al (1996) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => Y 24.39↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => A 1.284↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => Y 7.752↓ K(i) (Binding - Radioligand competition/displacement) (R)-SKF-38393 Cho W et al (1996) Vass M et al (2019)
drd1_human 347 C-term C => G 1.091↓ K(i) (Binding - Radioligand competition/displacement) spiperone Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.582↓ K(i) (Binding - Radioligand competition/displacement) spiperone Jensen AA et al (1995) Vass M et al (2019)
drd1_human 6.27x27 264 TM6 F => I 1.0 K(d) (Binding - Radioligand saturation) CHEMBL290118 Charpentier S et al (1996) Vass M et al (2019)
drd1_human 6.29x29 266 TM6 R => K 1.0 K(d) (Binding - Radioligand saturation) CHEMBL290118 Charpentier S et al (1996) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 4.525↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.214↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => A 1.769↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Cho W et al (1996) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => Y 21.739↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => Y 12.195↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL317741 Cho W et al (1996) Vass M et al (2019)
drd1_human 347 C-term C => G 1.047↓ K(i) (Binding - Radioligand competition/displacement) clozapine Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.143↓ K(i) (Binding - Radioligand competition/displacement) clozapine Jensen AA et al (1995) Vass M et al (2019)
drd1_human 347 C-term C => A 1.11↑ K(i) (Binding - Radioligand competition/displacement) haloperidol Jin H et al (1997) Vass M et al (2019)
drd1_human 351 C-term C => A 1.261↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Jin H et al (1997) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 9.091↓ K(i) (Binding - Radioligand competition/displacement) flupentixol Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.34↓ K(i) (Binding - Radioligand competition/displacement) flupentixol Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 347 C-term C => G 1.5↑ K(i) (Binding - Radioligand competition/displacement) flupentixol Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.429↑ K(i) (Binding - Radioligand competition/displacement) flupentixol Jensen AA et al (1995) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => A 1.754↓ K(i) (Binding - Radioligand competition/displacement) flupentixol Cho W et al (1996) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => Y 1.452↑ K(i) (Binding - Radioligand competition/displacement) flupentixol Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => A 1.555↓ K(i) (Binding - Radioligand competition/displacement) flupentixol Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => Y 2.0↓ K(i) (Binding - Radioligand competition/displacement) flupentixol Cho W et al (1996) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 9.174↓ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 4.717↓ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.61x60 81 TM2 K => E 1.795↓ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 9.901↓ K(i) (Binding - Radioligand competition/displacement) dopamine Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 47.619↓ K(i) (Binding - Radioligand competition/displacement) dopamine Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => A 1.316↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1996) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => Y 50.0↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1996) Vass M et al (2019)
drd1_human 6.27x27 264 TM6 F => I 1.902↑ K(i) (Binding - Radioligand competition/displacement) dopamine Charpentier S et al (1996) Vass M et al (2019)
drd1_human 6.29x29 266 TM6 R => K 1.358↑ K(i) (Binding - Radioligand competition/displacement) dopamine Charpentier S et al (1996) Vass M et al (2019)
drd1_human 6.46x46 283 TM6 C => V 2.309↓ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => A 1.583↑ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => Y 3.425↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1996) Vass M et al (2019)
drd1_human 7.41x40 319 TM7 F => L 1.017↑ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.43x42 321 TM7 W => Y 1.256↓ K(i) (Binding - Radioligand competition/displacement) dopamine Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 2.915↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 1.121↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.61x60 81 TM2 K => E 1.536↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 5.42x43 198 TM5 S => A Abolished effect K(m) (Binding - Radioligand saturation) SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 27.778↓ K(m) (Binding - Radioligand saturation) SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.183↓ K(m) (Binding - Radioligand saturation) SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 6.46x46 283 TM6 C => V 1.805↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.41x40 319 TM7 F => L 1.074↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.43x42 321 TM7 W => Y 2.506↓ K(d) (Binding - Radioligand saturation) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 347 C-term C => G 1.067↑ K(d) (Binding - Radioligand saturation) SCH-23390 Jensen AA et al (1995) Vass M et al (2019)
