Mutant Browser

Download
Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A 6.623↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 14.706↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A 15.152↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.513↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 6.757↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 5.888↑ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D 76.923↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <111.111↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A 2.088↓ pEC50 (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) biphenylindanone A Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A 1.318↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 2.288↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.202↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 2.817↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V 2.513↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A 1.862↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 1.072↑ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D <15.385↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <15.385↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-35814376 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A 3.021↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 4.274↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A 18.182↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.445↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 4.274↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V 4.274↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 1.349↑ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D 23.81↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <76.923↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A 3.311↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-40068782 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 3.236↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A <62.5↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.122↑ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 3.086↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V 2.137↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 1.905↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D <62.5↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <62.5↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL1669400 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A <55.556↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.148↑ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V <55.556↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V 1.047↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A <55.556↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D <55.556↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <55.556↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL594334 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A 142.857↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.122↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 3.717↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 14.493↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D 27.778↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A 32.258↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A 1.779↓ pEC50 (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) CHEMBL4103808 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A 58.824↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 3.39↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 7.576↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 6.024↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D 26.316↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A 9.524↓ pEC50 (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) JNJ-46281222 Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 1.548↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A 7.752↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.148↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 5.618↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V 2.571↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A 2.571↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A 3.021↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D 27.778↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <90.909↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A 1.096↓ pEC50 (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) THIIC Farinha A et al (2015)
grm2_human 2.49x49 616 TM2 C => S Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 2.55x55 622 TM2 I => F Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.32x32 635 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.33x33 636 TM3 R => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.36x36 639 TM3 L => A 4.167↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.38x38 641 TM3 T => S Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.39x39 642 TM3 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.40x40 643 TM3 F => A <58.824↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 3.41x41 644 TM3 S => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.34x34 681 TM4 A => F Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.41x41 688 TM4 S => L 1.175↑ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.42x42 689 TM4 G => V 1.175↑ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.46x46 693 TM4 I => M Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.48x48 695 TM4 V => S Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.49x49 696 TM4 A => V Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 4.53x53 700 TM4 V => L Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 706 ECL2 G => R Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 708 ECL2 E => Y Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 710 ECL2 A => L Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 711 ECL2 P => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 716 ECL2 V => T Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 718 ECL2 T => I Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 45.52x52 723 ECL2 H => V Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.37x37 725 TM5 D => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.38x38 726 TM5 A => S Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.40x40 728 TM5 M => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.42x42 730 TM5 G => I Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.43x43 731 TM5 S => A 5.0↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.44x44 732 TM5 L => A <58.824↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.45x45 733 TM5 A => T Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D <58.824↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.48x48 736 TM5 V => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.52x52 740 TM5 A => I Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 6.50x50 773 TM6 W => A <58.824↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 6.53x53 776 TM6 F => A <58.824↓ pEC50 (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 6.57x57 780 TM6 F => A Unchanged Single-point (Functional - [35S]GPTγS binding) 4-MPPTS Farinha A et al (2015)
grm2_human 5.47x47 735 TM5 N => D Abolished effect Single-point (Functional - Ca2+ accumulation) biphenylindanone A Hemstapat K et al (2007)
grm2_human 5.47x47 735 TM5 N => D Decreased effect Single-point (Functional - Ca2+ accumulation) 4-MPPTS Hemstapat K et al (2007)
grm2_human 5.47x47 735 TM5 N => D 1.14↓ IC50 (Functional - Ca2+ accumulation) MNI-135 Hemstapat K et al (2007)
grm2_human 5.47x47 735 TM5 N => D 1.046↓ IC50 (Functional - Ca2+ accumulation) MNI-136 Hemstapat K et al (2007)
grm2_human 5.47x47 735 TM5 N => D 1.49↓ IC50 (Functional - Ca2+ accumulation) CHEMBL5085417 Hemstapat K et al (2007)
grm2_human 4.34x34 681 TM4 A => F 1.149↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 4.41x41 688 TM4 S => L 1.065↑ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 4.42x42 689 TM4 G => V 1.164↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 45.52x52 723 ECL2 H => V 1.164↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 5.42x42 730 TM5 G => I 1.034↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 5.45x45 733 TM5 A => T 1.045↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 5.47x47 735 TM5 N => D 3.413↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 5.52x52 740 TM5 A => I 1.122↓ Single-point (Functional - IP accumulation) CHEMBL361358 Rowe BA et al (2008)
grm2_human 4.34x34 681 TM4 A => F 1.154↑ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 4.41x41 688 TM4 S => L 1.244↑ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 4.42x42 689 TM4 G => V 1.154↑ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 45.52x52 723 ECL2 H => V 1.258↓ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 5.42x42 730 TM5 G => I 1.068↓ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 5.45x45 733 TM5 A => T 1.09↑ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 5.47x47 735 TM5 N => D 5.587↓ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
grm2_human 5.52x52 740 TM5 A => I 1.115↓ Single-point (Functional - IP accumulation) 4-MPPTS Schaffhauser H et al (2003)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM2
2x53 2.49x49 C616
2x59 2.55x55 I622
TM3
3x28 3.32x32 R635
3x29 3.33x33 R636
3x32 3.36x36 L639
3x34 3.38x38 T641
3x35 3.39x39 A642
3x36 3.40x40 F643
3x37 3.41x41 S644
TM4
4x44 4.34x34 A681
4x51 4.41x41 S688
4x52 4.42x42 G689
4x56 4.46x46 I693
4x58 4.48x48 V695
4x59 4.49x49 A696
4x63 4.53x53 V700
TM5
5x37 5.37x37 D725
5x38 5.38x38 A726
5x40 5.40x40 M728
5x42 5.42x42 G730
5x43 5.43x43 S731
5x44 5.44x44 L732
5x45 5.45x45 A733
5x47 5.47x47 N735
5x48 5.48x48 V736
5x52 5.52x52 A740
TM6
6x48 6.50x50 W773
6x51 6.53x53 F776
6x55 6.57x57 F780