Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
mshr_human 3.25x25 117 TM3 D => A N/A N/A Frandberg PA et al (1994)
mshr_human 4.60x60 179 TM4 F => A N/A N/A Frandberg PA et al (1994)
mshr_human 5.60x60 209 TM5 H => A N/A N/A Frandberg PA et al (1994)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Frandberg PA et al (1994)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.60x60 179 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 183 ECL2 Y => A N/A N/A Yang Yk et al (1997)
mshr_human 4.63x63 182 TM4 Y => A N/A N/A Yang Yk et al (1997)
mshr_human 5.46x46 195 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 7.35x34 280 TM7 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6 N-term S => A N/A N/A Chhajlani V et al (1996)
mshr_human 2.68x68 102 TM2 E => A N/A N/A Chhajlani V et al (1996)
mshr_human 3.17x17 109 TM3 R => A N/A N/A Chhajlani V et al (1996)
mshr_human 184 ECL2 D => A N/A N/A Chhajlani V et al (1996)
mshr_human 269 ECL3 E => A N/A N/A Chhajlani V et al (1996)
mshr_human 272 ECL3 T => A N/A N/A Chhajlani V et al (1996)
mshr_human 34.52x52 151 ICL2 R => C N/A N/A Frandberg PA et al (1998)
mshr_human 2.58x58 92 TM2 V => M N/A N/A Xu X et al (1996)
mshr_human 5.64x64 213 TM5 R => A N/A N/A Frandberg PA et al (1998)
mshr_human 5.68x68 217 TM5 H => A N/A N/A Frandberg PA et al (1998)
mshr_human 5.74x74 223 TM5 R => A N/A N/A Frandberg PA et al (1998)
mshr_human 5.77x77 226 TM5 K => A N/A N/A Frandberg PA et al (1998)
mshr_human 227 ICL3 R => A N/A N/A Frandberg PA et al (1998)
mshr_human 228 ICL3 Q => A N/A N/A Frandberg PA et al (1998)
mshr_human 229 ICL3 R => A N/A N/A Frandberg PA et al (1998)
mshr_human 232 ICL3 H => A N/A N/A Frandberg PA et al (1998)
mshr_human 6.27x27 233 TM6 Q => A N/A N/A Frandberg PA et al (1998)
mshr_human 6.32x32 238 TM6 K => A N/A N/A Frandberg PA et al (1998)
mshr_human 35 N-term C => G N/A N/A Frandberg PA et al (2001)
mshr_human 35 N-term C => S N/A N/A Frandberg PA et al (2001)
mshr_human 1.54x54 60 TM1 V => L N/A N/A Schioth HB et al (1999)
mshr_human 2.41x41 75 TM2 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 2.44x44 78 TM2 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 2.45x45 79 TM2 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 2.49x49 83 TM2 S => F N/A N/A Prusis P et al (1997)
mshr_human 2.50x50 84 TM2 D => E N/A N/A Valverde P et al (1996)
mshr_human 2.50x50 84 TM2 D => E N/A N/A Koppula SV et al (1997)
mshr_human 2.50x50 84 TM2 D => E N/A N/A Prusis P et al (1997)
mshr_human 2.50x50 84 TM2 D => E N/A N/A Ringholm A et al (2004)
mshr_human 2.57x57 91 TM2 N => D N/A N/A Valverde P et al (1996)
mshr_human 2.58x58 92 TM2 V => M N/A N/A Valverde P et al (1996)
mshr_human 2.58x58 92 TM2 V => M N/A N/A Koppula SV et al (1997)
mshr_human 2.58x58 92 TM2 V => M N/A N/A Prusis P et al (1997)
mshr_human 2.58x58 92 TM2 V => M N/A N/A Ringholm A et al (2004)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => K N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => K N/A N/A Prusis P et al (1997)
mshr_human 2.60x60 94 TM2 E => R N/A N/A Prusis P et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Schioth HB et al (1999)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Schioth HB et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Prusis P et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => L N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.33x33 125 TM3 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 3.33x33 125 TM3 C => R N/A N/A Prusis P et al (1997)
mshr_human 3.41x41 133 TM3 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 3.50x50 142 TM3 R => H N/A N/A Schioth HB et al (1999)
mshr_human 34.52x52 151 ICL2 R => C N/A N/A Schioth HB et al (1999)
mshr_human 34.52x52 151 ICL2 R => C N/A N/A Frandberg PA et al (1998)
mshr_human 4.41x41 160 TM4 R => W N/A N/A Schioth HB et al (1999)
mshr_human 4.44x44 163 TM4 R => Q N/A N/A Ringholm A et al (2004)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.60x60 179 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.60x60 179 TM4 F => A N/A N/A Prusis P et al (1997)
mshr_human 4.63x63 182 TM4 Y => A N/A N/A Yang Yk et al (1997)