drd1_human 347 C-term C => A 1.3↓ K(d) (Binding - Radioligand saturation) SCH-23390 Jin H et al (1997) Vass M et al (2019)
drd1_human 351 C-term C => G 1.0 K(d) (Binding - Radioligand saturation) SCH-23390 Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => A 1.277↓ K(d) (Binding - Radioligand saturation) SCH-23390 Jin H et al (1997) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => A 1.919↑ K(d) (Binding - Radioligand saturation) SCH-23390 Cho W et al (1996) Vass M et al (2019)
drd1_human 5.49x49 205 TM5 I => Y 7.299↓ K(d) (Binding - Radioligand saturation) SCH-23390 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => A 1.55↓ K(d) (Binding - Radioligand saturation) SCH-23390 Cho W et al (1996) Vass M et al (2019)
drd1_human 6.49x49 286 TM6 L => Y 2.538↓ K(d) (Binding - Radioligand saturation) SCH-23390 Cho W et al (1996) Vass M et al (2019)
drd1_human 12.52x52 56 ICL1 S => L 2.304↑ K(d) (Binding - Radioligand saturation) SCH-23390 Jin H et al (1998) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 4.762↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 1.103↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.61x60 81 TM2 K => E 1.859↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 71.429↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.377↑ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 6.46x46 283 TM6 C => V 1.715↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.41x40 319 TM7 F => L 1.25↑ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.43x42 321 TM7 W => Y 2.915↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 347 C-term C => G 1.211↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Jensen AA et al (1995) Vass M et al (2019)
drd1_human 347 C-term C => A 1.256↑ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Jin H et al (1997) Vass M et al (2019)
drd1_human 351 C-term C => G 1.727↑ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => A 1.504↓ K(i) (Binding - Radioligand competition/displacement) SCH-23390 Jin H et al (1997) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 1.122↓ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.50x50 70 TM2 D => V 1.267↑ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 2.61x60 81 TM2 K => E 1.342↓ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 5.43x44 199 TM5 S => A 5.495↓ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 5.46x461 202 TM5 S => A 1.719↑ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Pollock NJ et al (1992) Vass M et al (2019)
drd1_human 6.46x46 283 TM6 C => V 4.032↓ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.41x40 319 TM7 F => L 1.108↑ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 7.43x42 321 TM7 W => Y 2.024↓ K(i) (Binding - Radioligand competition/displacement) (+)-SCH-23390 Tomic M et al (1993) Vass M et al (2019)
drd1_human 347 C-term C => G 1.025↓ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.379↑ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Jensen AA et al (1995) Vass M et al (2019)
drd1_human 347 C-term C => G 1.4↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.167↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Jensen AA et al (1995) Vass M et al (2019)
drd1_human 6.27x27 264 TM6 F => I 1.163↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Charpentier S et al (1996) Vass M et al (2019)
drd1_human 6.29x29 266 TM6 R => K 1.274↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Charpentier S et al (1996) Vass M et al (2019)
drd1_human 347 C-term C => A 1.205↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Jin H et al (1997) Vass M et al (2019)
drd1_human 351 C-term C => A 1.339↓ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Jin H et al (1997) Vass M et al (2019)
drd1_human 347 C-term C => G 1.0 K(i) (Binding - Radioligand competition/displacement) eticlopride Jensen AA et al (1995) Vass M et al (2019)
drd1_human 351 C-term C => G 1.0 K(i) (Binding - Radioligand competition/displacement) eticlopride Jensen AA et al (1995) Vass M et al (2019)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM2
2x50 2.50x50 D70
2x60 2.61x60 K81
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
5x49 5.49x49 I205
TM6
6x27 6.27x27 F264
6x29 6.29x29 R266
6x46 6.46x46 C283
6x49 6.49x49 L286
TM7
7x40 7.41x40 F319
7x42 7.43x42 W321