Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
par2_human 30 N-term N => A N/A N/A Compton SJ et al (2002)
par2_human 36 N-term R => A N/A N/A Mirza H et al (1997)
par2_human 37 N-term S => P N/A N/A Loew D et al (2000)
par2_human 4.46x46 195 TM4 S => A N/A N/A Olivot JM et al (2001)
par2_human 4.46x46 195 TM4 S => A N/A N/A Crago AM et al (1995)
par2_human 4.46x46 195 TM4 S => A N/A N/A Jenkins AL et al (1995)
par2_human 221 ECL2 L => A N/A N/A Compton SJ et al (2002)
par2_human 222 ECL2 N => A N/A N/A Compton SJ et al (2002)
par2_human 222 ECL2 N => Q N/A N/A Compton SJ et al (2002)
par2_human 223 ECL2 I => A N/A N/A Compton SJ et al (2002)
par2_human 8.60x60 361 H8 C => A N/A N/A Botham A et al (2011)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T K K K ICL1ECL1 G N N W I Y ECL1ICL2 P M G H S R K ICL2ECL2 V K Q T I F I P A L N I T T C H D V L P E Q L ECL2ICL3 A M D ICL3ECL3 G Q S H ECL3N-term M R S P S A A W L L G A A I L L A A S L S C S G T I Q G T N R S S K G R S L I G K V D G T S H V T G K G V T V E T V F S V D E F S A S V L T N-termC-term S V R T V K Q M Q V S L T S K K H S R K S S S Y S S S S T T V K T S Y C-term G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N K A N I A I G I S L A I W L L I L L V T I P L Y V L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D A K N R F R D H A L L C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
G N S P L G V V F V I T Y V I P L F V T 1 A N L A L A D L L S V I W F P L K I A Y 2 C T M F L I S C Y M N G Y F F G I L V N 3 A I G I S L A I W L L I L L V T I P L 4 Y A S A T L F A P F L F V G I A L S L F Y 5 I V T V L A M Y I L C F T P S N L L L V V 6 F P D I C S N L T S L C L A V I Y L A 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAR2
TM4
4x46 4.46x46 S195
H8
8x60 8.60x60 C361