mshr_human 183 ECL2 Y => A N/A N/A Yang Yk et al (1997)
mshr_human 184 ECL2 D => A N/A N/A Chhajlani V et al (1996)
mshr_human 5.42x42 191 TM5 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 5.46x46 195 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.60x60 209 TM5 H => A N/A N/A Prusis P et al (1997)
mshr_human 5.66x66 215 TM5 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 6.47x47 253 TM6 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.52x52 258 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Schioth HB et al (1999)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Frandberg PA et al (1994)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Schioth HB et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Prusis P et al (1997)
mshr_human 6.61x61 267 TM6 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 6.61x61 267 TM6 C => S N/A N/A Frandberg PA et al (2001)
mshr_human 273 ECL3 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 273 ECL3 C => S N/A N/A Frandberg PA et al (2001)
mshr_human 275 ECL3 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 275 ECL3 C => S N/A N/A Frandberg PA et al (2001)
mshr_human 7.35x34 280 TM7 F => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 7.44x43 289 TM7 C => G N/A N/A Frandberg PA et al (2001)
mshr_human 7.49x49 294 TM7 D => H N/A N/A Schioth HB et al (1999)
mshr_human 7.49x49 294 TM7 D => H N/A N/A Valverde P et al (1996)
mshr_human 7.49x49 294 TM7 D => H N/A N/A Prusis P et al (1997)
mshr_human 7.49x49 294 TM7 D => H N/A N/A Ringholm A et al (2004)
mshr_human 315 C-term C => G N/A N/A Frandberg PA et al (2001)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 6.54x54 260 TM6 H => A N/A N/A Yang Yk et al (1997)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 6.51x51 257 TM6 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 5.47x47 196 TM5 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 4.56x56 175 TM4 F => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 7.36x35 281 TM7 N => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => K N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => N N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.29x29 121 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 3.25x25 117 TM3 D => A N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 2.60x60 94 TM2 E => A N/A N/A Yang Yk et al (1997)
mshr_human 3.36x36 128 TM3 M => L N/A N/A Yang Y et al (2009)
mshr_human 3.38x38 130 TM3 S => L N/A N/A Yang Y et al (2009)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R N L H ICL1ECL1 A L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R Q R P V H ICL3ECL3 P E H P T C G C I F K ECL3N-term M A V Q G S Q R R L L G S L N S T P T A I P Q L G L A A N Q T G A R C L E V S I N-termC-term L K E V L T C S W C-term S D G L F L S L G L V S L V E N A L V V A T I A K N S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y T L P R A R R A V A A I W V A S V V F S T L F I A Y H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K Q G F G L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N E V L S V L G L S L F L G D S 1 C C L A L S D L L V S G S N V L E T A V 2 A G L F C L S S L M S S C T I V D I V N 3 A R R A V A A I W V A S V V F S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L H L T L 6 L P D I I A N C I I L A L F L N F N 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC1 receptor
TM1
1x54 1.54x54 V60
TM2
2x41 2.41x41 C75
2x44 2.44x44 C78
2x45 2.45x45 C79
2x49 2.49x49 S83
2x50 2.50x50 D84
2x57 2.57x57 N91
2x58 2.58x58 V92
2x60 2.60x60 E94
2x68 2.68x68 E102
TM3
3x17 3.17x17 R109
3x25 3.25x25 D117
3x29 3.29x29 D121
3x33 3.33x33 C125
3x36 3.36x36 M128
3x38 3.38x38 S130
3x41 3.41x41 C133
3x50 3.50x50 R142
TM4
4x41 4.41x41 R160
4x44 4.44x44 R163
4x56 4.56x56 F175
4x60 4.60x60 F179
4x63 4.63x63 Y182
TM5
5x42 5.42x42 C191
5x46 5.46x46 F195
5x47 5.47x47 F196
5x60 5.60x60 H209
5x64 5.64x64 R213
5x66 5.66x66 C215
5x68 5.68x68 H217
5x74 5.74x74 R223
5x77 5.77x77 K226
TM6
6x27 6.27x27 Q233
6x32 6.32x32 K238
6x47 6.47x47 C253
6x51 6.51x51 F257
6x52 6.52x52 F258
6x54 6.54x54 H260
6x61 6.61x61 C267
TM7
7x34 7.35x34 F280
7x35 7.36x35 N281
7x43 7.44x43 C289
7x49 7.49x49 D294