Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
mshr_mouse 2.37x37 69 TM2 S => L N/A N/A Robbins LS et al (1993)
mshr_mouse 2.60x60 92 TM2 E => K N/A N/A Robbins LS et al (1993)
mshr_mouse 2.39x39 71 TM2 M => K N/A N/A Vage DI et al (1999)
mshr_mouse 3.29x29 119 TM3 D => N N/A N/A Vage DI et al (1999)
mshr_mouse 2.60x60 92 TM2 E => K N/A N/A Ling MK et al (2003)
mshr_mouse 2.60x60 92 TM2 E => K N/A N/A Yang Yk et al (1997)
mshr_mouse 2.60x60 92 TM2 E => K N/A N/A Vage DI et al (1999)
mshr_mouse 4.39x39 156 TM4 L => M N/A N/A Yang Y et al (2009)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R N L H ICL1ECL1 I L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y K ECL2ICL3 R R R S I R ICL3ECL3 P Q H P T C S C I F K ECL3N-term M S T Q E P Q K S L L G S L N S N A T S H L G L A T N Q S E P W C L Y V S I N-termC-term L K E V L L C S W C-term P D G L F L S L G L V S L V E N V L V V I A I T K N S P M Y Y F I C C L A L S D L M V S V S I V L E T T I I L L L E A G R V A L V Q Q L D N L I D V L I C G S M V S S L C F L G I I A I D R Y I S I F Y T L P R A R R A V V G I W M V S I V S S T L F I T Y H T A V L L C L V T F F L A M L A L M A I L Y A H M F T R A C Q H A Q G I A Q L H K Q G F C L K G A A T L T I L L G I F F L C W G P F F L H L L L I V L C N F N L F L L L I V L S S T V D P L I Y A F R S Q E L R M T
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N E V L S V L G L S L F L G D P 1 C C L A L S D L M V S V S I V L E T T I 2 I G L F C L S S V M S G C I L V D I L N 3 A R R A V V G I W M V S I V S S T L F I 4 Y L I A M L A L M A L F F T V L C L L V 5 T I L L G I F F L C W G P F F L H L L L 6 L P D V T S S L V I L L L F L N F N 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC1 receptor
TM2
2x37 2.37x37 S69
2x39 2.39x39 M71
2x60 2.60x60 E92
TM3
3x29 3.29x29 D119
TM4
4x39 4.39x39 L156