Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
grm2_rat 2.49x49 616 TM2 C => S 1.038↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 2.50x50 617 TM2 Y => F 1.309↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 2.53x53 620 TM2 T => A 1.25↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.32x32 635 TM3 R => A 15.152↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.33x33 636 TM3 R => A 4.149↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.36x36 639 TM3 L => A 1.2↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.39x39 642 TM3 A => S 1.055↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.40x40 643 TM3 F => A 19.231↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.41x41 644 TM3 S => A 1.122↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 3.44x44 647 TM3 Y => V 2.874↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 45.52x52 723 ECL2 H => F 2.89↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 45.52x52 723 ECL2 H => V 8.197↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 5.40x40 728 TM5 M => A 3.056↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 5.43x43 731 TM5 S => A 1.41↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 5.44x44 732 TM5 L => A 9.091↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 5.47x47 735 TM5 N => D 1.381↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 5.48x48 736 TM5 V => A 2.037↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.46x46 769 TM6 T => S 2.391↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.46x46 769 TM6 T => V 2.037↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.50x50 773 TM6 W => A 166.667↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.50x50 773 TM6 W => F 11.364↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.54x54 777 TM6 L => A 1.122↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 6.57x57 780 TM6 F => A 7.937↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 7.31x32 793 TM7 T => A 1.058↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 7.32x33 794 TM7 M => A 1.41↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 7.33x34 795 TM7 C => A 1.618↑ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 7.35x36 797 TM7 S => A 1.272↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 7.36x37 798 TM7 V => A 1.473↓ IC50 (Functional - Ca2+ accumulation) RO4988546 Lundstrom L et al (2011)
grm2_rat 2.49x49 616 TM2 C => S 1.281↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 2.50x50 617 TM2 Y => F 1.079↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 2.53x53 620 TM2 T => A 1.035↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.32x32 635 TM3 R => A 2.342↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.33x33 636 TM3 R => A >90.909↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.36x36 639 TM3 L => A 1.745↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.39x39 642 TM3 A => S 1.58↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.40x40 643 TM3 F => A 1.193↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.41x41 644 TM3 S => A 1.131↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 3.44x44 647 TM3 Y => V 2.342↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 45.52x52 723 ECL2 H => F 28.571↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 45.52x52 723 ECL2 H => V 8.197↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 5.40x40 728 TM5 M => A 3.257↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 5.43x43 731 TM5 S => A 1.046↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 5.44x44 732 TM5 L => A 30.303↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 5.47x47 735 TM5 N => D 1.272↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 5.48x48 736 TM5 V => A 2.151↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.46x46 769 TM6 T => S 1.129↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.46x46 769 TM6 T => V 1.2↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.50x50 773 TM6 W => A Abolished effect IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.50x50 773 TM6 W => F 1.859↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.54x54 777 TM6 L => A 1.046↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 6.57x57 780 TM6 F => A 1.267↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 7.31x32 793 TM7 T => A 1.14↑ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 7.32x33 794 TM7 M => A 1.088↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 7.33x34 795 TM7 C => A 1.157↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 7.35x36 797 TM7 S => A 1.527↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 7.36x37 798 TM7 V => A 5.495↓ IC50 (Functional - Ca2+ accumulation) RO5488608 Lundstrom L et al (2011)
grm2_rat 146 N-term D => S N/A N/A Kubo Y et al (1998)
grm2_rat 12.53x53 601 ICL1 S => A N/A N/A Schaffhauser H et al (2000)
grm2_rat 4.28x28 675 TM4 S => A N/A N/A Schaffhauser H et al (2000)
grm2_rat 837 C-term S => A N/A N/A Schaffhauser H et al (2000)
grm2_rat 843 C-term S => A N/A N/A Schaffhauser H et al (2000)
grm2_rat 843 C-term S => G N/A N/A Schaffhauser H et al (2000)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M E S L L G F L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E E C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H S D A P T A V T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A T Q R L N A S F T W V A S D G W G A L E S V V A G S E R A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E E R F H C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T H L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T D D E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S F I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A P R A S A N L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F V F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V A A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F V F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V A A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM2
2x53 2.49x49 C616
2x54 2.50x50 Y617
2x57 2.53x53 T620
TM3
3x28 3.32x32 R635
3x29 3.33x33 R636
3x32 3.36x36 L639
3x35 3.39x39 A642
3x36 3.40x40 F643
3x37 3.41x41 S644
3x40 3.44x44 Y647
TM4
4x38 4.28x28 S675
TM5
5x40 5.40x40 M728
5x43 5.43x43 S731
5x44 5.44x44 L732
5x47 5.47x47 N735
5x48 5.48x48 V736
TM6
6x44 6.46x46 T769
6x48 6.50x50 W773
6x52 6.54x54 L777
6x55 6.57x57 F780
TM7
7x37 7.31x32 T793
7x38 7.32x33 M794
7x39 7.33x34 C795
7x41 7.35x36 S797
7x42 7.36x37 V798